chemokine ccl3


Summary: A CC chemokine with specificity for CCR1 RECEPTORS and CCR5 RECEPTORS. It is a chemoattractant for NK CELLS; MONOCYTES; and a variety of other immune cells. This chemokine is encoded by multiple genes.

Top Publications

  1. Wagner L, Yang O, Garcia Zepeda E, Ge Y, Kalams S, Walker B, et al. Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans. Nature. 1998;391:908-11 pubmed
    ..This association appears to have a functional significance, because heparan sulphate facilitates RANTES inhibition of HIV-1 infection of monocytes. ..
  2. Burger J, Okkenhaug K. Haematological cancer: idelalisib-targeting PI3K? in patients with B-cell malignancies. Nat Rev Clin Oncol. 2014;11:184-6 pubmed publisher
  3. Deniffel D, Nuyen B, Pak K, Suzukawa K, Hung J, Kurabi A, et al. Otitis Media and Nasopharyngeal Colonization in ccl3-/- Mice. Infect Immun. 2017;85: pubmed publisher
    ..Therapies based on CCL3 could prove useful in treating or preventing persistent disease. ..
  4. Wong H, Cvijanovich N, Anas N, Allen G, Thomas N, Bigham M, et al. Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017;196:494-501 pubmed publisher
    ..PERSEVERE-XP significantly improves on PERSEVERE and suggests a role for TP53-related cellular division, repair, and metabolism in the pathophysiology of septic shock. ..
  5. Balashov K, Rottman J, Weiner H, Hancock W. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci U S A. 1999;96:6873-8 pubmed
    ..Furthermore, these results provide a rationale for the use of agents that block CCR5 and/or CXCR3 as a therapeutic approach in the treatment of MS. ..
  6. Arnoldi J, Moll H. Langerhans cell migration in murine cutaneous leishmaniasis: regulation by tumor necrosis factor alpha, interleukin-1 beta, and macrophage inflammatory protein-1 alpha. Dev Immunol. 1998;6:3-11 pubmed
    ..Our data demonstrate that TNF alpha and IL-1 beta are regulating the LC-mediated transport of Leishmania and also provide evidence for the involvement of macrophage attractant chemokines in this process. ..
  7. Simpson J, Newcombe J, Cuzner M, Woodroofe M. Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol. 1998;84:238-49 pubmed
    ..Glial cells may be stimulated to produce chemokines and continue the local inflammatory response by forming chemotactic gradients to attract T cells and mononuclear phagocytes from the circulation and surrounding tissue. ..
  8. Lin C, Sewell A, Gao G, Whelan K, Phillips R, Austyn J. Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis. J Exp Med. 2000;192:587-94 pubmed
    ..Consequently, recruitment of DC by HIV-1 could combine with the ability of DC-SIGN to capture and transmit the virus to T cells, and so facilitate dissemination of virus within an infected individual. ..
  9. Glez P, Franco Y, Matheu V. MIP-1?, MCP-1, and desensitization in anaphylaxis from cow's milk. N Engl J Med. 2012;367:282-4 pubmed publisher

More Information


  1. Dieu M, Vanbervliet B, Vicari A, Bridon J, Oldham E, Ait Yahia S, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med. 1998;188:373-86 pubmed
  2. Sprokholt J, Kaptein T, van Hamme J, Overmars R, Gringhuis S, Geijtenbeek T. RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation. J Immunol. 2017;198:4764-4771 pubmed publisher
    ..Therefore, we identified RIG-I and MDA5 as critical players in innate and adaptive immune responses against DENV, and targeting these receptors has the potential to decrease hemorrhagic fever in patients. ..
  3. Chen C, Chen Q, Li L, Yu X, Ke J, He M, et al. [Effects of recombinant fusion protein interleukin-18 on expression of immune-inflammatory factors in mice infected with Staphylococcus aureus]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:705-711 pubmed
  4. Kunstfeld R, Lechleitner S, Wolff K, Petzelbauer P. MCP-1 and MIP-1alpha are most efficient in recruiting T cells into the skin in vivo. J Invest Dermatol. 1998;111:1040-4 pubmed
    ..At this site all tested chemokines attracted human T cells to an equal extent. In summary, our experiments point towards an important role for MCP-1 and MIP-1alpha as T cell chemoattractants for skin inflammatory conditions. ..
  5. Vicenzi E, Alfano M, Ghezzi S, Gatti A, Veglia F, Lazzarin A, et al. Divergent regulation of HIV-1 replication in PBMC of infected individuals by CC chemokines: suppression by RANTES, MIP-1alpha, and MCP-3, and enhancement by MCP-1. J Leukoc Biol. 2000;68:405-12 pubmed
    ..Altogether these observations suggest that MCP-1 may represent an important factor enhancing HIV spreading, particularly in anatomical sites, such as the brain, where infection of macrophages and microglial cells plays a dominant role. ..
  6. Kologlu T, Ucar S, Levent E, Akcay Y, Coker M, Sozmen E. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children. J Pediatr Endocrinol Metab. 2014;27:701-8 pubmed publisher
    ..ChT and YKL-40 seem to be the more predictable markers of atherosclerosis even in early ages (<6 years old) than other classical inflammation markers such as hs-CRP, IL-6 and TNF-?. ..
  7. Bernin H, Marggraff C, Jacobs T, Brattig N, Le V, Blessmann J, et al. Immune markers characteristic for asymptomatically infected and diseased Entamoeba histolytica individuals and their relation to sex. BMC Infect Dis. 2014;14:621 pubmed publisher
  8. Patterson S, Pesenacker A, Wang A, Gillies J, Mojibian M, Morishita K, et al. T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. J Clin Invest. 2016;126:1039-51 pubmed publisher
    ..Together, these results demonstrate a previously unappreciated facet of Treg function and suggest that chemokine secretion by Tregs is a fundamental aspect of their therapeutic effect in autoimmunity and transplantation. ..
  9. Nenasheva T, Nikolaev A, Diykanov D, Sukhanova A, Tcyganov E, Panteleev A, et al. The introduction of mesenchymal stromal cells induces different immunological responses in the lungs of healthy and M. tuberculosis infected mice. PLoS ONE. 2017;12:e0178983 pubmed publisher
    ..The findings emphasize the importance of the evaluation of MSC effects locally at the site of their predominant post-injection localization and question MSC usefulness as anti-TB treatment. ..
  10. Charrier A, Chen R, Kemper S, Brigstock D. Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2). Immunology. 2014;141:564-76 pubmed publisher
    ..The early production of CTGF/CCN2 by PAC to drive inflammation is distinct from its previously reported production by pancreatic stellate cells to drive fibrosis at later stages of pancreatic injury. ..
  11. Schoeman J, Moutloatse G, Harms A, Vreeken R, Scherpbier H, van Leeuwen L, et al. Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants. J Infect Dis. 2017;216:436-446 pubmed publisher
    ..Taken together, these data demonstrate that the fetal metabolism is impacted by maternal factors (cART and HIV-1) and skews physiological immune responses toward inflammation in the newborn infant. ..
  12. Caslin H, McLeod J, Spence A, Qayum A, Kolawole E, Taruselli M, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. Cell Immunol. 2017;319:10-16 pubmed publisher
    ..These results suggest that Didox attenuates IL-33-induced mast cell activation and should be further studied as a potential therapeutic agent for inflammatory diseases involving IL-33. ..