Summary: A clinical syndrome with intermittent abdominal pain characterized by sudden onset and cessation that is commonly seen in infants. It is usually associated with obstruction of the INTESTINES; of the CYSTIC DUCT; or of the URINARY TRACT.

Top Publications

  1. Angulo J, Gaspar M, Rodriguez N, García Tello A, Torres G, Nunez C. The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion. Urology. 2010;76:301-6 pubmed publisher
    To analyze whether C-reactive protein (CRP) predicts the need for urgent urinary diversion in patients with renal colic and urolithiasis. CRP may help in the differential diagnosis of complicated hydronephrosis.
  2. Reinthal M, Andersson S, Gustafsson M, Plos K, Lund I, Lundeberg T, et al. Effects of minimal acupuncture in children with infantile colic - a prospective, quasi-randomised single blind controlled trial. Acupunct Med. 2008;26:171-82 pubmed
    b>Colic causes crying in 10-30% of infants and is one of the primary reasons parents seek health care. Treatments are generally not totally effective and some cause side effects...
  3. Djaladat H, Tajik P, Fard S, Alehashemi S. The effect of aminophylline on renal colic: a randomized double blind controlled trial. South Med J. 2007;100:1081-4 pubmed
    To evaluate the efficacy of aminophylline infusion as a painkiller compared with placebo in patients with acute renal colic.
  4. Ongom P, Lukande R, Jombwe J. Anal protrusion of an ileo-colic intussusception in an adult with persistent ascending and descending mesocolons: a case report. BMC Res Notes. 2013;6:42 pubmed publisher
    ..It is usually covert (concealed) in its clinical presentation. The ileo-colic type with accompanying anal protrusion is extremely rare...
  5. Arikan D, Alp H, Gozum S, Orbak Z, Cifçi E. Effectiveness of massage, sucrose solution, herbal tea or hydrolysed formula in the treatment of infantile colic. J Clin Nurs. 2008;17:1754-61 pubmed
    The aim of the study was to evaluate the effectiveness of massage, sucrose solution, herbal tea or hydrolysed formula, each used individually in the treatment of infantile colic.
  6. Sung V, Hiscock H, Tang M, Mensah F, Heine R, Stock A, et al. Probiotics to improve outcomes of colic in the community: protocol for the Baby Biotics randomised controlled trial. BMC Pediatr. 2012;12:135 pubmed publisher
    Infant colic, characterised by excessive crying/fussing for no apparent cause, affects up to 20% of infants under three months of age and is a great burden to families, health professionals and the health system...
  7. Eisner B, Reese A, Sheth S, Stoller M. Ureteral stone location at emergency room presentation with colic. J Urol. 2009;182:165-8 pubmed publisher
    ..Textbooks describe these 3 sites as the most likely places for ureteral stones to lodge. We defined the stone position in the ureter when patients first present to the emergency department with colic.
  8. de Weerth C, Fuentes S, Puylaert P, de Vos W. Intestinal microbiota of infants with colic: development and specific signatures. Pediatrics. 2013;131:e550-8 pubmed publisher
    To provide a comprehensive analysis of the fecal microbiota in infants with colic, as compared with control infants, during their first 100 days of life.
  9. Watkins S, Bowra J, Sharma P, Holdgate A, Giles A, Campbell L. Validation of emergency physician ultrasound in diagnosing hydronephrosis in ureteric colic. Emerg Med Australas. 2007;19:188-95 pubmed
    ..Emergency physician ultrasound (EPU) could allow rapid diagnosis and disposition. If accurate it might avert the need for formal radiological imaging, exclude an obstruction and improve patient flow through the ED...

Scientific Experts

More Information


  1. Gupta S. Update on infantile colic and management options. Curr Opin Investig Drugs. 2007;8:921-6 pubmed
    Infant colic is a common but poorly defined and understood clinical entity and, while several causative factors have been suggested, a unifying theory of its pathogenesis is still required...
  2. Ernst E. Chiropractic spinal manipulation for infant colic: a systematic review of randomised clinical trials. Int J Clin Pract. 2009;63:1351-3 pubmed publisher
    Some chiropractors claim that spinal manipulation is an effective treatment for infant colic. This systematic review was aimed at evaluating the evidence for this claim...
  3. Voigt A, Saulez M, Donnellan C, Gummow B. Causes of gastrointestinal colic at an equine referral hospital in South Africa (1998-2007). J S Afr Vet Assoc. 2009;80:192-8 pubmed
    The most common causes of gastrointestinal colic at an equine referral hospital in South Africa were determined following retrieval of the medical records of horses admitted during a 10-year study period...
  4. Abacı F, Gokce S, Tuygun N, Karacan C, Oner O. Psychosocial status and quality of life in mothers of infants with colic. Turk J Pediatr. 2013;55:391-5 pubmed
    We aimed to measure the psychosocial status and quality of life in mothers of babies with infantile colic (IC)...
  5. Landgren K, Kvorning N, Hallström I. Acupuncture reduces crying in infants with infantile colic: a randomised, controlled, blind clinical study. Acupunct Med. 2010;28:174-9 pubmed publisher
    To investigate whether acupuncture reduces the duration and intensity of crying in infants with colic. Patients and methods 90 otherwise healthy infants, 2-8 weeks old, with infantile colic were randomised in this controlled blind study...
  6. Rosen L, Bukutu C, Le C, Shamseer L, Vohra S. Complementary, holistic, and integrative medicine: colic. Pediatr Rev. 2007;28:381-5 pubmed
  7. Moravej H, Imanieh M, Kashef S, Handjani F, Eghterdari F. Predictive value of the cow's milk skin prick test in infantile colic. Ann Saudi Med. 2010;30:468-70 pubmed publisher
    Infantile colic is a common problem among young infants. Cow's milk allergy has been suggested as one of the causes...
  8. Wang J, Shen S, Huang S, Chang C. Prospective comparison of unenhanced spiral computed tomography and intravenous urography in the evaluation of acute renal colic. J Chin Med Assoc. 2008;71:30-6 pubmed publisher
    ..purpose of this prospective study was to evaluate the feasibility of replacing intravenous urography (IVU) with unenhanced computed tomography (CT) as the first line diagnostic modality for acute renal colic in the emergency department.
  9. Yalcin S, Orün E, Mutlu B, Madendag Y, Sinici I, Dursun A, et al. Why are they having infant colic? A nested case-control study. Paediatr Perinat Epidemiol. 2010;24:584-96 pubmed publisher
    ..status, mother-child bonding, family structure, support for the mother, familial atopy) risk factors for infant colic and to follow infants with respect to physical growth, sleeping status up to 8 months of age in a nested case-..
  10. Haupt J, McAndrews A, Chaney K, Labbe K, Holcombe S. Surgical treatment of colic in the miniature horse: a retrospective study of 57 cases (1993-2006). Equine Vet J. 2008;40:364-7 pubmed publisher
    ..However, few reports exist in the veterinary literature describing complications and long-term survival following surgical treatment of colic in these horses.
  11. Anabrees J, Indrio F, Paes B, Alfaleh K. Probiotics for infantile colic: a systematic review. BMC Pediatr. 2013;13:186 pubmed publisher
    Infantile colic is a common paediatric condition which causes significant parental distress...
  12. Fogle C, Gerard M, Elce Y, Little D, Morton A, Correa M, et al. Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease. Vet Surg. 2008;37:558-63 pubmed publisher
    To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic.
  13. Cohen Engler A, Hadash A, Shehadeh N, Pillar G. Breastfeeding may improve nocturnal sleep and reduce infantile colic: potential role of breast milk melatonin. Eur J Pediatr. 2012;171:729-32 pubmed publisher
    ..breast milk, which consists of melatonin, may have an effect on improving infants' sleep and reducing infantile colic. Our first goal was to assess the differences in the prevalence and severity of infantile colic and nocturnal ..
  14. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2013;162:257-62 pubmed publisher
    To determine whether administration of Lactobacillus reuteri (L reuteri) DSM 17938 is beneficial in breastfed infants with infantile colic.
  15. Brand S, Furlano R, Sidler M, Schulz J, Holsboer Trachsler E. 'Oh, baby, please don't cry!': in infants suffering from infantile colic hypothalamic-pituitary-adrenocortical axis activity is related to poor sleep and increased crying intensity. Neuropsychobiology. 2011;64:15-23 pubmed publisher
    Infantile colic (IC) is considered to represent the upper end of the spectrum of early developmental crying behavior. Little is known about hypothalamic-pituitary-adrenocortical axis activity and sleep in relation to infants' crying...
  16. Milidou I, Henriksen T, Jensen M, Olsen J, Søndergaard C. Nicotine replacement therapy during pregnancy and infantile colic in the offspring. Pediatrics. 2012;129:e652-8 pubmed publisher
    To investigate the associations between use of nicotine replacement therapy (NRT) and smoking during pregnancy and infantile colic in the offspring.
  17. Olsen J, McGrath N, Schwarz D, Cutcliffe B, Stern J. A double-blind randomized clinical trial evaluating the analgesic efficacy of ketorolac versus butorphanol for patients with suspected biliary colic in the emergency department. Acad Emerg Med. 2008;15:718-22 pubmed publisher
    Patients presenting to the emergency department (ED) with suspected biliary colic often require intravenous (IV) analgesia. The choice of IV analgesia typically includes opioids and ketorolac...
  18. Guichard G, Fromajoux C, Cellarier D, Loock P, Chabannes E, Bernardini S, et al. [Management of renal colic in pregnant women, based on a series of 48 cases]. Prog Urol. 2008;18:29-34 pubmed publisher
    ..Urinary stones are relatively frequent in pregnant women and raise specific diagnostic and therapeutic problems. The authors conducted a retrospective review of the management of this disease in their establishment...
  19. Boscolo Berto R, Dal Moro F, Abate A, Arandjelovic G, Tosato F, Bassi P. Do weather conditions influence the onset of renal colic? A novel approach to analysis. Urol Int. 2008;80:19-25 pubmed publisher
    To investigate the seasonal variations of the incidence of renal colic by a computerized analysis of cyclic climatic features.
  20. Gurusamy K, Koti R, Fusai G, Davidson B. Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic. Cochrane Database Syst Rev. 2013;:CD007196 pubmed publisher
    Uncomplicated biliary colic is one of the commonest indications for laparoscopic cholecystectomy. Laparoscopic cholecystectomy involves several months of waiting if performed electively...
  21. Sung V, Collett S, De Gooyer T, Hiscock H, Tang M, Wake M. Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr. 2013;167:1150-7 pubmed publisher
    ..OBJECTIVE To examine whether probiotics are effective in the prevention/management of crying ("colic") in infants 3 months or younger...
  22. Chowdhury F, Kotwal S, Raghunathan G, Wah T, Joyce A, Irving H. Unenhanced multidetector CT (CT KUB) in the initial imaging of suspected acute renal colic: evaluating a new service. Clin Radiol. 2007;62:970-7 pubmed
    To evaluate a new imaging pathway for the investigation of patients presenting with suspected acute renal colic.
  23. Savino F. Focus on infantile colic. Acta Paediatr. 2007;96:1259-64 pubmed
    Infantile colic is a widespread clinical condition in the first 3 months of life, which is easily recognized, but incompletely understood and difficult to solve...
  24. Al Jassim R, Andrews F. The bacterial community of the horse gastrointestinal tract and its relation to fermentative acidosis, laminitis, colic, and stomach ulcers. Vet Clin North Am Equine Pract. 2009;25:199-215 pubmed publisher
  25. Shergill Bonner R. Infantile colic: practicalities of management, including dietary aspects. J Fam Health Care. 2010;20:206-9 pubmed
    The incidence of infantile colic is between 5-20%. It occurs equally in breast- and bottle-fed infants, and in both sexes. The aetiology is unknown...
  26. Romanello S, Spiri D, Marcuzzi E, Zanin A, Boizeau P, Riviere S, et al. Association between childhood migraine and history of infantile colic. JAMA. 2013;309:1607-12 pubmed publisher
    Infantile colic is a common cause of inconsolable crying during the first months of life and has been thought to be a pain syndrome. Migraine is a common cause of headache pain in childhood...
  27. Sung V, Hiscock H, Tang M, Mensah F, Nation M, Satzke C, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014;348:g2107 pubmed publisher
    To determine whether the probiotic Lactobacillus reuteri DSM 17938 reduces crying or fussing in a broad community based sample of breastfed infants and formula fed infants with colic aged less than 3 months.
  28. Savoie P, Lafolie T, Gabaudan C, Biance N, Avaro J, Andre M, et al. [Late complication of selective renal arterial embolization after percutaneous surgery: renal "colic"]. Prog Urol. 2007;17:869-71 pubmed
    ..One of the coils was deployed too distally. It was not efficient, it rolled itself up in the pseudoaneurysm cavity. Different physio pathological hypothesis are developed to explain this expulsion...
  29. Nelms J, Patel J, Atkinson D, Raves J. Metastatic malignant melanoma of the gallbladder presenting as biliary colic: a case report and review of literature. Am Surg. 2007;73:833-5 pubmed
    ..We present the case of a 48-year-old man with MM metastatic to the gallbladder and a brief review of the literature...
  30. Vos B, Laureys M. [Giant renal cyst as cause of colic obstruction]. Rev Med Brux. 2009;30:107-9 pubmed
    ..She presented an important colic distension associated to an inflammatory syndrome...
  31. Edner A, Nyman G, Essen Gustavsson B. Metabolism before, during and after anaesthesia in colic and healthy horses. Acta Vet Scand. 2007;49:34 pubmed
    Many colic horses are compromised due to the disease state and from hours of starvation and sometimes long trailer rides. This could influence their muscle energy reserves and affect the horses' ability to recover...
  32. Valentine B, Lohr C. Myonecrosis in three horses with colic: evidence for endotoxic injury. Vet Rec. 2007;161:786-9 pubmed
    Three horses with colic, clinical evidence of endotoxaemia and high serum activities of creatine kinase and aspartate aminotransferase were examined postmortem...
  33. Besselink M, Venneman N, Go P, Broeders I, Siersema P, Gooszen H, et al. Is complicated gallstone disease preceded by biliary colic?. J Gastrointest Surg. 2009;13:312-7 pubmed publisher
    Cholecystectomy in cases of "warning" episodes of biliary colic may prevent biliary pancreatitis...
  34. Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014;168:228-33 pubmed publisher
    Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, ..
  35. Archer D, Pinchbeck G, French N, Proudman C. Risk factors for epiploic foramen entrapment colic: an international study. Equine Vet J. 2008;40:224-30 pubmed publisher
    ..Epiploic foramen entrapment (EFE) is one of the most common causes of small intestinal strangulation in the horse. Identification of risk factors would generate hypotheses about causation and may suggest preventive strategies...
  36. Sutton G, Dahan R, Turner D, Paltiel O. A behaviour-based pain scale for horses with acute colic: scale construction. Vet J. 2013;196:394-401 pubmed publisher
    A validated tool for assessing the severity of acute abdominal pain is needed for the effective management of colic in horses...
  37. Shirazi Beechey S. Molecular insights into dietary induced colic in the horse. Equine Vet J. 2008;40:414-21 pubmed publisher
    Equine colic, a disorder manifested in abdominal pain, is the most frequent cause of emergency treatment and death in horses...
  38. Landgren K, Hallström I. Parents' experience of living with a baby with infantile colic--a phenomenological hermeneutic study. Scand J Caring Sci. 2011;25:317-24 pubmed publisher
    About 10% of newborn babies have infantile colic which means that they cry more than 3 hours per day. The baby's crying risks disturbing the early parent-child interaction.
  39. Catherine N, Ko J, Barr R. Getting the word out: advice on crying and colic in popular parenting magazines. J Dev Behav Pediatr. 2008;29:508-11 pubmed publisher
    ..whether advice in parenting magazines reflects current evidence-based understanding of early infant crying and colic, where (1) "colic" is the upper end of a spectrum of crying behavior reflective of normal infant ..
  40. Torfs S, Delesalle C, Dewulf J, Devisscher L, Deprez P. Risk factors for equine postoperative ileus and effectiveness of prophylactic lidocaine. J Vet Intern Med. 2009;23:606-11 pubmed publisher
    Postoperative ileus (POI) is a frequent and often fatal complication of colic surgery. Reliably effective treatments are not available.
  41. Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics. 2011;127:720-33 pubmed publisher
    Complementary and alternative medicines often are advocated for infantile colic, yet there has been no synthesis of the evidence to inform current practice about their use.
  42. Vik T, Grote V, Escribano J, Socha J, Verduci E, Fritsch M, et al. Infantile colic, prolonged crying and maternal postnatal depression. Acta Paediatr. 2009;98:1344-8 pubmed publisher
    ..To study if infant crying is associated with maternal postnatal depression...
  43. Savino F, Cordisco L, Tarasco V, Calabrese R, Palumeri E, Matteuzzi D. Molecular identification of coliform bacteria from colicky breastfed infants. Acta Paediatr. 2009;98:1582-8 pubmed publisher
    ..To determine the presence of intestinal coliform bacteria in colicky vs healthy infants...
  44. Savino F, Tarasco V. New treatments for infant colic. Curr Opin Pediatr. 2010;22:791-7 pubmed publisher
    Infantile colic is a common problem within the first 3 months of life and causes considerable distress for parents and paediatricians...
  45. Savino F, Cordisco L, Tarasco V, Locatelli E, Di Gioia D, Oggero R, et al. Antagonistic effect of Lactobacillus strains against gas-producing coliforms isolated from colicky infants. BMC Microbiol. 2011;11:157 pubmed publisher
    Infantile colic is a common disturb within the first 3 months of life, nevertheless the pathogenesis is incompletely understood and treatment remains an open issue...
  46. Keppie N, Rosenstein D, Holcombe S, Schott H. Objective radiographic assessment of abdominal sand accumulation in horses. Vet Radiol Ultrasound. 2008;49:122-8 pubmed
    Gastrointestinal sand accumulation is a common cause of equine colic. Subjective assessment of sand accumulation on abdominal radiographs has been used as a diagnostic aid; however, there is poor correlation between clinical, diagnostic, ..
  47. Hall B, Chesters J, Robinson A. Infantile colic: a systematic review of medical and conventional therapies. J Paediatr Child Health. 2012;48:128-37 pubmed publisher
    Infantile colic is a prevalent and distressing condition for which there is no proven standard therapy. The aim of this paper is to review medical and conventional treatments for infantile colic.
  48. Skjeie H, Skonnord T, Fetveit A, Brekke M. A pilot study of ST36 acupuncture for infantile colic. Acupunct Med. 2011;29:103-7 pubmed publisher
    To conduct a pilot study to assess the feasibility of a proposed design of an acupuncture trial to relieve symptoms of infantile colic.
  49. Onur M, Cubuk M, Andic C, Kartal M, Arslan G. Role of resistive index in renal colic. Urol Res. 2007;35:307-12 pubmed
    ..we evaluated the intrarenal hemodynamics of 27 patients who presented to the emergency department with renal colic. We performed Doppler ultrasonography on patients in whom US did not reveal any pathology causing renal colic and ..
  50. Howard C, Lanphear N, Lanphear B, Eberly S, Lawrence R. Parental responses to infant crying and colic: the effect on breastfeeding duration. Breastfeed Med. 2006;1:146-55 pubmed
    Infant crying can cause parental distress, and colic is associated with low maternal self-efficacy and heightened risk for depression...
  51. Diniz D, Blay S, Schor N. Anxiety and depression symptoms in recurrent painful renal lithiasis colic. Braz J Med Biol Res. 2007;40:949-55 pubmed
    ..Our objective was to evaluate the association of symptoms of anxiety, depression and recurrent painful renal colic in a case-control study involving 64 subjects (32 cases/32 controls) matched for age and sex...
  52. Andreoiu M, MacMahon R. Renal colic in pregnancy: lithiasis or physiological hydronephrosis?. Urology. 2009;74:757-61 pubmed publisher
    ..the reliability and accuracy of diagnostic investigations in differentiating urinary calculi from physiological hydronephrosis as the cause of renal colic. The appropriateness and efficacy of the treatments used were was also examined.