Summary: The N-acetyl derivative of glucosamine.

Top Publications

  1. Ande S, Moulik S, Mishra S. Interaction between O-GlcNAc modification and tyrosine phosphorylation of prohibitin: implication for a novel binary switch. PLoS ONE. 2009;4:e4586 pubmed publisher
    ..Here we report for the first time that PHB interacts with O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) and is O-GlcNAc modified; and also undergoes tyrosine ..
  2. Schimpl M, Schüttelkopf A, Borodkin V, van Aalten D. Human OGA binds substrates in a conserved peptide recognition groove. Biochem J. 2010;432:1-7 pubmed publisher
    Modification of cellular proteins with O-GlcNAc (O-linked N-acetylglucosamine) competes with protein phosphorylation and regulates a plethora of cellular processes...
  3. Pérez Mendoza D, Coulthurst S, Sanjuan J, Salmond G. N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels. Microbiology. 2011;157:3340-8 pubmed publisher
    ..A modest but consistent increase in pga transcript levels was associated with high intracellular levels of c-di-GMP. Our results indicate tight control of PGA-dependent biofilm formation by c-di-GMP in Pba...
  4. Xie J, Du H, Guan G, Tong Y, Kourkoumpetis T, Zhang L, et al. N-acetylglucosamine induces white-to-opaque switching and mating in Candida tropicalis, providing new insights into adaptation and fungal sexual evolution. Eukaryot Cell. 2012;11:773-82 pubmed publisher
    ..Here we show that N-acetylglucosamine (GlcNAc), an inducer of white-to-opaque switching in C...
  5. Morrison M, Imperiali B. Biochemical analysis and structure determination of bacterial acetyltransferases responsible for the biosynthesis of UDP-N,N'-diacetylbacillosamine. J Biol Chem. 2013;288:32248-60 pubmed publisher
    ..Last, a phylogenetic analysis of the aforementioned acetyltransferases was employed to illuminate the diversity among N- and O-linked glycosylation pathway enzymes. ..
  6. Gust A, Willmann R, Desaki Y, Grabherr H, Nürnberger T. Plant LysM proteins: modules mediating symbiosis and immunity. Trends Plant Sci. 2012;17:495-502 pubmed publisher
    ..Plant lysin motif (LysM) domain proteins serve as modules mediating recognition of these different N-acetylglucosamine (GlcNAc)-containing ligands, suggesting that this class of proteins evolved from an ancient sensor for ..
  7. Rodriguez Diaz J, Rubio Del Campo A, Yebra M. Lactobacillus casei ferments the N-Acetylglucosamine moiety of fucosyl-?-1,3-N-acetylglucosamine and excretes L-fucose. Appl Environ Microbiol. 2012;78:4613-9 pubmed publisher
    ..In this work, we have shown that L. casei is able to grow in the presence of fucosyl-?-1,3-N-acetylglucosamine (Fuc-?-1,3-GlcNAc) as a carbon source. Interestingly, L...
  8. Trinidad J, Barkan D, Gulledge B, Thalhammer A, Sali A, Schoepfer R, et al. Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics. 2012;11:215-29 pubmed publisher
    O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic, reversible monosaccharide modifier of serine and threonine residues on intracellular protein domains. Crosstalk between O-GlcNAcylation and phosphorylation has been hypothesized...
  9. Fong J, Nguyen B, Bridger R, Medrano E, Wells L, Pan S, et al. ?-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3. J Biol Chem. 2012;287:12195-203 pubmed publisher
    O-Linked ?-N-acetylglucosamine, or O-GlcNAc, is a dynamic post-translational modification that cycles on and off serine and threonine residues of nucleocytoplasmic proteins...

More Information


  1. Yuzwa S, Shan X, Macauley M, Clark T, Skorobogatko Y, Vosseller K, et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012;8:393-9 pubmed publisher
    ..Tau is modified by O-linked N-acetylglucosamine (O-GlcNAc), and O-GlcNAc can influence tau phosphorylation in certain cases...
  2. Mehdy A, Morelle W, Rosnoblet C, Legrand D, Lefebvre T, Duvet S, et al. PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells. J Biochem. 2012;151:439-46 pubmed publisher
    ..This study clearly points out another off target effects of PUGNAc that need to be taken into account in the use of this drug. ..
  3. Zhu Mauldin X, Marsh S, Zou L, Marchase R, Chatham J. Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. J Biol Chem. 2012;287:39094-106 pubmed publisher
    ..Further, since SOCE is a fundamental mechanism underlying Ca(2+) signaling in most cells and tissues, it is possible that STIM1 represents a nexus linking protein O-GlcNAcylation with Ca(2+)-mediated transcription. ..
  4. Allison D, Wamsley J, Kumar M, Li D, Gray L, Hart G, et al. Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-?B acetylation and transcription. Proc Natl Acad Sci U S A. 2012;109:16888-93 pubmed publisher
    ..transcription factor, we show that cells use the hexosamine biosynthesis pathway and O-linked ?-N-acetylglucosamine (O-GlcNAc) transferase (OGT) to potentiate gene expression in response to tumor necrosis factor (TNF) or ..
  5. Al Makishah N, Mitchell W. Dual substrate specificity of an N-acetylglucosamine phosphotransferase system in Clostridium beijerinckii. Appl Environ Microbiol. 2013;79:6712-8 pubmed publisher
    ..In this study, we demonstrate that extracts of Clostridium beijerinckii grown on N-acetylglucosamine (GlcNAc) exhibit PTS activity for the amino sugar...
  6. Qian Y, Flanagan Steet H, van Meel E, Steet R, Kornfeld S. The DMAP interaction domain of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase is a substrate recognition module. Proc Natl Acad Sci U S A. 2013;110:10246-51 pubmed publisher
    UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase) is an ?2?2?2 heterohexamer that mediates the initial step in the formation of the mannose 6-phosphate recognition signal on lysosomal acid ..
  7. Carzaniga T, Antoniani D, Deh G, Briani F, Landini P. The RNA processing enzyme polynucleotide phosphorylase negatively controls biofilm formation by repressing poly-N-acetylglucosamine (PNAG) production in Escherichia coli C. BMC Microbiol. 2012;12:270 pubmed publisher
    ..Cell aggregation is dependent on the EPS poly-N-acetylglucosamine (PNAG), thus suggesting negative regulation of the PNAG biosynthetic operon pgaABCD by PNPase...
  8. Dias W, Cheung W, Hart G. O-GlcNAcylation of kinases. Biochem Biophys Res Commun. 2012;422:224-8 pubmed publisher
    ..Our results suggest that O-GlcNAcylation may directly regulate a substantial number of kinases and illustrates the increasingly complex relationship between O-GlcNAcylation and phosphorylation in cellular signaling. ..
  9. Miwa H, Song Y, Alvarez R, Cummings R, Stanley P. The bisecting GlcNAc in cell growth control and tumor progression. Glycoconj J. 2012;29:609-18 pubmed publisher
    ..This review will describe evidence that the bisecting GlcNAc of N-glycans regulates cellular signaling and tumor progression, apparently through modulating N-glycan/galectin interactions. ..
  10. Breloy I, Pacharra S, Ottis P, Bonar D, Grahn A, Hanisch F. O-linked N,N'-diacetyllactosamine (LacdiNAc)-modified glycans in extracellular matrix glycoproteins are specifically phosphorylated at subterminal N-acetylglucosamine. J Biol Chem. 2012;287:18275-86 pubmed publisher
    The terminal modification of glycans by ?4 addition of N-acetylgalactosamine to N-acetylglucosamine with formation of the N,N-diacetyllactosediamine (LacdiNAc) moiety has been well documented for a number of N-linked glycoproteins and ..
  11. Hoffmann B, Liu Y, Mosher D. Modification of EGF-like module 1 of thrombospondin-1, an animal extracellular protein, by O-linked N-acetylglucosamine. PLoS ONE. 2012;7:e32762 pubmed publisher
    ..We now describe a fourth: O-?-N-acetylglucosaminylation. Previously, O-?-N-acetylglucosamine (O-?-GlcNAc) was found on a threonine in the loop between the fifth and sixth cysteines of the 20(th) ..
  12. Liu Y, Liu L, Shin H, Chen R, Li J, Du G, et al. Pathway engineering of Bacillus subtilis for microbial production of N-acetylglucosamine. Metab Eng. 2013;19:107-15 pubmed publisher
    Glucosamine (GlcN) and its acetylated derivative, N-acetylglucosamine (GlcNAc), are widely used in nutraceutical and pharmaceutical industries...
  13. Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, et al. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Biochem Biophys Res Commun. 2012;419:14-9 pubmed publisher
    O-linked-?-N-acetylglucosamine (O-GlcNAc) modification is a unique cytoplasmic and nuclear protein modification that is common in nearly all eukaryotes, including filamentous fungi, plants, and animals...
  14. Zachara N. The roles of O-linked ?-N-acetylglucosamine in cardiovascular physiology and disease. Am J Physiol Heart Circ Physiol. 2012;302:H1905-18 pubmed publisher
    More than 1,000 proteins of the nucleus, cytoplasm, and mitochondria are dynamically modified by O-linked ?-N-acetylglucosamine (O-GlcNAc), an essential post-translational modification of metazoans...
  15. Lynch T, Ferrer C, Jackson S, Shahriari K, Vosseller K, Reginato M. Critical role of O-Linked ?-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. J Biol Chem. 2012;287:11070-81 pubmed publisher
    ..the hexosamine biosynthetic pathway leads to increases in the post-translational addition of O-linked ?-N-acetylglucosamine (O-GlcNAc) to various nuclear and cytosolic proteins...
  16. Rexach J, Clark P, Mason D, Neve R, Peters E, Hsieh Wilson L. Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nat Chem Biol. 2012;8:253-61 pubmed publisher
    ..Moreover, we identify a previously unknown mechanism for the regulation of activity-dependent gene expression, neural development and memory. ..
  17. Lunde I, Aronsen J, Kvaløy H, Qvigstad E, Sjaastad I, Tønnessen T, et al. Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure. Physiol Genomics. 2012;44:162-72 pubmed publisher
    ..This not only provides an exciting basis for discovery of new mechanisms underlying pathological cardiac remodeling but also implies protein O-GlcNAcylation as a possible new therapeutic target in heart failure. ..
  18. Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, et al. GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature. 2011;480:557-60 pubmed publisher
    ..In metazoans, reversible protein modification by O-linked N-acetylglucosamine (GlcNAc) is catalysed by two enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA)...
  19. Kwei K, Baker J, Pelham R. Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection. PLoS ONE. 2012;7:e46518 pubmed publisher
    ..These candidate biomarkers will offer useful tools to begin a more thorough understanding of determinants of patient response to PI3K inhibitors and merit exploration in human cancer patients treated with PI3K inhibitors. ..
  20. Henry R, Vithanage N, Harrison P, Seemann T, Coutts S, Moffatt J, et al. Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-?-1,6-N-acetylglucosam. Antimicrob Agents Chemother. 2012;56:59-69 pubmed publisher
    ..In addition, genes involved in the synthesis and transport of poly-?-1,6-N-acetylglucosamine (PNAG) also were upregulated, and a corresponding increase in PNAG production was observed...
  21. Gawlowski T, Suarez J, Scott B, Torres Gonzalez M, Wang H, Schwappacher R, et al. Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-?-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes. J Biol Chem. 2012;287:30024-34 pubmed publisher
    ..In conclusion, this report shows, for the first time, that O-GlcNAcylation modulates DRP1 functionality in cardiac muscle cells. ..
  22. Andrés Bergós J, Tardio L, Larrañaga Vera A, Gomez R, Herrero Beaumont G, Largo R. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012;287:33615-28 pubmed
    ..whether insulin-induced chondrocyte hypertrophy occurs through a modification in the amount of O-linked N-acetylglucosamine (O-GlcNAc)-modified proteins and in the expression of the key enzymes of this pathway, O-GlcNAc transferase ..
  23. Sakaidani Y, Nomura T, Matsuura A, Ito M, Suzuki E, Murakami K, et al. O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Nat Commun. 2011;2:583 pubmed publisher
    The O-linked-N-acetylglucosamine (O-GlcNAc) modification of cytoplasmic and nuclear proteins regulates basic cellular functions and is involved in the aetiology of diabetes and neurodegeneration...
  24. Berk J, Maitra S, Dawdy A, Shabanowitz J, Hunt D, Wilson K. O-Linked ?-N-acetylglucosamine (O-GlcNAc) regulates emerin binding to barrier to autointegration factor (BAF) in a chromatin- and lamin B-enriched "niche". J Biol Chem. 2013;288:30192-209 pubmed publisher
    ..quot; These results reveal direct control of a conserved LEM domain nuclear lamina component by ?-N-acetylglucosaminyltransferase, a nutrient sensor that regulates cell stress responses, mitosis, and epigenetics. ..
  25. Kenny D, Skoog E, Linden S, Struwe W, Rudd P, Karlsson N. Presence of terminal N-acetylgalactosamine?1-4N-acetylglucosamine residues on O-linked oligosaccharides from gastric MUC5AC: involvement in Helicobacter pylori colonization?. Glycobiology. 2012;22:1077-85 pubmed publisher
    ..These are epitopes known to bind the H. pylori BabA and SabA adhesins. ..
  26. Katta S, Ankati S, Podile A. Chitooligosaccharides are converted to N-acetylglucosamine by N-acetyl-?-hexosaminidase from Stenotrophomonas maltophilia. FEMS Microbiol Lett. 2013;348:19-25 pubmed publisher
    ..StmHex hydrolysed chitooligosaccharides (up to hexamer) into GlcNAc within 60 min, suggesting that this enzyme has potential for use in large-scale production of GlcNAc from chitooligosaccharides. ..
  27. Zhang F, Snead C, Catravas J. Hsp90 regulates O-linked ?-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked ?-N-acetylglucosamine modification in endothelial cells. Am J Physiol Cell Physiol. 2012;302:C1786-96 pubmed publisher
    O-linked ?-N-acetylglucosamine (O-GlcNAc) modification of proteins is involved in many important cellular processes...
  28. Bond M, Hanover J. O-GlcNAc cycling: a link between metabolism and chronic disease. Annu Rev Nutr. 2013;33:205-29 pubmed publisher
    ..Evidence suggests that the O-linked N-acetylglucosamine (O-GlcNAc) posttranslational modification of serine and threonine residues functions as a critical regulator ..
  29. Zhai Y, Liang M, Fang J, Wang X, Guan W, Liu X, et al. NahK/GlmU fusion enzyme: characterization and one-step enzymatic synthesis of UDP-N-acetylglucosamine. Biotechnol Lett. 2012;34:1321-6 pubmed publisher
    The availability of uridine 5'-diphosphate N-acetylglucosamine (UDP-GlcNAc) is a prerequisite for the GlcNAc-transferase-catalyzed glycosylation reaction...
  30. Schimpl M, Rush C, Betou M, Eggleston I, Recklies A, van Aalten D. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties. Biochem J. 2012;446:149-57 pubmed publisher
    ..A glycan screen identified oligomers of N-acetylglucosamine as preferred binding partners...
  31. Yi W, Clark P, Mason D, Keenan M, Hill C, Goddard W, et al. Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science. 2012;337:975-80 pubmed publisher
    ..We demonstrated that the dynamic posttranslational modification of proteins by O-linked ?-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism...
  32. Chiribao M, Libisch M, Osinaga E, Parodi Talice A, Robello C. Cloning, localization and differential expression of the Trypanosoma cruzi TcOGNT-2 glycosyl transferase. Gene. 2012;498:147-54 pubmed publisher
    ..Its localization was determined, showing that the protein predicted to be in the Golgi apparatus is also present in reservosomes. Finally our results indicate that this enzyme, when overexpressed, enhances T. cruzi infectivity. ..
  33. Morrison M, Imperiali B. Biosynthesis of UDP-N,N'-diacetylbacillosamine in Acinetobacter baumannii: Biochemical characterization and correlation to existing pathways. Arch Biochem Biophys. 2013;536:72-80 pubmed publisher
    ..Additionally, characterization of these pathway enzymes highlights the opportunity for investigating the significance of highly-modified sugars in bacterial pathogenesis. ..
  34. Shen D, Gloster T, Yuzwa S, Vocadlo D. Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. J Biol Chem. 2012;287:15395-408 pubmed publisher
    Cellular O-linked N-acetylglucosamine (O-GlcNAc) levels are modulated by two enzymes: uridine diphosphate-N-acetyl-D-glucosamine:polypeptidyltransferase (OGT) and O-GlcNAcase (OGA)...
  35. Grigorian A, Araujo L, Naidu N, Place D, Choudhury B, Demetriou M. N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis. J Biol Chem. 2011;286:40133-41 pubmed publisher
    ..The sugar N-acetylglucosamine (GlcNAc) enhances N-glycan branching and inhibits T cell activity and adoptive transfer experimental ..
  36. Jiang S, Chen Y, Wang M, Yin Y, Pan Y, Gu B, et al. A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine. Biochem J. 2012;443:369-78 pubmed publisher
    ..isolated from the mushroom Agrocybe aegerita (designated AAL-2) by affinity chromatography with GlcNAc (N-acetylglucosamine)-coupled Sepharose 6B after ammonium sulfate precipitation...
  37. Chi W, Lee S, Lee J. Functional analysis of SGR4635-induced enhancement of pigmented antibiotic production in Streptomyces lividans. J Microbiol. 2011;49:828-33 pubmed publisher
    ..N-acetylglucosamine (GlcNAc) produced by cell-wall lysis acts as a signal molecule, triggering the production of secondary ..
  38. Leung M, Hitchen P, Ward D, Messer A, Marston S. Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked ?-N-acetylglucosamine-substituted protein in human heart myofibrils. J Biol Chem. 2013;288:4891-8 pubmed publisher
    We studied O-linked ?-N-acetylglucosamine (O-GlcNAc) modification of contractile proteins in human heart using SDS-PAGE and three detection methods: specific enzymatic conjugation of O-GlcNAc with UDP-N-azidoacetylgalactosamine (UDP-..
  39. Gurel Z, Sieg K, Shallow K, Sorenson C, Sheibani N. Retinal O-linked N-acetylglucosamine protein modifications: implications for postnatal retinal vascularization and the pathogenesis of diabetic retinopathy. Mol Vis. 2013;19:1047-59 pubmed
    ..Uridine diphosphate N-acetylglucosamine (GlcNAc) is the product of the hexosamine biosynthetic pathway and the substrate for O-linked GlcNAc (O-..
  40. Bandini G, Mariño K, Güther M, Wernimont A, Kuettel S, Qiu W, et al. Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase. Mol Microbiol. 2012;85:513-34 pubmed publisher
    The enzymes phosphomannomutase (PMM), phospho-N-acetylglucosamine mutase (PAGM) and phosphoglucomutase (PGM) reversibly catalyse the transfer of phosphate between the C6 and C1 hydroxyl groups of mannose, N-acetylglucosamine and glucose ..
  41. Mélida H, Sandoval Sierra J, Diéguez Uribeondo J, Bulone V. Analyses of extracellular carbohydrates in oomycetes unveil the existence of three different cell wall types. Eukaryot Cell. 2013;12:194-203 pubmed publisher
    ..thereby unveiling the existence of 3 clearly different cell wall types: type I is devoid of N-acetylglucosamine (GlcNAc) but contains glucuronic acid and mannose; type II contains up to 5% GlcNAc and residues indicative ..
  42. Gyore J, Parameswar A, Hebbard C, Oh Y, Bi E, Demchenko A, et al. 2-Acylamido analogues of N-acetylglucosamine prime formation of chitin oligosaccharides by yeast chitin synthase 2. J Biol Chem. 2014;289:12835-41 pubmed publisher
    Chitin, a homopolymer of ?1,4-linked N-acetylglucosamine (GlcNAc) residues, is a key component of the cell walls of fungi and the exoskeletons of arthropods...
  43. Alfaro J, Gong C, Monroe M, Aldrich J, Clauss T, Purvine S, et al. Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A. 2012;109:7280-5 pubmed publisher
    O-linked N-acetylglucosamine (O-GlcNAc) is a reversible posttranslational modification of Ser and Thr residues on cytosolic and nuclear proteins of higher eukaryotes catalyzed by O-GlcNAc transferase (OGT)...
  44. Chen C, Liang C, Chen Y, Tai M, Lu D, Chen J. Glucosamine modulates TNF-?-induced ICAM-1 expression and function through O-linked and N-linked glycosylation in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2012;53:2281-91 pubmed publisher
    ..and therefore on ICAM-1 expression, were compared after the addition of alloxan, an inhibitor of O-linked N-acetylglucosamine transferase (OGT), or O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc), an ..
  45. Napoletano C, Zizzari I, Rughetti A, Rahimi H, Irimura T, Clausen H, et al. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur J Immunol. 2012;42:936-45 pubmed publisher
    ..These results demonstrate that the targeting of MGL receptor on human DCs has an adjuvant effect and that this strategy can be used to design novel anticancer vaccines. ..
  46. Hanover J, Krause M, Love D. The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta. 2010;1800:80-95 pubmed publisher
    ..It will emphasize the impact O-GlcNAcylation has upon signaling pathways that may be become deregulated in diseases of the immune system, diabetes mellitus, cancer, cardiovascular disease, and neurodegenerative diseases. ..
  47. Ryan C, Mehlert A, Richardson J, Ferguson M, Johnson P. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (?1-4/3) N-acetylglucosamine repeats in host cell interaction. J Biol Chem. 2011;286:40494-508 pubmed publisher
    ..analyzed the structure of this glycoconjugate, previously described to contain the sugars rhamnose (Rha), N-acetylglucosamine (GlcNAc), galactose (Gal), xylose (Xyl), N-acetylgalactosamine (GalNAc), and glucose (Glc), using gas ..
  48. Goldberg H, Whiteside C, Fantus I. O-linked ?-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells. Am J Physiol Endocrinol Metab. 2011;301:E713-26 pubmed publisher
    ..Thus, O-GlcNAcylation is coupled to profibrotic p38 MAPK signaling by high glucose in part through Akt and possibly through ROS. ..
  49. Ngoh G, Facundo H, Hamid T, Dillmann W, Zachara N, Jones S. Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury. Circ Res. 2009;104:41-9 pubmed publisher
    Metabolic signaling through the posttranslational linkage of N-acetylglucosamine (O-GlcNAc) to cellular proteins represents a unique signaling paradigm operative during lethal cellular stress and a pathway that we and others have ..
  50. Lim K, Chang H. O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y. Biochem Biophys Res Commun. 2009;382:593-7 pubmed publisher
    O-linked N-acetylglucosamine (O-GlcNAc), a monosaccharide N-acetylglucosamine addition on nucleocytoplasmic proteins, is abundant in transcription regulators and has been implicated in gene regulation...
  51. Ngoh G, Facundo H, Zafir A, Jones S. O-GlcNAc signaling in the cardiovascular system. Circ Res. 2010;107:171-85 pubmed publisher
    ..Known as the beta-O-linkage of N-acetylglucosamine (ie, O-GlcNAc) to cellular proteins, this unique monosaccharide is involved in a diverse array of ..
  52. Yang W, Park S, Ji S, Kang J, Kim J, Song H, et al. O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Biochem Biophys Res Commun. 2010;391:756-61 pubmed publisher
    ..Here, we report that hyperglycemia-induced protein glycosylation by O-linked N-acetylglucosamine (O-GlcNAc) is crucial for activation of GPX1 and for its binding to c-Abl and Arg kinases...
  53. Tallent M, Varghis N, Skorobogatko Y, Hernandez Cuebas L, Whelan K, Vocadlo D, et al. In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem. 2009;284:174-81 pubmed publisher
    O-Linked N-acetylglucosamine (O-GlcNAc) is a cytosolic and nuclear carbohydrate post-translational modification most abundant in brain...
  54. Jacobsen K, Iverfeldt K. O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-? precursor protein (APP). Biochem Biophys Res Commun. 2011;404:882-6 pubmed publisher
    ..Our results implicate O-GlcNAcylation as a potential therapeutic target for Alzheimer's disease. ..
  55. Teo C, Ingale S, Wolfert M, Elsayed G, Nöt L, Chatham J, et al. Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol. 2010;6:338-43 pubmed publisher
    ..The monoclonal antibodies made it possible to delineate differentially modified proteins of liver in response to trauma-hemorrhage and resuscitation in a rat model. ..
  56. Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol. 2008;10:1224-31 pubmed publisher
    ..components of the hexosamine biosynthetic pathway, which reversibly modifies proteins with O-linked N-acetylglucosamine (O-GlcNAc) in response to stress, are required for SG and PB assembly...
  57. Al Dabbagh B, Blanot D, Mengin Lecreulx D, Bouhss A. Preparative enzymatic synthesis of polyprenyl-pyrophosphoryl-N-acetylglucosamine, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope polymers. Anal Biochem. 2009;391:163-5 pubmed publisher
    ..large-scale enzymatic synthesis, purification, and characterization of the undecaprenyl-pyrophosphoryl-N-acetylglucosamine product of the WecA transferase...
  58. Chatham J, Marchase R. The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta. 2010;1800:57-66 pubmed publisher
    The modification of serine and threonine residues of nuclear and cytoplasmic proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc) has emerged as a highly dynamic post-translational modification that plays a critical role in ..
  59. Wang Z, Udeshi N, Slawson C, Compton P, Sakabe K, Cheung W, et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal. 2010;3:ra2 pubmed publisher
    Like phosphorylation, the addition of O-linked beta-N-acetylglucosamine (O-GlcNAcylation) is a ubiquitous, reversible process that modifies serine and threonine residues on nuclear and cytoplasmic proteins...
  60. Rajapakse A, Ming X, Carvas J, Yang Z. O-linked beta-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system. Oxid Med Cell Longev. 2009;2:172-5 pubmed
    Elevated cellular levels of protein O-linked beta-N-acetylglucosamine (O-GlcNAc) through hexosamine biosynthesis pathway (HBP) are suggested to contribute to cardiovascular adverse effects under chronic hyperglycemic condition associated ..
  61. Lima V, Giachini F, Carneiro F, Carvalho M, Fortes Z, Webb R, et al. O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway. Cardiovasc Res. 2011;89:614-22 pubmed publisher
    Glycosylation with ?-N-acetylglucosamine (O-GlcNAcylation) is one of the most complex post-translational modifications. The cycling of O-GlcNAc is controlled by two enzymes: UDP-NAc transferase (OGT) and O-GlcNAcase (OGA)...
  62. Korgaonkar A, Whiteley M. Pseudomonas aeruginosa enhances production of an antimicrobial in response to N-acetylglucosamine and peptidoglycan. J Bacteriol. 2011;193:909-17 pubmed publisher
    ..Previous work from our laboratory revealed that five genes predicted to be important for catabolism of N-acetylglucosamine (GlcNAc) are induced during in vitro growth in CF lung secretions (sputum)...
  63. Wang J, Torii M, Liu H, Hart G, Hu Z. dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. BMC Bioinformatics. 2011;12:91 pubmed publisher
    Protein O-GlcNAcylation (or O-GlcNAc-ylation) is an O-linked glycosylation involving the transfer of ?-N-acetylglucosamine to the hydroxyl group of serine or threonine residues of proteins...
  64. Slawson C, Hart G. O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer. 2011;11:678-84 pubmed publisher
    O-GlcNAcylation is the covalent attachment of ?-D-N-acetylglucosamine (GlcNAc) sugars to serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in extensive crosstalk with other post-translational ..