meconium aspiration syndrome

Summary

Summary: A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.

Top Publications

  1. Mokry J, Mokra D, Antosova M, Bulikova J, Calkovska A, Nosalova G. Dexamethasone alleviates meconium-induced airway hyperresponsiveness and lung inflammation in rabbits. Pediatr Pulmonol. 2006;41:55-60 pubmed
    ..01). Dexamethasone decreased neutrophils (P < 0.05) compared to the Meco group. Meconium-induced airway hyperreactivity to histamine and lung inflammation were alleviated by dexamethasone...
  2. da Costa D, Nair A, Pai M, Al Khusaiby S. Steroids in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur J Pediatr. 2001;160:150-3 pubmed
    Persistent pulmonary hypertension of the newborn (PPHN) due to meconium aspiration syndrome (MAS), has a high morbidity and mortality especially in centres with limited access to extra-corporeal membrane oxygenation or nitric oxide ..
  3. Okazaki K, Kondo M, Kato M, Kakinuma R, Nishida A, Noda M, et al. Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. Pediatrics. 2008;121:e748-53 pubmed publisher
    Various inflammatory cytokines and chemokines are thought to be associated with the pathophysiology of meconium aspiration syndrome. To clarify any such association, we compared various serum cytokine and chemokine profiles in patients ..
  4. Lin H, Su B, Lin T, Peng C, Tsai C. Risk factors of mortality in meconium aspiration syndrome: review of 314 cases. Acta Paediatr Taiwan. 2004;45:30-4 pubmed
    b>Meconium aspiration syndrome (MAS) is a common severe respiratory disease in full-term infants. To investigate the risk factors for mortality of MAS, a retrospective chart-review study of MAS was conducted from 1995 to 2001...
  5. Short B. Extracorporeal membrane oxygenation: use in meconium aspiration syndrome. J Perinatol. 2008;28 Suppl 3:S79-83 pubmed publisher
    ..been successful as a rescue therapy for infants with respiratory failure with some diagnoses such as meconium aspiration syndrome (MAS) having a survival rate of more than 94%...
  6. Kirimi E, Tuncer O, Kosem M, Ceylan E, Tas A, Tasal I, et al. The effects of prednisolone and serum malondialdehyde levels in puppies with experimentally induced meconium aspiration syndrome. J Int Med Res. 2003;31:113-22 pubmed
    ..was to investigate the effect of different doses of prednisolone in puppies experimentally induced with meconium aspiration syndrome (MAS)...
  7. Angert R, Pilon A, Chester D, Davis J. CC10 reduces inflammation in meconium aspiration syndrome in newborn piglets. Pediatr Res. 2007;62:684-8 pubmed
    Complications from meconium aspiration syndrome (MAS) remain significant despite a variety of therapeutic interventions...
  8. Mokra D, Mokry J, Drgova A, Bulikova J, Petraskova M, Calkovska A. Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits. J Physiol Pharmacol. 2007;58 Suppl 5:379-87 pubmed
    ..We conclude that two-dose dexamethasone is superior to single-dose dexamethasone in prevention lung injury in meconium-instilled rabbits. ..
  9. van Ierland Y, de Beaufort A. Why does meconium cause meconium aspiration syndrome? Current concepts of MAS pathophysiology. Early Hum Dev. 2009;85:617-20 pubmed publisher
    ..pregnancies ends with meconium-stained amniotic fluid and approximately 5% of these infants develop the meconium aspiration syndrome (MAS)...

More Information

Publications62

  1. Vidyasagar D, Zagariya A. Studies of meconium-induced lung injury: inflammatory cytokine expression and apoptosis. J Perinatol. 2008;28 Suppl 3:S102-7 pubmed publisher
    ..The balance of these interactions will determine the residual damage. We believe these new findings are very important in understanding of MILI...
  2. Nolent P, Hallalel F, Chevalier J, Flamant C, Renolleau S. [Meconium aspiration syndrome requiring mechanical ventilation: incidence and respiratory management in France (2000-2001)]. Arch Pediatr. 2004;11:417-22 pubmed
    To precise the number of term neonates with a meconium aspiration syndrome requiring mechanical ventilation in 2000 and 2001 in continental France and the related mortality. To study the different respiratory management...
  3. Avoine O, Bosse D, Beaudry B, Beaulieu A, Albadine R, Praud J, et al. Total liquid ventilation efficacy in an ovine model of severe meconium aspiration syndrome. Crit Care Med. 2011;39:1097-103 pubmed publisher
    ..a bronchoalveolar lavage performed with diluted surfactant in a newborn ovine model of severe acute meconium aspiration syndrome. Prospective, randomized, interventional study...
  4. Ivanov V. Meconium aspiration syndrome treatment - new approaches using old drugs. Med Hypotheses. 2006;66:808-10 pubmed
    Presently, modern medicine does not offer any disease-modifying treatment for meconium aspiration syndrome (MAS)...
  5. Salvia Roiges M, Carbonell Estrany X, Figueras Aloy J, Rodríguez Miguélez J. Efficacy of three treatment schedules in severe meconium aspiration syndrome. Acta Paediatr. 2004;93:60-5 pubmed
    To compare three different schedules in severe meconium aspiration syndrome (MAS) treatment: standard, bronchoalveolar lavage (BAL) with diluted surfactant, and diluted surfactant BAL plus a single early dexamethasone dose...
  6. Ghidini A, Spong C. Severe meconium aspiration syndrome is not caused by aspiration of meconium. Am J Obstet Gynecol. 2001;185:931-8 pubmed
    b>Meconium aspiration syndrome can present clinically with different degrees of severity, ranging from a mild form of respiratory compromise to severe forms that may result in perinatal death despite mechanical ventilation or extracorporeal ..
  7. Liu W, Harrington T. Delivery room risk factors for meconium aspiration syndrome. Am J Perinatol. 2002;19:367-78 pubmed
    The objective of this study is to identify risk factors for meconium aspiration syndrome (MAS) in newborns born through meconium-stained amniotic fluid (MSAF)...
  8. Khan A, Elidemir O, Epstein C, Lally K, Xue H, Blackburn M, et al. Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a murine model. Am J Physiol Lung Cell Mol Physiol. 2002;283:L785-90 pubmed
    b>Meconium aspiration syndrome is a cause of significant morbidity and mortality in the perinatal period and has been implicated in the pathogenesis of airway dysfunction...
  9. Dargaville P, Mills J, Headley B, Chan Y, Coleman L, Loughnan P, et al. Therapeutic lung lavage in the piglet model of meconium aspiration syndrome. Am J Respir Crit Care Med. 2003;168:456-63 pubmed
    Therapeutic lung lavage is an emerging treatment for meconium aspiration syndrome. Our objective was to investigate the type of fluid and aliquot volume most appropriate for lung lavage in this condition...
  10. Basu S, Kumar A, Bhatia B. Role of antibiotics in meconium aspiration syndrome. Ann Trop Paediatr. 2007;27:107-13 pubmed
    b>Meconium aspiration syndrome (MAS) is a major cause of severe respiratory distress in newborns and the role of antibiotics in its management is not well defined. To determine the role of routine antibiotic therapy in the management of MAS...
  11. Dargaville P, Mills J. Surfactant therapy for meconium aspiration syndrome: current status. Drugs. 2005;65:2569-91 pubmed
    b>Meconium aspiration syndrome (MAS) is an important cause of respiratory distress in the term infant...
  12. Dargaville P, Copnell B, Mills J, Haron I, Lee J, Tingay D, et al. Randomized controlled trial of lung lavage with dilute surfactant for meconium aspiration syndrome. J Pediatr. 2011;158:383-389.e2 pubmed publisher
    ..lung lavage with surfactant changes the duration of mechanical respiratory support or other outcomes in meconium aspiration syndrome (MAS). We conducted a randomized controlled trial that enrolled ventilated infants with MAS...
  13. Szymankiewicz M, Gadzinowski J, Kowalska K. Pulmonary function after surfactant lung lavage followed by surfactant administration in infants with severe meconium aspiration syndrome. J Matern Fetal Neonatal Med. 2004;16:125-30 pubmed
    ..of surfactant lung lavage (SLL) on pulmonary function was examined in neonates with severe form of meconium aspiration syndrome (MAS) (mean +/- standard deviation: birth weight, 3178.1 +/- 237.6 g; gestational age, 37.7 +/- 1...
  14. Kytölä J, Kääpä P, Uotila P. Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. Pediatr Res. 2003;53:731-6 pubmed
  15. Uhal B, Abdul Hafez A. Angiotensin II in apoptotic lung injury: potential role in meconium aspiration syndrome. J Perinatol. 2008;28 Suppl 3:S108-12 pubmed publisher
    ..more recent works that suggest the involvement of a RAS(L) in the perinatal lung damage associated with meconium aspiration syndrome (MAS)...
  16. Lin H, Su B, Tsai C, Lin T, Yeh T. Role of antibiotics in management of non-ventilated cases of meconium aspiration syndrome without risk factors for infection. Biol Neonate. 2005;87:51-5 pubmed
    There are limited data on the efficacy of antibiotics in the management for meconium aspiration syndrome (MAS)...
  17. Dargaville P, Mills J, Copnell B, Loughnan P, McDougall P, Morley C. Therapeutic lung lavage in meconium aspiration syndrome: a preliminary report. J Paediatr Child Health. 2007;43:539-45 pubmed
    To explore the effects of a large volume lung lavage procedure in ventilated infants with meconium aspiration syndrome. Infants with severe meconium aspiration requiring high-frequency ventilation underwent lung lavage using dilute bovine ..
  18. Kuo C, Chen J. Effect of meconium aspiration on plasma endothelin-1 level and pulmonary hemodynamics in a piglet model. Biol Neonate. 1999;76:228-34 pubmed
    ..changes in plasma endothelin-1 (ET-1) and pulmonary hemodynamics were studied in a piglet model of meconium aspiration syndrome (MAS)...
  19. Tølløfsrud P, Lindenskov P, Drevon C, Speer C, Seidenspinner S, Saugstad O. Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets. Biol Neonate. 2003;84:330-7 pubmed
    To understand the pathogenesis of meconium aspiration syndrome, we compared the pulmonary and inflammatory effects of the water and lipid extracts of human meconium instilled into the lungs of newborn piglets...
  20. Ross M. Meconium aspiration syndrome--more than intrapartum meconium. N Engl J Med. 2005;353:946-8 pubmed
  21. Soukka H, Ahotupa M, Ruutu M, Kaapa P. Meconium stimulates neutrophil oxidative burst. Am J Perinatol. 2002;19:279-84 pubmed
  22. Cayabyab R, Kwong K, Jones C, Minoo P, Durand M. Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. Pediatr Pulmonol. 2007;42:898-905 pubmed
    ..cellular profile, pro-inflammatory cytokines, and pulmonary function in intubated neonates with meconium aspiration syndrome (MAS). Sixteen term infants were studied...
  23. Tashiro K, Cui X, Kobayashi T, Curstedt T, Robertson B. Modified protocols for surfactant therapy in experimental meconium aspiration syndrome. Biol Neonate. 2003;83:49-56 pubmed
    In adult rats with experimental meconium aspiration syndrome, we investigated whether the therapeutic effect of exogenous surfactant was increased by addition of dextran or preceding airway lavage with diluted surfactant...
  24. Shin J, Shim J, Kim H, Sinn J, Kook J, Lee J. Rothia dentocariosa septicemia without endocarditis in a neonatal infant with meconium aspiration syndrome. J Clin Microbiol. 2004;42:4891-2 pubmed
    ..We report the first case of R. dentocariosa septicemia without endocarditis, which occurred in a neonatal infant with meconium aspiration syndrome.
  25. Kuo C, Chou Y, Lien R, Yang P. Study of plasma endothelin-1 concentrations in Taiwanese neonates with respiratory distress. Chang Gung Med J. 2001;24:239-44 pubmed
    ..of 22 with respiratory distress syndrome (RDS), 13 with transient tachypnea of newborn (TTNB), 4 with meconium aspiration syndrome, 10 healthy preterm and 11 healthy full-term infants were included for plasma ET-1 determination...
  26. Tripathi S, Saili A. The effect of steroids on the clinical course and outcome of neonates with meconium aspiration syndrome. J Trop Pediatr. 2007;53:8-12 pubmed
    b>Meconium Aspiration Syndrome (MAS) is an important cause of neonatal morbidity and mortality. The present study was undertaken to evaluate the role of steroids in the management of MAS...
  27. Vázquez Nava F, Salas Ramírez E, Sánchez Núncio H, Saldivar González A, Beltrán Saldaña J, Cadena Mata D, et al. Meconium aspiration syndrome, parental atopy and asthma symptoms in children under two years old. Rev Alerg Mex. 2006;53:130-5 pubmed
    To determine the association among meconium aspiration syndrome, parental atopy and asthma symptoms in children younger than two years...
  28. Lista G, Bianchi S, Castoldi F, Fontana P, Cavigioli F. Bronchoalveolar lavage with diluted porcine surfactant in mechanically ventilated term infants with meconium aspiration syndrome. Clin Drug Investig. 2006;26:13-9 pubmed
    To evaluate the efficacy and safety of bronchoalveolar lavage (BAL) with diluted porcine surfactant in mechanically ventilated term infants with severe acute respiratory distress syndrome (ARDS) due to meconium aspiration syndrome (MAS).
  29. Basu S, Kumar A, Bhatia B, Satya K, Singh T. Role of steroids on the clinical course and outcome of meconium aspiration syndrome-a randomized controlled trial. J Trop Pediatr. 2007;53:331-7 pubmed
    b>Meconium aspiration syndrome (MAS) is one of the major causes of severe respiratory distress in the newborn and there is no uniform protocol of management after the development of MAS...
  30. Beligere N, Rao R. Neurodevelopmental outcome of infants with meconium aspiration syndrome: report of a study and literature review. J Perinatol. 2008;28 Suppl 3:S93-101 pubmed publisher
    There is a paucity of information on long-term outcome of infants who have suffered from meconium aspiration syndrome (MAS) in the neonatal period...
  31. Rey Santano C, Mielgo V, Gastiasoro E, Alvarez Díaz F, Lafuente H, Valls i Soler A, et al. Comparative effects of bronchoalveolar lavage with saline, surfactant, or perfluorocarbon in experimental meconium aspiration syndrome. Pediatr Crit Care Med. 2012;13:e187-94 pubmed publisher
    Today, in meconium aspiration syndrome, treatment focuses on bronchoalveolar lavage, because it removes meconium and proinflammatory factors from airways...
  32. Dargaville P, Copnell B. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics. 2006;117:1712-21 pubmed
    ..population of live births, the incidence, risk factors, treatments, complications, and outcomes of meconium aspiration syndrome (MAS)...
  33. Blackwell S, Moldenhauer J, Hassan S, Redman M, Refuerzo J, Berry S, et al. Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: is it different?. Am J Obstet Gynecol. 2001;184:1422-5; discussion 1425-6 pubmed
    Our aim was to compare the clinical characteristics of meconium aspiration syndrome in cases with pH > or =7.20 and in those with pH <7.20...
  34. Shekerdemian L, Penny D, Ryhammer P, Reader J, Ravn H. Endothelin-A receptor blockade and inhaled nitric oxide in a porcine model of meconium aspiration syndrome. Pediatr Res. 2004;56:353-8 pubmed
    ..v. BQ-123 in a piglet model of meconium aspiration syndrome. Meconium aspiration was induced in 18 anesthetized piglets...
  35. Cleary G, Antunes M, Ciesielka D, Higgins S, Spitzer A, Chander A. Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. Pediatrics. 1997;100:998-1003 pubmed
    b>Meconium aspiration syndrome remains a common cause of respiratory failure in neonates. The acute effects of meconium aspiration are inactivation of lung surfactant in vivo and in vitro...
  36. Manganaro R, Mami C, Palmara A, Paolata A, Gemelli M. Incidence of meconium aspiration syndrome in term meconium-stained babies managed at birth with selective tracheal intubation. J Perinat Med. 2001;29:465-8 pubmed
    ..study was to evaluate maternal and neonatal characteristics of MSAF infants and the incidence of meconium aspiration syndrome (MAS) in routine delivery room management which reserved selective intubation for depressed/asphyxiated ..
  37. Yoder B, Kirsch E, Barth W, Gordon M. Changing obstetric practices associated with decreasing incidence of meconium aspiration syndrome. Obstet Gynecol. 2002;99:731-9 pubmed
    ..changes in neonatal and obstetric practices that may have contributed to the decreasing incidence of meconium aspiration syndrome in our population during this time...
  38. Mokra D, Tonhajzerova I, Mokry J, Drgova A, Petraskova M, Calkovska A, et al. Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury. Can J Physiol Pharmacol. 2008;86:804-14 pubmed publisher
    Glucocorticoids may improve lung function in newborns with meconium aspiration syndrome (MAS), but information on the acute side effects of glucocorticoids in infants is limited...
  39. Hilgendorff A, Doerner M, Rawer D, Leick J, Trotter A, Ebsen M, et al. Effects of a recombinant surfactant protein-C-based surfactant on lung function and the pulmonary surfactant system in a model of meconium aspiration syndrome. Crit Care Med. 2006;34:203-10 pubmed
    b>Meconium aspiration syndrome (MAS) remains a relevant cause of neonatal respiratory failure and is characterized by severe impairment of pulmonary gas exchange, surfactant inactivation, and pronounced inflammatory changes...
  40. Sriram S, Wall S, Khoshnood B, Singh J, Hsieh H, Lee K. Racial disparity in meconium-stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. Obstet Gynecol. 2003;102:1262-8 pubmed
    To estimate the prevalence of meconium-stained amniotic fluid and meconium aspiration syndrome, as well as the differences in case fatality from meconium aspiration syndrome, between non-Hispanic black and non-Hispanic white infants...
  41. Wiswell T, Knight G, Finer N, Donn S, Desai H, Walsh W, et al. A multicenter, randomized, controlled trial comparing Surfaxin (Lucinactant) lavage with standard care for treatment of meconium aspiration syndrome. Pediatrics. 2002;109:1081-7 pubmed
    Infants with meconium aspiration syndrome (MAS) have marked surfactant dysfunction. Airways and alveoli of affected neonates contain meconium, inflammatory cells, inflammatory mediators, edema fluid, protein, and other debris...
  42. Singh B, Clark R, Powers R, Spitzer A. Meconium aspiration syndrome remains a significant problem in the NICU: outcomes and treatment patterns in term neonates admitted for intensive care during a ten-year period. J Perinatol. 2009;29:497-503 pubmed publisher
    ..gestational age) who were admitted to a neonatal intensive care unit (NICU) for a diagnosis of meconium aspiration syndrome (MAS) during the years 1997 to 2007...
  43. Fraser W, Hofmeyr J, Lede R, Faron G, Alexander S, Goffinet F, et al. Amnioinfusion for the prevention of the meconium aspiration syndrome. N Engl J Med. 2005;353:909-17 pubmed
    ..thick meconium staining of the amniotic fluid reduces the risk of perinatal death, moderate or severe meconium aspiration syndrome, or both...
  44. Craig S, Lopez A, Hoskin D, Markham F. Meconium inhibits phagocytosis and stimulates respiratory burst in alveolar macrophages. Pediatr Res. 2005;57:813-8 pubmed
    The meconium aspiration syndrome is an important cause of respiratory distress in newborn infants...
  45. Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, Calkovska A. Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits. J Physiol Pharmacol. 2007;58 Suppl 5:389-98 pubmed
    ..The intratracheally administered corticosteroid budesonide effectively improved pulmonary functions and alleviated changes associated with inflammation in meconium-instilled rabbits. ..
  46. Goldsmith J. Continuous positive airway pressure and conventional mechanical ventilation in the treatment of meconium aspiration syndrome. J Perinatol. 2008;28 Suppl 3:S49-55 pubmed publisher
    b>Meconium aspiration syndrome (MAS) is a complex syndrome that ranges in severity from mild respiratory distress to severe respiratory failure, persistent pulmonary hypertension of the newborn and sometimes death...
  47. Ivanov V, Gewolb I, Uhal B. A new look at the pathogenesis of the meconium aspiration syndrome: a role for fetal pancreatic proteolytic enzymes in epithelial cell detachment. Pediatr Res. 2010;68:221-4 pubmed publisher
    ..These results afford a new perspective on the pathophysiology of meconium aspiration syndrome (MAS)...
  48. Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, et al. Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. J Biol Chem. 1999;274:17813-9 pubmed
    ..These features are similar to those of a severe type of human meconium aspiration syndrome. The increased expression of the hypoxia inducible genes suggests that hypoxia occurs in the mutant ..
  49. Bhutani V. Developing a systems approach to prevent meconium aspiration syndrome: lessons learned from multinational studies. J Perinatol. 2008;28 Suppl 3:S30-5 pubmed publisher
    ..Respiratory failure secondary to meconium aspiration syndrome (MAS) remains a major cause of morbidity and mortality in the neonatal population...
  50. Castellheim A, Lindenskov P, Pharo A, Aamodt G, Saugstad O, Mollnes T. Meconium aspiration syndrome induces complement-associated systemic inflammatory response in newborn piglets. Scand J Immunol. 2005;61:217-25 pubmed
    The pathophysiology of meconium aspiration syndrome (MAS) is complex. We recently showed that meconium is a potent activator of complement...
  51. Mokra D, Drgova A, Mokry J, Bulikova J, Pullmann R, Durdik P, et al. Combination of budesonide and aminophylline diminished acute lung injury in animal model of meconium aspiration syndrome. J Physiol Pharmacol. 2008;59 Suppl 6:461-71 pubmed
    ..However, no additive effect of budesonide was observed on lung peroxidation and in vitro airway reactivity...
  52. Choi H, Hahn S, Lee J, Park B, Lee S, Kim H, et al. Surfactant lavage therapy for meconium aspiration syndrome: a systematic review and meta-analysis. Neonatology. 2012;101:183-91 pubmed publisher
    Lung lavage with diluted surfactant has emerged as an innovative treatment for meconium aspiration syndrome (MAS). However, the treatment effect has not yet been fully established...
  53. Tripathi S, Saili A, Dutta R. Inflammatory markers in meconium induced lung injury in neonates and effect of steroids on their levels: a randomized controlled trial. Indian J Med Microbiol. 2007;25:103-7 pubmed
    To determine the levels of TNFa and IL-1beta in tracheal aspirates of neonates with meconium aspiration syndrome (MAS) and to ascertain whether the use of steroids by systemic or nebulized routes suppresses the levels of these ..