chemokine cxcl2


Summary: A CXC chemokine that is synthesized by activated MONOCYTES and NEUTROPHILS. It has specificity for CXCR2 RECEPTORS.

Top Publications

  1. Rajasagi N, Bhela S, Varanasi S, Rouse B. Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology. J Leukoc Biol. 2017;102:1159-1171 pubmed publisher
    ..These findings demonstrate that AT-RvD1 treatment could represent a useful strategy for the management of virus-induced immunopathological lesions. ..
  2. Shibata F, Konishi K, Kato H, Komorita N, Al Mokdad M, Fujioka M, et al. Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3. Eur J Biochem. 1995;231:306-11 pubmed
    ..These data indicate CINC-2 alpha, 2 beta and 3 as well as CINC-1 are chemoattractants specific for neutrophil in vivo. ..
  3. Standiford T, Danforth J. Ethanol feeding inhibits proinflammatory cytokine expression from murine alveolar macrophages ex vivo. Alcohol Clin Exp Res. 1997;21:1212-7 pubmed
  4. Singh R, Furze R, Birrell M, Rankin S, Hume A, Seabra M. A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol. 2014;15:39 pubmed publisher
    ..These data taken together implicate Rab27b in the regulation of neutrophil chemotaxis, likely through the regulation of primary granule exocytosis. ..
  5. Ngamsri K, Müller A, Bösmüller H, Gamper Tsigaras J, Reutershan J, Konrad F. The Pivotal Role of CXCR7 in Stabilization of the Pulmonary Epithelial Barrier in Acute Pulmonary Inflammation. J Immunol. 2017;198:2403-2413 pubmed publisher
    ..In conclusion, our data identified the pivotal role of the receptor CXCR7 in pulmonary inflammation with a predominant effect on the pulmonary epithelium and PMNs. ..
  6. De la Varga Martínez R, Rodríguez Bayona B, Añez G, Medina Varo F, Pérez Venegas J, Brieva J, et al. Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation. Eur J Immunol. 2017;47:1211-1219 pubmed publisher
    ..Thus, patients with circulating anti-dsDNA antibody-secreting cells and active disease could potentially benefit from therapies targeting the JAK/STAT3 pathway. ..
  7. Mylonas K, Turner N, Bageghni S, Kenyon C, White C, McGregor K, et al. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI. J Endocrinol. 2017;233:315-327 pubmed publisher
  8. Wang H, Qu Y, Dai B, Zhu Y, Shi G, Zhu Y, et al. PBRM1 regulates proliferation and the cell cycle in renal cell carcinoma through a chemokine/chemokine receptor interaction pathway. PLoS ONE. 2017;12:e0180862 pubmed publisher
    ..These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of ACHN cells through the chemokine/chemokine receptor pathway. ..
  9. Li N, Cao M, Yi S, Cheng J, Wang L, Tao Y, et al. Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice. Biochem Biophys Res Commun. 2018;495:1573-1579 pubmed publisher
    ..pylori. These results were beneficial for understanding the in vivo function of KSRP on innate immune response against pathogen infection. ..

More Information


  1. Angele M, KNOFERL M, Schwacha M, Ayala A, Bland K, Cioffi W, et al. Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection. Ann Surg. 1999;229:651-60; discussion 660-1 pubmed
    ..Therefore, attempts to enhance or restore wound cell immune function might be helpful for decreasing the incidence of wound infections in trauma victims. ..
  2. Mehrad B, Strieter R, Moore T, Tsai W, Lira S, Standiford T. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J Immunol. 1999;163:6086-94 pubmed
    ..We conclude that CXCR2 ligands are essential mediators of host defense against A. fumigatus, and may be important targets in devising future therapeutic strategies in this disease. ..
  3. Mei X, Wang H, Li J, Liu X, Lu X, Li Y, et al. Dusuqing granules (DSQ) suppress inflammation in Klebsiella pneumonia rat via NF-?B/MAPK signaling. BMC Complement Altern Med. 2017;17:216 pubmed publisher
    ..The protective effects of DSQ on Klebsiella pneumonia might be attributed to its inactivative effects of NF-?B/ MAPK pathway. ..
  4. Chaochao Q, Lou G, Yang Y, Liu Y, Hu Y, Min Z, et al. Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide. Cell Physiol Biochem. 2017;42:913-928 pubmed publisher
    ..The mechanisms may occur through down-regulation of p38-MAPK, STAT3 and Akts phosphorylation and translocation of NF-?B p65. MIP-2 plays an important role in inflammation induced by LPS. ..
  5. Boro M, Balaji K. CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2. J Immunol. 2017;199:1660-1671 pubmed publisher
  6. Rentzsch I, Santos C, Huhle R, Ferreira J, Koch T, Schnabel C, et al. Variable stretch reduces the pro-inflammatory response of alveolar epithelial cells. PLoS ONE. 2017;12:e0182369 pubmed publisher
    ..This effect was mediated by the ERK1/2 signaling pathway, and might partly explain the findings of reduced lung inflammation during mechanical ventilation modes that enhance breath-by-breath variability of the respiratory pattern. ..