Summary: Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.

Top Publications

  1. Lee M, Kim J, Kim D, Kang D, Park J, Ahn K, et al. Effect of home-based exercise intervention on fasting insulin and Adipocytokines in colorectal cancer survivors: a randomized controlled trial. Metabolism. 2017;76:23-31 pubmed publisher
    ..2m in the exercise group with no change in the control group (p=0.061 for group and time interaction). The 12week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors. ..
  2. Sakurai T, Ogasawara J, Shirato K, Izawa T, Oh ishi S, Ishibashi Y, et al. Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue. Oxid Med Cell Longev. 2017;2017:9410954 pubmed publisher
    ..inflammatory changes in white adipose tissue (WAT), which caused dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-? and monocyte chemoattractant protein-1, contribute to the development ..
  3. Karimi G, Jamaluddin R, Mohtarrudin N, Ahmad Z, Khazaai H, Parvaneh M. Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity. Nutr Metab Cardiovasc Dis. 2017;27:910-918 pubmed publisher
    ..B. longum supplementation in obesity was more beneficial in metabolic profile changes than the mixture species. ..
  4. Zapata R, Meachem M, Cardoso N, Mehain S, McMillan C, Snead E, et al. Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats. BMC Vet Res. 2017;13:85 pubmed publisher
    ..Thus, despite having similar body condition, overweight and diabetic cats have differential circulating concentrations of adiponectin and adropin. ..
  5. Cao J, Singh S, McClung J, Joseph G, Vanella L, Barbagallo I, et al. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. Am J Physiol Heart Circ Physiol. 2017;313:H368-H380 pubmed publisher
    ..EET reduced levels of fasting blood glucose and proinflammatory adipokines, including nephroblastoma overexpressed (NOV) signaling, while increasing echocardiographic fractional ..
  6. Kang Y, Park H, Kang M, Lee H, Lee S, Lee S, et al. Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis. Arthritis Res Ther. 2013;15:R194 pubmed
    ..We hypothesised that adipokines could be a link between inflammation, insulin resistance, and atherosclerosis in RA...
  7. Adams A, Halstead C, Hansen B, Irizarry A, Martin J, Myers S, et al. LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys. PLoS ONE. 2013;8:e65763 pubmed publisher
    ..In addition, we observed favorable changes in circulating profiles of adipokines, with increased adiponectin and reduced leptin indicative of direct FGF21 action on adipose tissue...
  8. Horska K, Kucerova J, Suchy P, Kotolová H. Metabolic syndrome - dysregulation of adipose tissue endocrine function. Ceska Slov Farm. 2014;63:152-9 pubmed
    ..Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong ..
  9. Felso R, Lohner S, Hollody K, Erhardt E, Molnar D. Relationship between sleep duration and childhood obesity: Systematic review including the potential underlying mechanisms. Nutr Metab Cardiovasc Dis. 2017;27:751-761 pubmed publisher
    ..There are numerous evidence gaps. To answer the remaining questions, there is a need for studies meeting high methodological standards and including a large number of children. ..

More Information


  1. Murakami S. The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity. Life Sci. 2017;186:80-86 pubmed publisher
    ..enlarged hypertrophied adipocytes, increased infiltration by macrophages and marked changes in the secretion of adipokines and free fatty acids...
  2. Yamawaki H. Mechanisms of action of novel adipocytokines on the vascular system. Nihon Yakurigaku Zasshi. 2011;137:131-5 pubmed publisher
  3. Sahin Efe A, Katsikeris F, Mantzoros C. Advances in adipokines. Metabolism. 2012;61:1659-65 pubmed publisher
  4. Hajagos Tóth J, Ducza E, Samavati R, Vari S, Gaspar R. Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility. Croat Med J. 2017;58:96-104 pubmed
    ..which is the largest endocrine and paracrine organ, especially in obesity, is responsible for the production of adipokines and various cytokines and chemokines, and there are no reliable data available describing the relation between ..
  5. Adams A, Kharitonenkov A. FGF21 drives a shift in adipokine tone to restore metabolic health. Aging (Albany NY). 2013;5:386-7 pubmed
  6. Yahya R, Atwa M, El Sayed I, El Ghanaam D, Hussein D, El Taweel F. Adipocytokines in Patients with Chronic Kidney Disease Stage 5. Clin Lab. 2016;62:21-30 pubmed
    ..In CKD adipokines, especially leptin and adiponectin (ADPN), accumulate in serum due to reduced renal clearance...
  7. Minatoya M, Itoh S, Miyashita C, Araki A, Sasaki S, Miura R, et al. Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health. Environ Res. 2017;156:175-182 pubmed publisher
    ..There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited...
  8. Wade C, Baer L, Wu X, Silliman D, Walters T, Wolf S. Severe burn and disuse in the rat independently adversely impact body composition and adipokines. Crit Care. 2013;17:R225 pubmed publisher
    ..determine the effects of burn and disuse independently and in combination on body composition, food intake and adipokines. Male rats were assigned to four groups 1) sham ambulatory (SA), 2) sham hindlimb unloaded (SH), 3) 40% total ..
  9. Wu A, Lasky Su J, Rogers C, Klanderman B, Litonjua A. Polymorphisms of chitinases are not associated with asthma. J Allergy Clin Immunol. 2010;125:754-7, 757.e1-757.e2 pubmed publisher
  10. Castellano I, Mistrangelo M, Crudo V, Chiusa L, Lupo R, Ricardi U, et al. YKL-40 expression in anal carcinoma predicts shorter overall and disease-free survival. Histopathology. 2009;55:238-40 pubmed publisher
  11. Habib S, Eshki A, AlTassan B, Fatani D, Helmi H, Alsaif S. Relationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women. Eur Rev Med Pharmacol Sci. 2017;21:1296-1302 pubmed
    ..Serum chemerin levels are elevated in patients with type 2 DM compared to healthy control subjects and are positively correlated with adiposity and Insulin resistance in patients with type 2 DM. ..
  12. Kurotani K, Sato M, Yasuda K, Kashima K, Tanaka S, Hayashi T, et al. Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines. PLoS ONE. 2017;12:e0178192 pubmed publisher
    ..Limited studies of Western populations examined the associations of circulating saturated fatty acids with adipokines, an important role in glucose metabolism...
  13. Guelfi K, Ong M, Li S, Wallman K, Doherty D, Fournier P, et al. Maternal circulating adipokine profile and insulin resistance in women at high risk of developing gestational diabetes mellitus. Metabolism. 2017;75:54-60 pubmed publisher
    Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM)...
  14. Rajan A, Housden B, Wirtz Peitz F, Holderbaum L, Perrimon N. A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell. 2017;43:83-98.e6 pubmed publisher
    Adipocytes sense systemic nutrient status and systemically communicate this information by releasing adipokines. The mechanisms that couple nutritional state to adipokine release are unknown...
  15. Canizares O, Thomson J, Allen R, Davidson E, Tutela J, Saadeh P, et al. The Effect of Processing Technique on Fat Graft Survival. Plast Reconstr Surg. 2017;140:933-943 pubmed publisher
    ..Wide variations in fat graft survival have been reported. The authors hypothesize that treating the adipose tissue on Telfa gauze creates a processed lipoaspirate with a more functional adipokine profile that improves fat graft survival...
  16. Lapeire L, Denys H, Cocquyt V, De Wever O. When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer. Horm Mol Biol Clin Investig. 2015;23:21-38 pubmed publisher
    ..This review is part of the special issue on "Adiposopathy in Cancer and (Cardio)Metabolic Diseases". ..
  17. Turkyilmaz A, Devrimsel G, Kirbas A, Ciçek Y, Karkucak M, Capkin E, et al. Relationship between pulse wave velocity and serum YKL-40 level in patients with early rheumatoid arthritis. Rheumatol Int. 2013;33:2751-6 pubmed
    ..In addition, there was an association between CF-PWV values and serum YKL-40 levels in patients with ERA. As a result, we believe that serum YKL-40 level and CF-PWV might reflect early atherosclerosis in patients with ERA. ..
  18. Ashrafian H, le Roux C, Darzi A, Athanasiou T. Effects of bariatric surgery on cardiovascular function. Circulation. 2008;118:2091-102 pubmed publisher
  19. Farr O, Rifas Shiman S, Oken E, Taveras E, Mantzoros C. Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis. Metabolism. 2017;76:70-80 pubmed publisher
    ..associations of parent-reported child or maternal snoring with cardiometabolic outcomes, including adiposity, adipokines, and insulin resistance...
  20. Huda S, Jordan F, Bray J, Love G, Payne R, Sattar N, et al. Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys. Clin Sci (Lond). 2017;131:1529-1540 pubmed publisher
    ..We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in PE and healthy pregnancy...
  21. Ma F, Li W, Tang R, Liu Z, Ouyang S, Cao D, et al. Long Non-Coding RNA Expression Profiling in Obesity Mice with Folic Acid Supplement. Cell Physiol Biochem. 2017;42:416-426 pubmed publisher
    ..In a nutshell, the present study identified a panel of lncRNAs and mRNAs that may be potential biomarkers or drug targets relevant to the high-fat diet related obesity. ..
  22. Castro C, da Silva K, Buffo M, Pinto K, Duarte F, Nonaka K, et al. Experimental type 2 diabetes induction reduces serum vaspin, but not serum omentin, in Wistar rats. Int J Exp Pathol. 2017;98:26-33 pubmed publisher
    Vaspin and omentin are adipose tissue adipokines that have often been related to obesity and its comorbidities. The aim of this study was to investigate the behaviour of serum omentin and vaspin in models of type 2 diabetes...
  23. Dixon A. Adipokines and asthma. Chest. 2009;135:255-256 pubmed publisher
  24. Esteve E, Ricart W, Fernandez Real J. Adipocytokines and insulin resistance: the possible role of lipocalin-2, retinol binding protein-4, and adiponectin. Diabetes Care. 2009;32 Suppl 2:S362-7 pubmed publisher
  25. Li X, Zhao Y, Jin Y, Zhang T, Chang X, Liao S, et al. Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population. PLoS ONE. 2017;12:e0182273 pubmed publisher
    ..The present study suggests that adiponectin and leptin play a role in the development of insulin resistance and diabetes independent of metabolic syndrome. ..
  26. Dupont J, Pollet Villard X, Reverchon M, Mellouk N, Levy R. Adipokines in human reproduction. Horm Mol Biol Clin Investig. 2015;24:11-24 pubmed publisher
    ..tissue communicates with other central and peripheral organs by the synthesis and release of substances called adipokines. The most studied adipokine is leptin but others have been recently identified including resistin, adiponectin, ..
  27. Kasper P, Vohlen C, Dinger K, Mohr J, Hucklenbruch Rother E, Janoschek R, et al. Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPK? Signaling in Male Offspring of Obese Dams. Endocrinology. 2017;158:3399-3415 pubmed publisher
    ..This study shows a link between maternal obesity and metabolic programming of renal structure and function and intrinsic-renal Stat3/Akt/AMPK? signaling in the offspring. ..
  28. Oh D, Olefsky J. Medicine. Wnt fans the flames in obesity. Science. 2010;329:397-8 pubmed publisher
  29. O Flanagan C, Bowers L, Hursting S. A weighty problem: metabolic perturbations and the obesity-cancer link. Horm Mol Biol Clin Investig. 2015;23:47-57 pubmed publisher
    ..Here, we discuss the many ways in which excess adiposity can impact cancer development and progression and address potential preventive and therapeutic strategies to reduce the burden of obesity-related cancers. ..
  30. Steiner J, Lang C. Alcohol, Adipose Tissue and Lipid Dysregulation. Biomolecules. 2017;7: pubmed publisher
    ..As an endocrine organ, white adipose tissue (WAT) releases several adipokines that are negatively modulated following chronic alcohol consumption including adiponectin, leptin, and resistin...
  31. Conde J, Scotece M, Lopez V, Abella V, Hermida M, Pino J, et al. Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals. Ann Rheum Dis. 2014;73:631-3 pubmed publisher
  32. Ma Z, Yuan Y, Xu S, Wei W, Xu C, Zhang X, et al. CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. Diabetologia. 2017;60:1126-1137 pubmed publisher
    ..CTRP3 protected against DCM via activation of the AMPK? pathway. CTRP3 has therapeutic potential for the treatment of DCM. ..
  33. Murugesan V, Degerman E, Holmen Pålbrink A, Dunér P, Knutsson A, Hultgårdh Nilsson A, et al. ?-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice. J Vasc Res. 2017;54:235-245 pubmed publisher
    ..Furthermore, the results show the effects of ?-sarcoglycan deficiency on adipose tissue and lipid metabolism, which may also have contributed to the atherosclerotic plaque reduction. ..
  34. Eurich K, Segawa M, Toei Shimizu S, Mizoguchi E. Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells. World J Gastroenterol. 2009;15:5249-59 pubmed
    ..Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells. ..
  35. Hajri T, Gharib M, Kaul S, Karpeh M. Association between adipokines and critical illness outcomes. J Trauma Acute Care Surg. 2017;83:507-519 pubmed publisher
    ..role in immunity and metabolism by virtue of a large number of hormones and cytokines, collectively termed adipokines. Dysregulation of adipokines has been linked to the pathogenesis of multiple diseases, but some questions have ..
  36. Nadal A, Quesada I, Tudurí E, Nogueiras R, Alonso Magdalena P. Endocrine-disrupting chemicals and the regulation of energy balance. Nat Rev Endocrinol. 2017;13:536-546 pubmed publisher
    ..MDCs affect gene expression and the biosynthesis of key enzymes, hormones and adipokines that are essential for controlling energy homeostasis...
  37. Neumann E, Frommer K, Vasile M, Müller Ladner U. Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?. Arthritis Rheum. 2011;63:1159-69 pubmed publisher
  38. Tang H, Shi Z, Xiu Q, Li B, Sun Y. YKL-40-mediated interleukin 8 production may be closely associated with remodeling of bronchial smooth muscle cells. Am J Respir Crit Care Med. 2012;186:386; author reply 386-7 pubmed
  39. Mizuno H, Hatano T, Taketomi A, Kawabata M, Nakabayashi T. Bergamottin Promotes Adipocyte Differentiation and Inhibits Tumor Necrosis Factor-?-induced Inflammatory Cytokines Induction in 3T3-L1 Cells. Yakugaku Zasshi. 2017;137:775-781 pubmed publisher
    ..In addition, Bergamottin decreased the TNF-?-induced increase in the mRNA levels of pro-inflammatory adipokines, monocyte chemoattractant protein-1 and interleukin-6...
  40. O Carroll A, Salih S, Griffiths P, Bijabhai A, Knepper M, Lolait S. Expression and functional implications of the renal apelinergic system in rodents. PLoS ONE. 2017;12:e0183094 pubmed publisher
    ..The comparative distribution of apela, apelin and aplnr in the rodent kidney lays the foundation for future work on how the renal apelinergic system interacts. ..
  41. Sarmento Cabral A, L López F, Luque R. Adipokines and Their Receptors Are Widely Expressed and Distinctly Regulated by the Metabolic Environment in the Prostate of Male Mice: Direct Role Under Normal and Tumoral Conditions. Endocrinology. 2017;158:3540-3552 pubmed publisher
    Adipose tissue-derived adipokines (i.e., leptin/adiponectin/resistin) play important roles in the regulation of several pathophysiologic processes through the activation of specific receptors...
  42. Iozzo P. Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue. Diabetes Care. 2009;32 Suppl 2:S168-73 pubmed publisher
  43. Dong Y, Betancourt A, Belfort M, Yallampalli C. Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies. J Clin Endocrinol Metab. 2017;102:3425-3436 pubmed publisher
    ..To our knowledge, manipulation of AM and its receptors in adipocytes might represent an approach in reducing the risk of GDM and fetal overgrowth. ..
  44. Fietta P, Delsante G. Focus on adipokines. Theor Biol Forum. 2013;106:103-29 pubmed
    ..the products predominantly or exclusively synthesized by and released from adipocytes are categorized as "adipokines"...
  45. Kologlu T, Ucar S, Levent E, Akcay Y, Coker M, Sozmen E. Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children. J Pediatr Endocrinol Metab. 2014;27:701-8 pubmed publisher
    ..ChT and YKL-40 seem to be the more predictable markers of atherosclerosis even in early ages (<6 years old) than other classical inflammation markers such as hs-CRP, IL-6 and TNF-?. ..
  46. Mazur Bialy A, Pochec E. Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development. Life Sci. 2017;178:9-16 pubmed publisher
    ..Moreover, mRNA expression, as well as crucial pro-inflammatory cytokines (TNF?, IL-6) and adipokines (adiponectin, leptin, resistin) release and NF?B activation, were evaluated...
  47. Stringa N, Brahimaj A, Zaciragic A, Dehghan A, Ikram M, Hofman A, et al. Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study. Metabolism. 2017;71:171-181 pubmed publisher
    ..These findings suggest that overall antioxidant capacity of diet and low levels of UA are associated with circulating adipocytokines whereas no consistent association was found with hs-CRP. ..
  48. Camarena V, Sant D, Mohseni M, Salerno T, Zaleski M, Wang G, et al. Novel atherogenic pathways from the differential transcriptome analysis of diabetic epicardial adipose tissue. Nutr Metab Cardiovasc Dis. 2017;27:739-750 pubmed publisher
    ..This suggests a unique and novel atherogenic pathway in diabetes. ..
  49. Lunde L, Skare Ø, Aass H, Mamen A, Einarsdóttir E, Ulvestad B, et al. Physical activity initiated by employer induces improvements in a novel set of biomarkers of inflammation: an 8-week follow-up study. Eur J Appl Physiol. 2017;117:521-532 pubmed publisher
    ..Exercising several times a week was associated with less inflammation compared to exercising once a week or less. During the 8-week follow-up, total levels of biomarkers of inflammation improved. ..
  50. Liu Z, Li C, Chen J, Shen Y, Gao J, Shen W, et al. C1q/TNF-related protein 1 promotes endothelial barrier dysfunction under disturbed flow. Biochem Biophys Res Commun. 2017;490:580-586 pubmed publisher
    ..Inhibition of CTRP1 may inhibit the pathogenesis of atherosclerosis at early stage. ..
  51. O Rourke R. Inflammation in obesity-related diseases. Surgery. 2009;145:255-9 pubmed publisher
  52. Popovic D, Tomić Naglić D, Stokić E. Relation of resistin, leptin and adiponectin--trinity of adipose tissue dysfunction assessment. Eur J Intern Med. 2014;25:e80-1 pubmed publisher
  53. Lohse Z, Bytoft B, Knorr S, Clausen T, Beck Jensen R, Beck Nielsen H, et al. Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes - Results from the EPICOM study. Metabolism. 2017;72:47-56 pubmed publisher
    ..These results suggest that abnormal regulation of adipokines is a consequence of being born to mothers with T1D...