chemokine cxcl13


Summary: A CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.

Top Publications

  1. Moura R, Quaresma C, Vieira A, Goncalves M, Polido Pereira J, Romão V, et al. B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis. PLoS ONE. 2017;12:e0182927 pubmed publisher
    ..In RA patients, the use of TNF-inhibitors and/ or tocilizumab treatment affects B-cell phenotype and IgD-CD27- memory B cells in circulation, but not B-cell gene expression levels. ..
  2. Kennedy W, Simón J, Offutt C, Horn P, Herman A, Townsend M, et al. Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study). Arthritis Res Ther. 2014;16:467 pubmed publisher
    ..Adalimumab demonstrated efficacy and safety comparable to published results in this head-to-head comparison in DMARD-IR RA patients. NCT01225393, Registered 18 October 2010. ..
  3. Wang S, Yang T, Wan J, Zhang Y, Fan Y. Elevated C-X-C motif ligand 13 and B-cell-activating factor levels in neuromyelitis optica during remission. Brain Behav. 2017;7:e00648 pubmed publisher
    ..During remission, serum CXCL13 and BAFF levels have not decreased to normal in NMO patients, and B-cell-related autoimmune response persists. Immunosuppressive therapy decreased serum BAFF levels, but did not affect CXCL13 expression. ..
  4. Yu Q, Cheng Y, Wang Y, Wang C, Lu H, Guan Z, et al. Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid. J Infect Dis. 2017;216:534-544 pubmed publisher
    ..CXCL13/CXCR5 mediated the aggregation of B cells, that directed the aberrant humoral immune responses via the formation of EGCs, which suggests a molecular mechanism of neurological damage in neurosyphilis. ..
  5. Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson J, et al. Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen. Infect Immun. 2017;85: pubmed publisher
  6. Pattarini L, Trichot C, Bogiatzi S, Grandclaudon M, Meller S, Keuylian Z, et al. TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. J Exp Med. 2017;214:1529-1546 pubmed publisher
    ..Mechanistically, TSLP-induced Tfh differentiation depended on OX40-ligand, but not on ICOS-ligand. Our results delineate a pathway of human Tfh differentiation in Th2 environments. ..
  7. Nakamura H, Kawakami A, Hayashi T, Nakamura T, Iwamoto N, Yamasaki S, et al. Low prevalence of ectopic germinal centre formation in patients with HTLV-I-associated Sjogren's syndrome. Rheumatology (Oxford). 2009;48:854-5 pubmed publisher
  8. Wutte N, Kovacs G, Berghold A, Reiter H, Aberer W, Aberer E. CXCL13 and B-cell activating factor as putative biomarkers in systemic sclerosis. Br J Dermatol. 2013;169:723-5 pubmed publisher
  9. Eddens T, Elsegeiny W, Garcia Hernadez M, Castillo P, Trevejo Nuñez G, Serody K, et al. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017;18:3078-3090 pubmed publisher
    ..Together, these findings uncover a role for Th2/Th17 cells in regulating Cxcl13 expression and provide an experimental model for fungal-driven iBALT formation. ..

More Information


  1. Orr C, Najm A, Biniecka M, McGarry T, Ng C, Young F, et al. Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis. Arthritis Rheumatol. 2017;69:2114-2123 pubmed publisher
    ..The EULAR response to therapy in ACPA+ RA patients was associated with increased levels of T cell and macrophage markers. ..
  2. El Haibi C, Sharma P, Singh R, Gupta P, Taub D, Singh S, et al. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer. 2013;12:64 pubmed publisher
    ..These findings offer insight into molecular mechanisms of PCa progression and can help to design some therapeutic strategies involving CXCR5 and/or CXCL13 blockade and specific G protein inhibition to abrogate PCa metastasis. ..
  3. Jiang B, Cao D, Zhang X, Zhang Z, He L, Li C, et al. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. J Clin Invest. 2016;126:745-61 pubmed publisher
    ..Thus, miR-186-5p and CXCL13/CXCR5-mediated astrocyte signaling may be suitable therapeutic targets for neuropathic pain. ..
  4. Carubbi F, Cipriani P, Marrelli A, Benedetto P, Ruscitti P, Berardicurti O, et al. Efficacy and safety of rituximab treatment in early primary Sjögren's syndrome: a prospective, multi-center, follow-up study. Arthritis Res Ther. 2013;15:R172 pubmed publisher
    ..We showed that RTX is a safe and effective agent to be employed in pSS patients with systemic, extra-glandular involvement. Furthermore, our data on pSS-MSGs provide additional biological basis to employ RTX in this disease. ..
  5. Verstappen G, Meiners P, Corneth O, Visser A, Arends S, Abdulahad W, et al. Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome. Arthritis Rheumatol. 2017;69:1850-1861 pubmed publisher
    ..Lower numbers of activated circulating Tfh cells contribute to attenuated Tfh cell-dependent B cell hyperactivity and may underlie the efficacy of abatacept. ..
  6. Li Z, Li M. Improvement in orthopedic outcome score and reduction in IL-1?, CXCL13, and TNF-? in synovial fluid of osteoarthritis patients following arthroscopic knee surgery. Genet Mol Res. 2017;16: pubmed publisher
    ..Moreover, reduced presence of these molecules correlates with clinical improvement of this condition. Therefore, reduction in IL-1?, CXCL13, and TNF-? expression might be used as a factor for long-term osteoarthritis prognosis. ..
  7. Murray K, Godinez D, Brust Mascher I, Miller E, Gareau M, Reardon C. Neuroanatomy of the spleen: Mapping the relationship between sympathetic neurons and lymphocytes. PLoS ONE. 2017;12:e0182416 pubmed publisher
    ..Together, we demonstrated that there does not appear to be a basis for synaptic neuro-immune communication, and that sympathetic innervation can modulate immune function through altering stromal cell chemokine production. ..
  8. Garg R, Blando J, Perez C, Abba M, Benavides F, Kazanietz M. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway. Cell Rep. 2017;19:375-388 pubmed publisher
    ..that PKCε overexpression and Pten loss individually and synergistically upregulate the production of the chemokine CXCL13, which involves the transcriptional activation of the CXCL13 gene via the non-canonical nuclear factor κB (..
  9. Jones J, Hamilton B, Challener G, de Brum Fernandes A, Cossette P, Liang P, et al. Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels. Arthritis Res Ther. 2014;16:R103 pubmed publisher
    ..Elevated serum CXCL13 levels may identify a subset of seropositive RA patients whose disease is shaped by or responsive to RF production. ..
  10. Han F, Liang F, Jiang T, Liu M. Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. Eur Rev Med Pharmacol Sci. 2017;21:1860-1867 pubmed
    ..The current study established an association between CXCR5/CXCL13, autoimmune myocarditis and pro-inflammatory cytokines, and provided sound basis for further studies on mechanism and treatment of autoimmune myocarditis. ..
  11. Fava R, Browning J, Gatumu M, Skarstein K, Bolstad A. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. Adv Exp Med Biol. 2011;691:383-90 pubmed publisher