leptin

Summary

Summary: A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Top Publications

  1. Chatterjee S, Ganini D, Tokar E, Kumar A, Das S, Corbett J, et al. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. J Hepatol. 2013;58:778-84 pubmed publisher
    ..These lesions have been associated with increased oxidative stress, often ascribed to high levels of leptin and other proinflammatory mediators...
  2. Liao L, Schwartz K, Pollak M, Graubard B, Li Z, Ruterbusch J, et al. Serum leptin and adiponectin levels and risk of renal cell carcinoma. Obesity (Silver Spring). 2013;21:1478-85 pubmed publisher
    ..Adipokines, such as leptin and adiponectin, may link obesity and cancer, with different quantitative effects by race...
  3. Cha J, Hyun Y, Jee Y, Lee M, Han K, Kang Y, et al. Plasma concentration of soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in type 2 diabetic patients, and sICAM-1 synthesis is associated with leptin-induced activation of the mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2013;36:878-87 pubmed publisher
    The intercellular adhesion molecule-1 (ICAM-1) and leptin are important inflammatory biomarkers. We investigated whether plasma-soluble ICAM-1 levels were related to the diabetic nephropathy and systemic inflammation...
  4. Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, et al. Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain. J Neurosci. 2013;33:14767-77 pubmed publisher
    ..Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that these mice show hyperphagia...
  5. Pijet M, Pijet B, Litwiniuk A, Pajak B, Gajkowska B, Orzechowski A. Leptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways. Cytokine. 2013;61:445-54 pubmed publisher
    ..mass in genetically obese (ob/ob) or anorectic/cachectic subjects prompted us to verify the hypothesis whether leptin, white adipose tissue cytokine, might be a negative organizer of myogenesis...
  6. Sutin A, Zonderman A, Uda M, Deiana B, Taub D, Longo D, et al. Personality traits and leptin. Psychosom Med. 2013;75:505-9 pubmed publisher
    ..Hormones implicated in appetite and metabolism, such as leptin, may also be related to personality and may contribute to the association between these traits and obesity...
  7. Oh H, Choi Y, Yang Y, Kim J, Leung P, Choi J. Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. Mol Hum Reprod. 2013;19:160-8 pubmed publisher
    b>Leptin acts as a potential growth stimulator in several normal and neoplastic cells...
  8. Rasmussen Torvik L, Wassel C, Ding J, Carr J, Cushman M, Jenny N, et al. Associations of body mass index and insulin resistance with leptin, adiponectin, and the leptin-to-adiponectin ratio across ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA). Ann Epidemiol. 2012;22:705-9 pubmed publisher
    Associations of adiponectin and leptin and their ratio with body mass index (BMI) and homeostasis model assessment of insulin resistance (HOMA-IR) have been investigated in different ethnic groups but variability in both assays and ..
  9. Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
    b>Leptin signaling has received considerable attention in the Alzheimer disease (AD) field...

More Information

Publications32

  1. Kloiber S, Ripke S, Kohli M, Reppermund S, Salyakina D, Uher R, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. Eur Neuropsychopharmacol. 2013;23:653-62 pubmed publisher
    b>Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and ..
  2. Scarpace P, Matheny M, Kirichenko N, Gao Y, Tümer N, Zhang Y. Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes. Neuropharmacology. 2013;65:90-100 pubmed publisher
    High-fat feeding or CNS leptin overexpression in chow-fed rats results in a region-specific cellular leptin resistance in medial basal hypothalamic regions and the ventral tegmental area (VTA)...
  3. Mariano G, Stilo R, Terrazzano G, Coccia E, Vito P, Varricchio E, et al. Effects of recombinant trout leptin in superoxide production and NF-?B/MAPK phosphorylation in blood leukocytes. Peptides. 2013;48:59-69 pubmed publisher
    Studies in mammals indicate that leptin is a multifunctional cytokine involved in regulation of energy metabolism and the modulation of the immune function...
  4. Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, et al. Obesity induced a leptin-Notch signaling axis in breast cancer. Int J Cancer. 2014;134:1605-16 pubmed publisher
    To investigate whether obesity induces a leptin-Notch signaling axis in breast cancer (BC), leptin-induced Notch was determined in human MCF-7 and MDA-MB231 and mouse E0771 cells and in E0771-BC hosted by syngeneic lean and diet-induced ..
  5. Becer E, Mehmetçik G, Bareke H, Serakinci N. Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects. Gene. 2013;529:16-20 pubmed publisher
    b>Leptin is a hormone secreted from adipocytes. It regulates metabolism and energy homeostasis through the leptin receptor (LEPR) which is localized centrally in hypothalamus as well as in peripheral tissues...
  6. Chen P, Kryukova Y, Shyng S. Leptin regulates KATP channel trafficking in pancreatic ?-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA). J Biol Chem. 2013;288:34098-109 pubmed publisher
    ..b>Leptin, a hormone secreted by adipocytes, inhibits insulin secretion by increasing KATP channel conductance in ?-cells...
  7. Leifheit Nestler M, Wagner N, Gogiraju R, Didié M, Konstantinides S, Hasenfuss G, et al. Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. J Transl Med. 2013;11:170 pubmed publisher
    The adipokine leptin and its receptor are expressed in the heart, and leptin has been shown to promote cardiomyocyte hypertrophy in vitro...
  8. Gulcelik N, Halil M, Ariogul S, Usman A. Adipocytokines and aging: adiponectin and leptin. Minerva Endocrinol. 2013;38:203-10 pubmed
    ..The adipocytokine leptin is traditionally viewed as a product of adipocytes that can exert endocrine effects...
  9. Siawrys G, Smolinska N. In vitro effects of luteinizing hormone, progesterone and oestradiol-17? on leptin gene expression and leptin secretion by porcine luteal cells obtained in early pregnancy. J Physiol Pharmacol. 2013;64:513-20 pubmed
    b>Leptin, the product of the ob gene, is involved in the control of ovarian functions...
  10. Aleksandrova K, Boeing H, Jenab M, Bueno de Mesquita H, Jansen E, van Duijnhoven F, et al. Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Cancer Res. 2012;72:5328-37 pubmed publisher
    b>Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC)...
  11. Nazarians Armavil A, Menchella J, Belsham D. Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription. Mol Endocrinol. 2013;27:990-1003 pubmed publisher
    Central resistance to the actions of insulin and leptin is associated with the onset of obesity and type 2 diabetes mellitus, whereas leptin and insulin signaling is essential for both glucose and energy homeostasis...
  12. Rezai Zadeh K, Munzberg H. Integration of sensory information via central thermoregulatory leptin targets. Physiol Behav. 2013;121:49-55 pubmed publisher
    The adipocyte derived hormone leptin acts in the brain to regulate body weight, food intake and energy expenditure...
  13. Olofsson L, Unger E, CHEUNG C, Xu A. Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A. 2013;110:E697-706 pubmed publisher
    Chronic consumption of a fat-rich diet leads to attenuation of leptin signaling in hypothalamic neurons, a hallmark feature of cellular leptin resistance...
  14. Bilbao M, Di Yorio M, Faletti A. Different levels of leptin regulate different target enzymes involved in progesterone synthesis. Fertil Steril. 2013;99:1460-6 pubmed publisher
    To study the effects of different doses of leptin on the expression of proteins involved in P synthesis, such as steroidogenic acute regulatory protein (StAR), cytochrome P450 side chain cleavage (P450scc), and 3?-hydroxysteroid ..
  15. Abbasihormozi S, Shahverdi A, Kouhkan A, Cheraghi J, Akhlaghi A, Kheimeh A. Relationship of leptin administration with production of reactive oxygen species, sperm DNA fragmentation, sperm parameters and hormone profile in the adult rat. Arch Gynecol Obstet. 2013;287:1241-9 pubmed publisher
    b>Leptin, an adipose tissue-derived hormone, plays an important role in energy homeostasis and metabolism, and in the neuroendocrine and reproductive systems...
  16. Yadav A, Kataria M, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta. 2013;417:80-4 pubmed publisher
    ..It is also a source of major adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin action is impaired in adipose tissue and is more strongly ..
  17. Zhou C, Huang S, Liu J, Qiu S, Xie F, Song H, et al. Sweet tea leaves extract improves leptin resistance in diet-induced obese rats. J Ethnopharmacol. 2013;145:386-92 pubmed publisher
    Dietary obesity is usually characterized by leptin resistance and abnormal lipid metabolism. Lithocarpus polystachyus Rehd...
  18. Zhang S, Zhang Q, Zhang L, Li C, Jiang H. Expression of ghrelin and leptin during the development of type 2 diabetes mellitus in a rat model. Mol Med Rep. 2013;7:223-8 pubmed publisher
    The aim of this study was to investigate the syste-matic changes in ghrelin and leptin expression, as well as their correlation with insulin resistance (IR) during the development of type 2 diabetes mellitus (T2DM) in a rat model...
  19. Prokop J, Duff R, Ball H, Copeland D, Londraville R. Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides. 2012;38:326-36 pubmed publisher
    b>Leptin is a circulating protein which regulates dietary intake through binding the leptin receptor. Numerous labs have used known structures and mutagenesis to study this binding process in common animal models (human, mouse and rat)...
  20. Liao Y, Liang K, Lee W, Lee W, Lee I, Wang J, et al. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. Biomarkers. 2013;18:44-50 pubmed publisher
    ..Adipokines were measured by ELISA tests. The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0...
  21. Wu Z, Xu Y, Zhu Y, Sutton A, Zhao R, Lowell B, et al. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS ONE. 2012;7:e45167 pubmed publisher
    ..In addition, despite a normal food intake, these mice exhibit a blunted food intake response to leptin administration...
  22. Apolzan J, Harris R. Rapid onset and reversal of peripheral and central leptin resistance in rats offered chow, sucrose solution, and lard. Appetite. 2013;60:65-73 pubmed publisher
    ..We tested the effects of choice diet on the development of leptin resistance in rats...
  23. da Silva R, Ferraz J, Meirelles F, Eler J, Balieiro J, Cucco D, et al. Association of single nucleotide polymorphisms in the bovine leptin and leptin receptor genes with growth and ultrasound carcass traits in Nellore cattle. Genet Mol Res. 2012;11:3721-8 pubmed publisher
    Given the important role of leptin in metabolism, we looked for a possible association of leptin and leptin receptor polymorphisms with carcass and growth traits in Nellore cattle...