chemokine cxcl1


Summary: A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.

Top Publications

  1. Zhao W, Siegel D, Biton A, Tonqueze O, Zaitlen N, Ahituv N, et al. CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Nucleic Acids Res. 2017;45:10800-10810 pubmed publisher
    ..Our work demonstrates the duality and complexity of 3'-UTR sequences in regulation of gene expression and provides a useful approach for modulating gene expression and for functional annotation of 3'-UTRs in the native context. ..
  2. Damas J, Gullestad L, Ueland T, Solum N, Simonsen S, Frøland S, et al. CXC-chemokines, a new group of cytokines in congestive heart failure--possible role of platelets and monocytes. Cardiovasc Res. 2000;45:428-36 pubmed
    ..Our findings further suggest that activated monocytes and platelets may contribute to enhanced CXC-chemokine levels in CHF. ..
  3. Reins R, Courson J, Lema C, Redfern R. MyD88 contribution to ocular surface homeostasis. PLoS ONE. 2017;12:e0182153 pubmed publisher
    ..This work furthers our understanding of the importance of TLR signaling in corneal defense and immune homeostasis, showing that a lack of MyD88 may compromise the baseline innate response to insult. ..
  4. M C C C, N L L, C M F, J L G, D A, C G, et al. Comparing the effects of acute alcohol consumption in germ-free and conventional mice: the role of the gut microbiota. BMC Microbiol. 2014;14:240 pubmed publisher
    ..Furthermore, treatment with a high-fiber diet can counteract hepatocyte pathology and gut leakage and thus could be a promising therapeutic option. ..
  5. Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, et al. Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma. PLoS ONE. 2017;12:e0178635 pubmed publisher
    ..The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients. ..
  6. Sun X, Wei H, Young D, Bein K, Smiley Jewell S, Zhang Q, et al. Differential pulmonary effects of wintertime California and China particulate matter in healthy young mice. Toxicol Lett. 2017;278:1-8 pubmed publisher
    ..The findings suggest that Sacramento PM2.5 was associated with a greater inflammatory response compared to that of Taiyuan PM2.5 that may be due to a higher oxidized state of organic carbon and copper content. ..
  7. Nenasheva T, Nikolaev A, Diykanov D, Sukhanova A, Tcyganov E, Panteleev A, et al. The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice. PLoS ONE. 2017;12:e0178983 pubmed publisher
    ..The findings emphasize the importance of the evaluation of MSC effects locally at the site of their predominant post-injection localization and question MSC usefulness as anti-TB treatment. ..
  8. Huang S, Feng C, Chen L, Huang Z, Zhou X, Li B, et al. Molecular Mechanisms of Mild and Severe Pneumonia: Insights from RNA Sequencing. Med Sci Monit. 2017;23:1662-1673 pubmed
    ..CONCLUSIONS S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia. ..
  9. Shibata F, Konishi K, Kato H, Komorita N, Al Mokdad M, Fujioka M, et al. Recombinant production and biological properties of rat cytokine-induced neutrophil chemoattractants, GRO/CINC-2 alpha, CINC-2 beta and CINC-3. Eur J Biochem. 1995;231:306-11 pubmed
    ..These data indicate CINC-2 alpha, 2 beta and 3 as well as CINC-1 are chemoattractants specific for neutrophil in vivo. ..

More Information


  1. Wang D, Sun H, Wei J, Cen B, DuBois R. CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer. Cancer Res. 2017;77:3655-3665 pubmed publisher
    ..Moreover, our work also provides a rationale for development of CXCR2 antagonists to inhibit or prevent metastatic spread of disease. Cancer Res; 77(13); 3655-65. ©2017 AACR. ..
  2. Megra B, Eugenin E, Berman J. The Role of Shed PrPc in the Neuropathogenesis of HIV Infection. J Immunol. 2017;199:224-232 pubmed publisher
    ..We propose that shedding of PrPc could be a potential target for therapeutics to limit the cognitive impairment characteristic of neuroAIDS. ..
  3. Yang Z, Mao G, Zhang J, Wen X, Jia B, Bao Y, et al. IFN-? induces senescence-like characteristics in mouse bone marrow mesenchymal stem cells. Adv Clin Exp Med. 2017;26:201-206 pubmed publisher
    ..Moreover, IL-6 and CXCL1 secretions were upregulated by IFN-?. Our study shows IFN-? can induce senescence-like characteristics in mBM-MSC, suggesting a novel target for anti-aging therapy. ..
  4. Kunisada M, Hosaka C, Takemori C, Nakano E, Nishigori C. CXCL1 Inhibition Regulates UVB-Induced Skin Inflammation and Tumorigenesis in Xpa-Deficient Mice. J Invest Dermatol. 2017;137:1975-1983 pubmed publisher
    ..This indicates that the UVB-induced strong inflammatory response of Xpa-deficient mice plays a role in skin tumor development, which could be suppressed by regulating chemokines such as CXCL1. ..
  5. Ngamsri K, Müller A, Bösmüller H, Gamper Tsigaras J, Reutershan J, Konrad F. The Pivotal Role of CXCR7 in Stabilization of the Pulmonary Epithelial Barrier in Acute Pulmonary Inflammation. J Immunol. 2017;198:2403-2413 pubmed publisher
    ..In conclusion, our data identified the pivotal role of the receptor CXCR7 in pulmonary inflammation with a predominant effect on the pulmonary epithelium and PMNs. ..
  6. Sokolove J, Pisetsky D. Bone loss, pain and inflammation: three faces of ACPA in RA pathogenesis. Ann Rheum Dis. 2016;75:637-9 pubmed publisher
  7. Käfer R, Schrick K, Schmidtke L, Montermann E, Hobernik D, Bros M, et al. Inactivation of the KSRP gene modifies collagen antibody induced arthritis. Mol Immunol. 2017;87:207-216 pubmed publisher
    ..On cytokine level IFN-? production was increased in spleen cells of KSRP-/- mice compared to WT samples. These data surprisingly suggest that the absence of KSRP protects against the induction of inflammatory arthritis. ..
  8. Young H, Rowling E, Bugatti M, Giurisato E, Luheshi N, Arozarena I, et al. An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. J Exp Med. 2017;214:1691-1710 pubmed publisher
    ..We conclude that melanoma inflammatory niches adapt to and confer drug tolerance toward BRAF and MEK inhibitors early during treatment. ..
  9. Yamamoto M, Umebashi K, Tokito A, Imamura J, Jougasaki M. Interleukin-33 induces growth-regulated oncogene-? expression and secretion in human umbilical vein endothelial cells. Am J Physiol Regul Integr Comp Physiol. 2017;313:R272-R279 pubmed publisher
  10. Bustamante A, López Cancio E, Pich S, Penalba A, Giralt D, García Berrocoso T, et al. Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study. Stroke. 2017;48:2419-2425 pubmed publisher
    ..Additional discovery of new biomarkers and improvement on laboratory techniques seem necessary for achieving a molecular diagnosis of stroke. ..
  11. Divella R, Daniele A, De Luca R, Simone M, Naglieri E, Savino E, et al. Circulating Levels of VEGF and CXCL1 Are Predictive of Metastatic Organotropismin in Patients with Colorectal Cancer. Anticancer Res. 2017;37:4867-4871 pubmed
    ..This suggests an additional role for circulating cytokines as a predictive tool for cancer prognosis and diagnosis, as well as for assessment of tumor sensitivity to anticancer therapy. ..
  12. Mehrad B, Strieter R, Moore T, Tsai W, Lira S, Standiford T. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J Immunol. 1999;163:6086-94 pubmed
    ..We conclude that CXCR2 ligands are essential mediators of host defense against A. fumigatus, and may be important targets in devising future therapeutic strategies in this disease. ..
  13. Jentho E, Bodden M, Schulz C, Jung A, Seidel K, Schmeck B, et al. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1. PLoS ONE. 2017;12:e0176204 pubmed publisher
    ..pneumophila infection with regard to MyD88 signaling and identified NTAN1 as a target of miR-125a-3p. This finding unravels a yet unknown feature of Legionella-host cell interaction, potentially relevant for new treatment options. ..
  14. Boro M, Balaji K. CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2. J Immunol. 2017;199:1660-1671 pubmed publisher
  15. Kehoe O, Kalia N, King S, Eustace A, Boyes C, Reizes O, et al. Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice. Arthritis Res Ther. 2014;16:R148 pubmed publisher
    ..In the joint it is selectively pro-inflammatory, functioning in endothelial chemokine presentation and leukocyte recruitment and cartilage damage in an RA model. Conversely, in skin and cremaster it is anti-inflammatory. ..
  16. Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3. Cell Physiol Biochem. 2017;42:1961-1972 pubmed publisher
    ..Collectively, the results suggest that IL-33 plays a negative regulatory role in sepsis progression by inhibiting IL-17 pathway through activating SOCS3. This finding would inspire a new therapeutic strategy for treating sepsis. ..
  17. Zhong C, Ding J. New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4. Acta Biochim Biophys Sin (Shanghai). 2011;43:337-8 pubmed publisher
  18. Sowa J, Slusarczyk J, Trojan E, Chamera K, Leskiewicz M, Regulska M, et al. Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures. J Neuroimmunol. 2017;311:79-87 pubmed publisher
    ..Taken together, malfunctions caused by prenatal stress may adversely influence brain development, leading to long-term effects on adult brain function and behavior. ..
  19. Jin L, Batra S, Jeyaseelan S. Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis, which can be rescued by CXCL1. PLoS Pathog. 2017;13:e1006637 pubmed publisher