radiation induced abnormalities


Summary: Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.

Top Publications

  1. De Santis M, Di Gianantonio E, Straface G, Cavaliere A, Caruso A, Schiavon F, et al. Ionizing radiations in pregnancy and teratogenesis: a review of literature. Reprod Toxicol. 2005;20:323-9 pubmed
    ..Diagnostic radiological procedures should be avoided in pregnant women unless the information cannot be obtained by other techniques. ..
  2. Domingo J. Reproductive and developmental toxicity of natural and depleted uranium: a review. Reprod Toxicol. 2001;15:603-9 pubmed
    ..Data on the toxic effects of depleted uranium on reproduction and development are also reviewed. ..
  3. Feshchenko S, Schröder H, Muller W, Lazjuk G. Congenital malformations among newborns and developmental abnormalities among human embryos in Belarus after Chernobyl accident. Cell Mol Biol (Noisy-le-grand). 2002;48:423-6 pubmed
    ..The data revealed that the incidences of developmental anomalies and congenital malformation from the mostly radionuclide-contaminated rural regions of Belarus reliably exceed the indices in control areas. ..
  4. Ju Y, Jhun H, Kim J, Kim J. Non-cancer diseases of Korean atomic bomb survivors in residence at Hapcheon, Republic of Korea. J Korean Med Sci. 2006;21:385-90 pubmed
    ..06-1.44), chronic liver disease (2.07; 1.51-2.84), and hypercholesterolemia (1.79; 1.11-2.90) than controls. This study suggests that A-bomb exposure is associated with a higher prevalence of non-cancer diseases in Korean survivors. ..
  5. Wolf N, Pendergrass W, Singh N, Swisshelm K, Schwartz J. Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. Mol Vis. 2008;14:274-85 pubmed
  6. Mitchel R, Dolling J, Misonoh J, Boreham D. Influence of prior exposure to low-dose adapting radiation on radiation-induced teratogenic effects in fetal mice with varying Trp53 function. Radiat Res. 2002;158:458-63 pubmed
    ..We conclude that radiation-induced teratogenesis reflects both Trp53-dependent and independent processes that lead to apoptosis, and these respond differently to prior adapting doses. ..
  7. Okazaki R, Ootsuyama A, Uchida S, Norimura T. Effects of a 4.7 T static magnetic field on fetal development in ICR mice. J Radiat Res. 2001;42:273-83 pubmed
    ..Based on these results, we suggest that while SMF exposure promoted the endochondral ossification of chondrocytes, it did not induce any harmful effects on fetal development in ICR mice. ..
  8. Hirshfeld J, Balter S, Brinker J, Kern M, Klein L, Lindsay B, et al. ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures: a report of the American College of Cardiology Foundation/American Hear. Circulation. 2005;111:511-32 pubmed
  9. Kurishita A, Ono T, Okada S, Mori Y, Sawada S. Induction of external abnormalities in offspring of male mice irradiated with 252Cf neutron. Mutat Res. 1992;268:323-8 pubmed
    ..7 x 10(-4)/gamete/cGy based on the linear regression. These results indicated that fission neutron effectively induces external abnormalities in F1 fetuses after spermatogonial irradiation. ..

More Information


  1. Doi M. [Implications of health risk of radiation exposures less than 100 mGy: focused on the linear non-threshold hypothesis]. Nihon Hoshasen Gijutsu Gakkai Zasshi. 2004;60:635-45 pubmed
  2. Heynick L, Merritt J. Radiofrequency fields and teratogenesis. Bioelectromagnetics. 2003;Suppl 6:S174-86 pubmed
    ..The findings of studies on pregnancy outcomes of female physiotherapists occupationally exposed while treating patients with RFEMF were mixed, but taken collectively, the findings were negative. ..
  3. Rafiee P, Binion D, Wellner M, Behmaram B, Floer M, Mitton E, et al. Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B. Am J Physiol Gastrointest Liver Physiol. 2010;298:G865-77 pubmed publisher
    ..Curcumin may be a potential radiosensitizing agent for enhanced antiangiogenic effect in colorectal cancer radiation therapy. ..
  4. Herrmann T, Thiede G, Trott K, Voigtmann L. [Offsprings of preconceptionally irradiated parents. Final report of a longitudinal study 1976-1994 and recommendations for patients' advisory]. Strahlenther Onkol. 2004;180:21-30 pubmed
    ..1% (after gonadal exposure of 1 Gy). However, at present, heritable damage potentially induced by chemotherapy cannot be adequately quantified yet. ..
  5. Dobrzyńska M, Czajka U. Male-mediated developmental toxicity in mice after 8 weeks'exposure to low doses of X-rays. Int J Radiat Biol. 2005;81:793-9 pubmed
    ..After subchronic exposure to low doses the majority of mutations caused premature death. Subchronic exposure to low doses of X-rays did not induce external and skeletal malformations of surviving foetuses. ..
  6. Solon L. Health aspects of low-level ionizing radiation. Ann N Y Acad Sci. 1987;502:32-42 pubmed
    ..Practical cost-effective decision-making consistent with sound radiologic health must take into account the breadth of current scientific uncertainties. ..
  7. Sawada S. Cover-up of the effects of internal exposure by residual radiation from the atomic bombing of Hiroshima and Nagasaki. Med Confl Surviv. 2007;23:58-74 pubmed
    ..The effects of internal exposure due to intake of tiny radioactive particles are more severe than those of external exposure, explaining the difference between the official criteria and the actual state of the survivors. ..
  8. Meistrich M, Wilson G, Shetty G, Shuttlesworth G. Restoration of spermatogenesis after exposure to toxicants: genetic implications. Adv Exp Med Biol. 2003;518:227-37 pubmed
  9. Inagaki S, Kotani T. Lens formation in the absence of optic cup in rat embryos irradiated with soft X-ray. Vet Ophthalmol. 2003;6:61-6 pubmed
    ..Thus, this sequential analysis on ocular abnormalities during the early stage of development supports the notion that the presence of the retina is not always necessary for the development of the lens...
  10. Tsougos I, Mavroidis P, Theodorou K, Rajala J, Pitkänen M, Holli K, et al. Clinical validation of the LKB model and parameter sets for predicting radiation-induced pneumonitis from breast cancer radiotherapy. Phys Med Biol. 2006;51:L1-9 pubmed
  11. Cook C. Comment on the article "Lens formation in the absence of optic cup in rat embryos irradiated with soft X-ray". Vet Ophthalmol. 2004;7:69 pubmed
  12. Gómez Camello A, Garcia Garcia J. [Late progressive radiation myelopathy]. Neurologia. 2008;23:179-80 pubmed
  13. Müller W. Radiation and malformations in a murine model. Adv Exp Med Biol. 2003;518:163-8 pubmed
  14. Strzelczyk J, Damilakis J, Marx M, MacUra K. Facts and controversies about radiation exposure, part 2: low-level exposures and cancer risk. J Am Coll Radiol. 2007;4:32-9 pubmed
    ..The limitations of epidemiologic studies at low-level exposures and recent new findings in radiobiology, some of which are summarized, challenge the notion that any amount of radiation causes adverse effects. ..
  15. von Hofe E, Brent R, Kennedy A. Inhibition of X-ray-induced exencephaly by protease inhibitors. Radiat Res. 1990;123:108-11 pubmed
    ..Given our results, further investigation is warranted into preventive effects of protease inhibitors on the inhibition of neural tube defects. ..
  16. Ma W, Lozanoff S. External craniofacial features, body size, and renal morphology in prenatal brachyrrhine mice. Teratology. 1993;47:321-32 pubmed
    ..The results indicate that a proportion of prenatal offspring from Br matings exhibits midfacial and renal hypoplasia and that these animals segregate completely from nonaffected embryos. ..
  17. Laposa R, Henderson J, Xu E, Wells P. Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM. FASEB J. 2004;18:896-8 pubmed
    ..These results show that Atm is a novel teratologic suppressor gene protecting embryos from pathological cell death and teratogenesis initiated by even mild DNA damage. ..
  18. Byrne J. Long-term genetic and reproductive effects of ionizing radiation and chemotherapeutic agents on cancer patients and their offspring. Teratology. 1999;59:210-5 pubmed
    ..The relatively small numbers of survivors, and the few types of exposures studied so far, provide only limited grounds for reassurance. More comprehensive, properly designed, studies of modern new agents are urgently need. ..
  19. Kim S, Lee J, Oh H, Kim S, Lee C, Jo S, et al. Dependence of malformation upon gestational age and exposed dose of gamma radiation. J Radiat Res. 2001;42:255-64 pubmed
    ..The threshold doses of radiation that induced a cleft palate and dilatation of the cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively. ..
  20. Hall E. Scientific view of low-level radiation risks. Radiographics. 1991;11:509-18 pubmed
    ..The balance of risk versus benefit in diagnostic radiology is heavily weighted toward benefit, but the risks are there, and constant efforts are needed to reduce radiation doses to the minimum necessary. ..
  21. Gu Y, Hasegawa T, Suzuki I. Combined effects of radiation and ultrasound on ICR mice in the preimplantation stage. Ultrasound Med Biol. 2002;28:831-6 pubmed
    ..It appears that US may act to repair DNA damaged by ionizing radiation. The cell cycle of the fertilized egg is delayed, which may be the mechanism by which lesions induced by ionizing radiation are healed by ultrasonic irradiation. ..
  22. Zonenberg A, Leoniak M, Zarzycki W. [The effect of Chernobyl accident on the development of non malignant diseases]. Endokrynol Pol. 2006;57:38-44 pubmed
  23. Takeuchi Y, Takeuchi I. Critical period for induction of congenital hydrocephalus and dysplasia of subcommissural organ by prenatal X-irradiation in rats. Experientia. 1990;46:446-9 pubmed
    ..Neither 1.05 Gy nor 1.22 Gy X-irradiation of pregnant rats at 18.30 h resulted in any hydrocephalic offspring. Dysplasia of the subcommissural organ was noticed in all the hydrocephalic brains histologically examined. ..
  24. Orecchia R, Lucignani G, Tosi G. Prenatal irradiation and pregnancy: the effects of diagnostic imaging and radiation therapy. Recent Results Cancer Res. 2008;178:3-20 pubmed
  25. Shoji S, Watanabe H, Katoh O, Masaoka Y, Matsuura S, Tauchi H, et al. Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol. 1998;73:705-9 pubmed
    ..This mechanism involves cell killing. Residual DNA damage, such as double-strand breaks, could be associated with radiation-induced teratogenesis. ..
  26. Straume T. Tritium risk assessment. Health Phys. 1993;65:673-82 pubmed
    ..The risks from exposure to organically bound tritiated molecules are estimated to range from values that are similar to those for tritiated water to about a factor of 2 higher. ..
  27. Dubrova Y, Grant G, Chumak A, Stezhka V, Karakasian A. Elevated minisatellite mutation rate in the post-chernobyl families from ukraine. Am J Hum Genet. 2002;71:801-9 pubmed
    ..The mechanisms of mutation induction at human minisatellite loci are discussed. ..
  28. Jhun H, Ju Y, Kim J, Kim J. Korean atomic bomb survivors' report on the present status and health of their children: a mail questionnaire survey. Med Confl Surviv. 2006;22:275-82 pubmed
    ..18%) and congenital bone disorders (0.18%). Further study and administrative support are needed to more accurately determine the status of Korean A-bomb survivors and their children. ..
  29. Darzy K, Shalet S. Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement. Growth Horm IGF Res. 2006;16 Suppl A:S30-40 pubmed
    ..Such long-term GH treatment in patients treated previously for a brain tumor means that critical and continuous surveillance must be devoted to the risk of tumor recurrence and the possibility of second neoplasms. ..
  30. Pergams O. Unnatural coverage of Chernobyl tragedy. Nature. 2003;425:763 pubmed
  31. Mjøen G, Saetre D, Lie R, Tynes T, Blaasaas K, Hannevik M, et al. Paternal occupational exposure to radiofrequency electromagnetic fields and risk of adverse pregnancy outcome. Eur J Epidemiol. 2006;21:529-35 pubmed
    ..70), and a decreased risk for a category of "other syndromes" (OR: 0.75, 95% CI: 0.56, 0.99) and upper gastrointestinal defects (OR: 0.61, 95% CI: 0.40, 0.93). The study is partly reassuring for occupationally exposed fathers. ..
  32. Kainz W, Chan D, Casamento J, Bassen H. Calculation of induced current densities and specific absorption rates (SAR) for pregnant women exposed to hand-held metal detectors. Phys Med Biol. 2003;48:2551-60 pubmed
    ..Based on the very low specific absorption rate and an induced current density below the recommended exposure limits, significant temperature rise or nerve stimulation in the pregnant woman or in the foetus can be excluded. ..
  33. Doyle P, Maconochie N, Roman E, Davies G, Smith P, Beral V. Fetal death and congenital malformation in babies born to nuclear industry employees: report from the nuclear industry family study. Lancet. 2000;356:1293-9 pubmed
    ..The findings relating maternal preconceptual monitoring to increased risk of fetal death are equivocal and require further investigation. ..
  34. Moore G, Schiller J, Moore G. Radiation-induced histopathologic changes of the breast: the effects of time. Am J Surg Pathol. 2004;28:47-53 pubmed
    ..The absence of regression of the radiation-induced histologic changes over time mandates the surgical pathologist be alert to the possibility of RT or CT even without that therapeutic history. ..
  35. Ratnapalan S, Bentur Y, Koren G. "Doctor, will that x-ray harm my unborn child?". CMAJ. 2008;179:1293-6 pubmed publisher
    ..We describe exposure to radiodiagnostic procedures during pregnancy and suggest an approach to assess the potential risk. ..
  36. Scherb H, Weigelt E. [Cleft lip and cleft palate birth rate in Bavaria before and after the Chernobyl nuclear power plant accident]. Mund Kiefer Gesichtschir. 2004;8:106-10 pubmed
    ..6% (p=0.02) after 1986. The presumption of a long-term increase of CLP after exposure to Chernobyl fallout is corroborated by the analysis of the Bavarian congenital malformation data. ..
  37. Kim S, Kim S, Lee Y, Kim T, Jo S, Lee C. Influence of gestational age at exposure on the prenatal effects of gamma-radiation. J Vet Sci. 2001;2:37-42 pubmed
    ..5 of gestation. Our results indicate that the late period of organogenesis in the mouse is a particularly sensitive phase in terms of the development of the brain, skull and extremities. ..
  38. Tamminga J, Koturbash I, Baker M, Kutanzi K, Kathiria P, Pogribny I, et al. Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle. 2008;7:1238-45 pubmed
  39. Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou El Ardat K, Ghardi M, et al. Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. Dev Biol. 2008;322:302-13 pubmed publisher
  40. Møller A, Mousseau T. Mutation and sexual selection: a test using barn swallows from Chernobyl. Evolution. 2003;57:2139-46 pubmed
    ..These findings are consistent with the hypothesis that traits most important for sexual selection are particularly susceptible to the effects of deleterious mutations. ..
  41. Brent R. Counseling patients exposed to ionizing radiation during pregnancy. Rev Panam Salud Publica. 2006;20:198-204 pubmed
    ..Counseling patients requires knowledge of embryology, genetics, radiation teratology, and the principles of teratology in order for the counselor to provide sympathetic, accurate, scholarly advice. ..
  42. Hall E. Radiation biology for pediatric radiologists. Pediatr Radiol. 2009;39 Suppl 1:S57-64 pubmed publisher
    ..It is for this reason that every effort should be made to reduce the doses associated with procedures such as CT scans, particularly in children, in the spirit of ALARA. ..
  43. Fairlie I. Childhood cancers near German nuclear power stations: hypothesis to explain the cancer increases. Med Confl Surviv. 2009;25:206-20 pubmed publisher
    ..The article concludes with recommendations for further research. ..
  44. Nelson B, Snyder D, Shaw P. Developmental toxicity interactions of methanol and radiofrequency radiation or 2-methoxyethanol in rats. Int J Toxicol. 2001;20:89-100 pubmed
    ..It is important that combined exposure effects be considered when developing both physical agent and chemical agent exposure guidelines and intervention strategies. ..
  45. Reinmuth S, Liebeskind A, Wickmann L, Bockelbrink A, Keil T, Henze G, et al. Having children after surviving cancer in childhood or adolescence - results of a Berlin survey. Klin Padiatr. 2008;220:159-65 pubmed publisher
    ..This nationwide survey 'FeCt' will be supported by the Deutsche Kinderkrebsstiftung. ..
  46. Haberer S, Assouline A, Mazeron J. [Normal tissue tolerance to external beam radiation therapy: brain and hypophysis]. Cancer Radiother. 2010;14:263-8 pubmed publisher
    ..Recent data on tolerance of normal central nervous system to radiation therapy are reviewed here, early and delayed radiation-induced effects are described and dose recommendations are suggested for clinical practice. ..
  47. Sulaiman A, Nawaz H, Munajat I, Sallehudin A. Proximal femoral focal deficiency as a manifestation of Antley-Bixler syndrome: a case report. J Orthop Surg (Hong Kong). 2007;15:84-6 pubmed
    ..Her mother was exposed to radiation during an intravenous urogram done in the first trimester of pregnancy. Exposure to radiation has not been implicated as a cause of Antley-Bixler syndrome. ..
  48. Wall R, Schnapp L. Radiation pneumonitis. Respir Care. 2006;51:1255-60 pubmed
  49. Schull W. The children of atomic bomb survivors: a synopsis. J Radiol Prot. 2003;23:369-84 pubmed
    ..This report summarises the findings of these studies and offers an estimate of the genetic risk based on these findings. ..
  50. Brandão C, Miranda A, Correa N, Sieiro Netto L, Corbo R, Vaisman M. Radioiodine therapy and subsequent pregnancy. Arq Bras Endocrinol Metabol. 2007;51:534-40 pubmed
    ..No statistical difference was observed between the studied and control groups. Radioiodine was followed by no significant increase in untoward effects in neither the pregnancy nor the offspring. ..
  51. von Wolff M, Eisenhardt S, Strowitzki T. [Pregnancy and tumor diseases--new perspectives of the modern reproduction medicine]. Kinderkrankenschwester. 2006;25:71-7 pubmed
  52. Shen S, Duan J, Meredith R, Buchsbaum D, Brezovich I, Pareek P, et al. Model prediction of treatment planning for dose-fractionated radioimmunotherapy. Cancer. 2002;94:1264-9 pubmed
    ..Given a maximum tolerated level of thrombocytopenia, the model can be used to determine a dosing scheme for optimal tumor response. ..
  53. Nolan M, Pressman E, Starklauf B, Gregory R. Consent documents, reproductive issues, and the inclusion of women in clinical trials. Acad Med. 1999;74:275-81 pubmed
    ..The authors present a template with language that can be used in consent documents and recommend ongoing discussion of reproductive and fetal risks with women subjects throughout the study period. ..