nucleic acids


Summary: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.

Top Publications

  1. Ma C, Li C, He N, Wang F, Ma N, Zhang L, et al. Preparation and characterization of monodisperse core-shell Fe3O4@SiO2 microspheres and its application for magnetic separation of nucleic acids from E. coli BL21. J Biomed Nanotechnol. 2012;8:1000-5 pubmed
    ..And then, the prepared monodisperse core-shell Fe3O4@SiO2 microspheres were subsequently applied to separate nucleic acids from the bacteria (E...
  2. Gusachenko O, Zenkova M, Vlassov V. Nucleic acids in exosomes: disease markers and intercellular communication molecules. Biochemistry (Mosc). 2013;78:1-7 pubmed publisher
    ..present review summarizes the up to date knowledge on the composition and probable physiological functions of nucleic acids released by different cells as components of exosomes...
  3. Jounai N, Kobiyama K, Takeshita F, Ishii K. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol. 2012;2:168 pubmed publisher
  4. Sípová H, Homola J. Surface plasmon resonance sensing of nucleic acids: a review. Anal Chim Acta. 2013;773:9-23 pubmed publisher
    ..b>Nucleic acids (NAs) play a vital role in numerous biological processes and therefore have been one of the major groups of ..
  5. Buneva V, Krasnorutskii M, Nevinsky G. Natural antibodies to nucleic acids. Biochemistry (Mosc). 2013;78:127-43 pubmed publisher
    ..A possible role of these autoantibodies and the reasons of their exceptional diversity in normal organisms and in organisms with different autoimmune diseases are discussed. ..
  6. Staff S, Kujala P, Karhu R, Rökman A, Ilvesaro J, Kares S, et al. Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives. J Clin Pathol. 2013;66:807-10 pubmed publisher
    ..Alternative tissue stabilisation methods are therefore needed. We analysed the preservation of nucleic acids, immunohistochemical staining properties and tissue morphology in paraffin-embedded clinical tissue samples ..
  7. Gorska K, Winssinger N. Reactions templated by nucleic acids: more ways to translate oligonucleotide-based instructions into emerging function. Angew Chem Int Ed Engl. 2013;52:6820-43 pubmed publisher
  8. Gosu V, Basith S, Kwon O, Choi S. Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling. Molecules. 2012;17:13503-29 pubmed publisher
    ..Specifically intracellular TLRs such as TLR3, TLR7, TLR8 and TLR9 recognize nucleic acids such as double-stranded RNA, single-stranded RNA and CpG DNA respectively derived from microbial components...
  9. Young K, Scott A, Hao L, Mirkin S, Liu G, Mirkin C. Hollow spherical nucleic acids for intracellular gene regulation based upon biocompatible silica shells. Nano Lett. 2012;12:3867-71 pubmed publisher
    Cellular transfection of nucleic acids is necessary for regulating gene expression through antisense or RNAi pathways...

More Information


  1. Allen P, Arshad S, Li B, Chen X, Ellington A. DNA circuits as amplifiers for the detection of nucleic acids on a paperfluidic platform. Lab Chip. 2012;12:2951-8 pubmed publisher
    ..By bridging the gap between the low concentrations of LAMP amplicons and the limits of fluorescence detection, the non-enzymatic amplifier allowed us to detect as few as 1200 input templates in a paperfluidic format. ..
  2. Hatakeyama H, Akita H, Harashima H. The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. Biol Pharm Bull. 2013;36:892-9 pubmed
    ..Then, endosomal fusogenic peptides are discussed. Finally, pH-sensitive liposomes using pH-sensitive lipids are described. ..
  3. Chaput J, Yu H, Zhang S. The emerging world of synthetic genetics. Chem Biol. 2012;19:1360-71 pubmed publisher
    ..Moving beyond natural nucleic acids requires organic chemistry to synthesize unnatural analogues and polymerase engineering to create enzymes that ..
  4. Ma C, Li C, Wang F, Ma N, Li X, Li Z, et al. Magnetic nanoparticles-based extraction and verification of nucleic acids from different sources. J Biomed Nanotechnol. 2013;9:703-9 pubmed
    ..In this paper, the extraction efficiency of genomic nucleic acids based on magnetic nanoparticles from four different sources including bacteria, yeast, human blood and virus ..
  5. Buschmann M, Merzouki A, Lavertu M, Thibault M, Jean M, Darras V. Chitosans for delivery of nucleic acids. Adv Drug Deliv Rev. 2013;65:1234-70 pubmed publisher
    ..In each, we present the obstacles to efficient transfection and the strategies adopted over time to surmount these impediments. ..
  6. Rehman Z, Zuhorn I, Hoekstra D. How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances. J Control Release. 2013;166:46-56 pubmed publisher
    ..polymer-based nanodevices are considered appropriate alternatives for virus-based particles for delivery of nucleic acids, including genes and siRNA, into eukaryotic cells...
  7. Vinayanuwattikun C, Winayanuwattikun P, Chantranuwat P, Mutirangura A, Sriuranpong V. The impact of non-tumor-derived circulating nucleic acids implicates the prognosis of non-small cell lung cancer. J Cancer Res Clin Oncol. 2013;139:67-76 pubmed publisher
    ..002) as independent prognostic parameters. The level of total cirDNA in NSCLC is an important prognostic parameter that demonstrates the contributions from both tumor-derived sources and non-tumor-derived sources. ..
  8. Vashisth H, Skiniotis G, Brooks C. Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy maps. J Phys Chem B. 2013;117:3738-46 pubmed publisher
    ..In this work, we aim to systematically examine the quality of structural models of various nucleic acids obtained via MDFF by varying the map resolution and the strength of structural restraints...
  9. Cornett E, O Steen M, Kolpashchikov D. Operating Cooperatively (OC) sensor for highly specific recognition of nucleic acids. PLoS ONE. 2013;8:e55919 pubmed publisher
    ..offers several advantages, including: improved genotyping accuracy and the possibility to analyse folded nucleic acids. Here we report on a new design for MB-based sensor, called 'Operating Cooperatively' (OC), which takes ..
  10. Padirac A, Fujii T, Rondelez Y. Nucleic acids for the rational design of reaction circuits. Curr Opin Biotechnol. 2013;24:575-80 pubmed publisher
    ..Future applications of these chemical smart systems will benefit from the rapidly growing ability to design, construct, and model nucleic acid circuits of increasing size. ..
  11. Machlin E, Sarnow P, Sagan S. Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids. Curr Gene Ther. 2012;12:301-6 pubmed
    ..Recently, it has become apparent that one class of antisense oligonucleotides, locked nucleic acids, can be used to sequester microRNAs in the liver of a variety of animals including humans, opening the ..
  12. Fischer S, Preissner K. Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease. Hamostaseologie. 2013;33:37-42 pubmed publisher
    Upon vascular injury or tissue damage, the exposed intracellular material such as nucleic acids, histones and other macromolecules may come into contact with vessel wall cells and circulating blood cells and may thus, have an enduring ..
  13. Mayer J, Soller J, Beck J, Purwins V, Wemheuer W, Schütz E, et al. Early pregnancy diagnosis in dairy cows using circulating nucleic acids. Theriogenology. 2013;79:173-9 pubmed publisher
    ..Recently, circulating nucleic acids (CNAs) have been used successfully as biomarkers in prenatal diagnosis at different gestational stages in ..
  14. Chen Z, Abrams W, Geva E, de Dood C, GONZALEZ J, Tanke H, et al. Development of a generic microfluidic device for simultaneous detection of antibodies and nucleic acids in oral fluids. Biomed Res Int. 2013;2013:543294 pubmed publisher
    ..The serological result is available in less than 30?min, and the confirmation by RNA amplification takes another 60?min. This approach combines a core serological portable diagnostic with a nucleic acid-based confirmatory test. ..
  15. König S, Kowerko D, Sigel R. Kinetic subpopulations detected by single-molecule spectroscopy: fundamental property of functional nucleic acids or experimental artefact?. Chimia (Aarau). 2013;67:240-3 pubmed
    ..Further examples of dynamic heterogeneity in functional nucleic acids are provided and the possible origins of this phenomenon are discussed.
  16. Kenny G, Bienemann A, Tagalakis A, Pugh J, Welser K, Campbell F, et al. Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the brain. Biomaterials. 2013;34:9190-200 pubmed publisher
    ..Thus, anionic RTN formulations can achieve both widespread dispersal and effective gene expression in brains after administration of a single dose by CED. ..
  17. Castronovo M, Stopar A, Coral L, Redhu S, Vidonis M, Kumar V, et al. Effects of nanoscale confinement on the functionality of nucleic acids: implications for nanomedicine. Curr Med Chem. 2013;20:3539-57 pubmed
    The facile self-assembly and nanomanipulation of nucleic acids hold great promise in the design of innovative, programmable materials, with applications ranging from biosensing to cellular targeting and drug delivery...
  18. He X, Jia H, Jing Z, Liu D. Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors. Acta Biochim Biophys Sin (Shanghai). 2013;45:241-58 pubmed publisher
    Foreign nucleic acids, the essential signature molecules of invading pathogens that act as danger signals for host cells, are detected by endosomal nucleic acid-sensing toll-like receptors (TLRs) 3, 7, 8, 9, and 13...
  19. Poletto M, Vascotto C, Scognamiglio P, Lirussi L, Marasco D, Tell G. Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin). Biochem J. 2013;452:545-57 pubmed publisher
    ..In the present study, we characterized the requirements for the interaction of hAPE1 with NPM1 and undamaged nucleic acids. We show that DNA/RNA secondary structure has an impact on hAPE1 binding in the absence of damage...
  20. Brencicova E, Diebold S. Nucleic acids and endosomal pattern recognition: how to tell friend from foe?. Front Cell Infect Microbiol. 2013;3:37 pubmed publisher
    The innate immune system has evolved endosomal and cytoplasmic receptors for the detection of viral nucleic acids as sensors for virus infection...
  21. Pinheiro V, Taylor A, Cozens C, Abramov M, Renders M, Zhang S, et al. Synthetic genetic polymers capable of heredity and evolution. Science. 2012;336:341-4 pubmed publisher
    ..from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]...
  22. Friel A, Corcoran C, Crown J, O Driscoll L. Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer. Breast Cancer Res Treat. 2010;123:613-25 pubmed publisher
    ..Circulating tumor cells and extracellular nucleic acids have been detected within blood, plasma, and sera of cancer patients...
  23. Kuwahara M, Sugimoto N. Molecular evolution of functional nucleic acids with chemical modifications. Molecules. 2010;15:5423-44 pubmed publisher
    b>Nucleic acids are attractive materials for creating functional molecules that have applications as catalysts, specific binders, and molecular switches...
  24. Vlassov V, Laktionov P, Rykova E. Circulating nucleic acids as a potential source for cancer biomarkers. Curr Mol Med. 2010;10:142-65 pubmed
    ..The aim of this publication was to review the recently reported studies on the circulating DNA and RNA in cancer patients and to estimate their impact on making the ongoing research closer to clinical application. ..
  25. Inoue R, Nagino T, Hoshino G, Ushida K. Nucleic acids of Enterococcus faecalis strain EC-12 are potent Toll-like receptor 7 and 9 ligands inducing interleukin-12 production from murine splenocytes and murine macrophage cell line J774.1. FEMS Immunol Med Microbiol. 2011;61:94-102 pubmed publisher
    ..faecalis strain EC-12 when both TLR7 and 9 were antagonized. These facts indicate that the nucleic acids of E...
  26. Shibata A, Abe H, Ito Y. Oligonucleotide-templated reactions for sensing nucleic acids. Molecules. 2012;17:2446-63 pubmed publisher
    ..Major scientific interests are focused on the development of signal amplification systems and signal generation systems. We introduce the recent advances of oligonucleotide-templated reaction in consideration of the above two points. ..
  27. Hahn S, Rusterholz C, Hösli I, Lapaire O. Cell-free nucleic acids as potential markers for preeclampsia. Placenta. 2011;32 Suppl:S17-20 pubmed publisher
    ..Circulating cell-free nucleic acids in plasma and serum are novel biomarkers with promising clinical applications in different medical fields, ..
  28. Koynova R, Tenchov B. Recent patents in cationic lipid carriers for delivery of nucleic acids. Recent Pat DNA Gene Seq. 2011;5:8-27 pubmed
    ..This review summarizes the recent patents on new cationic lipids as well as on multicomponent formulations enhancing their efficiency as nucleotide carriers. ..
  29. Arian D, Kovbasyuk L, Mokhir A. Control of the photocatalytic activity of bimetallic complexes of pyropheophorbide-a by nucleic acids. Inorg Chem. 2011;50:12010-7 pubmed publisher
    ..In this way the catalytic activity of the PS can be controlled by the specific nucleic acids. We applied this reaction earlier for the amplified detection of ribonucleic acids in live cells (Arian, D...
  30. Dumousseau M, Rodriguez N, Juty N, Le Novère N. MELTING, a flexible platform to predict the melting temperatures of nucleic acids. BMC Bioinformatics. 2012;13:101 pubmed publisher
    ..MELTING is a free open source software which computes the enthalpy, entropy and melting temperature of nucleic acids. MELTING 4...
  31. Zhao P, Zhang W, Chen S. Predicting secondary structural folding kinetics for nucleic acids. Biophys J. 2010;98:1617-25 pubmed publisher
    ..The approach presented here may provide a robust first step for further systematic development of a predictive theory for the folding kinetics for large RNAs. ..
  32. Peña A, Gewartowski K, Mroczek S, Cuellar J, Szykowska A, Prokop A, et al. Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. EMBO J. 2012;31:1605-16 pubmed publisher
    ..Furthermore, we show that THO directly interacts with nucleic acids through the unfolded C-terminal region of Tho2, whose removal reduces THO recruitment to active chromatin ..
  33. Pechlaner M, Sigel R. Characterization of metal ion-nucleic acid interactions in solution. Met Ions Life Sci. 2012;10:1-42 pubmed publisher
    Metal ions are inextricably involved with nucleic acids due to their polyanionic nature...
  34. Kocic G, Radenkovic S, Cvetkovic T, Cencic A, Carluccio F, Musovic D, et al. Circulating nucleic acids as possible damage-associated molecular patterns in different stages of renal failure. Ren Fail. 2010;32:486-92 pubmed publisher
    ..Up to now, a number of DAMP molecules were identified. We hypothesized that the available circulating nucleic acids, acting as DAMPs, may modulate immunoinflammatory reaction in CRF...
  35. Preusser M, Plumer S, Dirnberger E, Hainfellner J, Mannhalter C. Fixation of brain tumor biopsy specimens with RCL2 results in well-preserved histomorphology, immunohistochemistry and nucleic acids. Brain Pathol. 2010;20:1010-20 pubmed publisher
    RCL2 is an alcohol-based fixative reported to preserve histomorphology and nucleic acids in non-CNS neoplasms...
  36. Kontaki E, Boumpas D. Innate immunity in systemic lupus erythematosus: sensing endogenous nucleic acids. J Autoimmun. 2010;35:206-11 pubmed publisher
    ..According to the current paradigm, nucleosomes containing nucleic acids (RNA and/or DNA) and other endogenous danger ligands that can bind to pathogen associated molecular pattern ..
  37. Jensen T, Henriksen J, Rasmussen B, Rasmussen L, Andresen T, Wengel J, et al. Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer. Bioorg Med Chem. 2011;19:4739-45 pubmed publisher
    ..Most of the studied variants bind thrombin, albeit with decreased affinity in reference to unmodified TBA. Thrombin time assay studies indicate three variants as being as potent as TBA in fibrin clotting inhibition. ..
  38. Doessing H, Vester B. Locked and unlocked nucleosides in functional nucleic acids. Molecules. 2011;16:4511-26 pubmed publisher
    b>Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology...
  39. Terns M, Terns R. CRISPR-based adaptive immune systems. Curr Opin Microbiol. 2011;14:321-7 pubmed publisher
    ..CRISPR loci (CRISPR (cr)RNAs) guide Cas proteins to recognize and degrade (or otherwise silence) the invading nucleic acids. There are multiple variations of the pathway found among prokaryotes, each mediated by largely distinct ..
  40. Muller J. Functional metal ions in nucleic acids. Metallomics. 2010;2:318-27 pubmed publisher gives a compact overview of the multifaceted situations in which metal ions exert specific functions in nucleic acids, also including a discussion of structural metal ions in regular DNA and RNA as well as triple helices, ..
  41. Smith R. Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses. Retrovirology. 2010;7:112 pubmed publisher
    ..These findings raise important questions regarding the provenance of XMRV and its potential connection to human disease...
  42. Palte M, Raines R. Interaction of nucleic acids with the glycocalyx. J Am Chem Soc. 2012;134:6218-23 pubmed publisher
    Mammalian cells resist the uptake of nucleic acids. The lipid bilayer of the plasma membrane presents one barrier. Here, we report on a second physicochemical barrier for uptake...
  43. Garcia Remesal M, Cuevas A, Pérez Rey D, Martín L, Anguita A, De La Iglesia D, et al. PubDNA Finder: a web database linking full-text articles to sequences of nucleic acids. Bioinformatics. 2010;26:2801-2 pubmed publisher
    ..Finder is an online repository that we have created to link PubMed Central manuscripts to the sequences of nucleic acids appearing in them...
  44. Pabit S, Finkelstein K, Pollack L. Using anomalous small angle X-ray scattering to probe the ion atmosphere around nucleic acids. Methods Enzymol. 2009;469:391-410 pubmed publisher
    ..This chapter, which briefly describes the origin of the ASAXS signal, focuses on the experimental methods required to carry out these measurements and the interpretation of the anomalous signals. ..
  45. Kuwahara M, Takano Y, Kasahara Y, Nara H, Ozaki H, Sawai H, et al. Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids using base/sugar modified nucleoside triphosphates. Molecules. 2010;15:8229-40 pubmed publisher
    Recently, KOD and its related DNA polymerases have been used for preparing various modified nucleic acids, including not only base-modified nucleic acids, but also sugar-modified ones, such as bridged/locked nucleic acid (BNA/LNA) which ..
  46. Burgemeister R. Nucleic acids extraction from laser microdissected FFPE tissue sections. Methods Mol Biol. 2011;724:117-29 pubmed publisher
    ..Optimized protocols may help to make the RNA from FFPE material suitable for expression studies. ..
  47. Li H, Zhai J, Sun X. Electrostatic-assembly-driven formation of supramolecular rhombus microparticles and their application for fluorescent nucleic acid detection. PLoS ONE. 2011;6:e18958 pubmed publisher
    ..In the following assay, specific hybridization with its target to form double-stranded DNA (dsDNA) results in desorption of ssDNA from SRM surface and subsequent fluorescence recovery. ..
  48. Parameswaran S, Balasubramanian S, Rao M, Ahmad I. Concise review: non-cell autonomous reprogramming: a nucleic acid-free approach to induction of pluripotency. Stem Cells. 2011;29:1013-20 pubmed publisher
  49. Röthlingshöfer M, Gorska K, Winssinger N. Nucleic acid-templated energy transfer leading to a photorelease reaction and its application to a system displaying a nonlinear response. J Am Chem Soc. 2011;133:18110-3 pubmed publisher
    ..Programming a specific hierarchical relationship among the four components enabled the design of a system that responded first positively and then negatively to increasing levels of an analyte. ..
  50. Tsai Y, Hu C, Chu C, Imae T. Intrinsically fluorescent PAMAM dendrimer as gene carrier and nanoprobe for nucleic acids delivery: bioimaging and transfection study. Biomacromolecules. 2011;12:4283-90 pubmed publisher
    ..Our preliminary results clearly indicated that intrinsic fluorescent PAMAM dendrimers show promise as gene vehicles that can achieve delivery, transfection, and bioimaging at the same time. ..
  51. Röthlingshöfer M, Gorska K, Winssinger N. Nucleic acid templated uncaging of fluorophores using Ru-catalyzed photoreduction with visible light. Org Lett. 2012;14:482-5 pubmed publisher
    ..The reaction could be performed with as little as 2% of the Ru nucleic acid probe and was shown to productively unquench 7-azido-coumarin as well as uncage a small molecule. ..
  52. Lehto T, Kurrikoff K, Langel U. Cell-penetrating peptides for the delivery of nucleic acids. Expert Opin Drug Deliv. 2012;9:823-36 pubmed publisher
    ..Recently, non-viral delivery of nucleic acids and their analogs has gained significant interest...
  53. Chen D, Mauk M, Qiu X, Liu C, Kim J, Ramprasad S, et al. An integrated, self-contained microfluidic cassette for isolation, amplification, and detection of nucleic acids. Biomed Microdevices. 2010;12:705-19 pubmed publisher
    ..sample introduction; lysis of cells and viruses; solid-phase extraction, concentration, and purification of nucleic acids from the lysate; elution of the nucleic acids into a thermal cycling chamber and mixing with pre-stored (RT-)..