arboviruses group A

Summary

Alias: Alphavirus, Alphaviridae

Top Publications

  1. Baer A, Lundberg L, Swales D, Waybright N, Pinkham C, Dinman J, et al. Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. J Virol. 2016;90:3558-72 pubmed publisher
    ..Venezuelan equine encephalitis virus (VEEV) is an alphavirus that is prevalent in the Americas and that is capable of infecting horses and humans...
  2. Abraham R, Mudaliar P, Jaleel A, Srikanth J, Sreekumar E. High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection. J Proteomics. 2015;120:126-41 pubmed publisher
    ..The Asian genotype of this positive-stranded RNA virus of the Alphavirus genus has been attributed in these outbreaks...
  3. Carey B, Ammosova T, Pinkham C, Lin X, Zhou W, Liotta L, et al. Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. J Virol. 2018;92: pubmed publisher
    ..Inhibition of PP1 also inhibited multiple biomedically important alphaviruses, indicating that PP1 may be a potential therapeutic target for alphavirus-induced disease.
  4. Kendra J, de La Fuente C, Brahms A, Woodson C, Bell T, Chen B, et al. Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. J Virol. 2017;91: pubmed publisher
    ..Here, the alphavirus -1 PRF signals were characterized, revealing novel -1 PRF stimulatory structures...
  5. Nasar F, Gorchakov R, Tesh R, Weaver S. Eilat virus host range restriction is present at multiple levels of the virus life cycle. J Virol. 2015;89:1404-18 pubmed publisher
    ..Recently, a new alphavirus, Eilat virus (EILV), was described, and in contrast to all other mosquito-borne viruses, it is unable to ..
  6. Lundstrom K. Oncolytic Alphaviruses in Cancer Immunotherapy. Vaccines (Basel). 2017;5: pubmed publisher
    ..colon, cervix, and lung cancer as well as melanoma have been conducted with naturally occurring oncolytic alphavirus strains such as M1 and Sindbis AR339...
  7. Boucher A, Herrmann J, Morand P, Buzelé R, Crabol Y, Stahl J, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect. 2017;47:221-235 pubmed publisher
    ..and Northern Europe/Eastern Russia and the tick-borne encephalitis virus, Northern America and Flavivirus or Alphavirus. Bacteria can also be incriminated: Mycobacterium tuberculosis and Listeria monocytogenes are the most frequent, ..
  8. Manivannan S, Baxter V, Schultz K, Slusher B, Griffin D. Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis. J Virol. 2016;90:9251-62 pubmed publisher
    ..Therefore, more definitive treatment for alphaviral encephalomyelitis should inhibit virus replication as well as neuroinflammatory damage. ..
  9. Gupta P, Sharma A, Han J, Yang A, Bhomia M, Knollmann Ritschel B, et al. Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus. BMC Infect Dis. 2017;17:309 pubmed publisher
    Venezuelan equine encephalitis virus (VEEV) is an alphavirus in the family Togaviridae. VEEV causes a bi-phasic illness in mice where primary replication in lymphoid organs is followed by entry into the central nervous system (CNS)...

More Information

Publications228 found, 100 shown here

  1. Ferreira A, Reis P, de Freitas C, Sacramento C, Villas Boas Hoelz L, Bastos M, et al. Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication. Antimicrob Agents Chemother. 2019;63: pubmed publisher
    ..Our data demonstrate that a prototypic alphavirus, CHIKV, is also susceptible to sofosbuvir...
  2. Langsjoen R, Auguste A, Rossi S, Roundy C, Penate H, Kastis M, et al. Host oxidative folding pathways offer novel anti-chikungunya virus drug targets with broad spectrum potential. Antiviral Res. 2017;143:246-251 pubmed publisher
    ..Finally, auranofin reduced footpad swelling and viremia in the C57BL/6 murine model of CHIKV infection. Our results suggest that targeting oxidative folding pathways represents a potential new anti-alphavirus therapeutic strategy.
  3. Amaya M, Keck F, Lindquist M, Voss K, Scavone L, Kehn Hall K, et al. The ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection. PLoS ONE. 2015;10:e0124792 pubmed publisher
    ..This study will aid future investigations in identifying host proteins as potential broad spectrum therapeutic targets for treating alphavirus infections.
  4. Lim E, Supramaniam A, Lui H, Coles P, Lee W, Liu X, et al. Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production. Viruses. 2018;10: pubmed publisher
    Arthritogenic alphavirus infections often result in debilitating musculoskeletal disorders that affect the joints, muscle, and bone...
  5. Schultz K, Vernon P, Griffin D. Differentiation of neurons restricts Arbovirus replication and increases expression of the alpha isoform of IRF-7. J Virol. 2015;89:48-60 pubmed publisher
    Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis...
  6. Li C, Guillén J, Rabah N, Blanjoie A, Debart F, Vasseur J, et al. mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research. J Virol. 2015;89:8292-303 pubmed publisher
    ..Final guanylyltransfer onto RNA was observed for the first time with an alphavirus nsP1 using a 5'-diphosphate RNA oligonucleotide whose sequence corresponds to the 5' end of the viral genome...
  7. Stone D, Lyons A, Huang Y, Vanlandingham D, Higgs S, Blitvich B, et al. Serological evidence of widespread exposure of Grenada fruit bats to chikungunya virus. Zoonoses Public Health. 2018;65:505-511 pubmed publisher
    ..encephalitis virus by epitope-blocking enzyme-linked immunosorbent assay (ELISA); and (iii) antibodies to the alphavirus chikungunya (CHIKV) by PRNT...
  8. Kim D, Reynaud J, Rasalouskaya A, Akhrymuk I, Mobley J, Frolov I, et al. New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes. PLoS Pathog. 2016;12:e1005810 pubmed publisher
    ..Despite being in different families, these proteins share common characteristics, which determine their role in alphavirus replication, namely, the abilities for RNA-binding and for self-assembly into large structures...
  9. Cain M, Salimi H, Gong Y, Yang L, Hamilton S, Heffernan J, et al. Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection. J Neuroimmunol. 2017;308:118-130 pubmed publisher
    ..These findings indicate that TC83 gains CNS access via anterograde axonal migration without directly altering BBB function and that mononuclear and endothelial cell interactions may underlie BBB disruption during alphavirus encephalitis.
  10. Ahmed A, Siman Tov G, Keck F, Kortchak S, Bakovic A, Risner K, et al. Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections. Antiviral Res. 2019;164:61-69 pubmed publisher
    Venezuelan equine encephalitis virus (VEEV), a new world alphavirus belonging to the Togaviridae family, causes periodic disease outbreaks in humans and equines with high associated mortality and morbidity...
  11. Johansen L, Thim H, Jørgensen S, Afanasyev S, Strandskog G, Taksdal T, et al. Comparison of transcriptomic responses to pancreas disease (PD) and heart and skeletal muscle inflammation (HSMI) in heart of Atlantic salmon (Salmo salar L). Fish Shellfish Immunol. 2015;46:612-23 pubmed publisher
    ..disease (PD) and heart and skeletal muscle inflammation (HSMI) are viral diseases associated with SAV (salmonid alphavirus) and PRV (piscine reovirus), which induce systemic infections and pathologies in cardiac and skeletal muscle ..
  12. Mainou B, Ashbrook A, Smith E, Dorset D, Denison M, Dermody T. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J Virol. 2015;89:8701-12 pubmed publisher
    ..We also found that treatment of cells with 5-NT decreased the infectivity of alphavirus chikungunya virus and coronavirus mouse hepatitis virus...
  13. Lwande O, Obanda V, Bucht G, Mosomtai G, Otieno V, Ahlm C, et al. Global emergence of Alphaviruses that cause arthritis in humans. Infect Ecol Epidemiol. 2015;5:29853 pubmed publisher
    ..more common in the tropics, whereas others are also found in temperate regions, but the actual factors driving Alphavirus emergence and re-emergence remain unresolved...
  14. Zhang R, Miner J, Gorman M, Rausch K, Ramage H, White J, et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 2016;535:164-8 pubmed
    ..Nile, Dengue, Zika, yellow fever, Japanese encephalitis, and hepatitis C viruses), but had little impact on alphavirus, bunyavirus, or rhabdovirus infection or the surface expression or secretion of diverse host proteins...
  15. Wang X, Li M, Zhao J, Li S, Macdonald M, Rice C, et al. Sindbis Virus Can Exploit a Host Antiviral Protein To Evade Immune Surveillance. J Virol. 2016;90:10247-10258 pubmed publisher
    ..Sindbis virus, a prototypic member of the Alphavirus genus, has been used to study the pathogenesis of acute viral encephalitis in mice for many years...
  16. Byler K, Collins J, Ogungbe I, Setzer W. Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation. Comput Biol Chem. 2016;64:163-184 pubmed publisher
    ..The alphavirus non-structural protein 2 (nsP2) contains a papain-like protease, which is considered to be a promising target ..
  17. Remenyi R, Gao Y, Hughes R, Curd A, Zothner C, Peckham M, et al. Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3. J Virol. 2018;92: pubmed publisher
    ..b>IMPORTANCE Chikungunya virus (CHIKV) is a reemerging alphavirus transmitted by mosquitos and causes transient sickness but also chronic disease affecting muscles and joints...
  18. Sali T, Pryke K, Abraham J, Liu A, Archer I, Broeckel R, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015;11:e1005324 pubmed publisher
    ..This led to the establishment of a cellular state that prevented replication of emerging Alphavirus species including Chikungunya virus, Venezuelan Equine Encephalitis virus, and Sindbis virus...
  19. Teo T, Her Z, Tan J, Lum F, Lee W, Chan Y, et al. Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology. J Virol. 2015;89:7955-69 pubmed publisher
    Chikungunya virus (CHIKV) is a mosquito-borne arthralgic alphavirus that has garnered international attention as an important emerging pathogen since 2005. More recently, it invaded the Caribbean islands and the Western Hemisphere...
  20. Carissimo G, Pain A, Belda E, Vernick K. Highly focused transcriptional response of Anopheles coluzzii to O'nyong nyong arbovirus during the primary midgut infection. BMC Genomics. 2018;19:526 pubmed publisher
    ..only arbovirus known to be consistently transmitted by Anopheles mosquitoes is O'nyong nyong virus (ONNV, genus Alphavirus, family Togaviridae). The interaction of Anopheles mosquitoes with RNA viruses has been relatively unexamined...
  21. Suschak J, BAGLEY K, Six C, Shoemaker C, Kwilas S, Spik K, et al. The genetic adjuvant IL-12 enhances the protective efficacy of a DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular injection in mice. Antiviral Res. 2018;159:113-121 pubmed publisher
    We have previously shown that DNA vaccines expressing codon-optimized alphavirus envelope glycoprotein genes protect both mice and non-human primates from viral challenge when delivered by intramuscular electroporation (IM-EP)...
  22. Ferguson M, Saul S, Fragkoudis R, Weisheit S, Cox J, Patabendige A, et al. Ability of the Encephalitic Arbovirus Semliki Forest Virus To Cross the Blood-Brain Barrier Is Determined by the Charge of the E2 Glycoprotein. J Virol. 2015;89:7536-49 pubmed publisher
    ..Together with studies on Sindbis virus (SINV), this study provides an important advance in understanding alphavirus, and probably other virus, encephalitis.
  23. Wilson J, Prow N, Schroder W, Ellis J, Cumming H, Gearing L, et al. RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation. PLoS Pathog. 2017;13:e1006155 pubmed publisher
    Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease...
  24. Lo Presti A, Lai A, Cella E, Zehender G, Ciccozzi M. Chikungunya virus, epidemiology, clinics and phylogenesis: A review. Asian Pac J Trop Med. 2014;7:925-32 pubmed publisher
    Chikungunya virus is a mosquito-transmitted alphavirus that causes chikungunya fever, a febrile illness associated with severe arthralgia and rash...
  25. Phillips A, Stauft C, Aboellail T, Toth A, Jarvis D, Powers A, et al. Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice. PLoS ONE. 2013;8:e53462 pubmed publisher
    Western equine encephalitis virus (WEEV; Alphavirus) is a mosquito-borne virus that can cause severe encephalitis in humans and equids...
  26. Long K, Ferris M, Whitmore A, Montgomery S, Thurlow L, McGee C, et al. γδ T Cells Play a Protective Role in Chikungunya Virus-Induced Disease. J Virol. 2016;90:433-43 pubmed publisher
    Chikungunya virus (CHIKV) is an alphavirus responsible for causing epidemic outbreaks of polyarthralgia in humans...
  27. Ashbrook A, Lentscher A, Zamora P, Silva L, May N, Bauer J, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016;7: pubmed publisher
    Chikungunya virus (CHIKV) is a reemerging alphavirus that has caused epidemics of fever, arthralgia, and rash worldwide...
  28. Luciani K, Abadía I, Martínez Torres A, Cisneros J, Guerra I, García M, et al. Madariaga virus infection associated with a case of acute disseminated encephalomyelitis. Am J Trop Med Hyg. 2015;92:1130-2 pubmed publisher
    ..a pediatric case of acute disseminated encephalomyelitis (ADEM) associated with Madariaga virus infection (MADV, Alphavirus, Togaviridae; formerly known as South American variants of eastern equine encephalitis virus [EEEV]) in a ..
  29. Varghese F, Rausalu K, Hakanen M, Saul S, Kummerer B, Susi P, et al. Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..In conclusion, obatoclax is a novel inhibitor of endosomal acidification that prevents viral fusion and that could be pursued as a potential broad-spectrum antiviral candidate. ..
  30. Broeckel R, Haese N, Messaoudi I, Streblow D. Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model). Pathogens. 2015;4:662-81 pubmed publisher
    Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. CHIKV is a reemerging Alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints...
  31. Kantor I. [Dengue, Zika and Chikungunya]. Medicina (B Aires). 2016;76:93-7 pubmed
    Arboviruses are transmitted by arthropods, including those responsible for the current pandemic: alphavirus (Chikungunya) and flaviviruses (dengue and Zika). Its importance increased in the Americas over the past 20 years...
  32. Purcell M, Powers R, Evered J, Kerwin J, Meyers T, Stewart B, et al. Molecular testing of adult Pacific salmon and trout (Oncorhynchus spp.) for several RNA viruses demonstrates widespread distribution of piscine orthoreovirus in Alaska and Washington. J Fish Dis. 2017;: pubmed publisher
    ..of these samples for ISAV RNA with three additional published molecular assays, as well as for RNA from salmonid alphavirus (SAV), piscine myocarditis virus (PMCV) and piscine orthoreovirus (PRV)...
  33. Lulla V, Karo Astover L, Rausalu K, Saul S, Merits A, Lulla A. Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase. J Virol. 2018;92: pubmed publisher
    ..b>IMPORTANCE The polyprotein expression strategy is a cornerstone of alphavirus replication...
  34. Ahola T, Karlin D. Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses. Biol Direct. 2015;10:16 pubmed publisher
    Members of the alphavirus supergroup include human pathogens such as chikungunya virus, hepatitis E virus and rubella virus...
  35. Honnold S, Mossel E, Bakken R, Lind C, Cohen J, Eccleston L, et al. Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure. Virol J. 2015;12:154 pubmed publisher
    Eastern equine encephalitis virus (EEEV) is an alphavirus with a case fatality rate estimated to be as high as 75 % in humans and 90 % in horses. Surviving patients often have long-lasting and severe neurological sequelae...
  36. Fox J, Long F, Edeling M, Lin H, van Duijl Richter M, Fong R, et al. Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. Cell. 2015;163:1095-1107 pubmed publisher
    ..Our results suggest that B domain antigenic determinants could be targeted for vaccine or antibody therapeutic development against multiple alphaviruses of global concern. ..
  37. Kulcsar K, Griffin D. T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis. J Neuroimmunol. 2016;295-296:60-7 pubmed publisher
    ..Th17 and Th1/Th17 cells were increased in mice that lacked T cell IL-10 production, although less than in the absence of IL-10. Morbidity and mortality were not affected suggesting an IL-10 threshold for disease exacerbation. ..
  38. Lawrence R, Zook J, Hogue B. Full inactivation of alphaviruses in single particle and crystallized forms. J Virol Methods. 2016;236:237-244 pubmed publisher
    ..We demonstrate the inactivation of Sindbis alphavirus particles in solution, as well as in crystallized form...
  39. Gayen M, Gupta P, Morazzani E, Gaidamakova E, Knollmann Ritschel B, Daly M, et al. Deinococcus Mn2+-peptide complex: A novel approach to alphavirus vaccine development. Vaccine. 2017;35:3672-3681 pubmed publisher
    Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance...
  40. Nogueira M, Nogueira M, Pacca C. Arboviral encephalitis and RNAi treatment. Cent Nerv Syst Agents Med Chem. 2011;11:296-304 pubmed
    ..article is a general overview of the most common viral encephalitides, divided into two families, Flavivirus and Alphavirus, and provides details about virus and RNA interference...
  41. Chen W, Foo S, Taylor A, Lulla A, Merits A, Hueston L, et al. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. J Virol. 2015;89:581-93 pubmed publisher
    ..disease and suggest that inhibition of MCPs with bindarit may be an effective therapy for patients affected with alphavirus-induced bone loss...
  42. Rougeron V, Sam I, Caron M, Nkoghe D, LeRoy E, Roques P. Chikungunya, a paradigm of neglected tropical disease that emerged to be a new health global risk. J Clin Virol. 2015;64:144-52 pubmed publisher
    Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family that causes chronic and incapacitating arthralgia in human populations. Since its discovery in 1952, CHIKV was responsible for sporadic and infrequent outbreaks...
  43. Lopez Jimena B, Lyons P, Herath T, Richards R, Leaver M, Bell J, et al. The effect of dietary n-3/n-6 polyunsaturated fatty acid ratio on salmonid alphavirus subtype 1 (SAV-1) replication in tissues of experimentally infected rainbow trout (Oncorhynchus mykiss). Vet Microbiol. 2015;178:19-30 pubmed publisher
    ..We experimentally infected fish with salmonid alphavirus subtype 1 (SAV-1), the causative agent of SPD...
  44. Wintachai P, Kaur P, Lee R, Ramphan S, Kuadkitkan A, Wikan N, et al. Activity of andrographolide against chikungunya virus infection. Sci Rep. 2015;5:14179 pubmed publisher
    Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world...
  45. Kallio K, Hellström K, Jokitalo E, Ahola T. RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins. J Virol. 2016;90:1687-92 pubmed publisher
    ..Mutants capable of negative-strand synthesis, including those defective in RNA capping, gave rise to spherules. Recruitment of RNA to membranes in the absence of spherule formation was not detected. ..
  46. Varghese F, Kaukinen P, Gläsker S, Bespalov M, Hanski L, Wennerberg K, et al. Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses. Antiviral Res. 2016;126:117-24 pubmed publisher
    Chikungunya virus (CHIKV) is an arthritogenic arbovirus of the Alphavirus genus, which has infected millions of people after its re-emergence in the last decade...
  47. Taylor A, Melton J, Herrero L, Thaa B, Karo Astover L, Gage P, et al. Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus. J Virol. 2016;90:4150-4159 pubmed publisher
    ..Here, we characterized the role of the6kproteins in the arthritogenic alphavirus Ross River virus (RRV) in infected cells and in mice, using a novel6kin-frame deletion mutant...
  48. Blakely P, Huber A, Irani D. Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice. J Neuroinflammation. 2016;13:196 pubmed publisher
    ..Central nervous system (CNS) host responses contribute to alphavirus pathogenesis in experimental models and are logical therapeutic targets...
  49. Røsæg M, Lund M, Nyman I, Markussen T, Aspehaug V, Sindre H, et al. Immunological interactions between Piscine orthoreovirus and Salmonid alphavirus infections in Atlantic salmon. Fish Shellfish Immunol. 2017;64:308-319 pubmed publisher
    ..The respective causative agents, Piscine orthoreovirus (PRV) and Salmonid alphavirus (SAV), are widespread and often concurrently present in farmed salmon...
  50. Ramsey J, Mukhopadhyay S. Disentangling the Frames, the State of Research on the Alphavirus 6K and TF Proteins. Viruses. 2017;9: pubmed publisher
    For 30 years it was thought the alphavirus 6K gene encoded a single 6 kDa protein...
  51. Atieh T, El Ayoubi M, Aubry F, Priet S, de Lamballerie X, Nougairede A. Haiku: New paradigm for the reverse genetics of emerging RNA viruses. PLoS ONE. 2018;13:e0193069 pubmed publisher
    ..procedure was successfully applied to the rescue of a wide range of viruses belonging to genera Flavivirus, Alphavirus and Enterovirus in mosquito or mammalian cells using only standard PCR amplification techniques and starting ..
  52. Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, et al. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-12 pubmed publisher
    ..Here, we identify a naturally occurring alphavirus (M1) as a novel selective killer targeting zinc-finger antiviral protein (ZAP)-deficient cancer cells...
  53. Abdullah A, Olsen C, Hodneland K, Rimstad E. A polyprotein-expressing salmonid alphavirus replicon induces modest protection in atlantic salmon (Salmo salar) against infectious pancreatic necrosis. Viruses. 2015;7:252-67 pubmed publisher
    ..In this study, a heterologous gene expression system, based on a replicon construct of salmonid alphavirus (SAV), was used for in vitro and in vivo expression of IPN virus proteins...
  54. Thaa B, Biasiotto R, Eng K, Neuvonen M, Götte B, Rheinemann L, et al. Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization. J Virol. 2015;89:11420-37 pubmed publisher
    ..We report that this pathway was strongly activated in cells upon infection with the Old World alphavirus Semliki Forest virus (SFV), even under conditions of complete nutrient starvation...
  55. Burrack K, Tan J, McCarthy M, Her Z, Berger J, Ng L, et al. Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells. PLoS Pathog. 2015;11:e1005191 pubmed publisher
    ..Collectively, these data enhance our understanding of the immune response following arthritogenic alphavirus infection and suggest that immunosuppressive myeloid cells may contribute to the duration or severity of these ..
  56. Sakata M, Mori Y. [The life cycle of Rubella Virus]. Uirusu. 2014;64:137-46 pubmed publisher
    ..In this review, the RV life cycle from the virus entry to budding is illustrated in comparison with those of member viruses of the genus alphavirus in the same family. The multiple functions of the RV capsid protein are also introduced.
  57. Utt A, Quirin T, Saul S, Hellström K, Ahola T, Merits A. Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein. PLoS ONE. 2016;11:e0151616 pubmed publisher
    Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people...
  58. Liu X, Tharmarajah K, Taylor A. Ross River virus disease clinical presentation, pathogenesis and current therapeutic strategies. Microbes Infect. 2017;19:496-504 pubmed publisher
    Ross River virus (RRV) is an arthitogenic alphavirus capable of causing outbreaks of debilitating musculoskeletal inflammatory disease in humans...
  59. Prosser S, Xiao H, Li C, Nelson R, Meng B. Subcellular localization and membrane association of the replicase protein of grapevine rupestris stem pitting-associated virus, family Betaflexiviridae. J Gen Virol. 2015;96:921-32 pubmed publisher
    ..ORF1 encodes a putative replicase polyprotein typical of the alphavirus superfamily of positive-strand ssRNA viruses...
  60. Ooi Y, Dubé M, Kielian M. BST2/tetherin inhibition of alphavirus exit. Viruses. 2015;7:2147-67 pubmed publisher
    ..b>Alphavirus release was also inhibited by the endogenous levels of tetherin in HeLa cells...
  61. van Duijl Richter M, Hoornweg T, Rodenhuis Zybert I, Smit J. Early Events in Chikungunya Virus Infection-From Virus Cell Binding to Membrane Fusion. Viruses. 2015;7:3647-74 pubmed publisher
    Chikungunya virus (CHIKV) is a rapidly emerging mosquito-borne alphavirus causing millions of infections in the tropical and subtropical regions of the world...
  62. Porta J, Mangala Prasad V, WANG C, Akahata W, Ng L, Rossmann M. Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell Transmission. J Virol. 2016;90:1169-77 pubmed publisher
    Chikungunya virus is a positive-stranded RNA alphavirus. Structures of chikungunya virus-like particles in complex with strongly neutralizing antibody Fab fragments (8B10 and 5F10) were determined using cryo-electron microscopy and X-ray ..
  63. Stiles K, Kielian M. Role of TSPAN9 in Alphavirus Entry and Early Endosomes. J Virol. 2016;90:4289-97 pubmed publisher
    ..fusion is well studied, we still know relatively little about the host cell proteins that are involved in alphavirus entry. Here we characterized the role of the host membrane protein TSPAN9 in alphavirus infection...
  64. Singh A, Kumar A, Yadav R, Uversky V, Giri R. Deciphering the dark proteome of Chikungunya virus. Sci Rep. 2018;8:5822 pubmed publisher
    Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere...
  65. Martikainen M, Niittykoski M, von und zu Fraunberg M, Immonen A, Koponen S, van Geenen M, et al. MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma. J Virol. 2015;89:10637-47 pubmed publisher
    ..This is the first evidence of orthotopic syngeneic mouse glioma eradication following peripheral alphavirus administration...
  66. Xu C, Evensen Ã, Munang andu H. De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection. BMC Genomics. 2015;16:96 pubmed publisher
    ..salmonids, we used RNA-seq to characterize the transcriptomic changes induced by type I IFN treatment and salmon alphavirus subtype 3 (SAV-3) infection in TO-cells, a macrophage/dendritic like cell-line derived from Atlantic salmon (..
  67. Hellström K, Kallio K, Utt A, Quirin T, Jokitalo E, Merits A, et al. Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template. J Virol. 2017;91: pubmed publisher
    ..We have previously shown that the wild-type alphavirus replicase requires a functional RNA template and active polymerase to generate spherule structures...
  68. Reed D, Glass P, Bakken R, Barth J, Lind C, Da Silva L, et al. Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses. J Virol. 2014;88:12077-86 pubmed publisher
    b>Alphavirus replicons were evaluated as potential vaccine candidates for Venezuelan equine encephalitis virus (VEEV), western equine encephalitis virus (WEEV), or eastern equine encephalitis virus (EEEV) when given individually or in ..
  69. Steel J, Geiss B. A novel system for visualizing alphavirus assembly. J Virol Methods. 2015;222:158-63 pubmed publisher
    ..To help visualize and understand the intracellular assembly of alphavirus virions we have developed a bimolecular fluorescence complementation-based system (BiFC) that allows ..
  70. Das P, Puusepp L, Varghese F, Utt A, Ahola T, Kananovich D, et al. Design and Validation of Novel Chikungunya Virus Protease Inhibitors. Antimicrob Agents Chemother. 2016;60:7382-7395 pubmed
    Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever...
  71. Mutso M, Morro A, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, et al. Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses. 2018;10: pubmed publisher
    ..Similar to CD2AP, its homolog SH3KBP1 also bound the identified motif in CHIKV and SFV nsP3. ..
  72. Lundstrom K. Alphaviruses in gene therapy. Viruses. 2015;7:2321-33 pubmed publisher
    b>Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction...
  73. Jose J, Tang J, Taylor A, Baker T, Kuhn R. Fluorescent Protein-Tagged Sindbis Virus E2 Glycoprotein Allows Single Particle Analysis of Virus Budding from Live Cells. Viruses. 2015;7:6182-99 pubmed publisher
    Sindbis virus (SINV) is an enveloped, mosquito-borne alphavirus. Here we generated and characterized a fluorescent protein-tagged (FP-tagged) SINV and found that the presence of the FP-tag (mCherry) affected glycoprotein transport to the ..
  74. Deeba F, Islam A, Kazim S, Naqvi I, Broor S, Ahmed A, et al. Chikungunya virus: recent advances in epidemiology, host pathogen interaction and vaccine strategies. Pathog Dis. 2016;74: pubmed publisher
    The Chikungunya virus is a re-emerging alphavirus that belongs to the family Togaviridae. The symptoms include fever, rashes, nausea and joint pain that may last for months...
  75. Biacchesi S, Jouvion G, Mérour E, Boukadiri A, Desdouits M, Ozden S, et al. Rainbow trout (Oncorhynchus mykiss) muscle satellite cells are targets of salmonid alphavirus infection. Vet Res. 2016;47:9 pubmed publisher
    ..necrosis and atrophy of red skeletal muscle induced by the sleeping disease virus (SDV), also called salmonid alphavirus 2...
  76. Fox J, Diamond M. Immune-Mediated Protection and Pathogenesis of Chikungunya Virus. J Immunol. 2016;197:4210-4218 pubmed
    Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis...
  77. Agnihothram S, Menachery V, Yount B, Lindesmith L, Scobey T, Whitmore A, et al. Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. J Virol. 2018;92: pubmed publisher
    ..In this work, we report the generation and characterization of an alphavirus replicon vaccine platform based on a non-select agent, attenuated Venezuelan equine encephalitis (VEE) virus ..
  78. Russell J, Campos B, Stone J, Blosser E, Burkett Cadena N, Jacobs J. Unbiased Strain-Typing of Arbovirus Directly from Mosquitoes Using Nanopore Sequencing: A Field-forward Biosurveillance Protocol. Sci Rep. 2018;8:5417 pubmed publisher
    ..metatranscriptome sequencing on the Oxford Nanopore MinION and shown to contain Everglades Virus (EVEV), an alphavirus in the VEEV serocomplex...
  79. Mackenzie Liu D, Sokoloski K, Purdy S, Hardy R. Encapsidated Host Factors in Alphavirus Particles Influence Midgut Infection of Aedes aegypti. Viruses. 2018;10: pubmed publisher
    ..The infectivity of Sindbis virus (SINV), the type species of the Alphavirus genus, is influenced by both the original and new host cell...
  80. Voss K, Amaya M, Mueller C, Roberts B, Kehn Hall K, Bailey C, et al. Inhibition of host extracellular signal-regulated kinase (ERK) activation decreases new world alphavirus multiplication in infected cells. Virology. 2014;468-470:490-503 pubmed publisher
    ..Finally, Ag-126 exerted a broad-spectrum inhibitory effect on New World alphavirus multiplication, thus indicating that the host kinase, ERK, is a broad-spectrum candidate for development of ..
  81. Schulte T, Liu L, Panas M, Thaa B, Dickson N, Götte B, et al. Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication. Open Biol. 2016;6: pubmed publisher
    Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon ..
  82. Agopian A, Quetin M, Castano S. Structure and interaction with lipid membrane models of Semliki Forest virus fusion peptide. Biochim Biophys Acta. 2016;1858:2671-2680 pubmed publisher
    Semliki Forest virus (SFV) is a well-characterized alphavirus that infects cells via endocytosis and an acid-triggered fusion step using class II fusion proteins...
  83. Romeiro M, de Souza W, Tolardo A, Vieira L, Henriques D, de Araujo J, et al. A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses. Arch Virol. 2016;161:3171-7 pubmed publisher
    ..Therefore, the development of methods to enable early diagnosis of infections by alphavirus is essential...
  84. Liu S, Li X, Zhang Y, Gao A, Deng C, Li J, et al. Detection, isolation, and characterization of chikungunya viruses associated with the Pakistan outbreak of 2016-2017. Virol Sin. 2017;32:511-519 pubmed publisher
    The chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus, which has infected millions of people in Africa, Asia, Americas, and Europe since it reemerged in India and Indian Ocean regions in 2005-2006...
  85. Garcia Moreno M, Sanz M, Carrasco L. Initiation codon selection is accomplished by a scanning mechanism without crucial initiation factors in Sindbis virus subgenomic mRNA. RNA. 2015;21:93-112 pubmed publisher
    Translation initiation of alphavirus subgenomic mRNA (sgmRNA) can occur in the absence of several initiation factors (eIFs) in infected cells; however, the precise translation mechanism is still poorly understood...
  86. Schell J, Bahl K, Folta Stogniew E, Rose N, Buonocore L, Marx P, et al. Antigenic requirement for Gag in a vaccine that protects against high-dose mucosal challenge with simian immunodeficiency virus. Virology. 2015;476:405-412 pubmed publisher
    ..regimen employed a prime-boost using vectors based on recombinant vesicular stomatitis virus (VSV) and an alphavirus replicon expressing either SIV Gag or SIV Env...
  87. Luo Y, Li L, Austermann Busch S, Dong M, Xu J, Shao L, et al. Enhanced expression of the Erns protein of classical swine fever virus in yeast and its application in an indirect enzyme-linked immunosorbent assay for antibody differentiation of infected from vaccinated animals. J Virol Methods. 2015;222:22-7 pubmed publisher
    ..the control and eradication of CSF in China, the E2-based marker vaccine rAdV-SFV-E2, an adenovirus-delivered, alphavirus replicon-vectored vaccine, has been developed...
  88. Kulcsar K, Baxter V, Abraham R, Nelson A, Griffin D. Distinct Immune Responses in Resistant and Susceptible Strains of Mice during Neurovirulent Alphavirus Encephalomyelitis. J Virol. 2015;89:8280-91 pubmed publisher
    Susceptibility to alphavirus encephalomyelitis is dependent on a variety of factors, including the genetic background of the host...
  89. Riabov V, Tretyakova I, Alexander R, Pushko P, Klyushnenkova E. Anti-tumor effect of the alphavirus-based virus-like particle vector expressing prostate-specific antigen in a HLA-DR transgenic mouse model of prostate cancer. Vaccine. 2015;33:5386-5395 pubmed publisher
    The goal of this study was to determine if an alphavirus-based vaccine encoding human Prostate-Specific Antigen (PSA) could generate an effective anti-tumor immune response in a stringent mouse model of prostate cancer...
  90. Heidari Z, Tinsley J, Bickerdike R, McLoughlin M, Zou J, Martin S. Antiviral and metabolic gene expression responses to viral infection in Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2015;42:297-305 pubmed publisher
    Salmonid alphavirus (SAV), the aetiological agent of pancreas disease, is recognized as a serious pathogen of farmed Atlantic salmon...
  91. Goo L, Dowd K, Lin T, Mascola J, Graham B, Ledgerwood J, et al. A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus Genotypes. J Infect Dis. 2016;214:1487-1491 pubmed
    Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden. There are 3 CHIKV genotypes: Asian, West African, and Eastern/Central/South African...
  92. Nair S, Poddar S, Shimak R, Diamond M. Interferon Regulatory Factor 1 Protects against Chikungunya Virus-Induced Immunopathology by Restricting Infection in Muscle Cells. J Virol. 2017;91: pubmed publisher
    ..Our studies show that IRF-1 controlled alphavirus replication and swelling in joint-associated tissues within days of infection...