Summary: The detection of genetic variability (e.g., PHARMACOGENOMIC VARIANTS) relevant to PHARMACOGENETICS and PRECISION MEDICINE. The purpose of such genetic testing is to help determine the most effective treatment options and their optimum dosages with least potential risks for DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS.
Verdoia M, Daffara V, Pergolini P, Rolla R, Marino P, Bellomo G, et al
. Vitamin D Binding Protein rs7041 polymorphism and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor. Vascul Pharmacol. 2017;93-95:42-47 pubmed publisher
Gage B, Bass A, Lin H, Woller S, Stevens S, Al Hammadi N, et al
. Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial. JAMA. 2017;318:1115-1124 pubmed publisher
..Further research is needed to determine the cost-effectiveness of personalized warfarin dosing. clinicaltrials.gov Identifier: NCT01006733. ..
Quaranta S, Thomas F. Pharmacogenetics of anti-cancer drugs: State of the art and implementation - recommendations of the French National Network of Pharmacogenetics. Therapie. 2017;72:205-215 pubmed publisher
..Other applications, for which the level of evidence is still discussed, will be evoked in the final section of this review. ..
Begum T, Ghosh T, Basak S. Systematic Analyses and Prediction of Human Drug Side Effect Associated Proteins from the Perspective of Protein Evolution. Genome Biol Evol. 2017;9:337-350 pubmed publisher
..By employing all these entities, our Support Vector Machine model predicts human SET/NSET proteins to a high degree of accuracy (?86%). ..
Meulendijks D, Henricks L, Jacobs B, Aliev A, Deenen M, de Vries N, et al
. Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity. Br J Cancer. 2017;116:1415-1424 pubmed publisher
Grotegut C, Ngan E, Garrett M, Miranda M, Ashley Koch A, Swamy G. The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes. Am J Obstet Gynecol. 2017;217:367.e1-367.e9 pubmed publisher
..With further research, pharmacogenomic approaches may potentially be utilized to develop personalized treatment to improve safety and efficacy outcomes among women undergoing induction of labor. ..
Chen L, Wang M, Yang H, Fan S, Chen S. Prospective observational pharmacogenetic study of side effects induced by intravenous morphine for postoperative analgesia. Medicine (Baltimore). 2017;96:e7009 pubmed publisher
..There was no significant difference between severity or incidence of IVPCA morphine-induced nausea and vomiting and genotype (11 SNPs). Further study should perhaps be focused on mRNA and proteinomics rather than SNPs. ..
Liu Z, Wang S, Qi W, Wang X, Sun D, Wang H, et al
. The relationship between ITPA rs1127354 polymorphisms and efficacy of antiviral treatment in Northeast Chinese CHC patients. Medicine (Baltimore). 2017;96:e7554 pubmed publisher
..IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the SVR to PEG-IFN plus ribavirin combination therapy in Chinese HCV-infected patients. ..
Plumpton C, Alfirevic A, Pirmohamed M, Hughes D. Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford). 2017;56:1729-1739 pubmed publisher