Summary: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
Pellegrini S, Sordi V, Bolla A, Saita D, Ferrarese R, Canducci F, et al
. Duodenal Mucosa of Patients With Type 1 Diabetes Shows Distinctive Inflammatory Profile and Microbiota. J Clin Endocrinol Metab. 2017;102:1468-1477 pubmed publisher
..Understanding the mechanisms underlying these features is critical to disentangle the complex pathogenesis of T1D and to gain new perspectives for future therapies targeting the intestine. ..
Jafarnejad M, Zawieja D, Brook B, Nibbs R, Moore J. A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4. J Immunol. 2017;199:2291-2304 pubmed publisher
..Moreover, it acts as a framework to investigate gradients at other locations, including those that cannot be visualized experimentally or involve other chemokines. ..
Termini J, Gupta S, Raffa F, Guirado E, Fischl M, Niu L, et al
. Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion. PLoS ONE. 2017;12:e0184915 pubmed publisher
..Overall, LMP1 matured and activated DC, induced migration to the lymph node, and generated high levels of IL-12p70 in a murine model. We propose LMP1 as a promising molecular adjuvant for DC vaccines. ..
Al Aoukaty A, Rolstad B, Giaid A, Maghazachi A. MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells. Immunology. 1998;95:618-24 pubmed
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Raju R, Gadakh S, Gopal P, George B, Advani J, Soman S, et al
. Differential ligand-signaling network of CCL19/CCL21-CCR7 system. Database (Oxford). 2015;2015: pubmed publisher
..Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46. ..
Penteado L, Dejani N, Verdan F, Orlando A, Niño V, Dias F, et al
. Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions. Immunology. 2017;151:304-313 pubmed publisher
..These data contribute to the understanding of how efferocytosis of sterile or infected cells may regulate the adaptive immune response, although the precise role of PGE2 in this process requires further investigation. ..
Xu B, Zhou M, Qiu W, Ye J, Feng Q. CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway. Cancer Med. 2017;6:1062-1071 pubmed publisher
..Our results suggested that CCR7 may regard as a therapeutic target for the breast cancer treatment. ..
Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson J, et al
. Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen. Infect Immun. 2017;85: pubmed publisher