Summary: The practical application of physical, mechanical, and mathematical principles. (Stedman, 25th ed)

Top Publications

  1. Csete M, Doyle J. Reverse engineering of biological complexity. Science. 2002;295:1664-9 pubmed
    ..This review describes insights from engineering theory and practice that can shed some light on biological complexity.
  2. Hamad I, Al Hanbali O, Hunter A, Rutt K, Andresen T, Moghimi S. Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. ACS Nano. 2010;4:6629-38 pubmed publisher
    ..complement activation is of clinical concern, our findings provide a rational basis for improved surface engineering and design of immunologically safer stealth and targetable nanosystems with polymers for use in clinical ..
  3. Macfarlane R, Lee B, Jones M, Harris N, Schatz G, Mirkin C. Nanoparticle superlattice engineering with DNA. Science. 2011;334:204-8 pubmed publisher
    A current limitation in nanoparticle superlattice engineering is that the identities of the particles being assembled often determine the structures that can be synthesized...
  4. Irvine D, Swartz M, Szeto G. Engineering synthetic vaccines using cues from natural immunity. Nat Mater. 2013;12:978-90 pubmed publisher
    ..Here we describe recent advances in the design of synthetic materials to direct immune responses, highlighting successes and challenges in prophylactic, therapeutic and tolerance-inducing vaccines. ..
  5. Collins L, Baker T, Mermelstein R, Piper M, Jorenby D, Smith S, et al. The multiphase optimization strategy for engineering effective tobacco use interventions. Ann Behav Med. 2011;41:208-26 pubmed publisher
    ..Conceptually rooted in engineering, MOST emphasizes efficiency and careful management of resources to move intervention science forward steadily ..
  6. Yin W, Wei S, Al Jassim M, Yan Y. Double-hole-mediated coupling of dopants and its impact on band gap engineering in TiO2. Phys Rev Lett. 2011;106:066801 pubmed
    ..Our results suggest a new path for semiconductor band gap engineering.
  7. Borenstein J. Responsible authorship in engineering fields: an overview of current ethical challenges. Sci Eng Ethics. 2011;17:355-64 pubmed publisher
    The primary aim of this article is to identify ethical challenges relating to authorship in engineering fields...
  8. Tu S, Feng S, Storch R, Yip M, Sohng H, Fu M, et al. Applying systems engineering to implement an evidence-based intervention at a community health center. J Health Care Poor Underserved. 2012;23:1399-409 pubmed publisher
    Impressive results in patient care and cost reduction have increased the demand for systems-engineering methodologies in large health care systems...
  9. Pasquale A, Reinhard B, Dal Negro L. Engineering photonic-plasmonic coupling in metal nanoparticle necklaces. ACS Nano. 2011;5:6578-85 pubmed publisher

More Information


  1. Sokolov A, Tee B, Bettinger C, Tok J, Bao Z. Chemical and engineering approaches to enable organic field-effect transistors for electronic skin applications. Acc Chem Res. 2012;45:361-71 pubmed publisher
    ..The development of an electronic material, inspired by the complexity of this organ is a tremendous, unrealized engineering challenge...
  2. Schuurbiers D. What happens in the lab does not stay in the lab [corrected]: Applying midstream modulation to enhance critical reflection in the laboratory. Sci Eng Ethics. 2011;17:769-88 pubmed publisher
    In response to widespread policy prescriptions for responsible innovation, social scientists and engineering ethicists, among others, have sought to engage natural scientists and engineers at the 'midstream': building interdisciplinary ..
  3. Conlon E, Zandvoort H. Broadening ethics teaching in engineering: beyond the individualistic approach. Sci Eng Ethics. 2011;17:217-32 pubmed publisher
    There is a widespread approach to the teaching of ethics to engineering students in which the exclusive focus is on engineers as individual agents and the broader context in which they do their work is ignored...
  4. Brummel B, Gunsalus C, Anderson K, Loui M. Development of role-play scenarios for teaching responsible conduct of research. Sci Eng Ethics. 2010;16:573-89 pubmed publisher
    ..for teaching central topics in the responsible conduct of research to graduate students in science and engineering. In response to formative evaluation surveys, students reported that the role-plays were more engaging and ..
  5. Sarkar D, Zhao W, Gupta A, Loh W, Karnik R, Karp J. Cell surface engineering of mesenchymal stem cells. Methods Mol Biol. 2011;698:505-23 pubmed publisher
    ..We also provide a brief description of cell characterization assays that can be used to examine the impact of the chemical modification regimen. ..
  6. Xiao D, Zhu W, Ran Y, Nagaosa N, Okamoto S. Interface engineering of quantum Hall effects in digital transition metal oxide heterostructures. Nat Commun. 2011;2:596 pubmed publisher
    ..Intriguing phenomena, such as fractional quantum Hall effect, associated with the nearly flat topologically non-trivial bands found in e(g) systems are also discussed. ..
  7. Liu M, Zhao H, Chen S, Yu H, Quan X. Interface engineering catalytic graphene for smart colorimetric biosensing. ACS Nano. 2012;6:3142-51 pubmed publisher
    ..We envision that the tunable graphene-based smart interface could find potential applications in the development of biocatalysis, bioassays, and smart material devices in the future. ..
  8. Lindquist N, Nagpal P, McPeak K, Norris D, Oh S. Engineering metallic nanostructures for plasmonics and nanophotonics. Rep Prog Phys. 2012;75:036501 pubmed publisher
    ..This review focuses on top-down nanofabrication techniques for engineering metallic nanostructures, along with computational and experimental characterization techniques...
  9. Wei X, Yu J, Shattuck P, McCracken M, Blackorby J. Science, technology, engineering, and mathematics (STEM) participation among college students with an autism spectrum disorder. J Autism Dev Disord. 2013;43:1539-46 pubmed publisher
    ..spectrum disorder (ASD) are more likely than the general population to gravitate toward science, technology, engineering, and mathematics (STEM) fields...
  10. Zhang B, Wang X, Liu F, Cheng Y, Shi D. Effective reduction of nonspecific binding by surface engineering of quantum dots with bovine serum albumin for cell-targeted imaging. Langmuir. 2012;28:16605-13 pubmed publisher
    ..BSA-coated QDs are further functionalized with cyclic Arg-Gly-Asp (cRGD) peptide. The cell assays indicate their high target-selectivity in integrin ?(v)?(3)-expressed cell imaging. ..
  11. Hendon C, Tiana D, Fontecave M, Sanchez C, D arras L, Sassoye C, et al. Engineering the optical response of the titanium-MIL-125 metal-organic framework through ligand functionalization. J Am Chem Soc. 2013;135:10942-5 pubmed publisher
  12. Ding C, Zhu A, Tian Y. Functional surface engineering of C-dots for fluorescent biosensing and in vivo bioimaging. Acc Chem Res. 2014;47:20-30 pubmed publisher
    ..a new type of quantum dot, are becoming both an important class of imaging probes and a versatile platform for engineering multifunctional nanosensors...
  13. Garrison H. Underrepresentation by race-ethnicity across stages of U.S. science and engineering education. CBE Life Sci Educ. 2013;12:357-63 pubmed publisher
    Blacks, Hispanics, and American Indians/Alaskan Natives are underrepresented in science and engineering fields. A comparison of race-ethnic differences at key transition points was undertaken to better inform education policy...
  14. van der Heide T, Eklöf J, Van Nes E, van der Zee E, Donadi S, Weerman E, et al. Ecosystem engineering by seagrasses interacts with grazing to shape an intertidal landscape. PLoS ONE. 2012;7:e42060 pubmed publisher
    Self-facilitation through ecosystem engineering (i.e., organism modification of the abiotic environment) and consumer-resource interactions are both major determinants of spatial patchiness in ecosystems...
  15. Zhang J, Chang C, Zhang Z, Wen J, Feng X, Li K, et al. Band structure engineering in (Bi(1-x)Sb(x))(2)Te(3) ternary topological insulators. Nat Commun. 2011;2:574 pubmed publisher
    ..Most remarkably, the band engineering leads to ideal TIs with truly insulating bulk and tunable surface states across the Dirac point that behaves ..
  16. Maton K, Pollard S, McDougall Weise T, Hrabowski F. Meyerhoff Scholars Program: a strengths-based, institution-wide approach to increasing diversity in science, technology, engineering, and mathematics. Mt Sinai J Med. 2012;79:610-23 pubmed publisher
    ..of a program that enhances the number of underrepresented minority students who pursue science, technology, engineering, and mathematics PhDs...
  17. Fong C, Le T, Drummond C. Lyotropic liquid crystal engineering-ordered nanostructured small molecule amphiphile self-assembly materials by design. Chem Soc Rev. 2012;41:1297-322 pubmed publisher
    ..We focus upon the generation of 'dilutable' lyotropic liquid crystal phases with two- and three-dimensional geometries from amphiphilic small molecules (225 references). ..
  18. Yu Y, Zhang Q, Xie J, Lee J. Engineering the architectural diversity of heterogeneous metallic nanocrystals. Nat Commun. 2013;4:1454 pubmed publisher
    Similar to molecular engineering where structural diversity is used to create more property variations for application explorations, the architectural engineering of heterogeneous metallic nanocrystals (HMNCs) can likewise increase the ..
  19. Wen A, Rambhia P, French R, Steinmetz N. Design rules for nanomedical engineering: from physical virology to the applications of virus-based materials in medicine. J Biol Phys. 2013;39:301-25 pubmed publisher
    ..We summarize and discuss the design rules that need to be considered for the successful development and translation of virus-based nanomaterials from bench to bedside. ..
  20. Li W, Yue Q, Deng Y, Zhao D. Ordered mesoporous materials based on interfacial assembly and engineering. Adv Mater. 2013;25:5129-52, 5128 pubmed publisher
    ..recent progresses in preparing ordered mesoporous materials from the viewpoint of interfacial assembly and engineering. Five interfacial assembly and synthesis are comprehensively highlighted, including liquid-solid interfacial ..
  21. Chiel H, McManus J, Shaw K. From biology to mathematical models and back: teaching modeling to biology students, and biology to math and engineering students. CBE Life Sci Educ. 2010;9:248-65 pubmed publisher students of biology and to teach biology to students with strong backgrounds in mathematics, physics, or engineering. The two groups of students have different ways of learning material and often have strong negative feelings ..
  22. Zhou W. Reversed crystal growth: implications for crystal engineering. Adv Mater. 2010;22:3086-92 pubmed publisher
    ..This article highlights the recent achievements in this topic, which might have a significant impact on crystal engineering, materials science, and mineralogy.
  23. Byars Winston A, Estrada Y, Howard C, Davis D, Zalapa J. Influence of social cognitive and ethnic variables on academic goals of underrepresented students in science and engineering: a multiple-groups analysis. J Couns Psychol. 2010;57:205-18 pubmed publisher
    ..Latino/a, Southeast Asian, and Native American undergraduate students in two groups: biological science and engineering (S/E) majors...
  24. Stout J, Dasgupta N, Hunsinger M, McManus M. STEMing the tide: using ingroup experts to inoculate women's self-concept in science, technology, engineering, and mathematics (STEM). J Pers Soc Psychol. 2011;100:255-70 pubmed publisher
    ..experts (advanced peers, professionals, professors) in academic environments involving science, technology, engineering, and mathematics (STEM) enhances women's self-concept in STEM, attitudes toward STEM, and motivation to pursue ..
  25. Massad Ivanir N, Shtenberg G, Tzur A, Krepker M, Segal E. Engineering nanostructured porous SiO2 surfaces for bacteria detection via "direct cell capture". Anal Chem. 2011;83:3282-9 pubmed publisher
    ..Our preliminary studies demonstrate the applicability of these biosensors for the detection of low bacterial concentrations. The current detection limit of E. coli K12 bacteria is 10(4) cells/mL within several minutes. ..
  26. Browne M, Chapman M. Ecologically informed engineering reduces loss of intertidal biodiversity on artificial shorelines. Environ Sci Technol. 2011;45:8204-7 pubmed publisher
    ..Currently infrastructure is designed to meet engineering and financial criteria, without considering its value as habitat, despite artificial shorelines causing loss of ..
  27. Zaman M. The role of engineering approaches in analysing cancer invasion and metastasis. Nat Rev Cancer. 2013;13:596-603 pubmed publisher
    ..the ability to model and predict complex processes in vivo, represent an integration of traditional with novel engineering approaches; and their potential effect on quantitatively understanding tumour progression and invasion looks ..
  28. Flynn M, Susi P. A review of engineering control technology for exposures generated during abrasive blasting operations. J Occup Environ Hyg. 2004;1:680-7 pubmed
    ..More research, particularly field studies, is needed to evaluate control interventions in this important and hazardous operation. ..
  29. Barfett J, Lanting B, Margaritis A, Herbert C, Silcox J. Integrating medical and engineering undergraduate training. CMAJ. 2005;172:1537 pubmed
  30. Pritchard M. Responsible engineering: the importance of character and imagination. Sci Eng Ethics. 2001;7:391-402 pubmed
    b>Engineering Ethics literature tends to emphasize wrongdoing, its avoidance, or its prevention. It also tends to focus on identifiable events, especially those that involve unfortunate, sometimes disastrous consequences...
  31. Chung C, Alfred M. Design, development, and evaluation of an interactive simulator for engineering ethics education (SEEE). Sci Eng Ethics. 2009;15:189-99 pubmed publisher
    ..pressures, accreditation organizations, and licensing agencies are emphasizing the importance of ethics in the engineering curriculum. Traditionally, this subject has been taught using dogma, heuristics, and case study approaches...
  32. Coeckelbergh M, Wackers G. Imagination, distributed responsibility and vulnerable technological systems: the case of Snorre A. Sci Eng Ethics. 2007;13:235-48 pubmed
    An influential approach to engineering ethics is based on codes of ethics and the application of moral principles by individual practitioners...
  33. Beach J, Ratti N, Walton C, McKiernan M. Surveillance of occupational and work-related diseases between 1993 and 1996 in an engineering company. Occup Med (Lond). 1999;49:377-81 pubmed
    ..The aim of this paper is to report the results from such a reporting scheme operated by a large multi-national engineering company during the period 1993-96. All UK sites of Lucas Industries (later LucasVarity) participated...
  34. Rosen L. Applying industrial engineering practices to radiology. Radiol Manage. 2004;26:32-5 pubmed
    ..By applying industrial engineering methodology to manufacturing processes, it is possible to manage these constraints, eliminate the obstacles to ..
  35. Kinge B, Midelfart A, Jacobsen G, Rystad J. The influence of near-work on development of myopia among university students. A three-year longitudinal study among engineering students in Norway. Acta Ophthalmol Scand. 2000;78:26-9 pubmed
    ..A three-year longitudinal refraction study was performed among 224 Norwegian engineering students (mean age 20...
  36. Sen R, Das S. An ergonomics study on compatibility of controls of overhead cranes in a heavy engineering factory in West Bengal. Appl Ergon. 2000;31:179-84 pubmed
    ..and the resultant movements of the cabins and the hooks in 51 electric overhead travelling cranes in a heavy engineering factory, showed that control-movement compatibility is absent in most of the cranes...
  37. Bongard J, Lipson H. Automated reverse engineering of nonlinear dynamical systems. Proc Natl Acad Sci U S A. 2007;104:9943-8 pubmed
    Complex nonlinear dynamics arise in many fields of science and engineering, but uncovering the underlying differential equations directly from observations poses a challenging task...
  38. Qin S, Caskey C, Ferrara K. Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering. Phys Med Biol. 2009;54:R27-57 pubmed publisher
    ..In this review, we focus on the physical aspects of these agents, exploring microbubble imaging modes, models for microbubble oscillation and the interaction of the microbubble with the endothelium. ..
  39. Chapman M, Blockley D. Engineering novel habitats on urban infrastructure to increase intertidal biodiversity. Oecologia. 2009;161:625-35 pubmed publisher learn how to build urban infrastructure that can maintain or enhance biodiversity while meeting societal and engineering criteria. Success requires melding engineering skills and ecological understanding...
  40. Gil Martín L, Hernández Montes E, Segura Naya A. A new experience: the course of ethics in engineering in the Department of Civil Engineering, University of Granada. Sci Eng Ethics. 2010;16:409-13 pubmed publisher
    ..Students were concerned about the law, but in their actions they were more concerned with their conscience, aware that it can be separate from the law. ..
  41. Salomons E, Polinder H, Lohman W, Zhou H, Borst H, Miedema H. Engineering modeling of traffic noise in shielded areas in cities. J Acoust Soc Am. 2009;126:2340-9 pubmed publisher
    ..Based on numerical boundary-element calculations of canyon-to-canyon propagation, an efficient engineering algorithm is developed to calculate the effect of multiple reflections in street canyons...
  42. Brekke J, Toth J. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res. 1998;43:380-98 pubmed
    This article presents a strategy for design, engineering, and fabrication of a bioresorbable, manufactured bone graft substitute (BGS) device...
  43. Friedman C, Costantino P, Takagi S, Chow L. BoneSource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction. J Biomed Mater Res. 1998;43:428-32 pubmed
    ..The general properties and clinical use guidelines are reviewed. The biomaterial and surgical applications offer insight into improved outcomes and potential new uses for hydroxyapatite cement systems. ..
  44. van de Poel I, Zandvoort H, Brumsen M. Ethics and engineering courses at Delft University of Technology: contents, educational setup and experiences. Sci Eng Ethics. 2001;7:267-82 pubmed
    This article reports on the development and teaching of compulsory courses on ethics and engineering at Delft University of Technology (DUT)...
  45. Herkert J. Future directions in engineering ethics research: microethics, macroethics and the role of professional societies. Sci Eng Ethics. 2001;7:403-14 pubmed
    Three frames of reference for engineering ethics are discussed--individual, professional and social--which can be further broken down into "microethics" concerned with individuals and the internal relations of the engineering ..
  46. Tadmor B, Tidor B. Interdisciplinary research and education at the biology-engineering-computer science interface: a perspective. Drug Discov Today. 2005;10:1183-9 pubmed
    ..more traditional component-based approach, involves the integration of biological research with approaches from engineering disciplines and computer science. The result is more than a new set of technologies...
  47. Mudd G, Chakrabarti S, Kodikara J. Evaluation of engineering properties for the use of leached brown coal ash in soil covers. J Hazard Mater. 2007;139:409-12 pubmed
    ..This paper will review the engineering issues involved in using leached brown coal ash in designing soil covers for potentially acid-forming ..
  48. Heinemann M, Panke S. Synthetic biology--putting engineering into biology. Bioinformatics. 2006;22:2790-9 pubmed
    Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications...
  49. Cummings M. Integrating ethics in design through the value-sensitive design approach. Sci Eng Ethics. 2006;12:701-15 pubmed
    The Accreditation Board of Engineering and Technology (ABET) has declared that to achieve accredited status, 'engineering programs must demonstrate that their graduates have an understanding of professional and ethical responsibility...
  50. Methner M. Engineering case reports. Effectiveness of local exhaust ventilation (LEV) in controlling engineered nanomaterial emissions during reactor cleanout operations. J Occup Environ Hyg. 2008;5:D63-9 pubmed publisher
  51. Harris C. The good engineer: giving virtue its due in engineering ethics. Sci Eng Ethics. 2008;14:153-64 pubmed publisher
    During the past few decades, engineering ethics has been oriented towards protecting the public from professional misconduct by engineers and from the harmful effects of technology...
  52. Wheelwright S, Baron Cohen S. The link between autism and skills such as engineering, maths, physics and computing: a reply to Jarrold and Routh. Autism. 2001;5:223-7 pubmed
    ..a paper reporting that fathers and grandfathers of children with autism were over-represented in the field of engineering. This result was interpreted as providing supporting evidence for the folk-psychology/folk-physics theory of ..
  53. McKenna D, Kadidlo D, Miller J, Orchard P, Wagner J, McCullough J. The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratory. Transfus Med Rev. 2005;19:217-28 pubmed
    ..Here we provide an overview of the Minnesota Molecular and Cellular Therapeutics (MMCT) Facility, detailing our approach to the manufacture of novel therapeutics and highlighting current and future activities. ..