Summary: A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
Raju R, Gadakh S, Gopal P, George B, Advani J, Soman S, et al
. Differential ligand-signaling network of CCL19/CCL21-CCR7 system. Database (Oxford). 2015;2015: pubmed publisher
..Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46. ..
Penteado L, Dejani N, Verdan F, Orlando A, Niño V, Dias F, et al
. Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions. Immunology. 2017;151:304-313 pubmed publisher
..These data contribute to the understanding of how efferocytosis of sterile or infected cells may regulate the adaptive immune response, although the precise role of PGE2 in this process requires further investigation. ..
Karlsen T, Reikvam T, Tofteberg A, Nikpey E, Skogstrand T, Wagner M, et al
. Lymphangiogenesis Facilitates Initial Lymph Formation and Enhances the Dendritic Cell Mobilizing Chemokine CCL21 Without Affecting Migration. Arterioscler Thromb Vasc Biol. 2017;37:2128-2135 pubmed publisher
..An expanded lymphatic network is capable of enhanced chemoattractant production, and lymphangiogenesis will facilitate initial lymph formation favoring increased clearance of fluid in situations of augmented fluid filtration. ..
Hock S, Hasenauer J, Theis F. Modeling of 2D diffusion processes based on microscopy data: parameter estimation and practical identifiability analysis. BMC Bioinformatics. 2013;14 Suppl 10:S7 pubmed publisher
..The profile likelihood based method provides more rigorous uncertainty bounds in contrast to local approximation methods. ..
Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, et al
. Essential role of CCL21 in establishment of central self-tolerance in T cells. J Exp Med. 2017;214:1925-1935 pubmed publisher
..These results indicate a nonredundant role of CCL21Ser in the establishment of self-tolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo. ..
Ruan L, Yang Y, Huang Y, Ding L, Zhang C, Wu X. Functional prediction of miR-3144-5p in human cardiac myocytes based on transcriptome sequencing and bioinformatics. Medicine (Baltimore). 2017;96:e7539 pubmed publisher
..This study may provide new insight into the mechanisms behind the progression of cardiac arrhythmia. ..
Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson J, et al
. Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen. Infect Immun. 2017;85: pubmed publisher