methyldopa

Summary

Summary: An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Top Publications

  1. Rosenthal T, Oparil S. The effect of antihypertensive drugs on the fetus. J Hum Hypertens. 2002;16:293-8 pubmed
  2. Nagaralli B, Seetharamappa J, Melwanki M, Ramesh K, Keshavayya J. Spectrophotometric investigations of the assay of physiologically active catecholamines in pharmaceutical formulations. J AOAC Int. 2002;85:1288-92 pubmed
    ..simple, sensitive, and accurate spectrophotometric methods are proposed for the determination of levodopa (LD), methyldopa (MD), dopamine hydrochloride (DP), and pyrocatechol (PC) in pure and pharmaceutical preparations...
  3. Ofor O. Oral enalapril-hydrochlorothiazide-methyldopa as first line treatment for severe hypertension in Nigerians. Trop Doct. 2004;34:32-3 pubmed
    A combination of low-dose oral enalapril, methyldopa and hydrochlorothiazide was evaluated in the acute treatment of severe hypertension...
  4. Kavak Z, Sezen D, Basgul A, Gokaslan H, Cakalagaoglu F. A rare case of early onset nephrotic syndrome in pregnancy. Clin Exp Obstet Gynecol. 2006;33:127-8 pubmed
  5. Marsh J, Erfle M, Leeds C. Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila. Genetics. 1986;114:453-67 pubmed
    ..describe the molecular mapping and sequencing of a full-length cDNA copy of a transcript that maps to the alpha-methyldopa hypersensitive region...
  6. Nielsen L, Muller C, Damm P, Mathiesen E. Reduced prevalence of early preterm delivery in women with Type 1 diabetes and microalbuminuria--possible effect of early antihypertensive treatment during pregnancy. Diabet Med. 2006;23:426-31 pubmed
    ..From April 2000 our routine was changed and early antihypertensive treatment with methyldopa was initiated if antihypertensive treatment was given prior to pregnancy, if urinary albumin excretion (UAE) was ..
  7. Zecevic M, Zivanovic L, Agatonovic Kustrin S, Minic D. The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets. J Pharm Biomed Anal. 2001;24:1019-25 pubmed
    A multifactor optimisation technique is successfully applied to develop a new HPLC method in which methyldopa, hydrochlorothiazide and amiloride were analysed and determined on a C18 column with detection at 286 nm...
  8. Elhassan E, Mirghani O, Habour A, Adam I. Methyldopa versus no drug treatment in the management of mild pre-eclampsia. East Afr Med J. 2002;79:172-5 pubmed
    To evaluate the efficacy of methyldopa in the treatment of mild pre-eclampsia, to prevent its progress and to investigate its effect on the pregnancy outcomes.
  9. Chamsaz M, Safavi A, Fadaee J. Simultaneous kinetic-spectrophotometric determination of carbidopa, levodopa and methyldopa in the presence of citrate with the aid of multivariate calibration and artificial neural networks. Anal Chim Acta. 2007;603:140-6 pubmed
    ..A set of synthetic mixtures of carbidopa (CD), levodopa (LD) and methyldopa (MD) was evaluated and the results obtained by the applications of these chemometric approaches were discussed ..

More Information

Publications62

  1. Marsh J, Wright T. Evidence for regulatory variants of the dopa decarboxylase and alpha-methyldopa hypersensitive loci in Drosophila. Genetics. 1986;112:249-65 pubmed
    ..RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls...
  2. Khalil A, Muttukrishna S, Harrington K, Jauniaux E. Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. PLoS ONE. 2008;3:e2766 pubmed publisher
    ..The aim of our study was to evaluate the impact of antihypertensive therapy with alpha methyldopa on maternal circulating levels and placental production of soluble fms-like tyrosine kinase 1 (sFlt-1), soluble ..
  3. Khalil A, Harrington K, Muttukrishna S, Jauniaux E. Effect of antihypertensive therapy with alpha-methyldopa on uterine artery Doppler in pregnancies with hypertensive disorders. Ultrasound Obstet Gynecol. 2010;35:688-94 pubmed publisher
    ..This study aimed to evaluate the impact of antihypertensive therapy with alpha-methyldopa on maternal uterine artery Doppler pulsatility index (PI) and resistance index (RI) in women presenting with ..
  4. Burckhardt Herold S, Klotz J, Funk F, Büchi R, Petrig Schaffland J, Geisser P. Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies. Arzneimittelforschung. 2007;57:360-9 pubmed
  5. Zidek W, Ottens E, Heckmann U. The effect of antihypertensive treatment on the circulating hypertensive factor in the spontaneously hypertensive rat. Clin Exp Hypertens A. 1987;9:2061-73 pubmed
    ..was not changed by cross circulation after pretreatment of the spontaneously hypertensive rats with alpha methyldopa. It is concluded that in this strain of spontaneously hypertensive rats a circulating hypertensive factor exists,..
  6. Robe L, Valente V, Budnik M, Loreto E. Molecular phylogeny of the subgenus Drosophila (Diptera, Drosophilidae) with an emphasis on Neotropical species and groups: a nuclear versus mitochondrial gene approach. Mol Phylogenet Evol. 2005;36:623-40 pubmed
    ..at least 41 Drosophilidae taxa to a phylogenetic analysis using a 516-base pair (bp) fragment of the alpha-methyldopa (Amd) nuclear gene and a 672 bp fragment of the mitochondrial cytochrome oxidase subunit II (COII) gene both ..
  7. Okoro E, Oyejola B. Inadequate control of blood pressure in Nigerians with diabetes. Ethn Dis. 2004;14:82-6 pubmed
    ..Nifedipine was the most frequently prescribed antihypertensive (44.30%), followed by alpha-methyldopa (15.7%) and then the angiotensin-converting enzyme inhibitors (ACEIs) captopril and lisinopril (11.3%)...
  8. Opezzo J, Hocht C, Taira C. Pharmacokinetic profile of methyldopa in the brain of sinaortic-denervated rats. Pharmacol Res. 2003;48:61-7 pubmed
    Pharmacokinetics of methyldopa (MD) and the effect on the dopaminergic metabolism was studied in anesthetized sham-operated (SO) and sinoaortic-denervated (SAD) rats by using the microdialysis technique...
  9. Arulkumaran N, Lightstone L. Severe pre-eclampsia and hypertensive crises. Best Pract Res Clin Obstet Gynaecol. 2013;27:877-84 pubmed publisher
    ..In the first instance, oral anti-hypertensive agents, including labetalol, nifedipine and methyldopa, should be tried...
  10. Mahmud H, Foller M, Lang F. Stimulation of erythrocyte cell membrane scrambling by methyldopa. Kidney Blood Press Res. 2008;31:299-306 pubmed publisher
    b>Methyldopa is used for treatment of hypertension in pregnancy. Side effects of methyldopa include anemia, which could result from decreased formation or accelerated death of circulating erythrocytes...
  11. Nielsen L, Damm P, Mathiesen E. Improved pregnancy outcome in type 1 diabetic women with microalbuminuria or diabetic nephropathy: effect of intensified antihypertensive therapy?. Diabetes Care. 2009;32:38-44 pubmed publisher
    ..To describe pregnancy outcome in type 1 diabetic women with normoalbuminuria, microalbuminuria, or diabetic nephropathy after implementation of an intensified antihypertensive therapeutic strategy...
  12. Herlitz H. ACE-inhibitors and quality of life. Scand J Prim Health Care Suppl. 1990;1:85-8 pubmed
    ..prospective multi-center randomised trials were conducted to determine the effect of captopril in comparison to methyldopa or an unselective beta-blocker on the quality of life in patients with mild to moderate hypertension (Hill et al...
  13. Homicskó K, Kertesz I, Radnai B, Tóth B, Toth G, Fulop F, et al. Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat. Neurochem Int. 2003;42:19-26 pubmed
    ..At the same time, L-dopa, carbidopa, benserazide and alpha-methyldopa were able to displace 3H-SAL...
  14. Wautier J, Rouger P. [Drug-induced hemolytic anemia]. Transfus Clin Biol. 2001;8:377-80 pubmed
    ..b>Methyldopa and antibiotics were first identified as inducers of auto-immune hemolytic anemia...
  15. Hall D, Odendaal H, Steyn D, Grove D. Expectant management of early onset, severe pre-eclampsia: maternal outcome. BJOG. 2000;107:1252-7 pubmed
    ..To evaluate the safety and outcome of women undergoing expectant management of early onset, severe pre-eclampsia...
  16. van den Buuse M. Pretreatment with quinpirole inhibits the central antihypertensive effects of rilmenidine and alpha-methyldopa in conscious rats. Eur J Pharmacol. 1997;322:191-9 pubmed
    ..In SHR which had been treated with quinpirole, the central antihypertensive effects of rilmenidine or alpha-methyldopa were significantly inhibited...
  17. El Guindy A, Nabhan A. A randomized trial of tight vs. less tight control of mild essential and gestational hypertension in pregnancy. J Perinat Med. 2008;36:413-8 pubmed publisher
    ..To assess the effects of applying a tight vs. a less tight control of mild chronic essential or gestational non-proteinuric hypertension in pregnancy...
  18. Slim R, Ben Salem C, Hmouda H, Bouraoui K. Hepatotoxicity of alpha-methyldopa in pregnancy. J Clin Pharm Ther. 2010;35:361-3 pubmed publisher
    Alpha-methyldopa is one of the most widely prescribed antihypertensive agents used during pregnancy...
  19. Sonneveld M, Brussé I, Duvekot J, Steegers E, Grüne F, Visser G. Cerebral perfusion pressure in women with preeclampsia is elevated even after treatment of elevated blood pressure. Acta Obstet Gynecol Scand. 2014;93:508-11 pubmed publisher
    ..blood pressure and middle cerebral artery blood flow velocity in 10 women with preeclampsia, all treated with methyldopa with or without nifedipine, and 18 healthy pregnant controls...
  20. Ostroumova T, Markova L. The effects of dopamine synthesis inhibitors and dopamine antagonists on regeneration in the hydra Hydra attenuata. Neurosci Behav Physiol. 2002;32:293-8 pubmed
    ..The possible role of neurotransmitters. particularly dopamine, in morphogenesis in hydras is discussed...
  21. Podjarny E, Benchetrit S, Katz B, Green J, Bernheim J. Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. Nephron. 2001;88:354-9 pubmed
    ..The aim of the present study is to evaluate whether the beneficial action of the sympathetic antagonist methyldopa (a first-choice hypotensive agent in the treatment of PIH) may be associated to changes in nitric-oxide synthesis...
  22. Tung C, Goldberg M, Hollister A, Sweetman B, Robertson D. Depletion of brainstem epinephrine stores by alpha-methyldopa: possible relation to attenuated sympathetic outflow. Life Sci. 1988;42:2365-71 pubmed
    The antihypertensive effect of alpha-methyldopa (MD) is believed to be critically dependent on its ability to deplete endogenous catecholamines or cause the synthesis of false neurotransmitters...
  23. Konrad K, Wang D, Marsh J. Vitelline membrane biogenesis in Drosophila requires the activity of the alpha-methyl dopa hypersensitive gene (I(2)amd) in both the germline and follicle cells. Insect Mol Biol. 1993;1:179-87 pubmed
    ..Given its unique role in insects and its demonstrated sensitivity to dietary inhibitors, the amd gene product poses an attractive target for insect control...
  24. Ramachandran P, Parthasarathy G, Gagare P. Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates. Org Lett. 2010;12:4474-7 pubmed publisher
    ..The preparation and application of bis-exo-bicyclo[2.2.1]heptan-2-ylboron triflate as a superior reagent for diastereospecific enolization has also been described...
  25. Moccelini S, Franzoi A, Vieira I, Dupont J, Scheeren C. A novel support for laccase immobilization: cellulose acetate modified with ionic liquid and application in biosensor for methyldopa detection. Biosens Bioelectron. 2011;26:3549-54 pubmed publisher
    ..Laccase (Lac) from Aspergillus oryzae was immobilized in this material to investigate the behavior of methyldopa by square-wave voltammetry...
  26. Black B, Pentz E, Wright T. The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism. Mol Gen Genet. 1987;209:306-12 pubmed
    ..We present data that provide direct evidence that the amd+ gene product is required for a step in the metabolism of dopa to one or more novel catecholamines involved in the colorless sclerotization of cuticle...
  27. Sica D. Centrally acting antihypertensive agents: an update. J Clin Hypertens (Greenwich). 2007;9:399-405 pubmed
    ..Central a agonists have had a lengthy history of use, starting with alpha-methyldopa, which has had a dramatic decline in use, in part, because of bothersome side effects...
  28. Fletcher A. Adverse treatment effects in the trial of the European Working Party on High Blood Pressure in the Elderly. Am J Med. 1991;90:42S-44S pubmed
    ..randomly assigned to active treatment (a combination of triamterene and hydrochlorothiazide) or placebo; methyldopa was added to the regimen in one third of the treated patients...
  29. De Jong W, Sandor P, Cox van Put J, van den Berg M, van Giersbergen P. Beta-endorphin and central control of arterial blood pressure during challenge of circulatory homeostasis. Resuscitation. 1989;18:173-82 pubmed
    ..to test blood pressure regulation during hemorrhage, and secondly, for the central hypotensive action of alpha-methyldopa. In the first model hypotension was produced by stepwise bleeding to respectively 80, 60 and 40 mmHg mean ..
  30. Rona K, Ary K, Gachalyi B, Klebovich I. Determination of alpha-methyldopa in human plasma by validated high-performance liquid chromatography with fluorescence detection. J Chromatogr A. 1996;730:125-31 pubmed
    ..liquid chromatographic method with fluorescence detection has been developed for the determination of alpha-methyldopa (AMD) in human plasma...
  31. Khalil A, Jauniaux E, Harrington K. Antihypertensive therapy and central hemodynamics in women with hypertensive disorders in pregnancy. Obstet Gynecol. 2009;113:646-54 pubmed publisher
    ..To estimate the changes in central hemodynamics features of pregnant women presenting with hypertensive disorders and to analyze the effects of standard antihypertensive treatment on maternal central hemodynamics...
  32. Shibao C, Arzubiaga C, Roberts L, Raj S, Black B, Harris P, et al. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension. 2005;45:385-90 pubmed
    ..These patients often present with a typical hyperadrenergic response, but beta-blockers should be used with great caution, if at all, and treatment directed against mast cell mediators may be required...
  33. Loprinzi C, Stearns V, Barton D. Centrally active nonhormonal hot flash therapies. Am J Med. 2005;118 Suppl 12B:118-23 pubmed
    ..Toxicity from this agent limits its utility in the clinic. Methyldopa is another centrally active agent that has been studied but to a more limited degree...
  34. Elghozi J, Head G, Wolf W, Anderson C, Korner P. Importance of spinal noradrenergic pathways in cardiovascular reflexes and central actions of clonidine and alpha-methyldopa in the rabbit. Brain Res. 1989;499:39-52 pubmed
    ..c.) clonidine and alpha-methyldopa (alpha-MD), and (v) the acute NA release response produced by i.e. 6-OHDA...
  35. El Mas M, Abdel Rahman A. Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha(2)-adrenergic, but not I(1)-imidazoline, receptor activation in female rats. Life Sci. 2009;84:111-8 pubmed publisher
    This study dealt with the effect of chronic ethanol administration on hemodynamic responses elicited by alpha(2)-adrenergic (alpha-methyldopa) or I(1)-imidazoline (rilmenidine) receptor activation in telemetered female rats.
  36. Sharma K, Sharma S, Lahiri S. Spectrophotometric, Fourier transform infrared spectroscopic and theoretical studies of the charge-transfer complexes between methyldopa [(S)-2 amino-3-(3,4-dihydroxyphenyl)-2-methyl propanoic acid] and the acceptors (chloranilic acid, o-chloranil an. Spectrochim Acta A Mol Biomol Spectrosc. 2012;92:212-24 pubmed publisher
    b>Methyldopa is a much used antihypertensive drug. It is the subject matter of study mostly for the determination and estimation of methyldopa in pharmaceutical properties...
  37. Koucký M. [Current perspective of treating hypertension in pregnancy]. Vnitr Lek. 2011;57:728-31 pubmed
    ..Inadequate treatment may have adverse effects on uteroplacental flow with potential risks to the fetus. The treatment of choice in pregnancy relatedy hypertension are methyldopa, calcium antagonists and labetalol.
  38. Muzzi C, Bertocci E, Terzuoli L, Porcelli B, Ciari I, Pagani R, et al. Simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and alpha-methyldopa by HPLC. Biomed Pharmacother. 2008;62:253-8 pubmed
    ..to develop an HPLC method for the simultaneous determination of serum concentrations of levodopa, dopamine, 3-O-methyldopa and alpha-methyldopa. We compared UV and fluorimetric detection of native and derivatised compounds...
  39. Kohno M, Yasunari K, Murakawa K, Yokokawa K, Horio T, Kurihara N, et al. Effect on atrial natriuretic peptides of chronic treatment with alpha-methyldopa and hydralazine in spontaneously hypertensive rats. Am J Hypertens. 1990;3:111-6 pubmed
    ..concentration of atrial natriuretic peptides (ANP) in spontaneously hypertensive rats (SHR) by using alpha-methyldopa and hydralazine. Methyldopa and hydralazine treatment reduced blood pressure (P less than .05, P less than ...
  40. Rosenau L, Douay O, Morel B, Lebouvier B, Grosieux P. [Serum alkaline phosphatase levels in pregnancy]. J Gynecol Obstet Biol Reprod (Paris). 1994;23:175-9 pubmed
    ..The elevation was greater in cases of vomiting during the first trimester, alpha-methyldopa intake. It was less after hypodroxyapatite intake and was positively correlated with weight gain...
  41. Bar On D, Amir M. Reexamining the quality of life of hypertensive patients. A new self-structured measure. Am J Hypertens. 1993;6:62S-66S pubmed
    ..of 268 men with mild hypertension, aged 40 to 65 years, who were randomly allocated to three treatment groups (methyldopa, isradipine, and placebo) with that of 155 normotensive subjects...
  42. Li S, Scanlon M, Jarai Z, Varga K, Gantenberg N, Lazar Wesley E, et al. alpha-2-Adrenergic activation of proopiomelanocortin-containing neurons in the arcuate nucleus causes opioid-mediated hypotension and bradycardia. Neuroendocrinology. 1996;63:275-83 pubmed
    Treatment of rats for 4 days with alpha-methyldopa, 200 mg/kg/day i.p., increases steady state levels of proopiomelanocortin (POMC) mRNA in the mediobasal hypothalamus, as measured by DNA excess solution hybridization...
  43. Baden H, Kollias N, Anderson R, Hopkins T, Raftery L. Drosophila melanogaster larvae detect low doses of UVC radiation as manifested by a writhing response. Arch Insect Biochem Physiol. 1996;32:187-96 pubmed
    ..Possible targets for the UVC radiation are catecholic compounds secreted and processed into the cuticle of third instar larvae just to pupariation whose primary function is to crosslink the protein and carbohydrate components...
  44. Ostroumova T, Markova L. [Effect of inhibitors of synthesis of dopamine and its antagonists on Hydra attenuata regeneration]. Ross Fiziol Zh Im I M Sechenova. 2000;86:1246-54 pubmed
    ..alpha-Methyldopa induced a slight inhibition but a considerable morphological change: ectopic tentacles, projections, bipolar ..
  45. Asanuma M, Miyazaki I, Kikkawa Y, Kimoto N, Takeshima M, Murakami S, et al. Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity. Neurochem Res. 2012;37:1944-51 pubmed publisher
  46. Bateman B, Hernandez diaz S, Huybrechts K, Palmsten K, Mogun H, Ecker J, et al. Outpatient calcium-channel blockers and the risk of postpartum haemorrhage: a cohort study. BJOG. 2013;120:1668-76; dicussion 1676-7 pubmed publisher
    ..To determine whether outpatient exposure to calcium-channel blockers (CCBs) at the time of delivery is associated with an increased risk for postpartum haemorrhage (PPH)...
  47. Terada H. [Drug-induced hemolytic anemia]. Nihon Rinsho. 2007;65 Suppl 8:473-7 pubmed
  48. Traub Y. Comparison of oxprenolol vs methyldopa as second-line antihypertensive agents in the elderly. Arch Intern Med. 1988;148:77-80 pubmed
    ..In the present study, 32 elderly hypertensive patients were treated with a diuretic. Methyldopa (500 mg/d) (16 patients, subgroup A) or slow-release oxprenolol (80 mg/d) (subgroup B) was added as a second-..
  49. Yodfat Y, Cristal N. A multicenter, double-blind, randomized, placebo-controlled study of isradipine and methyldopa as monotherapy or in combination with captopril in the treatment of hypertension. The LOMIR-MCT-IH Research Group. Am J Hypertens. 1993;6:57S-61S pubmed
    ..multicenter, double-blind, randomized trial of 1 year's duration compared the safety and efficacy of isradipine, methyldopa, and placebo in 368 men, aged 40 to 65 years, with mild-to-moderate essential hypertension...
  50. Scriba G, Borchardt R. Metabolism of catecholamine esters by cultured bovine brain microvessel endothelial cells. J Neurochem. 1989;53:610-5 pubmed
    ..The permeabilities of epinine and the diester prodrugs through endothelial cell monolayers grown on porous supports were related to their lipophilicity and molecular weight...
  51. Merz W, Gembruch U. Severe, early-onset hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome episode with spontaneous remission during pregnancy. J Matern Fetal Neonatal Med. 2007;20:631-2 pubmed
    ..Expectant management resulted in rapid improvement of all HELLP parameters. Subsequently preeclampsia developed and uteroplacental dysfunction deteriorated. Intrauterine fetal death occured at 22 + 3 weeks of gestation...
  52. Csonka D, Zupko I, Minorics R, Márki A, Csík G, Falkay G. The effects of alpha-methyldopa on myometrial noradrenaline release and myometrial contractility in rat. Acta Obstet Gynecol Scand. 2007;86:986-94 pubmed
    alpha-Methyldopa is a classic antihypertensive agent, used routinely in the treatment of pregnancy-induced hypertension. However, only a few data are available about its direct uterotropic effect...
  53. Skudicky D, Sareli P, Libhaber E, Candy G, Radevski I, Valtchanova Z, et al. Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial. Circulation. 2002;105:830-6 pubmed