neonatal sepsis


Summary: Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.

Top Publications

  1. Ulas T, Pirr S, Fehlhaber B, Bickes M, Loof T, Vogl T, et al. S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol. 2017;18:622-632 pubmed publisher
    ..impaired responses by innate immune cells; however, the clinical observation of hyperinflammatory courses of neonatal sepsis contradicts this concept...
  2. Easter S, Molina R, Venkatesh K, Kaimal A, Tuomala R, Riley L. Clinical Risk Factors Associated With Peripartum Maternal Bacteremia. Obstet Gynecol. 2017;130:710-717 pubmed publisher
    ..5% of cases of bacteremia occurred in women with maximum fevers below this threshold. Obstetricians should maintain a heightened suspicion for an infectious source of fever in women with these clinical characteristics. ..
  3. Vogel L. Sepsis kills one million newborns a year: WHO. CMAJ. 2017;189:E1272 pubmed publisher
  4. Saha S, El Arifeen S, Schrag S. Aetiology of Neonatal Infection in South Asia (ANISA): An Initiative to Identify Appropriate Program Priorities to Save Newborns. Pediatr Infect Dis J. 2016;35:S6-8 pubmed publisher
  5. Rozanska A, Wójkowska Mach J, Adamski P, Borszewska Kornacka M, Gulczynska E, Nowiczewski M, et al. Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland. Ann Clin Microbiol Antimicrob. 2017;16:20 pubmed publisher
    ..Nevertheless, the assessment of antibiotic consumption in neonatal units represents a methodological challenge and requires the use of different measurement tools. ..
  6. Wu I, Tsai M, Lai M, Hsu L, Chiang M, Lien R, et al. Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus. BMC Infect Dis. 2017;17:465 pubmed publisher
    ..Neonatal BSIs with concurrent meningitis, VAP, or NEC are significantly more likely to have infectious complications. This association independently leads to sepsis-attributable mortality. ..
  7. Khan A, Morris S, Bhutta Z. Neonatal and Perinatal Infections. Pediatr Clin North Am. 2017;64:785-798 pubmed publisher
    ..The emergence of new infections and increasing antimicrobial resistance present public health challenges that must be addressed to achieve substantial reductions in neonatal mortality. ..
  8. Dai J, Jiang W, Min Z, Yang J, Tan Y, Ma T, et al. Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis. Adv Clin Exp Med. 2017;26:327-332 pubmed publisher
    ..Several studies have investigated the performance of nCD64 for diagnosing neonatal sepsis and the results are variable...
  9. Sun J, Sun B, Gao Y, He F, Yang L, Wang M, et al. Composition and Variation Analysis of the T Cell Receptor ?-Chain Complementarity Determining Region 3 Repertoire in Neonatal Sepsis. Scand J Immunol. 2017;86:418-423 pubmed publisher
    ..Our data showed the characteristics of the TCR repertoire in neonates with sepsis, which represents a potentially valuable data set. This result is useful for understanding neonatal susceptibility to infection. ..

More Information


  1. Li G, Standing J, Bielicki J, Hope W, van den Anker J, Heath P, et al. The Potential Role of Fosfomycin in Neonatal Sepsis Caused by Multidrug-Resistant Bacteria. Drugs. 2017;77:941-950 pubmed publisher
    ..b>Neonatal sepsis remains a substantial cause of morbidity and mortality at a global level, with evidence that MDR bacteria ..
  2. Kelly L, Shivananda S, Murthy P, Srinivasjois R, Shah P. Antibiotics for neonates born through meconium-stained amniotic fluid. Cochrane Database Syst Rev. 2017;6:CD006183 pubmed publisher
    ..The primary outcome was risk of early- and late-onset neonatal sepsis. Antibiotics did not decrease the risk of sepsis in neonates with a diagnosis of MAS (RR 1...
  3. Greenberg R, Kandefer S, Do B, Smith P, Stoll B, Bell E, et al. Late-onset Sepsis in Extremely Premature Infants: 2000-2011. Pediatr Infect Dis J. 2017;36:774-779 pubmed publisher
    ..The incidence of LOS decreased over time. Further investigation is warranted to determine which interventions have the greatest impact on infection rates. ..
  4. Kültürsay N, AÅŸkar N, Terek D, Yeniel A, Altun KöroÄŸlu Ã, Yalaz M, et al. The Change of Perinatal Mortality Over Three Decades in a Reference Centre in the Aegean Region: Neonatal Mortality has decreased but Foetal Mortality Remains Unchanged. Balkan Med J. 2017;34:553-558 pubmed publisher
    ..In order to decrease foetal and perinatal mortality rates more efficiently, reducing consanguineous marriages and providing better antenatal care for high risk pregnancies are needed. ..
  5. Brown R, Marchesi J, Lee Y, Smith A, Lehne B, Kindinger L, et al. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Med. 2018;16:9 pubmed publisher
    ..rupture of the fetal membranes (PPROM) precedes 30% of preterm births and is a risk factor for early onset neonatal sepsis. As PPROM is strongly associated with ascending vaginal infection, prophylactic antibiotics are widely used...
  6. Alcock G, Liley H, Cooke L, Gray P. Prevention of neonatal late-onset sepsis: a randomised controlled trial. BMC Pediatr. 2017;17:98 pubmed publisher
    ..Date: 06/03/2001; Australian New Zealand Clinical Trials Registry (ANZCTR), TRN registration number: ACTRN12617000455369 . Date: 28/03/2017 (retrospectively registered). ..
  7. Pammi M, O Brien J, Ajami N, Wong M, Versalovic J, Petrosino J. Development of the cutaneous microbiome in the preterm infant: A prospective longitudinal study. PLoS ONE. 2017;12:e0176669 pubmed publisher
    b>Neonatal sepsis in preterm infants is often due to organisms that colonize the skin including Staphylococcus spp. and Candida spp...