cherubism

Summary

Summary: A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.

Top Publications

  1. Carvalho V, Perdigão P, Pimenta F, de Souza P, Gomez R, De Marco L. A novel mutation of the SH3BP2 gene in an aggressive case of cherubism. Oral Oncol. 2008;44:153-5 pubmed
    b>Cherubism is an autosomal dominant inherited syndrome characterized by excessive bone degradation of upper and lower jaw and its replacement with large amounts of fibrous tissue, which causes a characteristic facial swelling...
  2. Jing X, Pu R. Fine-needle aspiration cytological features of Cherubism. Diagn Cytopathol. 2008;36:188-9 pubmed publisher
    b>Cherubism is a rare benign, non-neoplastic condition characterized by facial alteration due to symmetrically expansion of bilateral mandibles and maxillas...
  3. Ferguson P, El Shanti H. Autoinflammatory bone disorders. Curr Opin Rheumatol. 2007;19:492-8 pubmed
    ..This review provides an update on clinical, genetic, and immunologic aspects of the autoinflammatory bone disorders...
  4. de Lange J, Van den Akker H, Scholtemeijer M. Cherubism treated with calcitonin: report of a case. J Oral Maxillofac Surg. 2007;65:1665-7 pubmed
  5. Lietman S, Prescott N, Hicks D, Westra W, Levine M. SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism. Clin Orthop Relat Res. 2007;459:22-7 pubmed
    ..b>Cherubism is a benign lesion of the maxilla and mandible histologically similar to giant cell tumor of bone and giant cell ..
  6. Penarrocha M, Bonet J, Mínguez J, Bagan J, Vera F, Mínguez I. Cherubism: a clinical, radiographic, and histopathologic comparison of 7 cases. J Oral Maxillofac Surg. 2006;64:924-30 pubmed
    b>Cherubism is an uncommon fibro-osseous disorder of the jaws that presents with varying degrees of involvement and a tendency toward spontaneous remission...
  7. Font R, Blanco G, Soparkar C, Patrinely J, Ostrowski M. Giant cell reparative granuloma of the orbit associated with cherubism. Ophthalmology. 2003;110:1846-9 pubmed
    To report a case of cherubism with extensive, bilateral orbital involvement occurring in a 27-year-old woman who had the diagnosis established at the age of 4 years. Single interventional case report...
  8. Hanna N, Parfait B, Talaat I, Vidaud M, Elsedfy H. SOS1: a new player in the Noonan-like/multiple giant cell lesion syndrome. Clin Genet. 2009;75:568-71 pubmed publisher
    ..giant cell lesion syndrome is a rare condition with phenotypic overlap with Noonan syndrome (NS) and cherubism. PTPN11 gene mutations were described in several individuals with this phenotype, and it is recently considered ..
  9. Nicolae C, Olsen B. Unexpected matrix diseases and novel therapeutic strategies. Cell Tissue Res. 2010;339:155-65 pubmed publisher
    ..The first of these disorders, cherubism, is a case of inflammatory bone loss in the jaws of children for reasons that are surprisingly systemic in ..

More Information

Publications69

  1. Ogi K, Nakashima K, Chihara K, Takeuchi K, Horiguchi T, Fujieda S, et al. Enhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism. Genes Cells. 2011;16:951-60 pubmed publisher
    ..the effect of the proline to arginine substitution of 3BP2 in which is the most common mutation in patients with cherubism (P418R) on B-cell receptor signaling...
  2. Deckert M, Rottapel R. The adapter 3BP2: how it plugs into leukocyte signaling. Adv Exp Med Biol. 2006;584:107-14 pubmed
  3. Ueki Y, Lin C, Senoo M, Ebihara T, Agata N, Onji M, et al. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell. 2007;128:71-83 pubmed
    ..identify its function or explain why SH3BP2 missense mutations cause bone loss and inflammation in patients with cherubism. We demonstrate that Sh3bp2 "cherubism" mice exhibit trabecular bone loss, TNF-alpha-dependent ..
  4. Sukov W, Franco M, Erickson Johnson M, Chou M, Unni K, Wenger D, et al. Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of "myositis ossificans-like lesions" are the early phases in the formation of soft-tissue aneurysmal bone cys. Skeletal Radiol. 2008;37:321-7 pubmed publisher
    ..Several lesions show histologic features that may overlap with ABC, including myositis ossificans (MO), brown tumor, and cherubism. The objective of this study was to assess whether these lesions harbored USP6 rearrangements.
  5. Gomes M, de Souza Setúbal Destro M, de Freitas Banzi E, dos Santos S, Claro F, de Oliveira Nogueira T. Aggressive behaviour of cherubism in a teenager: 4-years of clinical follow-up associated with radiographic and histological features. Dentomaxillofac Radiol. 2005;34:313-8 pubmed
    b>Cherubism is a rare hereditary fibro-osseous childhood disease characterized by bone degradation and fibrous tissue replacement at the angles of the mandible and at the tuberosity areas of the maxilla that leads to prominence of the ..
  6. Wang C, Song Y, Peng B, Lu D, Fan M, Li J, et al. The aggressive form of cherubism: report of two cases in unrelated families. Br J Oral Maxillofac Surg. 2006;44:322-4 pubmed
    b>Cherubism is a benign lesion that causes painless symmetrical enlargement of the jaws, usually with a familial tendency...
  7. Hyckel P, Berndt A, Schleier P, Clement J, Beensen V, Peters H, et al. Cherubism - new hypotheses on pathogenesis and therapeutic consequences. J Craniomaxillofac Surg. 2005;33:61-8 pubmed
    The hereditary occurrence of cherubism indicates a probable genetic aetiology: a correlation with a mutation in the gene SH3BP2 has been demonstrated. A convincing concept of formal pathogenesis is not yet available...
  8. Yilmaz B, Ozan O, Karaagaclioglu L, Ersoy A. A prosthetic treatment approach for a cherubism patient: A clinical report. J Prosthet Dent. 2006;96:313-6 pubmed
    b>Cherubism is an early childhood disease that primarily involves the mandible and consists of painless mandibular enlargement with or without maxillary involvement and progresses rapidly over the course of several years...
  9. Petkovska L, Ramadan S, Aslam M. Cherubism: review of four affected members in a Kuwaiti family. Australas Radiol. 2004;48:408-10 pubmed
    b>Cherubism is a rare autosomal dominant fibro-osseous disorder of childhood, mostly limited to the maxilla and mandible. Extra-cranial skeletal involvement is rare...
  10. Ahmadi A, Pirinjian G, Sires B. Optic neuropathy and macular chorioretinal folds caused by orbital cherubism. Arch Ophthalmol. 2003;121:570-3 pubmed
  11. Roginsky V, Ivanov A, Ovtchinnikov I, Khonsari R. Familial cherubism: the experience of the Moscow Central Institute for Stomatology and Maxillo-Facial Surgery. Int J Oral Maxillofac Surg. 2009;38:218-23 pubmed publisher
    ..A series of 33 patients presenting with cherubism (24 children and 9 of their parents) is presented...
  12. Schultze Mosgau S, Holbach L, Wiltfang J. Cherubism: clinical evidence and therapy. J Craniofac Surg. 2003;14:201-6; discussion 207-8 pubmed
    b>Cherubism is a hereditary childhood disease of autosomal dominant inheritance that is more common in the male sex. Some cases have also revealed a mutation of the gene FGF-RIII (fibroblast growth factor receptor III)...
  13. Silva E, de Souza P, Barreto D, Dias R, Gomez R. An extreme case of cherubism. Br J Oral Maxillofac Surg. 2002;40:45-8 pubmed
    ..was revised in the light of laboratory investigations that were within the reference ranges, and normal appearance of the parathyroids on exploration to that of an extreme case of cherubism that behaved in a locally aggressive manner.
  14. Kozakiewicz M, Perczynska Partyka W, Kobos J. Cherubism--clinical picture and treatment. Oral Dis. 2001;7:123-30 pubmed
    b>Cherubism is a rare, painless, disfigurating disease primarily affecting bones of the jaws.
  15. de Lange J, Van Maarle M, Van den Akker H, Redeker E. A new mutation in the SH3BP2 gene showing reduced penetrance in a family affected with cherubism. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:378-81 pubmed
  16. Aliprantis A, Ueki Y, Sulyanto R, Park A, Sigrist K, Sharma S, et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008;118:3775-89 pubmed publisher
    ..quot;Cherubism mice", which carry a gain-of-function mutation in SH3-domain binding protein 2 (Sh3bp2), develop ..
  17. Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, et al. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 2011;147:1340-54 pubmed publisher
    ..Dysregulation of substrate recognition by Tankyrases underlies the human disease cherubism. Tankyrases recruit specific motifs (often called RxxPDG "hexapeptides") in their substrates via an N-..
  18. Papadaki M, Lietman S, Levine M, Olsen B, Kaban L, REICHENBERGER E. Cherubism: best clinical practice. Orphanet J Rare Dis. 2012;7 Suppl 1:S6 pubmed publisher
    b>Cherubism is a skeletal dysplasia characterized by bilateral and symmetric fibro-osseous lesions limited to the mandible and maxilla. In most patients, cherubism is due to dominant mutations in the SH3BP2 gene on chromosome 4p16.3...
  19. Tiziani V, Reichenberger E, Buzzo C, Niazi S, Fukai N, Stiller M, et al. The gene for cherubism maps to chromosome 4p16. Am J Hum Genet. 1999;65:158-66 pubmed
    b>Cherubism is an autosomal dominant disorder that may be related to tooth development and eruption...
  20. Shah N, Handa K, Sharma M. Malignant mesenchymal tumor arising from cherubism: a case report. J Oral Maxillofac Surg. 2004;62:744-9 pubmed
  21. Lee S, Cooper J. Noonan syndrome with giant cell lesions. Int J Paediatr Dent. 2005;15:140-5 pubmed
    ..It may be sporadic or inherited as an autosomal dominant trait and occurs between one in 1000-2500. Cherubism is a giant cell lesion of the jaws thought to be transmitted as an autosomal dominant trait...
  22. Prescott T, Redfors M, Rustad C, Eiklid K, Geirdal A, Storhaug K, et al. Characterization of a Norwegian cherubism cohort; molecular genetic findings, oral manifestations and quality of life. Eur J Med Genet. 2013;56:131-7 pubmed publisher
    Bilateral multilocular radiolucencies of the mandible are the main feature of cherubism (OMIM #118400), a rare autosomal dominant disorder primarily affecting the jaw...
  23. Raposo Amaral C, de Campos Guidi M, Warren S, Almeida A, Amstalden E, Tiziane V, et al. Two-stage surgical treatment of severe cherubism. Ann Plast Surg. 2007;58:645-51 pubmed
    b>Cherubism is an autosomal-dominant syndrome characterized by excessive bilateral maxillomandibular bony degeneration followed by fibrous tissue hyperplasia...
  24. Hatani T, Sada K. Adaptor protein 3BP2 and cherubism. Curr Med Chem. 2008;15:549-54 pubmed
    ..Point mutations of the 3BP2 gene cause the rare human inherited disorder cherubism, characterized by excessive bone resorption in the jaw bones...
  25. Li C, Yu S. A novel mutation in the SH3BP2 gene causes cherubism: case report. BMC Med Genet. 2006;7:84 pubmed
    b>Cherubism is a rare hereditary multi-cystic disease of the jaws, characterized by its typical appearance in early childhood, and stabilization and remission after puberty...
  26. Carvalho V, Perdigão P, Amaral F, de Souza P, De Marco L, Gomez R. Novel mutations in the SH3BP2 gene associated with sporadic central giant cell lesions and cherubism. Oral Dis. 2009;15:106-10 pubmed publisher
    ..The etiology is unknown and occurs more commonly in young adults. Cherubism, a rare disease found predominantly in females has histologic characteristics indistinguishable from those of ..
  27. Ongole R, Pillai R, Pai K. Cherubism in siblings: a case report. J Can Dent Assoc. 2003;69:150-4 pubmed
    b>Cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance...
  28. Suhanya J, Aggarwal C, Mohideen K, Jayachandran S, Ponniah I. Cherubism combined with epilepsy, mental retardation and gingival fibromatosis (Ramon syndrome): a case report. Head Neck Pathol. 2010;4:126-31 pubmed publisher
    b>Cherubism is an inherited, autosomal dominant disorder that characteristically affects the jaws of children...
  29. Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, et al. Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism. Cell. 2011;147:1324-39 pubmed publisher
    b>Cherubism is an autosomal-dominant syndrome characterized by inflammatory destructive bony lesions resulting in symmetrical deformities of the facial bones...
  30. REICHENBERGER E, Levine M, Olsen B, Papadaki M, Lietman S. The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis. 2012;7 Suppl 1:S5 pubmed publisher
    b>Cherubism is a rare bone dysplasia that is characterized by symmetrical bone resorption limited to the jaws. Bone lesions are filled with soft fibrous giant cell-rich tissue that can expand and cause severe facial deformity...
  31. Mortellaro C, Bello L, Lucchina A, Pucci A. Diagnosis and treatment of familial cherubism characterized by early onset and rapid development. J Craniofac Surg. 2009;20:116-20 pubmed publisher
    b>Cherubism is a benign maxillary bone dysplasia of childhood, usually showing an autosomically dominant inheritance with variable penetrance and spontaneously resolving after puberty...
  32. Beneteau C, Cave H, Moncla A, Dorison N, Munnich A, Verloes A, et al. SOS1 and PTPN11 mutations in five cases of Noonan syndrome with multiple giant cell lesions. Eur J Hum Genet. 2009;17:1216-21 pubmed publisher
    ..MGCL lesions were observed in jaws ('cherubism') and joints ('pigmented villonodular synovitis')...
  33. Mangion J, Rahman N, Edkins S, Barfoot R, Nguyen T, Sigurdsson A, et al. The gene for cherubism maps to chromosome 4p16.3. Am J Hum Genet. 1999;65:151-7 pubmed
    b>Cherubism is a rare familial disease of childhood characterized by proliferative lesions within the mandible and maxilla that lead to prominence of the lower face and an appearance reminiscent of the cherubs portrayed in Renaissance art...
  34. Jafarov T, Ferimazova N, Reichenberger E. Noonan-like syndrome mutations in PTPN11 in patients diagnosed with cherubism. Clin Genet. 2005;68:190-1 pubmed
  35. Wang C, Song Y, Peng B, Fan M, Li J, Zhu S, et al. Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors. Oncol Rep. 2006;15:589-94 pubmed
    b>Cherubism (CBM) and central giant cell granuloma (CGCG) of the jaw and giant cell tumor (GCT) of the long bone are clinically different diseases. Histologically, they are all multinucleated giant cell (MGC)-containing lesions...
  36. Carvalho Silva E, Carvalho Silva G, Vieira T. Cherubism: clinicoradiographic features, treatment, and long-term follow-up of 8 cases. J Oral Maxillofac Surg. 2007;65:517-22 pubmed
  37. Lee J, Tartaglia M, Gelb B, Fridrich K, Sachs S, Stratakis C, et al. Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome. J Med Genet. 2005;42:e11 pubmed
  38. Miah S, Hatani T, Qu X, Yamamura H, Sada K. Point mutations of 3BP2 identified in human-inherited disease cherubism result in the loss of function. Genes Cells. 2004;9:993-1004 pubmed
    ..Genetic study identified the point mutations of 3BP2 gene in human-inherited disease cherubism. The multiple cysts in cherubism lesion of jaw bones are filled with the activated osteoclasts and stromal cells,..
  39. Meng X, Yu S, Yu G. Clinicopathologic study of 24 cases of cherubism. Int J Oral Maxillofac Surg. 2005;34:350-6 pubmed
    The authors reviewed 24 cases of familial or nonfamilial cherubism. The age at onset was between 6 and 10 years...
  40. Ueki Y, Tiziani V, Santanna C, Fukai N, Maulik C, Garfinkle J, et al. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Nat Genet. 2001;28:125-6 pubmed
    b>Cherubism (MIM 118400) is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws followed by development of fibrous tissue masses, which causes a characteristic facial swelling...
  41. Ozan B, Muglali M, Celenk P, Gunhan O. Postpubertal nonfamilial cherubism and teeth transposition. J Craniofac Surg. 2010;21:1575-7 pubmed publisher
    b>Cherubism is a rare, nonneoplastic, fibro-osseous disease. It is an autosomal-dominant disorder in which the normal bone is replaced by cellular fibrous tissue and immature bone...
  42. Gupta N, Duggal R, Rajwanshi A, Rattan V. Fine needle aspiration cytologic features of Cherubism: a case report. Acta Cytol. 2010;54:595-7 pubmed
    b>Cherubism is characterized by hereditary and intraosseous fibrous swellings of the jaws. It presents with bilateral mandibular and maxillary involvement in young individuals...
  43. Colombo F, Cursiefen C, Neukam F, Holbach L. Orbital involvement in cherubism. Ophthalmology. 2001;108:1884-8 pubmed
    To demonstrate the clinical, radiologic, and histopathologic features of a patient with orbital involvement in cherubism that prompted surgical treatment.
  44. Jain V, Sharma R. Radiographic, CT and MRI features of cherubism. Pediatr Radiol. 2006;36:1099-104 pubmed
    b>Cherubism is a paediatric disease affecting the jaws. It is a close radiological mimic of giant cell lesions of the mandible...
  45. Petschler M, Stiller M, Hoffmeister B, Witkowski R, Opitz C, Bill J, et al. [Clinical and molecular genetic observations on families with cherubism over three generations]. Mund Kiefer Gesichtschir. 2003;7:83-7 pubmed
    b>Cherubism is a rare fibro-osseous disorder that almost exclusively affects the maxilla and mandible.
  46. Lee J, Jung Y, Kim S, Lee S, Ahn S, Yoon J. Investigation of the SH3BP2 gene mutation in cherubism. Acta Med Okayama. 2008;62:209-12 pubmed
    b>Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients...
  47. Martinez Tello F, Manjón Luengo P, Martin Pérez M, Montes Moreno S. Cherubism associated with neurofibromatosis type 1, and multiple osteolytic lesions of both femurs: a previously undescribed association of findings. Skeletal Radiol. 2005;34:793-8 pubmed
    We present a patient with neurofibromatosis type 1, with the clinical, radiological and histological features of cherubism mandibular lesions, and multiple osteolytic, geographic lesions in both femurs, consistent with multiple non-..
  48. Beaman F, Bancroft L, Peterson J, Kransdorf M, Murphey M, Menke D. Imaging characteristics of cherubism. AJR Am J Roentgenol. 2004;182:1051-4 pubmed
    We sought to describe the radiographic and imaging features of cherubism.
  49. van Capelle C, Hogeman P, van der Sijs Bos C, Heggelman B, Idowu B, Slootweg P, et al. Neurofibromatosis presenting with a cherubism phenotype. Eur J Pediatr. 2007;166:905-9 pubmed
    We report on a child who presented clinical manifestations of both neurofibromatosis type 1 (NF1) and cherubism. With genetic testing, we found a mutation in the NF-1 gene, confirming the neurocutaneous disorder...
  50. Ladhani S, Sundaram P, Joshi J. Sleep disordered breathing in an adult with cherubism. Thorax. 2003;58:552 pubmed
  51. Wang C, Chen I, Koczon Jaremko B, Boskey A, Ueki Y, Kuhn L, et al. Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties. Bone. 2010;46:1306-15 pubmed publisher
    b>Cherubism is an autosomal dominant disorder in children characterized by unwarranted symmetrical bone resorption of the jaws with fibrous tissue deposition. Mutations causing cherubism have been identified in the adaptor protein SH3BP2...
  52. Mukherjee P, Wang C, Chen I, Jafarov T, Olsen B, Ueki Y, et al. Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function. Am J Orthod Dentofacial Orthop. 2010;138:140.e1-140.e11; discussion 140-1 pubmed publisher
    b>Cherubism is a human genetic disorder that causes bilateral symmetrical enlargement of the maxilla and the mandible in children. It is caused by mutations in SH3BP2. The exact pathogenesis of the disorder is an area of active research...
  53. Pontes F, Ferreira A, Kato A, Pontes H, Almeida D, Rodini C, et al. Aggressive case of cherubism: 17-year follow-up. Int J Pediatr Otorhinolaryngol. 2007;71:831-5 pubmed
    b>Cherubism is an autosomal dominant disorder in which the normal bone is replaced by cellular fibrous and immature bone, resulting in painless symmetrical enlargement of the jaws...
  54. Brix M, Peters H, Ranfaing E, Ricbourg B. [Genetic aspects of cherubism]. Rev Stomatol Chir Maxillofac. 2006;107:105-8 pubmed
    b>Cherubism is an extensive kystic process of the mandibula. The diagnosis is often established in children presented swelling of the jaws...
  55. Idowu B, Thomas G, Frow R, Diss T, Flanagan A. Mutations in SH3BP2, the cherubism gene, were not detected in central or peripheral giant cell tumours of the jaw. Br J Oral Maxillofac Surg. 2008;46:229-30 pubmed
    ..non-familial, generally unilateral osteoclast-rich lesions that are histopathologically indistinguishable from cherubism. Cherubism is an autosomal dominant disease that is characterised by bilateral radiolucencies of the jaw, and ..
  56. Ozkan Y, Varol A, Turker N, Aksakalli N, Basa S. Clinical and radiological evaluation of cherubism: a sporadic case report and review of the literature. Int J Pediatr Otorhinolaryngol. 2003;67:1005-12 pubmed
    Many cases have been published on cherubism since Jones described it first time in three children of the same family [Am. J. Cancer 17 (1933) 946]...
  57. Lannon D, Earley M. Cherubism and its charlatans. Br J Plast Surg. 2001;54:708-11 pubmed
    b>Cherubism is a rare hereditary condition characterised by progressive cystic proliferation of the mandible and maxilla in childhood, followed by post-pubertal involution of the process and jaw remodelling in adulthood...
  58. Lietman S, Kalinchinko N, Deng X, Kohanski R, Levine M. Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activation. Hum Mutat. 2006;27:717-8 pubmed
    ..D419N (g.1371G>A, c.1255G>A) within exon 9 of SH3BP2 in a patient with cherubism, an autosomal dominant syndrome characterized by excessive osteoclastic bone resorption of the jaw...
  59. Carroll A, Sullivan T. Orbital involvement in cherubism. Clin Exp Ophthalmol. 2001;29:38-40 pubmed
    b>Cherubism is a rare, inherited condition characterized by fibro-osseous lesions of the maxilla and mandible. It has recently been localized to chromosome 4p16.3...
  60. Lo B, Faiyaz ul Haque M, Kennedy S, Aviv R, Tsui L, Teebi A. Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism. Am J Med Genet A. 2003;121A:37-40 pubmed
    b>Cherubism is a rare autosomal dominant inherited condition caused by mutations in the c-Abl-binding protein SH3BP2...