Chikungunya virus

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Top Publications

  1. Khan A, Morita K, Hasebe F, Mathenge E, Igarashi A. Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site. J Gen Virol. 2002;83:3075-84 pubmed publisher
    In this study, the complete genomic sequence of chikungunya virus (CHIK; S27 African prototype) was determined and the presence of an internal polyadenylation [I-poly(A)] site was confirmed within the 3' non-translated region (NTR) of ..
  2. Fros J, Liu W, Prow N, Geertsema C, Ligtenberg M, Vanlandingham D, et al. Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. J Virol. 2010;84:10877-87 pubmed publisher
    b>Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes...
  3. Tsetsarkin K, Weaver S. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence. PLoS Pathog. 2011;7:e1002412 pubmed publisher
    The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world ..
  4. Kuo S, Chen Y, Wang Y, Tsui P, Kuo M, Wu T, et al. Cell-based analysis of Chikungunya virus E1 protein in membrane fusion. J Biomed Sci. 2012;19:44 pubmed publisher
    Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV)...
  5. Henrik Gad H, Paulous S, Belarbi E, Diancourt L, Drosten C, K mmerer B, et al. The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry. Virology. 2012;434:27-37 pubmed publisher
    Human 2',5'-oligoadenylate synthetase 3 (OAS3) exerts antiviral effect against alphaviruses including Chikungunya virus (CHIKV) by inhibiting viral RNA accumulation...
  6. Rathore A, Haystead T, Das P, Merits A, Ng M, Vasudevan S. Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. Antiviral Res. 2014;103:7-16 pubmed publisher
    The global emergence of Chikungunya virus (CHIKV) infection is alarming and currently there is no licensed vaccine or antiviral treatment available to mitigate this disease...
  7. Voss J, Vaney M, Duquerroy S, Vonrhein C, Girard Blanc C, Crublet E, et al. Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography. Nature. 2010;468:709-12 pubmed publisher
    b>Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of debilitating human disease in the past five years...
  8. Boura M, Lucas Hourani M, Gad H, Drosten C, Jacob Y, Tafforeau L, et al. Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. J Virol. 2012;86:3121-34 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has been responsible for an epidemic outbreak of unprecedented magnitude in recent years...
  9. Akahata W, Nabel G. A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol. 2012;86:8879-83 pubmed publisher
    Virus-like particles (VLPs) can be generated from Chikungunya virus (CHIKV), but different strains yield variable quantities of particles...

More Information

Publications321 found, 100 shown here

  1. Fros J, Domeradzka N, Baggen J, Geertsema C, Flipse J, Vlak J, et al. Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic foci. J Virol. 2012;86:10873-9 pubmed publisher
    b>Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP)...
  2. Fros J, van der Maten E, Vlak J, Pijlman G. The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. J Virol. 2013;87:10394-400 pubmed publisher
    ..Mutations that individually rendered other alphaviruses noncytopathic were introduced into chikungunya virus nsP2...
  3. Das P, Merits A, Lulla A. Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity. J Biol Chem. 2014;289:5635-53 pubmed publisher
    b>Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is a multifunctional protein that is considered a master regulator of the viral life cycle and a main viral factor responsible for cytopathic effects and subversion of antiviral ..
  4. Onyango C, Loparev V, Lidechi S, Bhullar V, Schmid D, Radford K, et al. Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections. J Clin Microbiol. 2017;55:2035-2044 pubmed publisher
    ..virus, lyssavirus, herpes simplex viruses 1 and 2, Epstein-Barr virus, enterovirus, cytomegalovirus, and chikungunya virus)...
  5. Chang C, Ortiz K, Ansari A, Gershwin M. The Zika outbreak of the 21st century. J Autoimmun. 2016;68:1-13 pubmed publisher
    ..Because cross-reactivity of the Zika virus with dengue and Chikungunya virus is common, it may pose difficulty in being able to quickly develop such tests and vaccines...
  6. Lwande O, Obanda V, Bucht G, Mosomtai G, Otieno V, Ahlm C, et al. Global emergence of Alphaviruses that cause arthritis in humans. Infect Ecol Epidemiol. 2015;5:29853 pubmed publisher
    ..Presently, there is a great interest in the emergence of Alphaviruses because these viruses, including Chikungunya virus, O'nyong'nyong virus, Sindbis virus, Ross River virus, and Mayaro virus, have caused outbreaks in Africa, ..
  7. Stiles K, Kielian M. Role of TSPAN9 in Alphavirus Entry and Early Endosomes. J Virol. 2016;90:4289-97 pubmed publisher
    ..factor that promotes infection by the alphaviruses Sindbis virus (SINV), Semliki Forest virus (SFV), and chikungunya virus (CHIKV). Depletion of TSPAN9 specifically decreases SFV membrane fusion in endosomes...
  8. Byler K, Collins J, Ogungbe I, Setzer W. Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation. Comput Biol Chem. 2016;64:163-184 pubmed publisher
    Alphaviruses such as Chikungunya virus (CHIKV), O'Nyong-Nyong virus (ONNV), Ross River virus (RRV), Eastern equine encephalitis virus (EEEV), Venezuelan equine encephalitis virus (VEEV), and Western equine encephalitis virus (WEEV), are ..
  9. Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016;16:653-660 pubmed publisher
    ..The virus was not detected in their urine or serum. Tests for dengue virus, chikungunya virus, Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus, HIV, Treponema pallidum, and ..
  10. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..encephalitis virus, Xinjiang hemorrhagic fever virus, spotted fever group rickettsiae, ehrlichiae and chikungunya virus. The limit of detection was 10 copies of target gene...
  11. da Silva R, Vital W, da Fonseca R, Martins Y, Lemos F, da Silva Vaz I, et al. Hypometabolic strategy and glucose metabolism maintenance of Aedes aegypti egg desiccation. Comp Biochem Physiol B Biochem Mol Biol. 2019;227:56-63 pubmed publisher
    The mosquito Aedes aegypti is vector of several viruses including yellow fever virus, dengue virus chikungunya virus and Zika virus. One of the major problems involving these diseases transmission is that A...
  12. Mancera Páez O, Roman G, Pardo Turriago R, Rodríguez Y, Anaya J. Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity. J Neurol Sci. 2018;395:47-53 pubmed publisher
    ..She had preexisting immunity against Chikungunya virus (CHIKV) and Dengue virus (DENV) acquired before the arrival of ZIKV in Colombia...
  13. Nasar F, Gorchakov R, Tesh R, Weaver S. Eilat virus host range restriction is present at multiple levels of the virus life cycle. J Virol. 2015;89:1404-18 pubmed publisher
    ..virus [EEEV], Western equine encephalitis virus [WEEV], Venezuelan equine encephalitis virus [VEEV], and Chikungunya virus [CHIKV]) that cause severe disease in humans...
  14. Weiss C, Trobaugh D, Sun C, Lucas T, Diamond M, Ryman K, et al. The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins. mSphere. 2018;3: pubmed publisher
    ..Ectopic expression of the interferon-induced 20-kDa exonuclease ISG20 suppressed replication of chikungunya virus and Venezuelan equine encephalitis virus, two mosquito-vectored RNA alphaviruses...
  15. Schuchman R, Kilianski A, Piper A, Vancini R, Ribeiro J, Sprague T, et al. Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virion and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication. J Virol. 2018;92: pubmed publisher
    ..Identification of these factors is invaluable for the prophylaxis of this group of viruses. ..
  16. Jeong Y, Cha G, Cho J, Lee E, Jee Y, Lee W. Viral and serological kinetics in Zika virus-infected patients in South Korea. Virol J. 2017;14:70 pubmed publisher
    ..virus is a mosquito-borne flavivirus that causes clinical symptoms similar to those observed in dengue and chikungunya virus infections...
  17. Byrd E, Kielian M. An Alphavirus E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding. MBio. 2017;8: pubmed publisher
    ..are members of a group of small enveloped RNA viruses that includes important human pathogens such as Chikungunya virus and the equine encephalitis viruses...
  18. Kudchodkar S, Choi H, Reuschel E, Esquivel R, Jin Ah Kwon J, Jeong M, et al. Rapid response to an emerging infectious disease - Lessons learned from development of a synthetic DNA vaccine targeting Zika virus. Microbes Infect. 2018;20:676-684 pubmed publisher
    ..against infectious pathogens such as influenza, Human immunodeficiency virus (HIV), dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging...
  19. Langsjoen R, Auguste A, Rossi S, Roundy C, Penate H, Kastis M, et al. Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential. Antiviral Res. 2017;143:246-251 pubmed publisher
    ..reductase, TRX-R; endoplasmic reticulum oxidoreductin-1, ERO-1) inhibit the replication of CHIKV chikungunya virus (CHIKV) in vitro in a dose-dependent manner...
  20. Gayen M, Gupta P, Morazzani E, Gaidamakova E, Knollmann Ritschel B, Daly M, et al. Deinococcus Mn2+-peptide complex: A novel approach to alphavirus vaccine development. Vaccine. 2017;35:3672-3681 pubmed publisher
    Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance...
  21. Herrero L, Foo S, Sheng K, Chen W, Forwood M, Bucala R, et al. Pentosan Polysulfate: a Novel Glycosaminoglycan-Like Molecule for Effective Treatment of Alphavirus-Induced Cartilage Destruction and Inflammatory Disease. J Virol. 2015;89:8063-76 pubmed publisher
    Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) cause large-scale epidemics of severe musculoskeletal disease and have been progressively expanding their global distribution...
  22. Moreira Soto A, Cabral R, Pedroso C, Eschbach Bludau M, Rockstroh A, Vargas L, et al. Exhaustive TORCH Pathogen Diagnostics Corroborate Zika Virus Etiology of Congenital Malformations in Northeastern Brazil. mSphere. 2018;3: pubmed publisher
    ..We collected clinical and imaging data and assessed past exposure to ZIKV, Chikungunya virus (CHIKV), dengue virus, and 8 established TORCH (Toxoplasma gondii, Treponema pallidum, rubella ..
  23. Saucereau Y, Valiente Moro C, Dieryckx C, Dupuy J, Tran F, Girard V, et al. Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon. BMC Genomics. 2017;18:635 pubmed publisher
    ..albopictus C6/36 cells mono-infected by Wolbachia wAlbB strain or Chikungunya virus (CHIKV), and bi-infected. We first confirmed significant inhibition of CHIKV by Wolbachia...
  24. Donahue D, Amraoui S, Di Nunzio F, Kieffer C, Porrot F, Opp S, et al. SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV. J Virol. 2016;90:4199-4214 pubmed publisher
    ..in primary monocyte-derived dendritic cells inhibits the replication of HIV but not murine leukemia virus or chikungunya virus. We identified HIV-1 and HIV-2 strains that are unaffected by SUN2, suggesting that the effect is specific ..
  25. Russo R, dos Santos Junior N, Cintra A, Figueiredo L, Sampaio S, Aquino V. Expression, purification and virucidal activity of two recombinant isoforms of phospholipase A2 from Crotalus durissus terrificus venom. Arch Virol. 2019;: pubmed publisher
    ..The refolded recombinant proteins showed phospholipase activity and virucidal effects against chikungunya virus, dengue virus, yellow fever virus and Zika virus.
  26. Rodhain F. [Arboviruses also have an American dream]. Bull Soc Pathol Exot. 2017;110:147-159 pubmed publisher
    ..Then, Chikungunya virus arrived on Saint Martin Island in 2013 after its outbreak in Polynesia; it is now widespread in the ..
  27. Mathew A, Ganapati A, Kabeerdoss J, Nair A, Gupta N, Chebbi P, et al. Chikungunya Infection: a Global Public Health Menace. Curr Allergy Asthma Rep. 2017;17:13 pubmed publisher
    b>Chikungunya virus (CHIKV) has been involved in epidemics in African and Asian subcontinents and, of late, has transcended to affect the Americas...
  28. Schultz M, Tan A, Gray C, Isern S, Michael S, Frydman H, et al. Wolbachia wStri Blocks Zika Virus Growth at Two Independent Stages of Viral Replication. MBio. 2018;9: pubmed publisher
    ..for major vectors in the Aedes mosquito genus to transmit viruses, including dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus (ZIKV)...
  29. Torres J, Falleiros Arlant L, Dueñas L, Pleitez Navarrete J, Salgado D, Castillo J. Congenital and perinatal complications of chikungunya fever: a Latin American experience. Int J Infect Dis. 2016;51:85-88 pubmed publisher
    During the years 2014 and 2015, the Region of the Americas underwent a devastating epidemic of chikungunya virus (CHIKV) of the Asian genotype, resulting in millions of affected individuals...
  30. Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher
    ..In a murine model of chikungunya virus arthritis, Ifitm3(-/-) mice sustained greater joint swelling in the ipsilateral ankle at days 3 and 7 ..
  31. Haac M, Anderson M, Eggleston H, Myles K, Adelman Z. The hub protein loquacious connects the microRNA and short interfering RNA pathways in mosquitoes. Nucleic Acids Res. 2015;43:3688-700 pubmed publisher
    ..aegypti mosquitoes vector several arboviruses of global health significance, including dengue viruses and chikungunya virus. RNA interference (RNAi) plays an important role in antiviral immunity, gene regulation and protection from ..
  32. Petitdemange C, Wauquier N, Vieillard V. Control of immunopathology during chikungunya virus infection. J Allergy Clin Immunol. 2015;135:846-55 pubmed publisher
    After several decades of epidemiologic silence, chikungunya virus (CHIKV) has recently re-emerged, causing explosive outbreaks and reaching the 5 continents...
  33. Teo T, Her Z, Tan J, Lum F, Lee W, Chan Y, et al. Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology. J Virol. 2015;89:7955-69 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne arthralgic alphavirus that has garnered international attention as an important emerging pathogen since 2005. More recently, it invaded the Caribbean islands and the Western Hemisphere...
  34. Lancaster C, Pristatsky P, Hoang V, Casimiro D, Schwartz R, Rustandi R, et al. Characterization of N-glycosylation profiles from mammalian and insect cell derived chikungunya VLP. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1032:218-223 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes severe arthralgia. The envelope of CHIKV is composed of 240 copies of two glycoproteins: E1 and E2...
  35. Martínez Sánchez A, Martínez Ramos E, Chávez Angeles M. [Situational panorama of Mexico against the chikungunya virus pandemic]. Rev Med Inst Mex Seguro Soc. 2015;53:200-5 pubmed
  36. Deeba F, Islam A, Kazim S, Naqvi I, Broor S, Ahmed A, et al. Chikungunya virus: recent advances in epidemiology, host pathogen interaction and vaccine strategies. Pathog Dis. 2016;74: pubmed publisher
    The Chikungunya virus is a re-emerging alphavirus that belongs to the family Togaviridae. The symptoms include fever, rashes, nausea and joint pain that may last for months...
  37. Cherry C, Beer K, Fulton C, Wong D, Buttke D, Staples J, et al. Knowledge and use of prevention measures for chikungunya virus among visitors - Virgin Islands National Park, 2015. Travel Med Infect Dis. 2016;14:475-480 pubmed publisher
    In June 2014, the mosquito-borne chikungunya virus (CHIKV) emerged in the U.S. Virgin Islands (USVI), a location where tourists comprise the majority of the population during peak season (January-April)...
  38. Abdelnabi R, Staveness D, Near K, Wender P, Delang L, Neyts J, et al. Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism. Biochem Pharmacol. 2016;120:15-21 pubmed publisher
    Previously, we reported that salicylate-based analogs of bryostatin protect cells from chikungunya virus (CHIKV)-induced cell death...
  39. Sanders W, Long K, Rivera B, Vincent H, Heise M, Rodriguez Orengo J, et al. Complete Genome Sequences of 15 Chikungunya Virus Isolates from Puerto Rico. Genome Announc. 2017;5: pubmed publisher
    Here, we report the complete genome sequences of 15 chikungunya virus strains isolated from human plasma from infected patients in Puerto Rico...
  40. Eldi P, Cooper T, Liu L, Prow N, Diener K, Howley P, et al. Production of a Chikungunya Vaccine Using a CHO Cell and Attenuated Viral-Based Platform Technology. Mol Ther. 2017;25:2332-2344 pubmed publisher
    ..To illustrate the utility of the platform technology, a SCV vaccine against chikungunya virus (SCV-CHIK) was developed and shown to be multiplication-defective in a range of human cell lines and in ..
  41. Pybus O, Tatem A, Lemey P. Virus evolution and transmission in an ever more connected world. Proc Biol Sci. 2015;282:20142878 pubmed publisher
    ..between virus evolution and global dispersal in more depth for two pathogens: human influenza A virus and chikungunya virus. We discuss the opportunities for future research arising from new analyses of human transportation and ..
  42. Jain J, Okabayashi T, Kaur N, Nakayama E, Shioda T, Gaind R, et al. Evaluation of an immunochromatography rapid diagnosis kit for detection of chikungunya virus antigen in India, a dengue-endemic country. Virol J. 2018;15:84 pubmed publisher
    b>Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses that share the same Aedes mosquito vector, and there is much overlap in endemic areas. In India, co-infection with both viruses is often reported...
  43. Dagley A, Ennis J, Turner J, Rood K, Van Wettere A, Gowen B, et al. Protection against Chikungunya virus induced arthralgia following prophylactic treatment with adenovirus vectored interferon (mDEF201). Antiviral Res. 2014;108:1-9 pubmed publisher
    Recent outbreaks of Chikungunya virus (CHIKV) infection have resulted in millions of cases of disease with significant morbidity. No approved antiviral treatments exist for the prevention or treatment of this viral disease...
  44. Nuckols J, McAuley A, Huang Y, Horne K, Higgs S, Davey R, et al. pH-Dependent entry of chikungunya virus fusion into mosquito cells. Virol J. 2014;11:215 pubmed publisher
    ..Here we describe early chikungunya virus (CHIKV) infectious events in cells derived from one of the most important CHIKV vectors, Aedes albopictus...
  45. Scholte F, Tas A, Albulescu I, Zusinaite E, Merits A, Snijder E, et al. Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication. J Virol. 2015;89:4457-69 pubmed publisher
    ..Its homolog G3BP2 is a less extensively studied SG component. Here, we demonstrate that Chikungunya virus (CHIKV) infection induces cytoplasmic G3BP1- and G3BP2-containing granules that differ from bona fide SGs in ..
  46. Casal P, Chouhy D, Bolatti E, Perez G, Stella E, Giri A. Evidence for homologous recombination in Chikungunya Virus. Mol Phylogenet Evol. 2015;85:68-75 pubmed publisher
    b>Chikungunya Virus (CHIKV), a mosquito-transmitted alphavirus, causes acute fever and joint pain in humans. Recently, endemic CHIKV infection outbreaks have jeopardized public health in wider geographical regions...
  47. Weaver S, Forrester N. Chikungunya: Evolutionary history and recent epidemic spread. Antiviral Res. 2015;120:32-9 pubmed publisher
    b>Chikungunya virus (CHIKV) has a long history of emergence into urban transmission cycles from its ancestral, enzootic, sylvatic foci in Sub-Saharan Africa, most recently spreading to the Americas beginning in 2013...
  48. Mizuno Y, Kato Y, Takeshita N, Ujiie M, Kobayashi T, Kanagawa S, et al. Clinical and radiological features of imported chikungunya fever in Japan: a study of six cases at the National Center for Global Health and Medicine. J Infect Chemother. 2011;17:419-23 pubmed publisher
    ..Clinicians should be aware of the late consequences of infection by the chikungunya virus (CHIKV) and recognize the possible association of subacute and chronic arthritis features...
  49. Palacios Martínez D, Díaz Alonso R, Arce Segura L, Díaz Vera E. [Chikungunya, an emerging viral disease. Proposal of an algorithm for its clinical management]. Semergen. 2015;41:221-5 pubmed publisher
    Chikungunya fever (CHIK) is an emerging viral disease. It is caused by the Chikungunya virus, an alphavirus from the Togaviridae family...
  50. Kaur R, Mudgal R, Narwal M, Tomar S. Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme. Virus Res. 2018;256:209-218 pubmed publisher
    ..In the present study, chikungunya virus (CHIKV) nsP1 MTase and GT reactions were confirmed by an indirect non-radioactive colorimetric assay and ..
  51. Medlock J, Leach S. Effect of climate change on vector-borne disease risk in the UK. Lancet Infect Dis. 2015;15:721-30 pubmed publisher
    ..have become widely established across Europe, with subsequent transmission and outbreaks of dengue and chikungunya virus. Malaria has re-emerged in Greece, and West Nile virus has emerged throughout parts of eastern Europe...
  52. Abraham R, Manakkadan A, Mudaliar P, Joseph I, Sivakumar K, Nair R, et al. Correlation of phylogenetic clade diversification and in vitro infectivity differences among Cosmopolitan genotype strains of Chikungunya virus. Infect Genet Evol. 2016;37:174-84 pubmed publisher
    Cosmopolitan genotypes of Chikungunya virus caused the large-scale febrile disease outbreaks in the last decade in Asian and African continents...
  53. Taylor A, Melton J, Herrero L, Thaa B, Karo Astover L, Gage P, et al. Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus. J Virol. 2016;90:4150-4159 pubmed publisher
    ..load and accelerated viral elimination upon secondary infection with wild-type RRV or another alphavirus, chikungunya virus (CHIKV)...
  54. Knudsen M, Ljungberg K, Kakoulidou M, Kostic L, Hallengärd D, García Arriaza J, et al. Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations. J Virol. 2014;88:12438-51 pubmed publisher
    ..candidates against a number of diseases and are by themselves developed as vaccines against, for example, Chikungunya virus infection...
  55. Phillips J. Chikungunya Virus. Workplace Health Saf. 2015;63:280 pubmed publisher
    A mosquito-borne viral disease that is creating increased concern globally is Chikungunya virus (CHIKV). Occupational and environmental health nurses should educate workers about this emerging viral infection.
  56. Londono Renteria B, Troupin A, Colpitts T. Arbovirosis and potential transmission blocking vaccines. Parasit Vectors. 2016;9:516 pubmed
    ..With the recent introduction of West Nile virus (1999), chikungunya virus (2013) and Zika virus (2015) to the Americas, stopping or even preventing the expansion of viruses into ..
  57. Eckei L, Krieg S, Bütepage M, Lehmann A, Gross A, Lippok B, et al. The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases. Sci Rep. 2017;7:41746 pubmed publisher
    Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic strategies exist...
  58. Pryke K, Abraham J, Sali T, Gall B, Archer I, Liu A, et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio. 2017;8: pubmed publisher
    ..and in so doing generates a cellular state antagonistic to growth of currently emerging viruses: Zika virus, Chikungunya virus, and dengue virus...
  59. Wichit S, Diop F, Hamel R, Talignani L, Ferraris P, Cornelie S, et al. Aedes Aegypti saliva enhances chikungunya virus replication in human skin fibroblasts via inhibition of the type I interferon signaling pathway. Infect Genet Evol. 2017;55:68-70 pubmed publisher
    b>Chikungunya virus (CHIKV) transmission occurs through the bite of an infected Aedes mosquito which injects virus-containing saliva into the skin of the human host during blood feeding...
  60. Godaert L, Najioullah F, Bartholet S, Colas S, Yactayo S, Cabie A, et al. Atypical Clinical Presentations of Acute Phase Chikungunya Virus Infection in Older Adults. J Am Geriatr Soc. 2017;65:2510-2515 pubmed publisher
    We aimed to determine whether the presentation of Chikungunya virus (CHIKV) infection differs between older and younger adults with regard to clinical form during the acute phase defined by the World Health Organization: acute clinical, ..
  61. Fros J, Major L, Scholte F, Gardner J, van Hemert M, Suhrbier A, et al. Chikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein response. J Gen Virol. 2015;96:580-9 pubmed publisher
    ..Here, we demonstrated that transient expression of chikungunya virus (CHIKV) (family Togaviridae, genus Alphavirus) envelope glycoproteins induced the UPR and that CHIKV ..
  62. Sali T, Pryke K, Abraham J, Liu A, Archer I, Broeckel R, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015;11:e1005324 pubmed publisher
    ..to the establishment of a cellular state that prevented replication of emerging Alphavirus species including Chikungunya virus, Venezuelan Equine Encephalitis virus, and Sindbis virus...
  63. Neuberger A, Turgeman A, Lustig Y, Schwartz E. Dengue fever among Israeli expatriates in Delhi, 2015: implications for dengue incidence in Delhi, India. J Travel Med. 2016;23: pubmed publisher
    ..Another febrile patient was diagnosed with chikungunya virus infection. The reported incidence of dengue fever among people living in Delhi was lower than 0...
  64. Zhang N, Zhang L. Key components of COPI and COPII machineries are required for chikungunya virus replication. Biochem Biophys Res Commun. 2017;493:1190-1196 pubmed publisher
    ..Collectively, these observations demonstrate the importance of functional secretory pathways in the infectivity of CHIKV...
  65. Lindsey N, Staples J, Fischer M. Chikungunya Virus Disease among Travelers-United States, 2014-2016. Am J Trop Med Hyg. 2017;: pubmed publisher
    b>Chikungunya virus is a mosquito-borne alphavirus that causes an acute febrile illness with severe polyarthralgia. The first local transmission of chikungunya virus in the Western Hemisphere was reported in December 2013...
  66. Zouache K, Failloux A. Insect-pathogen interactions: contribution of viral adaptation to the emergence of vector-borne diseases, the example of chikungunya. Curr Opin Insect Sci. 2015;10:14-21 pubmed publisher
    ..b>Chikungunya virus (CHIKV) is a mosquito-borne virus that typically causes incapacitating arthralgia, rash, and fever...
  67. Okabayashi T, Sasaki T, Masrinoul P, Chantawat N, Yoksan S, Nitatpattana N, et al. Detection of chikungunya virus antigen by a novel rapid immunochromatographic test. J Clin Microbiol. 2015;53:382-8 pubmed publisher
    ..The present study aimed to develop a new immunochromatographic diagnosis test for the detection of chikungunya virus antigen in serum...
  68. Mounce B, Cesaro T, Vlajnić L, Vidiņa A, Vallet T, Weger Lucarelli J, et al. Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness. J Virol. 2017;91: pubmed publisher
    ..b>Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological ..
  69. Subudhi B, Chattopadhyay S, Mishra P, Kumar A. Current Strategies for Inhibition of Chikungunya Infection. Viruses. 2018;10: pubmed publisher
    Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with Dengue/Zika virus have highlighted the urgency for CHIKV management...
  70. Zhang X, Huang Y, Wang M, Yang F, Cheng J, Wan C, et al. Complete Genome Sequences of Two Chikungunya Viruses Imported into China. Genome Announc. 2018;6: pubmed publisher
    Here, we isolated two chikungunya virus strains (SZ1050 and SZ1239) from patients infected with chikungunya virus who were returning to China from India and Indonesia, respectively...
  71. Writer J, Hurt L. Chikungunya infection in DoD healthcare beneficiaries following the 2013 introduction of the virus into the Western Hemisphere, 1 January 2014 to 28 February 2015. MSMR. 2015;22:2-6 pubmed
    The introduction and rapid spread of chikungunya virus (CHIKV) into the Western Hemisphere after December 2013 pose a potentially significant risk to Department of Defense (DoD) personnel, operations, and the military healthcare system...
  72. Shrinet J, Bhavesh N, Sunil S. Understanding Oxidative Stress in Aedes during Chikungunya and Dengue Virus Infections Using Integromics Analysis. Viruses. 2018;10: pubmed publisher
    ..Significant number of information is available showing changes in the transcripts and/or proteins upon Chikungunya virus and Dengue virus mono-infections and as co-infections...
  73. Gay N, Rousset D, Huc P, Matheus S, Ledrans M, Rosine J, et al. Seroprevalence of Asian Lineage Chikungunya Virus Infection on Saint Martin Island, 7 Months After the 2013 Emergence. Am J Trop Med Hyg. 2016;94:393-6 pubmed publisher
    At the end of 2013, chikungunya virus (CHIKV) emerged in Saint Martin Island, Caribbean. The Asian lineage was identified. Seven months after this introduction, the seroprevalence was 16.9% in the population of Saint Martin and 39...
  74. Lim C. Virus Isolation and Preparation of Sucrose-Banded Chikungunya Virus Samples for Transmission Electron Microscopy. Methods Mol Biol. 2016;1426:153-62 pubmed publisher
    ..This chapter describes a large-scale Chikungunya virus (CHIKV) propagation and purification methods by using discontinuous sucrose gradient, and sample preparation ..
  75. Appassakij H, Promwong C, Rujirojindakul P, Khuntikij P, Silpapojakul K. Risk of transfusion-transmitted chikungunya infection and efficacy of blood safety implementation measures: experience from the 2009 epidemic in Songkhla Province, Thailand. Transfusion. 2016;56:2100-7 pubmed publisher
    ..7% (95% CI, 65.8%-100.0%) to 90.7% (95% CI, 72.1%-100.0%) by predonation screening for donors at risk of chikungunya virus infection alone...
  76. Abdelnabi R, Morais A, Leyssen P, Imbert I, Beaucourt S, Blanc H, et al. Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase. J Virol. 2017;91: pubmed publisher
    ..T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV)...
  77. Marques C, Duarte A, Ranzolin A, Dantas A, Cavalcanti N, Gonçalves R, et al. Recommendations of the Brazilian Society of Rheumatology for diagnosis and treatment of Chikungunya fever. Part 1 - Diagnosis and special situations. Rev Bras Reumatol Engl Ed. 2017;57 Suppl 2:421-437 pubmed publisher
    ..in Brazil in September 2014; until epidemiological week 37 of 2016, 236,287 probable cases of infection with Chikungunya virus had been registered, 116,523 of which had serological confirmation...
  78. Garcia A, Diego L, Judith B. New approaches to chikungunya virus vaccine development. Recent Pat Inflamm Allergy Drug Discov. 2015;9:31-7 pubmed
    b>Chikungunya virus (CHIKV) is a mosquito-borne human pathogen that affects millions of individuals each year by causing non-specific flu-like symptoms, with a characteristic rash accompanied by joint pain that may last for a long time ..
  79. Lani R, Hassandarvish P, Shu M, Phoon W, Chu J, Higgs S, et al. Antiviral activity of selected flavonoids against Chikungunya virus. Antiviral Res. 2016;133:50-61 pubmed publisher
    This study focuses on the antiviral activity of selected flavonoids against the Chikungunya virus (CHIKV), a mosquito-transmitted virus that can cause incapacitating arthritis in infected individuals...
  80. Khongwichit S, Wikan N, Abere B, Thepparit C, Kuadkitkan A, Ubol S, et al. Cell-type specific variation in the induction of ER stress and downstream events in chikungunya virus infection. Microb Pathog. 2016;101:104-118 pubmed publisher
    Over the last decade infections with the mosquito transmitted chikungunya virus (CHIKV) have become a major worldwide concern, and considerable efforts have been made in understanding the interaction of this virus with the host cell ..
  81. Doughty C, Yawetz S, Lyons J. Emerging Causes of Arbovirus Encephalitis in North America: Powassan, Chikungunya, and Zika Viruses. Curr Neurol Neurosci Rep. 2017;17:12 pubmed publisher
    ..Arboviruses are a common and an increasing cause of human illness in North America. Powassan virus, Chikungunya virus, and Zika virus are arboviruses that have all recently emerged as increasing causes of neurologic illness...
  82. Galán Huerta K, Martínez Landeros E, Delgado Gallegos J, Caballero Sosa S, Malo García I, Fernandez Salas I, et al. Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico. Viruses. 2018;10: pubmed publisher
    Chikungunya fever is an arthropod-borne infection caused by Chikungunya virus (CHIKV). Even though clinical features of Chikungunya fever in the Mexican population have been described before, there is no detailed information...
  83. Fernández Salas I, Danis Lozano R, Casas Martínez M, Ulloa A, Bond J, Marina C, et al. Historical inability to control Aedes aegypti as a main contributor of fast dispersal of chikungunya outbreaks in Latin America. Antiviral Res. 2015;124:30-42 pubmed publisher
    ..as dengue-endemic countries, abundant Aedes aegypti populations make this region highly vulnerable to chikungunya virus (CHIKV) circulation...
  84. Gabor J, Schwarz N, Esen M, Kremsner P, Grobusch M. Dengue and chikungunya seroprevalence in Gabonese infants prior to major outbreaks in 2007 and 2010: A sero-epidemiological study. Travel Med Infect Dis. 2016;14:26-31 pubmed publisher
    Apart from outbreak reports, little is known about the endemicity of dengue and chikungunya virus in African countries...
  85. Henß L, Beck S, Weidner T, Biedenkopf N, Sliva K, Weber C, et al. Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. Virol J. 2016;13:149 pubmed publisher
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans...
  86. Varghese F, Rausalu K, Hakanen M, Saul S, Kummerer B, Susi P, et al. Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..cellular membranes during viral entry is one such process that is used by many pathogenic viruses, including chikungunya virus, West Nile virus, and influenza virus...
  87. Bartholomeeusen K, Utt A, Coppens S, Rausalu K, Vereecken K, Ariën K, et al. A Chikungunya Virus trans-Replicase System Reveals the Importance of Delayed Nonstructural Polyprotein Processing for Efficient Replication Complex Formation in Mosquito Cells. J Virol. 2018;92: pubmed publisher
    b>Chikungunya virus (CHIKV) is a medically important alphavirus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes...
  88. Hogeboom C. Peptide motif analysis predicts alphaviruses as triggers for rheumatoid arthritis. Mol Immunol. 2015;68:465-75 pubmed publisher
    ..in the P6 position suggest that the HLA binding preference may vary by species, with Ross River virus, Chikungunya virus, and Mayaro virus peptides binding preferentially to DR4, and peptides from Sindbis/Ockelbo virus showing ..
  89. Suzuki Y, Chin W, Han Q, Ichiyama K, Lee C, Eyo Z, et al. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication. PLoS Pathog. 2016;12:e1005357 pubmed publisher
    ..RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus...
  90. Ruiz Silva M, van der Ende Metselaar H, Mulder H, Smit J, Rodenhuis Zybert I. Mechanism and role of MCP-1 upregulation upon chikungunya virus infection in human peripheral blood mononuclear cells. Sci Rep. 2016;6:32288 pubmed publisher
    ..During chikungunya virus (CHIKV) infection however, excessive production of MCP-1 has been linked to disease pathogenesis...
  91. Chen R, Puri V, Fedorova N, Lin D, Hari K, Jain R, et al. Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus. J Virol. 2016;90:10600-10611 pubmed publisher
    Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted...
  92. Yaqub T, Shabbir M, Mukhtar N, Tahir Z, Abbas T, Amir E, et al. Detection of selected arboviral infections in patients with history of persistent fever in Pakistan. Acta Trop. 2017;176:34-38 pubmed publisher
    ..fever (DHF) virus serotypes 1-4, West Nile virus fever (WNVF), Crimean-Congo haemorrhagic fever (CCHF), and Chikungunya virus (CGV)...