stem cell factor

Summary

Summary: A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.

Top Publications

  1. Wils E, Rombouts E, van Mourik I, Spits H, Legrand N, Braakman E, et al. Stem cell factor consistently improves thymopoiesis after experimental transplantation of murine or human hematopoietic stem cells in immunodeficient mice. J Immunol. 2011;187:2974-81 pubmed publisher
    ..b>Stem cell factor (SCF) is essentially involved in early thymopoiesis...
  2. Gibbs B, Yasinska I, Oniku A, Sumbayev V. Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells. PLoS ONE. 2011;6:e22502 pubmed publisher
    b>Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117...
  3. Geslain R, Uddin S, Liu H, Jiang H, Van Besien K, Pan T, et al. Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors. Cytokine. 2013;61:329-35 pubmed publisher
    Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen...
  4. Amagai Y, Tanaka A, Matsuda A, Jung K, Ohmori K, Matsuda H. Stem cell factor contributes to tumorigenesis of mast cells via an autocrine/paracrine mechanism. J Leukoc Biol. 2013;93:245-50 pubmed publisher
    ..These results indicate the possibility that targeting SCF production may become a novel treatment for mast cell malignancies. ..
  5. Horstmann M, Hennenlotter J, Geiger L, Vogel U, Schmid H, Kuehs U, et al. Evaluation of the KIT/stem cell factor axis in renal tumours. Anticancer Res. 2012;32:4339-45 pubmed
    To investigate the expression of the KIT/stem cell factor (SCF) axis in different renal cell carcinoma subtypes with regard to targeted therapies...
  6. Enomoto A, Yoshihisa Y, Yamakoshi T, Ur Rehman M, Norisugi O, Hara H, et al. UV-B radiation induces macrophage migration inhibitory factor-mediated melanogenesis through activation of protease-activated receptor-2 and stem cell factor in keratinocytes. Am J Pathol. 2011;178:679-87 pubmed publisher
    ..In addition, we showed that MIF stimulated stem cell factor (SCF) release in keratinocytes; however, MIF had no effect on the release of endothelin-1 or prostaglandin E2 ..
  7. Billerbeck E, Barry W, Mu K, Dorner M, Rice C, Ploss A. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R?(null) humanized mice. Blood. 2011;117:3076-86 pubmed publisher
    ..immunodeficiency/interleukin-2 receptor-?-null (NOD-SCID IL2R?(null)) mouse strain that expressed human stem cell factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3, termed NSG-SGM3...
  8. Bai C, Hou X, Wang F, Qiu C, Zhu Y, Huang L, et al. Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth. World J Gastroenterol. 2012;18:2929-37 pubmed publisher
    To clarify the biological role of stem cell factor (SCF)-mediated wild-type KIT receptor activation in gastrointestinal stromal tumor (GIST) growth...
  9. Kovacs D, Cardinali G, Aspite N, Cota C, Luzi F, Bellei B, et al. Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo. Br J Dermatol. 2010;163:1020-7 pubmed publisher
    ..the fibroblast-derived growth factors, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) and stem cell factor (SCF) in SL hyperpigmentation; to evaluate whether the photoageing process occurring in fibroblasts could be ..

More Information

Publications62

  1. Krasagakis K, Fragiadaki I, Metaxari M, Kruger Krasagakis S, Tzanakakis G, Stathopoulos E, et al. KIT receptor activation by autocrine and paracrine stem cell factor stimulates growth of merkel cell carcinoma in vitro. J Cell Physiol. 2011;226:1099-109 pubmed publisher
    The co-expression of KIT receptor and its ligand stem cell factor (SCF) has been reported in biopsy specimens of Merkel cell carcinoma (MCC)...
  2. Chen W, Jiang C, Jin X, Shen W, Song B, Li L. Roles of stem cell factor on loss of interstitial cells of Cajal in bladder of diabetic rats. Urology. 2011;78:1443.e1-6 pubmed publisher
    To explore the roles of stem cell factor (SCF) on the loss of interstitial cells (ICCs) in the bladder of diabetic rats, which have not been investigated...
  3. Jeong H, Cui W, Yang Y, Lu J, He J, Li A, et al. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS ONE. 2011;6:e18372 pubmed publisher
    Our previous work shows that the stem cell factor SALL4 plays a central role in embryonic and leukemic stem cells...
  4. Feyerabend T, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, et al. Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity. 2011;35:832-44 pubmed publisher
    ..Differences comparing Kit mutant mast cell deficiency models to selectively mast cell-deficient mice call for a systematic re-evaluation of immunological functions of mast cells beyond allergy. ..
  5. Zhang M, Ma Q, Hu H, Zhang D, Li J, Ma G, et al. Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1? under normoxic condition. Cancer Lett. 2011;303:108-17 pubmed publisher
    ..Therefore, our results suggest that the inhibition of both c-kit and HIF-1? may be an effective strategy for pancreatic cancer therapy. ..
  6. Laidlaw T, Steinke J, Tiñana A, Feng C, Xing W, Lam B, et al. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional Fc?RI. J Allergy Clin Immunol. 2011;127:815-22.e1-5 pubmed publisher
    ..cells derived from a donor with aspirin-exacerbated respiratory disease were cultured for 8 weeks with stem cell factor and IL-6 and with IL-3 for the first week only...
  7. Omatsu Y, Sugiyama T, Kohara H, Kondoh G, Fujii N, Kohno K, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010;33:387-99 pubmed publisher
    ..Thus, the niche composed of adipo-osteogenic progenitors is required for proliferation of HSCs and lymphoid and erythroid progenitors, as well as maintenance of HSCs in an undifferentiated state. ..
  8. Abu El Asrar A, Struyf S, Opdenakker G, Van Damme J, Geboes K. Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes. Mol Vis. 2010;16:1098-107 pubmed
    b>Stem cell factor (SCF)/c-kit signaling promotes recruitment of endothelial progenitor cells and contributes to ischemia-induced new vessel formation...
  9. Airiau K, Mahon F, Josselin M, Jeanneteau M, Belloc F. PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor. Cell Death Dis. 2013;4:e827 pubmed publisher
    ..We previously demonstrated that nilotinib-induced apoptosis was reduced by stem cell factor (SCF) addition. Here, the SCF-activated survival pathway was investigated...
  10. Cuchiara M, Horter K, Banda O, West J. Covalent immobilization of stem cell factor and stromal derived factor 1? for in vitro culture of hematopoietic progenitor cells. Acta Biomater. 2013;9:9258-69 pubmed publisher
    ..immobilized a fibronectin-derived adhesive peptide sequence, RGDS; a cytokine critical in HSC self-renewal, stem cell factor (SCF); and a chemokine important in HSC homing and lodging, stromal derived factor 1? (SDF1?), onto the ..
  11. Gagne J, Clark S. The Arabidopsis stem cell factor POLTERGEIST is membrane localized and phospholipid stimulated. Plant Cell. 2010;22:729-43 pubmed publisher
    ..Significantly, the findings presented here suggest that phospholipids play an important role in promoting stem cell specification. ..
  12. Zeuner A, Francescangeli F, Signore M, Venneri M, Pedini F, Felli N, et al. The Notch2-Jagged1 interaction mediates stem cell factor signaling in erythropoiesis. Cell Death Differ. 2011;18:371-80 pubmed publisher
    b>Stem cell factor (SCF), the ligand for the c-kit receptor, is essential for the production of red blood cells during development and stress erythropoiesis...
  13. Meng F, Francis H, Glaser S, Han Y, Demorrow S, Stokes A, et al. Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology. 2012;55:209-21 pubmed publisher
    ..g., post-transplantation) by functional deregulation of the activity of key signaling intermediates involved in cell expansion and multipotent differentiation. ..
  14. Deng J, Liu X, Yuan Q. [Effect of acupuncture on gastrointestinal stem cell factor/kit system after colocolic anastomosis in rats]. Zhen Ci Yan Jiu. 2011;36:176-80 pubmed
    To observe the effect of acupuncture on colonic stem cell factor (SCF)-receptor tyrosine kinase (Kit, a transmembrane protein c-kit) system in colocolic anastomosis rats so as to explore its underlying mechanism in regulating intestinal ..
  15. Piao C, Li B, Zhang L, Zhao L. Stem cell factor and granulocyte colony-stimulating factor promote neuronal lineage commitment of neural stem cells. Differentiation. 2012;83:17-25 pubmed publisher
    b>Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) were originally discovered as growth factors for hematopoietic stem cells (HSCs)...
  16. Dolgachev V, Petersen B, Budelsky A, Berlin A, Lukacs N. Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. J Immunol. 2009;183:5705-15 pubmed publisher
    In the present studies local neutralization of allergen-induced stem cell factor (SCF) leads to decreased production of Th2 cytokines, a reduction in inflammation, allergen-specific serum IgE/IgG1, and attenuation of severe asthma-like ..
  17. Lennartsson J, Ronnstrand L. Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev. 2012;92:1619-49 pubmed publisher
    b>Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction...
  18. Yaniz Galende E, Chen J, Chemaly E, Liang L, Hulot J, McCollum L, et al. Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circ Res. 2012;111:1434-45 pubmed publisher
    ..To determine whether stem cell factor gene transfer mediates cardiac regeneration in a rat myocardial infarction model, through survival and ..
  19. Stokman G, Stroo I, Claessen N, Teske G, Weening J, Leemans J, et al. Stem cell factor expression after renal ischemia promotes tubular epithelial survival. PLoS ONE. 2010;5:e14386 pubmed publisher
    ..The cytokine stem cell factor (SCF) has been shown to protect the tubular epithelium against apoptosis...
  20. Salmassi A, Zorn S, Mettler L, Koch K, Jonat W, Schmutzler A. Circulating concentration of stem cell factor in serum of stimulated IVF patients. Reprod Biomed Online. 2011;22:140-7 pubmed publisher
    b>Stem cell factor (SCF) plays a major role in haematopoiesis and spermatogenesis, and possibly female fertility. This study investigated the role of changes in SCF concentrations in 74 assisted conception patients...
  21. Ding L, Saunders T, Enikolopov G, Morrison S. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481:457-62 pubmed publisher
    ..Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF; also known as KITL) is a key niche component that maintains HSCs...
  22. Waltari M, Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, et al. Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma. Int J Cancer. 2011;129:619-28 pubmed publisher
    ..Presence of MCPyV DNA was assessed using quantitative PCR; p53, KIT, phospho-KIT, stem cell factor (SCF) and PDGFR? expression using immunohistochemistry and presence of mutations in KIT exons 9, 11, 13 and ..
  23. Wu Y, Li J, Saleem S, Yee S, Hardikar A, Wang R. c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Lab Invest. 2010;90:1373-84 pubmed publisher
    Recent evidence has shown that stem cell factor (SCF) and its receptor, c-Kit, have an important role in pancreatic islet development by promoting islet cell differentiation and proliferation...
  24. Ding L, Dolgachev V, Wu Z, Liu T, Nakashima T, Wu Z, et al. Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis. J Pathol. 2013;230:205-14 pubmed publisher
    b>Stem cell factor (SCF) and its receptor c-Kit have been implicated in tissue remodelling and fibrosis. Alveolar fibroblasts from patients with diffuse interstitial fibrosis secrete more SCF. However, its precise role remains unclear...
  25. Doycheva D, Shih G, CHEN H, Applegate R, Zhang J, Tang J. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a solitary treatment. Transl Stroke Res. 2013;4:171-8 pubmed publisher
    ..b>Stem cell factor (SCF) regulates hematopoietic stem cells in the bone marrow and has been reported to have neuroprotective ..
  26. Rovasio R, Faas L, Battiato N. Insights into stem cell factor chemotactic guidance of neural crest cells revealed by a real-time directionality-based assay. Eur J Cell Biol. 2012;91:375-90 pubmed publisher
    ..We show that the treatment of in vitro NCCs with skin extract (SE) or Stem Cell Factor (SCF) contributes to maintaining proliferative activity, accelerates melanocyte differentiation, and guides a ..
  27. Kratz C, Han S, Rosenberg P, Berndt S, Burdett L, Yeager M, et al. Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour. J Med Genet. 2011;48:473-6 pubmed publisher
    ..These findings imply that familial TGCT and sporadic TGCT share a common genetic basis. ..
  28. Kimura Y, Ding B, Imai N, Nolan D, Butler J, Rafii S. c-Kit-mediated functional positioning of stem cells to their niches is essential for maintenance and regeneration of adult hematopoiesis. PLoS ONE. 2011;6:e26918 pubmed publisher
    ..This c-Kit-mediated cellular adhesion was essential for long-term maintenance and expansion of HSPCs. These results lay the foundation for delivering KL within specific niches to maintain and restore hematopoiesis. ..
  29. Wu Z, Li Y, MacNeil A, Junkins R, Berman J, Lin T. Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. J Immunol. 2013;191:5885-94 pubmed publisher
    The receptor for stem cell factor (SCF) is expressed on mast cells and hematopoietic progenitors. SCF-induced signaling pathways remain incompletely defined...
  30. Polajeva J, Sjösten A, Lager N, Kastemar M, Waern I, Alafuzoff I, et al. Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12. PLoS ONE. 2011;6:e25222 pubmed publisher
    ..In line with these findings, strong expression of stem cell factor (SCF), i.e. the main MC growth factor, was detected, in particular around tumor blood vessels...
  31. Levina V, Marrangoni A, Wang T, Parikh S, Su Y, Herberman R, et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res. 2010;70:338-46 pubmed publisher
    ..In this study, we provide evidence that blocking stem cell factor (SCF)-c-kit signaling is sufficient to inhibit CSC proliferation and survival promoted by chemotherapy...
  32. Mengel From J, WONG T, Morling N, Rees J, Jackson I. Genetic determinants of hair and eye colours in the Scottish and Danish populations. BMC Genet. 2009;10:88 pubmed publisher
    ..We have found novel associations with SNPs in known pigmentation genes and colorimetrically assessed hair colour in a Scottish and a Danish population. ..
  33. Yao K, Ge W. Kit system in the zebrafish ovary: evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligand (kitlga and kitlgb) during folliculogenesis. Biol Reprod. 2010;82:1216-26 pubmed publisher
    ..This provides an example for neofunctionalization of duplicated genes in vertebrates. ..
  34. Wen J, Liu J, Song G, Liu L, Tang B, Li Z. Effects of 6-bromoindirubin-3'-oxime on the maintenance of pluripotency of porcine embryonic germ cells in combination with stem cell factor, leukemia inhibitory factor and fibroblast growth factor. Reproduction. 2010;139:1039-46 pubmed publisher
    ..28-day embryos, and were then treated with BIO either individually or in combination with other cytokines (stem cell factor (SCF), leukemia inhibitory factor (LIF), and fibroblast growth factor (FGF); abbreviated as '3F'), and the ..
  35. Izbeki F, Asuzu D, Lorincz A, Bardsley M, Popko L, Choi K, et al. Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol. 2010;588:3101-17 pubmed publisher
    ..Klotho-deficient mice were marantic and had low insulin, insulin-like growth factor-I and membrane-bound stem cell factor. Klotho deficiency accentuated oxidative stress and ICC loss...
  36. Pittoni P, Piconese S, Tripodo C, Colombo M. Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors. Oncogene. 2011;30:757-69 pubmed publisher
    c-Kit tyrosine kinase receptor and its ligand stem cell factor have multiple functions during development, whereas in adulthood they are mostly needed for stem cell (SC) maintenance and mast cell (MC) biology...
  37. Shin J, Kim J, Kim E. Repeated exposure of human fibroblasts to UVR induces secretion of stem cell factor and senescence. J Eur Acad Dermatol Venereol. 2012;26:1577-80 pubmed publisher
    ..After each irradiation, the supernatant medium was isolated from each dish and measured for levels of stem cell factor (SCF) and hepatocyte growth factor using an ELISA kit assay...
  38. Osada T, Watanabe M, Hasuo A, Imai M, Suyama K, Sakai D, et al. Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice. J Neurosurg Spine. 2010;13:516-23 pubmed publisher
    ..b>Stem cell factor (SCF) is also a hematopoietic cytokine that stimulates the differentiation and proliferation of neural stem ..
  39. Matlaf L, Harkins L, Bezrookove V, Cobbs C, Soroceanu L. Cytomegalovirus pp71 protein is expressed in human glioblastoma and promotes pro-angiogenic signaling by activation of stem cell factor. PLoS ONE. 2013;8:e68176 pubmed publisher
    ..Overexpression of pp71 in adult neural precursor cells resulted in potent induction of stem cell factor (SCF), an important pro-angiogenic factor in GBM...
  40. Skaznik Wikiel M, McGuire M, Sukhwani M, Donohue J, Chu T, Krivak T, et al. Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy. Fertil Steril. 2013;99:2045-54.e3 pubmed publisher
    ..gonadal protective properties of granulocyte colony-stimulating factor (G-CSF) alone or in combination with stem cell factor (SCF) in female mice treated with high-dose alkylating chemotherapy. Experimental laboratory animal study...
  41. Sihto H, Tynninen O, Halonen M, Puputti M, Karjalainen Lindsberg M, Kukko H, et al. Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. Histopathology. 2009;55:544-53 pubmed publisher
    To assess KIT receptor tyrosine kinase and stem cell factor (SCF, KIT ligand) expression in tumour microvessel endothelial cells...
  42. Gu Y, Runyan C, Shoemaker A, Surani M, Wylie C. Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration. PLoS ONE. 2011;6:e25984 pubmed publisher
    ..Escape from this niche causes cessation of motility and death by apoptosis of the ectopic germ cells. ..
  43. Nakajima H, Fukazawa K, Wakabayashi Y, Wakamatsu K, Imokawa G. Withania somnifera extract attenuates stem cell factor-stimulated pigmentation in human epidermal equivalents through interruption of ERK phosphorylation within melanocytes. J Nat Med. 2012;66:435-46 pubmed publisher
    ..pigmentation, we used an antioxidant-rich extract of the herb Withania somnifera to assess its effect on stem cell factor (SCF)-stimulated pigmentation in human epidermal equivalents and analyzed its biological mechanism of action...
  44. Miyamoto K, Kobayashi T, Hayashi Y, Zhang Y, Hara Y, Higashine M, et al. Involvement of stem cell factor and c-kit in corneal wound healing in mice. Mol Vis. 2012;18:1505-15 pubmed
    To study the roles played by stem cell factor (SCF) and SCF receptor c-kit in wound healing of corneal epithelial cells...
  45. Ye Z, Gulcicek E, Stone K, Lam T, Schulz V, Weissman S. Complex interactions in EML cell stimulation by stem cell factor and IL-3. Proc Natl Acad Sci U S A. 2011;108:4882-7 pubmed publisher
    ..are an established multipotent hematopoietic precursor cell line that can be maintained in medium including stem cell factor (SCF)...
  46. Nakajima H, Fukazawa K, Wakabayashi Y, Wakamatsu K, Senda K, Imokawa G. Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation. Arch Dermatol Res. 2012;304:803-16 pubmed publisher
    We established a model for the stem cell factor (SCF)-associated stimulation of human epidermal equivalent (HEE) pigmentation. The addition of SCF (at 5 nM) gradually stimulated the visible pigmentation of HEEs over 14 days of treatment...
  47. Elmasri H, Ghelfi E, Yu C, Traphagen S, Cernadas M, Cao H, et al. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012;15:457-68 pubmed publisher
    ..activation of several important signaling pathways in HUVECs, including downregulation of P38, eNOS, and stem cell factor (SCF)/c-kit signaling...
  48. Gagari E, Rand M, Tayari L, Vastardis H, Sharma P, Hauschka P, et al. Expression of stem cell factor and its receptor, c-kit, in human oral mesenchymal cells. Eur J Oral Sci. 2006;114:409-15 pubmed
    b>Stem cell factor (SCF) is the pleiotropic ligand for the tyrosine kinase receptor, c-kit...
  49. Samayawardhena L, Pallen C. Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem. 2008;283:29175-85 pubmed publisher
    ..Bone marrow-derived mast cells (BMMCs) lacking PTPalpha exhibit defective stem cell factor (SCF)-dependent polarization and migration...
  50. Wiesner C, Nabha S, dos Santos E, Yamamoto H, Meng H, Melchior S, et al. C-kit and its ligand stem cell factor: potential contribution to prostate cancer bone metastasis. Neoplasia. 2008;10:996-1003 pubmed
    The tyrosine kinase receptor c-kit and its ligand stem cell factor (SCF) have not been explored in prostate cancer (PC) bone metastasis...
  51. Milenkovic N, Frahm C, Gassmann M, Griffel C, Erdmann B, Birchmeier C, et al. Nociceptive tuning by stem cell factor/c-Kit signaling. Neuron. 2007;56:893-906 pubmed
    ..We demonstrate here a central role for stem cell factor (SCF) and its receptor, c-Kit, in tuning the responsiveness of sensory neurons to natural stimuli...
  52. Ali S, Ali S. Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST). Gene. 2007;401:38-45 pubmed
    ..The Kit ligand-stem cell factor (SCF) induces a rapid and complete receptor dimerization resulting in activation by autophosphorylation of ..
  53. Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, et al. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood. 2007;109:4264-71 pubmed
    ..Thus, our results provide new insights into the mechanisms underlying EPC recruitment and the bases for novel strategies to hinder pathological angiogenesis. ..