tumor necrosis factor ligand superfamily member 13
Summary: A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.
Ware C. APRIL and BAFF connect autoimmunity and cancer. J Exp Med. 2000;192:F35-8 pubmed
McWilliams T, Howard L, Wyatt S, Davies A. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Exp Neurol. 2017;298:97-103 pubmed publisher
Winter O, Mohr E, Manz R. Alternative cell types form a Multi-Component-Plasma-Cell-Niche. Immunol Lett. 2011;141:145-6 pubmed publisher
van Attekum M, Kater A, Eldering E. The APRIL paradox in normal versus malignant B cell biology. Cell Death Dis. 2016;7:e2276 pubmed publisher
Haselmayer P, Vigolo M, Nys J, Schneider P, Hess H. A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells. Eur J Immunol. 2017;47:1075-1085 pubmed publisher
..Targeting plasma cells with TACI-Fc might be beneficial to prevent autoantibody-mediated damages in SLE. ..
Anuradha R, Munisankar S, Bhootra Y, Dolla C, Kumaran P, Nutman T, et al
. Modulation of Mycobacterium tuberculosis-specific humoral immune responses is associated with Strongyloides stercoralis co-infection. PLoS Negl Trop Dis. 2017;11:e0005569 pubmed publisher
..Our data, therefore, reveal that Ss infection is associated with significant modulation of Mtb-specific antibody responses, the levels of B cell growth factors and the numbers of B cells (and their component subsets). ..
Floch P, Izotte J, Guillemaud J, Sifré E, Costet P, Rousseau B, et al
. A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species. Am J Pathol. 2017;187:1473-1484 pubmed publisher
..We believe that APRIL Tg mice infected by Helicobacter species may represent a novel animal model of gastric lymphomagenesis. ..
McCarron M, Park P, Fooksman D. CD138 mediates selection of mature plasma cells by regulating their survival. Blood. 2017;129:2749-2759 pubmed publisher
..We propose a model in which CD138 expression on fully mature ASCs provides a selective survival advantage over less mature, newly minted ASCs, by enhancing pro-survival cytokine signaling. ..
De la Varga Martínez R, Rodríguez Bayona B, Añez G, Medina Varo F, Pérez Venegas J, Brieva J, et al
. Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation. Eur J Immunol. 2017;47:1211-1219 pubmed publisher
..Thus, patients with circulating anti-dsDNA antibody-secreting cells and active disease could potentially benefit from therapies targeting the JAK/STAT3 pathway. ..