chemokine ccl20


Summary: A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES.

Top Publications

  1. Dieu M, Vanbervliet B, Vicari A, Bridon J, Oldham E, Ait Yahia S, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med. 1998;188:373-86 pubmed
  2. Bell D, Chomarat P, Broyles D, Netto G, Harb G, Lebecque S, et al. In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. J Exp Med. 1999;190:1417-26 pubmed
    ..In some cases, T cells are clustering around the mature DCs in peritumoral areas, thus resembling the DC-T cell clusters of secondary lymphoid organs, which are characteristic of ongoing immune reactions. ..
  3. Iwasaki A, Kelsall B. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med. 2000;191:1381-94 pubmed
  4. Wang Y, Balvers M, Hendriks H, Wilpshaar T, van Heek T, Witkamp R, et al. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:823-831 pubmed publisher
    ..Our findings may be of relevance in relation to intestinal inflammatory diseases like Crohn's disease and Ulcerative colitis. ..
  5. Couderc E, Morel F, Levillain P, Buffiere Morgado A, Camus M, Paquier C, et al. Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis. PLoS ONE. 2017;12:e0181486 pubmed publisher
    ..Keratinocytes could contribute to psoriasis pathogenesis via A-SAA production, maintaining a cutaneous inflammatory environment, activating innate immunity and Th17 lymphocyte recruitment. ..
  6. Ye J, Qi W, Liu M, Li Y. The combination of NK and CD8+T cells with CCL20/IL15-armed oncolytic adenoviruses enhances the growth suppression of TERT-positive tumor cells. Cell Immunol. 2017;318:35-41 pubmed publisher
    ..This study has provided preclinical evidence that combined treatment with cytotoxic effector cells and CRAd-CCL20-IL15 may offer alternative treatment options for tumor therapy. ..
  7. Alvarez Simón D, Munoz X, Gómez Ollés S, de Homdedeu M, Untoria M, Cruz M. Effects of diesel exhaust particle exposure on a murine model of asthma due to soybean. PLoS ONE. 2017;12:e0179569 pubmed publisher
    ..DEP monitoring may be a useful addition to allergen monitoring in order to prevent new asthma outbreaks. ..
  8. Rajavelu P, Chen G, Xu Y, Kitzmiller J, Korfhagen T, Whitsett J. Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J Clin Invest. 2015;125:2021-31 pubmed publisher
    ..Together, our results indicate that SPDEF causes goblet cell differentiation and Th2 inflammation during postnatal development and is required for goblet cell metaplasia and normal Th2 inflammatory responses to HDM aeroallergen. ..
  9. Lee J, Kao K, Chiu Y, Jung C, Liu C, Cheng S, et al. Enrichment of Human CCR6+ Regulatory T Cells with Superior Suppressive Activity in Oral Cancer. J Immunol. 2017;199:467-476 pubmed publisher
    ..These results suggest that CCR6 marks activated effector or memory Treg phenotypes with superior suppressive activity in humans. ..

More Information


  1. Al Aoukaty A, Rolstad B, Giaid A, Maghazachi A. MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells. Immunology. 1998;95:618-24 pubmed
  2. Thu Le H, Nakamura Y, Oh oka K, Ishimaru K, Nakajima S, Nakao A. The frequency of Th17 cells in the small intestine exhibits a day-night variation dependent on circadian clock activity. Biochem Biophys Res Commun. 2017;490:290-295 pubmed publisher
    ..The findings provide novel insight into the regulation of the Th17 cell population in the small intestine at steady state, which may have translational potential for mucosal vaccination strategies. ..
  3. Gao B, Xu M. Chemokines and alcoholic hepatitis: are chemokines good therapeutic targets?. Gut. 2014;63:1683-4 pubmed publisher
  4. Dieu Nosjean M, Massacrier C, Homey B, Vanbervliet B, Pin J, Vicari A, et al. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med. 2000;192:705-18 pubmed
    ..Results of this study suggest a major role of MIP-3alpha in epithelial colonization by LCs under inflammatory conditions and immune disorders, and might open new ways to control epithelial immunity. ..
  5. Lu G, Zhang X, Shen L, Qiao Q, Li Y, Sun J, et al. CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy. PLoS ONE. 2017;12:e0178352 pubmed publisher
    ..Therefore, HMC stimulated by IgA1 could produce CCL20 and consequently recruit inflammatory Th17 cells to the kidneys to induce further lesion in IgA nephropathy. ..
  6. Muscella A, Vetrugno C, Marsigliante S. CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture. Mol Carcinog. 2017;56:2461-2473 pubmed publisher
    ..These results reveal a role for CCL20 also in tumor breast cell and point to CCL20 as a novel therapeutic target in cancer. ..
  7. Trubiani O, Horenstein A, Caciagli F, Caputi S, Malavasi F, Ballerini P. Expression of P2X7 ATP receptor mediating the IL8 and CCL20 release in human periodontal ligament stem cells. J Cell Biochem. 2014;115:1138-46 pubmed
    ..Collectively, these results indicated that extracellular ATP mediate a pro-inflammatory response via P2X7 receptors in hPDLSCs opening a further approach to control hPDLSCs behavior in their possible application as therapeutic tool. ..
  8. Kim T, Jee H, Fuentes Duculan J, Wu W, Byamba D, Kim D, et al. Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis. J Invest Dermatol. 2014;134:1462-1465 pubmed publisher
  9. Shi T, He Y, Sun W, Wu Y, Li L, Jie Z, et al. Respiratory Syncytial virus infection compromises asthma tolerance by recruiting interleukin-17A-producing cells via CCR6-CCL20 signaling. Mol Immunol. 2017;88:45-57 pubmed publisher
    ..Taken together, RSV infection impairs asthma tolerance by recruiting IL-17A-producing cells via CCR6-CCL20 signaling. The findings provide novel insight into exacerbation and therapeutic strategy of asthma under RSV infection. ..
  10. Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger J, et al. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol. 2017;18:675-682 pubmed publisher
    ..Thus, the subepithelial mesenchymal cells that serve as M cell inducers have a fundamental role in the maintenance of intestinal immune homeostasis. ..