rna isoforms


Summary: The different gene transcripts generated from a single gene by RNA EDITING or ALTERNATIVE SPLICING of RNA PRECURSORS.

Top Publications

  1. Karlsson K, Linnarsson S. Single-cell mRNA isoform diversity in the mouse brain. BMC Genomics. 2017;18:126 pubmed publisher
    ..Our findings indicate that mRNA isoform diversity is an important source of biological variability also in single cells. ..
  2. Li R, Harvey A, Hodgetts S, Fox A. Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles. RNA. 2017;23:872-881 pubmed publisher
    ..This study highlights the complexity of lncRNA and showcases how genome editing tools are useful in dissecting the structural and functional roles of overlapping transcripts. ..
  3. Motti D, Lerch J, Danzi M, Gans J, Kuo F, Slepak T, et al. Identification of miRNAs involved in DRG neurite outgrowth and their putative targets. FEBS Lett. 2017;591:2091-2105 pubmed publisher
    ..MiR-298, let-7a, and let-7f enhance neurite growth and target the majority of isoforms in the differentially expressed network. ..
  4. Li B, Xia L, Liu J, Liao L, Zhang Y, Deng M, et al. miR-758-5p regulates cholesterol uptake via targeting the CD36 3'UTR. Biochem Biophys Res Commun. 2017;494:384-389 pubmed publisher
    ..Therefore, targeting miR-758-5p may offer a promising strategy to treat atherosclerotic vascular disease...
  5. Huizing M, Carrillo Carrasco N, Malicdan M, Noguchi S, Gahl W, Mitrani Rosenbaum S, et al. GNE myopathy: new name and new mutation nomenclature. Neuromuscul Disord. 2014;24:387-9 pubmed publisher
  6. Nariai N, Kojima K, Mimori T, Sato Y, Kawai Y, Yamaguchi Kabata Y, et al. TIGAR2: sensitive and accurate estimation of transcript isoform expression with longer RNA-Seq reads. BMC Genomics. 2014;15 Suppl 10:S5 pubmed publisher
    ..Our method performs better than existing methods for the fixed-length reads (100 bp, 250 bp, 500 bp, and 1000 bp of both single-end and paired-end) and variable-length reads, especially for reads longer than 250 bp. ..
  7. Barann M, Zimmer R, Birzele F. Manananggal - a novel viewer for alternative splicing events. BMC Bioinformatics. 2017;18:120 pubmed publisher
    ..In contrast to SpliceSeq and the DEXSeq splicing plot, Manananggal does not obscure the gene structure by showing full transcript models that makes it easier to determine which isoforms are expressed and which are not. ..
  8. Pinsonneault J, Frater J, Kompa B, Mascarenhas R, Wang D, Sadee W. Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits. PLoS ONE. 2017;12:e0179020 pubmed publisher
    ..0004). The first common ESR1 variant (MAF 12-33% across races) linked to regulatory functions, rs2144025 appears conditionally to affect ESR1 mRNA expression in the brain and modulate traits in behavioral disorders. ..
  9. Wang Y, Brulé E, Silander T, Bak B, Joustra S, Bernard D. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. PLoS ONE. 2017;12:e0180731 pubmed publisher
    ..Whether the protein plays intracellular functions or is trafficked through the secretory pathway under certain physiologic or pathophysiologic conditions has yet to be determined. ..

More Information


  1. Tan D, Chong F, Leong H, Toh S, Lau D, Kwang X, et al. Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma. Nat Med. 2017;23:1167-1175 pubmed publisher
    ..Our study reveals how a 'silent' mutation influences the levels of a lncRNA, resulting in noncanonical EGFR addiction, and delineates a new predictive biomarker suite for response to EGFR TKIs. ..
  2. Jung S, Bi Y, Davuluri R. Evaluation of data discretization methods to derive platform independent isoform expression signatures for multi-class tumor subtyping. BMC Genomics. 2015;16 Suppl 11:S3 pubmed publisher
    ..The approach presented here is generally applicable to other cancer types for classification and identification of molecular subgroups by integrating data across different gene expression platforms. ..
  3. Telonis A, Magee R, Loher P, Chervoneva I, Londin E, Rigoutsos I. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Nucleic Acids Res. 2017;45:2973-2985 pubmed publisher
    ..Given their ability to successfully classify datasets from 32 cancers, isomiRs and our resulting 'Pan-cancer Atlas' of isomiR expression could serve as a suitable framework to explore novel cancer biomarkers. ..