fullerenes

Summary

Summary: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.

Top Publications

  1. Norton S, Wijesinghe D, Dellinger A, Sturgill J, Zhou Z, BARBOUR S, et al. Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma. J Allergy Clin Immunol. 2012;130:761-769.e2 pubmed publisher
    b>Fullerenes are molecules being investigated for a wide range of therapeutic applications...
  2. Patel M, Kumar S, Valand N, Jasrai Y, Menon S. Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme. J Mol Model. 2013;19:3201-17 pubmed publisher
    ..We then explored the surface geometry of the protein to place the cage adjacent to the active site while optimizing its quinazolinone side arm to establish H bonding with active site residues. ..
  3. Stankov K, Borisev I, Kojic V, Rutonjski L, Bogdanovic G, Djordjevic A. Modification of antioxidative and antiapoptotic genes expression in irradiated K562 cells upon fullerenol C60(OH)24 nanoparticle treatment. J Nanosci Nanotechnol. 2013;13:105-13 pubmed
  4. Zhang Y, Wang L, Sun Y, Zhu Y, Zhong Z, Shi J, et al. Conjugation of dexamethasone to C60 for the design of an anti-inflammatory nanomedicine with reduced cellular apoptosis. ACS Appl Mater Interfaces. 2013;5:5291-7 pubmed publisher
    ..These findings help understand the mechanism of beneficial effects of this new nanomedicine, DEX-C60, and promote its clinical applications...
  5. Kolkman A, Emke E, Bäuerlein P, Carboni A, Tran D, Ter Laak T, et al. Analysis of (functionalized) fullerenes in water samples by liquid chromatography coupled to high-resolution mass spectrometry. Anal Chem. 2013;85:5867-74 pubmed publisher
    One of the main challenges in environmental risk assessment of fullerenes is to develop analytical methods that detect and quantify fullerenes at low concentrations...
  6. Yin X, Zhao L, Kang S, Pan J, Song Y, Zhang M, et al. Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules. Nanoscale. 2013;5:7341-8 pubmed publisher
    ..Compared to C60(OH)24, the interaction of Gd@C82(OH)22 with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils. ..
  7. Dunk P, Kaiser N, Hendrickson C, Quinn J, Ewels C, Nakanishi Y, et al. Closed network growth of fullerenes. Nat Commun. 2012;3:855 pubmed publisher
    Tremendous advances in nanoscience have been made since the discovery of the fullerenes; however, the formation of these carbon-caged nanomaterials still remains a mystery...
  8. Kaiser A, Zöttl S, Bartl P, Leidlmair C, Mauracher A, Probst M, et al. Methane adsorption on aggregates of fullerenes: site-selective storage capacities and adsorption energies. ChemSusChem. 2013;6:1235-44 pubmed publisher
    ..The effects of corrugation and curvature are discussed and compared with data for adsorption on graphite, graphene, and carbon nanotubes...
  9. Liu H, Yang X, Zhang Y, Dighe A, Li X, Cui Q. Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. J Orthop Res. 2012;30:1051-7 pubmed publisher
    ..The results indicated that fullerol can potentially be used for prevention and treatment of corticosteroid-induced osteonecrosis...

More Information

Publications62

  1. Miyake M, Nakajima H, Hemmi A, Yahiro M, Adachi C, Soh N, et al. Performance of an organic photodiode as an optical detector and its application to fluorometric flow-immunoassay for IgA. Talanta. 2012;96:132-9 pubmed publisher
    ..The detection limits for resorufin and IgA were 5.0?M and 16ng/mL, respectively. The photosensitivity of the OPD remained relatively constant for a minimum of one year...
  2. Tkach A, Yanamala N, Stanley S, Shurin M, Shurin G, Kisin E, et al. Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells. Small. 2013;9:1686-90 pubmed publisher
    Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells...
  3. Nedumpully Govindan P, Monticelli L, Salonen E. Mechanism of taq DNA polymerase inhibition by fullerene derivatives: insight from computer simulations. J Phys Chem B. 2012;116:10676-83 pubmed publisher
    ..The proposed mechanism of inhibition would be common for all DNA polymerase proteins, providing new possibilities in antiviral applications of fullerene derivatives...
  4. Matsuo Y, Kawai J, Inada H, Nakagawa T, Ota H, Otsubo S, et al. Addition of dihydromethano group to fullerenes to improve the performance of bulk heterojunction organic solar cells. Adv Mater. 2013;25:6266-9 pubmed publisher
    ..This class of compounds features reduced conjugation that raises the LUMO level, and a high electron mobility because of the small CH2 addend. ..
  5. Tramer F, Da Ros T, Passamonti S. Screening of fullerene toxicity by hemolysis assay. Methods Mol Biol. 2012;926:203-17 pubmed publisher
    ..The characterization of the toxicity potential of fullerenes is therefore of growing interest for any biomedical application...
  6. Kang S, Huynh T, Zhou R. Metallofullerenol Gd@C??(OH)?? distracts the proline-rich-motif from putative binding on the SH3 domain. Nanoscale. 2013;5:2703-12 pubmed publisher
  7. Nakamura S, Mashino T. Water-soluble fullerene derivatives for drug discovery. J Nippon Med Sch. 2012;79:248-54 pubmed
    b>Fullerenes (represented by buckminsterfullerene, C(60)) are a new kind of organic compound with a cage-like structure. A great deal of attention has been focused on their unique properties...
  8. Kang S, Huynh T, Zhou R. Non-destructive inhibition of metallofullerenol Gd@C(82)(OH)(22) on WW domain: implication on signal transduction pathway. Sci Rep. 2012;2:957 pubmed publisher
    ..Further analyses with binding free energy landscapes reveal that Gd@C(82)(OH)(22) can not only directly block the binding site of the WW domain, but also effectively distract the PRM from its native binding pocket...
  9. Kwag D, Park K, Oh K, Lee E. Hyaluronated fullerenes with photoluminescent and antitumoral activity. Chem Commun (Camb). 2013;49:282-4 pubmed publisher
    ..This fullerene allowed high-resolution fluorescent imaging of tumor sites in vivo and resulted in a significant regression of HCT-116 tumors...
  10. Xiao S, Wang Q, Yu F, Peng Y, Yang M, Sollogoub M, et al. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorg Med Chem. 2012;20:5616-22 pubmed publisher
    ..17 ?M level...
  11. Patel M, Harikrishnan U, Valand N, Modi N, Menon S. Novel cationic quinazolin-4(3H)-one conjugated fullerene nanoparticles as antimycobacterial and antimicrobial agents. Arch Pharm (Weinheim). 2013;346:210-20 pubmed publisher
    ..niger), respectively. All the compounds exhibited significant activity, with the most effective compounds having MIC values and zones of inhibition comparable to those of standard drugs...
  12. Liu X, Li L, Liu B, Wang D, Zhao Y, Gao X. Theoretical study on the ground state structure of uranofullerene U@C82. J Phys Chem A. 2012;116:11651-5 pubmed publisher
    ..The proposed geometry and electronic structure of U(3+)@(#9)C(82)(3-) are in good agreement with the experimental observation...
  13. Kelsey J, White J. Effect of C60 fullerenes on the accumulation of weathered p,p'-DDE by plant and earthworm species under single and multispecies conditions. Environ Toxicol Chem. 2013;32:1117-23 pubmed publisher
    ..Here, the effect of C60 fullerenes on the accumulation of weathered dichlorodiphenyldichloroethylene (p,p'-DDE; DDT metabolite) by Cucurbita pepo (..
  14. Grebowski J, Krokosz A, Puchala M. Fullerenol C??(OH)?? could associate to band 3 protein of human erythrocyte membranes. Biochim Biophys Acta. 2013;1828:2007-14 pubmed publisher
    ..The study shows that fullerenol slightly changed the morphology of the cells and, therefore, altered the intracellular organization of erythrocytes through the association with cytoskeletal proteins. ..
  15. Yumita N, Iwase Y, Imaizumi T, Sakurazawa A, Kaya Y, Nishi K, et al. Sonodynamically-induced anticancer effects by functionalized fullerenes. Anticancer Res. 2013;33:3145-51 pubmed
    Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials...
  16. Grebowski J, Krokosz A, Puchala M. Membrane fluidity and activity of membrane ATPases in human erythrocytes under the influence of polyhydroxylated fullerene. Biochim Biophys Acta. 2013;1828:241-8 pubmed publisher
    ..Moreover, fullerenol influences membrane ATPases so that it may modulate ion transport across membranes...
  17. Kang S, Zhou G, Yang P, Liu Y, Sun B, Huynh T, et al. Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine. Proc Natl Acad Sci U S A. 2012;109:15431-6 pubmed
    ..Our findings provide insights for de novo design of nanomedicines for fatal diseases such as pancreatic cancer...
  18. Bunz H, Plankenhorn S, Klein R. Effect of buckminsterfullerenes on cells of the innate and adaptive immune system: an in vitro study with human peripheral blood mononuclear cells. Int J Nanomedicine. 2012;7:4571-80 pubmed publisher
    ..Both fullerenes did not influence T cell reactivity, with no enhanced expression of CD69 and production of T cell cytokines ..
  19. Zha Y, Yang B, Tang M, Guo Q, Chen J, Wen L, et al. Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability. Int J Nanomedicine. 2012;7:3099-109 pubmed publisher
    ..This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons...
  20. Trpkovic A, Todorovic Markovic B, Trajkovic V. Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stress. Arch Toxicol. 2012;86:1809-27 pubmed publisher
    ..Moreover, the widespread industrial utilization of fullerenes may also have implications for human health...
  21. Schreiner K, Filley T, Blanchette R, Bowen B, Bolskar R, Hockaday W, et al. White-rot basidiomycete-mediated decomposition of C60 fullerol. Environ Sci Technol. 2009;43:3162-8 pubmed
    Industrially produced carbon-based nanomaterials (CNM), including fullerenes and nanotubes, will be introduced into the environment in increasing amounts in the next decades...
  22. Vakhrushev A, Suyetin M. Methane storage in bottle-like nanocapsules. Nanotechnology. 2009;20:125602 pubmed publisher
    ..The nanocapsule discussed can retain approximately 17.5 mass% of methane at an internal pressure of 10 MPa and a temperature of 300 K...
  23. Partha R, Mitchell L, Lyon J, Joshi P, Conyers J. Buckysomes: fullerene-based nanocarriers for hydrophobic molecule delivery. ACS Nano. 2008;2:1950-8 pubmed publisher
    ..The results of our studies suggest that buckysomes prepared from self-assembly of AF-1 at 70 degrees C are promising nanomaterials for the delivery of hydrophobic molecules...
  24. Teprovich J, Wellons M, Lascola R, Hwang S, Ward P, Compton R, et al. Synthesis and characterization of a lithium-doped fullerane (Li(x)-C60-H(y)) for reversible hydrogen storage. Nano Lett. 2012;12:582-9 pubmed publisher
    ..an onset temperature of ~270 °C, which is significantly less than the desorption temperature of hydrogenated fullerenes (C(60)H(x)) and pure lithium hydride (decomposition temperature 500-600 and 670 °C respectively)...
  25. Yin J, Lao F, Meng J, Fu P, Zhao Y, Xing G, et al. Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger. Mol Pharmacol. 2008;74:1132-40 pubmed publisher
  26. Zhu J, Ji Z, Wang J, Sun R, Zhang X, Gao Y, et al. Tumor-inhibitory effect and immunomodulatory activity of fullerol C60(OH)x. Small. 2008;4:1168-75 pubmed publisher
    ..The tumor necrosis factor alpha production of C60(OH)x-treated macrophages also increases in vitro. These results suggest that C60(OH)x can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor...
  27. Tang J, Xing G, Zhao F, Yuan H, Zhao Y. Modulation of structural and electronic properties of fullerene and metallofullerenes by surface chemical modifications. J Nanosci Nanotechnol. 2007;7:1085-101 pubmed
    ..The outer chemical modifications can sensitively influence the stability of final derivatives of fullerenes, depending on parameters such as the number of the modified groups, the unintended impurity groups on the cage ..
  28. Yang X, Chen L, Qiao X, Fan C. Photo-induced damages of cytoplasmic and mitochondrial membranes by a [C60]fullerene malonic acid derivative. Int J Toxicol. 2007;26:197-201 pubmed
    ..These data provided some novel clues to explain the mechanisms involved in the photo-induced cytotoxicity of fullerene derivatives...
  29. Dellinger A, Zhou Z, Lenk R, MacFarland D, Kepley C. Fullerene nanomaterials inhibit phorbol myristate acetate-induced inflammation. Exp Dermatol. 2009;18:1079-81 pubmed publisher
    ..Oxidative stress, the generation of reactive oxygen species, is thought to be one component of this response. Fullerenes can counteract reactive oxygen species due to their potent antioxidant capabilities...
  30. Nakagawa Y, Suzuki T, Ishii H, Nakae D, Ogata A. Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction. Arch Toxicol. 2011;85:1429-40 pubmed publisher
    The cytotoxic effects of hydroxylated fullerenes, also termed fullerenols or fullerols [C(60)(OH)( n )], which are known nanomaterials and water-soluble fullerene derivatives, were ..
  31. Shetab Boushehri S, Ostad S, Sarkar S, Kuznetsov D, Buchachenko A, Orlova M, et al. The C60-fullerene porphyrin adducts for prevention of the doxorubicin-induced acute cardiotoxicity in rat myocardial cells. Acta Med Iran. 2010;48:342-50 pubmed
  32. Aschberger K, Johnston H, Stone V, Aitken R, Tran C, Hankin S, et al. Review of fullerene toxicity and exposure--appraisal of a human health risk assessment, based on open literature. Regul Toxicol Pharmacol. 2010;58:455-73 pubmed publisher
    b>Fullerenes have gained considerable attention due to their anti-oxidant and radical scavenging properties. Their current applications include targeted drug delivery, energy application, polymer modifications and cosmetic products...
  33. Mroz P, Tegos G, Gali H, Wharton T, Sarna T, Hamblin M. Photodynamic therapy with fullerenes. Photochem Photobiol Sci. 2007;6:1139-49 pubmed
    b>Fullerenes are a class of closed-cage nanomaterials made exclusively from carbon atoms...
  34. Zettergren H, Wang Y, Lamsabhi A, Alcamí M, Martin F. Density functional theory study of multiply ionized weakly bound fullerene dimers. J Chem Phys. 2009;130:224302 pubmed publisher
    ..For the latter dimers, the calculated kinetic energy release in the binary fission yielding intact fullerenes is lower than those reported in recent experimental work...
  35. Horie M, Fukuhara A, Saito Y, Yoshida Y, Sato H, Ohi H, et al. Antioxidant action of sugar-pendant C60 fullerenes. Bioorg Med Chem Lett. 2009;19:5902-4 pubmed publisher
    ..In the present study, the reactivity of the two types of water-soluble, sugar-pendant C60 fullerenes, C60-1S and C60-2S, toward peroxyl radical and their effect against human plasma lipid peroxidation were ..
  36. Pinteala M, Dascalu A, Ungurenasu C. Binding fullerenol C(60)(OH)(24) to dsDNA. Int J Nanomedicine. 2009;4:193-9 pubmed
    ..3 ng mL(-1). Fullerenol C(60)(OH)(24) binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA...
  37. Chawla P, Chawla V, Maheshwari R, Saraf S, Saraf S. Fullerenes: from carbon to nanomedicine. Mini Rev Med Chem. 2010;10:662-77 pubmed
    b>Fullerenes, the third carbon allotrope, have emerged as agents which could revolutionize the treatment of many diseases...
  38. Basso A, Frenkel D, Quintana F, Costa Pinto F, Petrovic Stojkovic S, Puckett L, et al. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008;118:1532-43 pubmed publisher
    ..Our data demonstrate the neuroprotective effect of treatment with a fullerene compound combined with a NMDA receptor antagonist, which may be useful in the treatment of progressive MS and other neurodegenerative diseases...
  39. Denifl S, Zappa F, Mähr I, Mauracher A, Probst M, Urban J, et al. Ionization of doped helium nanodroplets: complexes of C60 with water clusters. J Chem Phys. 2010;132:234307 pubmed publisher
    ..For n=3, 4, or 6, fissionlike desorption of the entire water complex from C(60)(H(2)O)(n)(+) energetically competes with the evaporation of a single water molecule...
  40. Yan L, Zhao F, Li S, Hu Z, Zhao Y. Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes. Nanoscale. 2011;3:362-82 pubmed publisher
    ..to improve biocompatibility, regulate ADME, and reduce the toxicity of carbon nanomaterials (carbon nanotubes, fullerenes, metallofullerenes, and graphenes)...
  41. Isaacson C, Usenko C, Tanguay R, Field J. Quantification of fullerenes by LC/ESI-MS and its application to in vivo toxicity assays. Anal Chem. 2007;79:9091-7 pubmed
    ..with liquid chromatography/electrospray ionization mass spectrometry for the quantitative determination of fullerenes from C60 to C98. Isotopically enriched, 13C60, was used as an internal standard...
  42. Xiao Y, Wiesner M. Characterization of surface hydrophobicity of engineered nanoparticles. J Hazard Mater. 2012;215-216:146-51 pubmed publisher
    ..Fullerol was shown to be the least hydrophobic of seven NPs tested. The advantages and limitations of each method were also discussed...
  43. Zhu X, Zhu L, Lang Y, Chen Y. Oxidative stress and growth inhibition in the freshwater fish Carassius auratus induced by chronic exposure to sublethal fullerene aggregates. Environ Toxicol Chem. 2008;27:1979-85 pubmed
    ..This important work contributes to a better understanding of the potential health effects of exposure to manufactured nanomaterials on species in aquatic ecosystems...
  44. Henry T, Menn F, Fleming J, Wilgus J, Compton R, Sayler G. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Environ Health Perspect. 2007;115:1059-65 pubmed
    ..Previous research has indicated toxicity from C(60) aggregate; however, effects could be because of tetrahydrofuran (THF) vehicle used to prepare aggregates...
  45. Chaudhary S, Lu H, Müller A, Bardeen C, Ozkan M. Hierarchical placement and associated optoelectronic impact of carbon nanotubes in polymer-fullerene solar cells. Nano Lett. 2007;7:1973-9 pubmed
    ..We also observe that SWNTs deposited on the top of the active layer lead to major electro-optical changes in the device functionality, including an increased fluorescence lifetime of poly-3-hexylthiophene (P3HT)...
  46. Liu R, Cai X, Wang J, Li J, Huang Q, Li W. Research on the bioactivities of C60-dexamethasone. J Nanosci Nanotechnol. 2009;9:3171-6 pubmed
    ..The scavenging test for lipophilic DPPH free radical indicated that C60-dexamethasone was an efficient free radical remover or antioxidant, which was responsible for the reduction of side effects of C60-dexamethasone...
  47. Yudoh K, Karasawa R, Masuko K, Kato T. Water-soluble fullerene (C60) inhibits the development of arthritis in the rat model of arthritis. Int J Nanomedicine. 2009;4:217-25 pubmed
    ..These findings indicate that C60 is a potential therapeutic agent for inhibition of arthritis...
  48. Calvaresi M, Zerbetto F. Baiting proteins with C60. ACS Nano. 2010;4:2283-99 pubmed publisher
    ..A closer exam of the 10 top scorers is discussed in detail. New proteins that can interact with C60 are identified and discussed for possible future applications as drug targets and fullerene derivatives bioconjugate materials...
  49. Norton S, Dellinger A, Zhou Z, Lenk R, MacFarland D, Vonakis B, et al. A new class of human mast cell and peripheral blood basophil stabilizers that differentially control allergic mediator release. Clin Transl Sci. 2010;3:158-69 pubmed publisher
    ..No toxicity was observed with either compound. These findings demonstrate the biological effects of fullerenes critically depends on the moieties added to the carbon cage and suggest they act on different FcepsilonRI-..
  50. Bortolus M, Parisio G, Maniero A, Ferrarini A. Monomeric fullerenes in lipid membranes: effects of molecular shape and polarity. Langmuir. 2011;27:12560-8 pubmed publisher
    We report a combined theoretical and experimental study on the single-molecule interaction of fullerenes with phospholipid membranes...
  51. Kraszewski S, Tarek M, Ramseyer C. Uptake and translocation mechanisms of cationic amino derivatives functionalized on pristine C60 by lipid membranes: a molecular dynamics simulation study. ACS Nano. 2011;5:8571-8 pubmed publisher
    ..Finally, the fullerenes bearing too many cationic groups display mostly a hydrophilic character; thus, the lipophilic fullerene core is ..
  52. Blickley T, McClellan Green P. Toxicity of aqueous fullerene in adult and larval Fundulus heteroclitus. Environ Toxicol Chem. 2008;27:1964-71 pubmed
    ..Environmental factors influencing uptake, metabolism, and physiological response following exposure, however, need further investigation...
  53. Baati T, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A, et al. The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. Biomaterials. 2012;33:4936-46 pubmed publisher
    ..These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing...