chemokine cxcl9


Summary: An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.

Top Publications

  1. Shinde P, Liu W, Menoret A, Luster A, Vella A. Optimal CD4 T cell priming after LPS-based adjuvanticity with CD134 costimulation relies on CXCL9 production. J Leukoc Biol. 2017;102:57-69 pubmed publisher
    ..In sum, CXCL9 production is a key benchmark for productive CD4 T cell vaccination strategies. ..
  2. Liu L, Strassner J, Refat M, Harris J, King B. Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure. J Am Acad Dermatol. 2017;77:675-682.e1 pubmed publisher
    ..These results support a model wherein JAK inhibitors suppress T cell mediators of vitiligo and light exposure is necessary for stimulation of melanocyte regeneration. ..
  3. Muller W. New mechanisms and pathways for monocyte recruitment. J Exp Med. 2001;194:F47-51 pubmed
  4. Ganghammer S, Gutjahr J, Hutterer E, Krenn P, Pucher S, Zelle Rieser C, et al. Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors. Haematologica. 2016;101:e99-102 pubmed publisher
  5. Shino M, Weigt S, Li N, Palchevskiy V, Derhovanessian A, Saggar R, et al. The prognostic importance of CXCR3 chemokine during organizing pneumonia on the risk of chronic lung allograft dysfunction after lung transplantation. PLoS ONE. 2017;12:e0180281 pubmed publisher
    ..We further demonstrate for the first time, the prognostic importance of BALF CXCR3 ligand concentrations during OP on subsequent CLAD risk. ..
  6. Ke Y, Dang E, Shen S, Zhang T, Qiao H, Chang Y, et al. Semaphorin4D Drives CD8+ T-Cell Lesional Trafficking in Oral Lichen Planus via CXCL9/CXCL10 Upregulations in Oral Keratinocytes. J Invest Dermatol. 2017;137:2396-2406 pubmed publisher
    ..Our findings conclusively revealed an amplification feedback loop involving T cells, chemokines, and Sema4D-dependent signal that promotes OLP progression. ..
  7. Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, et al. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. J Clin Invest. 2017;127:3784-3795 pubmed publisher
    ..CD8+ T cell accumulation in infection sites by downregulating expression of the CD8+ T cell attractant chemokine CXCL9 in the CNS of infected mice, leading to increased HSV-1 mortality due to encephalitis...
  8. Strassner J, Rashighi M, Ahmed Refat M, Richmond J, Harris J. Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity. J Am Acad Dermatol. 2017;76:847-855.e5 pubmed publisher
    ..Additionally, use of the modified suction-blister technique supports investigation of inflammatory skin diseases using powerful tools like flow cytometry and protein quantification. ..
  9. Limongi F, Fallahi P. Hypersensitivity pneumonitis and alpha-chemokines. Clin Ter. 2017;168:e140-e145 pubmed publisher
    ..It has been suggested that differences in the expression of CXC chemokines and Th1 cytokines may contribute to different immunopathogenesis, clinical course and responsiveness to treatment of HP. ..

More Information


  1. Lu Y, Lin L, Tan J, Deng H, Li X, Zhang Z, et al. A correlation study between gene polymorphism of Th cell expressed chemokine receptor CXCR3 and its ligand levels with HCV infection prognosis. Eur Rev Med Pharmacol Sci. 2017;21:1290-1295 pubmed
    ..CXCR3 ligands IP-10, Mig and I-TAC levels were all significantly elevated in chronic hepatitis and HCV cirrhosis patients, possibly functioning as one clinical index for HCV prognosis. ..
  2. Chen M, Yao Y, Yue M, Zang F, Liu M, Wang J, et al. Polymorphisms of chemokine receptor genes and clearance of hepatitis C virus infection in Chinese population. Gene. 2017;624:1-5 pubmed publisher
    ..23, 95%CI: 1.26-3.95). These results suggest that CXCR6 rs2234358 is associated with spontaneous clearance of HCV and response to IFN-?/RBV therapy, which may be identified as a predictive marker in Chinese Han population of HCV. ..
  3. Sørensen T, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik V, et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest. 1999;103:807-15 pubmed
    ..Our results imply pathogenic roles for specific chemokine-chemokine receptor interactions in MS and suggest new molecular targets for therapeutic intervention. ..
  4. Shimoura N, Nagai H, Fujiwara S, Jimbo H, Yoshimoto T, Nishigori C. Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia. Arch Dermatol Res. 2017;309:315-321 pubmed publisher
    ..The current results suggest that IL-18 might synergize with IL-23 to induce a T helper 1 immune reaction, without inhibiting the IL-23/IL-17 axis, and thus may aggravate psoriatic inflammation. ..
  5. O Brien J, Rainwater Y, Malviya N, Cyrus N, Auer Hackenberg L, Hynan L, et al. Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea. J Invest Dermatol. 2017;137:1663-1670 pubmed publisher
    ..CXCL9 expression in lesional macrophages implicates the skin as the source of circulating cytokines. CXCL9 is a promising biomarker of disease activity in morphea. ..
  6. Spranger S, Dai D, Horton B, Gajewski T. Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell. 2017;31:711-723.e4 pubmed publisher
    ..Our data indicate that lack of CD103+ DCs within the tumor microenvironment dominantly resists the effector phase of an anti-tumor T cell response, contributing to immune escape. ..
  7. Fernández Paredes L, Casrouge A, Decalf J, de Andrés C, Villar L, Pérez de Diego R, et al. Multimarker risk stratification approach at multiple sclerosis onset. Clin Immunol. 2017;181:43-50 pubmed publisher