Sesbania mosaic virus

Summary

Alias: sesbania mosaic virus SMV

Top Publications

  1. Satheshkumar P, Lokesh G, Savithri H. Polyprotein processing: cis and trans proteolytic activities of Sesbania mosaic virus serine protease. Virology. 2004;318:429-38 pubmed publisher
    b>Sesbania mosaic virus (SeMV) polyprotein was shown to undergo proteolytic processing when expressed in E. coli...
  2. Roy Chowdhury S, Savithri H. Interaction of Sesbania mosaic virus movement protein with VPg and P10: implication to specificity of genome recognition. PLoS ONE. 2011;6:e15609 pubmed publisher
    b>Sesbania mosaic virus (SeMV) is a single strand positive-sense RNA plant virus that belongs to the genus Sobemovirus. The mechanism of cell-to-cell movement in sobemoviruses has not been well studied...
  3. Chowdhury S, Savithri H. Interaction of Sesbania mosaic virus movement protein with the coat protein--implications for viral spread. FEBS J. 2011;278:257-72 pubmed publisher
    b>Sesbania mosaic virus (SeMV) is a single-stranded positive-sense RNA plant virus belonging to the genus Sobemovirus...
  4. Govind K, Savithri H. Primer-independent initiation of RNA synthesis by SeMV recombinant RNA-dependent RNA polymerase. Virology. 2010;401:280-92 pubmed publisher
    b>Sesbania mosaic virus (SeMV), a single-strand positive-sense RNA plant virus, belongs to the genus Sobemoviruses. Mechanism of replication in Sobemoviruses is poorly understood...
  5. Nair S, Savithri H. Processing of SeMV polyproteins revisited. Virology. 2010;396:106-17 pubmed publisher
    Processing of Sesbania mosaic virus (SeMV) polyprotein 2a and 2ab was reanalyzed in the view of the new genome organization of sobemoviruses. Polyprotein 2a when expressed in E...
  6. Nair S, Gayathri P, Murthy M, Savithri H. Stacking interactions of W271 and H275 of SeMV serine protease with W43 of natively unfolded VPg confer catalytic activity to protease. Virology. 2008;382:83-90 pubmed publisher
    N-terminal serine protease domain of Sesbania mosaic virus polyprotein, requires fused VPg for its activity. W43 of VPg mediates aromatic stacking interactions (characterized by 230 nm positive CD peak) with protease...
  7. Sangita V, Lokesh G, Satheshkumar P, Saravanan V, Vijay C, Savithri H, et al. Structural studies on recombinant T = 3 capsids of Sesbania mosaic virus coat protein mutants. Acta Crystallogr D Biol Crystallogr. 2005;61:1402-5 pubmed publisher
    When expressed in Escherichia coli, the recombinant coat protein (rCP) of Sesbania mosaic virus (SeMV) was shown to self-assemble into T = 3 capsids encapsidating CP mRNA and 23S rRNA derived from the host...
  8. Satheshkumar P, Gayathri P, Prasad K, Savithri H. "Natively unfolded" VPg is essential for Sesbania mosaic virus serine protease activity. J Biol Chem. 2005;280:30291-300 pubmed
    ..In Sesbania mosaic virus, open reading frame-2 codes for a polyprotein that is cleaved into different functional proteins in cis by ..
  9. Lokesh G, Gopinath K, Satheshkumar P, Savithri H. Complete nucleotide sequence of Sesbania mosaic virus: a new virus species of the genus Sobemovirus. Arch Virol. 2001;146:209-23 pubmed
    The complete nucleotide sequence of the Sesbania mosaic virus (SeMV) genomic RNA was determined by sequencing overlapping cDNA clones...

More Information

Publications17

  1. Bakshi A, Sridhar S, Sistla S, Savithri H. Interaction of the intrinsically disordered C-terminal domain of the sesbania mosaic virus RNA-dependent RNA polymerase with the viral protein P10 in vitro: modulation of the oligomeric state and polymerase activity. Arch Virol. 2019;164:971-982 pubmed publisher
    The RNA-dependent RNA polymerase (RdRp) of sesbania mosaic virus (SeMV) was previously shown to interact with the viral protein P10, which led to enhanced polymerase activity...
  2. Vishnu Vardhan G, Hema M, Sushmitha C, Savithri H, Natraj U, Murthy M. Development of sesbania mosaic virus nanoparticles for imaging. Arch Virol. 2019;164:497-507 pubmed publisher
    ..We have carried out bioconjugation of sesbania mosaic virus (SeMV), a well characterized plant virus, with fluorophores using reactive lysine-N-hydroxysuccinimide ..
  3. Matsuura K, Mizuguchi Y, Kimizuka N. Peptide nanospheres self-assembled from a modified β-annulus peptide of Sesbania mosaic virus. Biopolymers. 2016;106:470-5 pubmed publisher
    A novel β-annulus peptide of Sesbania mosaic virus bearing an FKFE sequence at the C terminus was synthesized, and its self-assembling behavior in water was investigated...
  4. Gayathri P, Satheshkumar P, Prasad K, Nair S, Savithri H, Murthy M. Crystal structure of the serine protease domain of Sesbania mosaic virus polyprotein and mutational analysis of residues forming the S1-binding pocket. Virology. 2006;346:440-51 pubmed
    b>Sesbania mosaic virus (SeMV) polyprotein is processed by its N-terminal serine protease domain. The crystal structure of the protease domain was determined to a resolution of 2...
  5. Gulati A, Murthy A, Abraham A, Mohan K, Natraj U, Savithri H, et al. Structural studies on chimeric Sesbania mosaic virus coat protein: Revisiting SeMV assembly. Virology. 2016;489:34-43 pubmed publisher
    The capsid protein (CP) of Sesbania mosaic virus (SeMV, a T=3 plant virus) consists of a disordered N-terminal R-domain and an ordered S-domain. Removal of the R-domain results in the formation of T=1 particles...
  6. Vishnu Vardhan G, Savithri H, Murthy M, Hema M. Biodistribution and toxicity evaluation of sesbania mosaic virus nanoparticles in mice. Arch Virol. 2016;161:2673-81 pubmed publisher
    b>Sesbania mosaic virus (SeMV), a 30-nm spherical plant sobemovirus, is suitable for developing functionalized nanoparticles for biomedical applications...
  7. Nair S, Savithri H. Natively unfolded nucleic acid binding P8 domain of SeMV polyprotein 2a affects the novel ATPase activity of the preceding P10 domain. FEBS Lett. 2010;584:571-6 pubmed publisher
    Open reading frame (ORF) 2a of Sesbania mosaic virus (SeMV) codes for polyprotein 2a (Membrane anchor-protease-VPg-P10-P8)...
  8. Meena C, Borkotoky S, Murali A. Insight into virus encapsulation mechanism through in silico interaction study between coat protein and RNA operator loops of Sesbania mosaic virus. Mol Biosyst. 2016;12:1996-2009 pubmed publisher
    ..b>Sesbania mosaic virus (SeMV) is a spherical virus and its capsid is formed by a coat protein, which contains the Arginine Rich ..