JC virus

Summary

Alias: Human polyomavirus (type JC), JC polyomavirus, JC polyomavirus JCV, Polyomavirus hominis 2, human polyomavirus JCV, polyoma virus JC JCV, polyomavirus JC, JCPyV

Top Publications

  1. Martin J, King D, Slauch J, Frisque R. Differences in regulatory sequences of naturally occurring JC virus variants. J Virol. 1985;53:306-11 pubmed
    The regulatory region was sequenced for DNAs representative of seven independent isolates of JC virus, the probable agent of progressive multifocal leukoencephalopathy...
  2. Frisque R, Bream G, Cannella M. Human polyomavirus JC virus genome. J Virol. 1984;51:458-69 pubmed
    The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented...
  3. Safak M, Gallia G, Ansari S, Khalili K. Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen. J Virol. 1999;73:10146-57 pubmed
    ..We have previously shown that YB-1 modulates transcription from the promoters of the ubiquitous human polyomavirus JC virus (JCV)...
  4. Gee G, Tsomaia N, Mierke D, Atwood W. Modeling a sialic acid binding pocket in the external loops of JC virus VP1. J Biol Chem. 2004;279:49172-6 pubmed
    b>JC virus (JCV) is a common human polyomavirus that infects over 70% of the population worldwide...
  5. Zheng H, Takasaka T, Noda K, Kanazawa A, Mori H, Kabuki T, et al. New sequence polymorphisms in the outer loops of the JC polyomavirus major capsid protein (VP1) possibly associated with progressive multifocal leukoencephalopathy. J Gen Virol. 2005;86:2035-45 pubmed
    b>JC polyomavirus (JCPyV) causes progressive multifocal leukoencephalopathy (PML) in patients with decreased immune competence...
  6. Dang X, Koralnik I. A granule cell neuron-associated JC virus variant has a unique deletion in the VP1 gene. J Gen Virol. 2006;87:2533-7 pubmed
    The human polyomavirus JC (JCV) typically infects glial cells and is the aetiological agent of progressive multifocal leukoencephalopathy (PML), which occurs in immunosuppressed individuals...
  7. Delbue S, Branchetti E, Bertolacci S, Tavazzi E, Marchioni E, Maserati R, et al. JC virus VP1 loop-specific polymorphisms are associated with favorable prognosis for progressive multifocal leukoencephalopathy. J Neurovirol. 2009;15:51-6 pubmed publisher
    b>JC virus (JCV) is a human polyomavirus that causes progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease that mainly affects immunocompromised subjects...
  8. Sunyaev S, Lugovskoy A, Simon K, Gorelik L. Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). PLoS Genet. 2009;5:e1000368 pubmed publisher
    PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals...
  9. Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, et al. The human polyoma JC virus agnoprotein acts as a viroporin. PLoS Pathog. 2010;6:e1000801 pubmed publisher
    ..PML) is a fatal demyelinating disease resulting from lytic infection of oligodendrocytes by the polyomavirus JC virus (JCV)...

More Information

Publications224 found, 100 shown here

  1. Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, et al. Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity. J Infect Dis. 2011;204:103-14 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV) infection of oligodendrocytes, may develop in patients with immune disorders following reactivation of chronic benign infection...
  2. Spatola M, Du Pasquier R. Immune system's role in viral encephalitis. Rev Neurol (Paris). 2014;170:577-83 pubmed publisher
    ..namely human Herpes virus-1 encephalitis with the defect in innate immune response which favors this disease; JC virus-caused progressive multifocal leukoencephalopathy and the crucial role of adaptive immune response in this ..
  3. Bartsch T, Rempe T, Wrede A, Leypoldt F, Brück W, Adams O, et al. Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate. Ann Neurol. 2015;78:501-14 pubmed publisher
    ..MRI showed right hemispheric and brainstem lesions and JC virus DNA was undetectable in his cerebrospinal fluid...
  4. Vargas D, Tyor W. Update on disease-modifying therapies for multiple sclerosis. J Investig Med. 2017;65:883-891 pubmed publisher
    ..However, the high risk of progressive multifocal leukoencephalopathy (PML), which is caused by JC virus infection in the brain, tempers the more widespread use of this agent; nevertheless, JC virus antibody tests have ..
  5. Lima M, Silva M, Afonso L, Vaz B. Post-cART progressive multifocal leukoencephalopathy era in a Brazilian center. J Neurol Sci. 2017;381:321-324 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML) is lytic infection of oligodendrocytes caused by JC virus (JCV)...
  6. Wollebo H, Cotto B, Adiga R, Langford D, White M. Expression of Signaling Molecules in Progressive Multifocal Leukoencephalopathy. Curr HIV Res. 2016;14:47-53 pubmed
    ..is a debilitating demyelinating disease of the CNS caused by the infection and destruction of glial cells by JC virus (JCV) and is an AIDS-defining disease...
  7. Harel A, Horng S, Gustafson T, Ramineni A, Farber R, Fabian M. Successful treatment of progressive multifocal leukoencephalopathy with recombinant interleukin-7 and maraviroc in a patient with idiopathic CD4 lymphocytopenia. J Neurovirol. 2018;24:652-655 pubmed publisher
    ..PML was confirmed through detection of the JC virus by PCR in the cerebrospinal fluid and by brain biopsy, and she was started on mirtazapine and mefloquine...
  8. Ueno T, Sato N, Kon T, Haga R, Nunomura J, Nakamichi K, et al. Progressive multifocal leukoencephalopathy associated with thymoma with immunodeficiency: a case report and literature review. BMC Neurol. 2018;18:37 pubmed publisher
    ..Cerebrospinal fluid real-time polymerase chain reaction for JC virus was positive, showing 6,283,000 copies/mL...
  9. Yakkioui Y, Speel E, van Overbeeke J, Boderie M, Pujari S, Hausen A, et al. Oncogenic Viruses in Skull Base Chordomas. World Neurosurg. 2018;112:e7-e13 pubmed publisher
    ..HHV]- 6, HHV-7, and Kaposi's sarcoma-associated herpesvirus), polyomaviridea (parvovirus B19 [PVB19], BK virus, JC virus, Simian virus 40, Merkel cell polyomavirus, human polyomavirus [HPyV]-6, and HPyV-7), papillomaviridae, and ..
  10. Daniel D, Johnson E. PURA, the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functions. Gene. 2018;643:133-143 pubmed publisher
    ..In the brain Tat and Pura association in glial cells activates transcription and replication of JC polyomavirus, the agent causing the demyelination disease, progressive multifocal leukoencephalopathy...
  11. Qin Q, Shwetank -, Frost E, Maru S, Lukacher A. Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner. J Virol. 2016;90:5187-99 pubmed publisher
    ..Isolates of the human polyomavirus JC virus from patients with the frequently fatal demyelinating brain disease progressive multifocal ..
  12. Bauer J, Gold R, Adams O, Lassmann H. Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS). Acta Neuropathol. 2015;130:751-64 pubmed publisher
    ..We show that PML and PML-IRIS result from predominant JC virus infection of oligodendrocytes and, to a lesser extent, of infected neurons...
  13. Querido S, Weigert A, Adragao T, Henriques J, Birne R, Matias P, et al. Intravenous Immunoglobulin and Rituximab in HLA Highly Sensitized Kidney Transplant Recipients. Transplant Proc. 2018;50:723-727 pubmed publisher
    ..acute rejection, new-onset proteinuria, development of leukopenia, incidence of poliomavirus infection (BK or JC virus), fungal or bacterial infection after KT, de novo neoplasia, graft function, graft loss, or death with ..
  14. Domingues R. Treatment of viral encephalitis. Cent Nerv Syst Agents Med Chem. 2009;9:56-62 pubmed
    ..g. West-Nile virus, and Japanese B virus]. Citomegalovirus and JC virus are examples of infections of the brain that have been seen more frequently because they occur in ..
  15. Watanabe M, Kanda J, Hishizawa M, Kondo T, Yamashita K, Takaori Kondo A. Lymphocyte Area Under the Curve as a Predictive Factor for Viral Infection after Allogenic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2019;25:587-593 pubmed publisher
    ..day 0 to day +30 was calculated in the analysis of other viruses (cytomegalovirus [CMV], adenovirus, BK virus, JC virus, and varicella zoster virus)...
  16. Laukoter S, Rauschka H, Tröscher A, Köck U, Saji E, Jellinger K, et al. Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis. Acta Neuropathol. 2017;133:613-627 pubmed publisher
    ..in the 1980 and the 1990s, progressive multifocal leukoencephalopathy (PML), a viral encephalitis induced by the JC virus, was the leading opportunistic brain infection...
  17. Clavel G, Moulignier A, Semerano L. Progressive multifocal leukoencephalopathy and rheumatoid arthritis treatments. Joint Bone Spine. 2017;84:671-675 pubmed publisher
    ..leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to reactivation of the JC virus (JCV). PML is extremely uncommon despite the high prevalence of the virus in the general population...
  18. Moenster R, Jett R. Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient infected with human immunodeficiency virus. Am J Health Syst Pharm. 2012;69:496-8 pubmed publisher
    ..The results of a lumbar puncture revealed the presence of JC virus, and PML was diagnosed...
  19. Sharma K, Ballham S, Inglis K, Renowden S, Cottrell D. Does natalizumab treatment increase the risk of herpes simplex encephalitis in multiple sclerosis? Case and discussion. Mult Scler Relat Disord. 2013;2:385-7 pubmed publisher
    ..Reactivation of the JC virus causing progressive multifocal leucoencephalopathy (PML) and its association with natalizumab is well documented...
  20. Clifford D, De Luca A, Deluca A, Simpson D, Arendt G, Giovannoni G, et al. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol. 2010;9:438-46 pubmed publisher
    ..Clinical diagnosis by use of MRI and detection of JC virus in the CSF was established in all but one case...
  21. Donadieu J, Lamant M, Fieschi C, de Fontbrune F, Caye A, Ouachee M, et al. Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients. Haematologica. 2018;103:1278-1287 pubmed publisher
    ..leukemia, juvenile myelomonocytic leukemia, fatal progressive multifocal leukoencephalopathy related to the JC virus, and immune/inflammatory diseases...
  22. Boukoum H, Nahdi I, Sahtout W, Skiri H, Segondy M, Aouni M. BK and JC virus infections in healthy patients compared to kidney transplant recipients in Tunisia. Microb Pathog. 2016;97:204-8 pubmed publisher
    The human polyomaviruses BKPyV and JCPyV are members of Polyomaviridae family and after primary infections they persist as latent infection especially in the kidneys...
  23. Guidry J, Scott R. The interaction between human papillomavirus and other viruses. Virus Res. 2017;231:139-147 pubmed publisher
    ..herpes simplex virus (HSV) 1 and 2, human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), BK virus (BKV), JC virus (JCV), and adeno-associated virus (AAV) as viral cofactors in or therapeutic factors against the development of ..
  24. Tsai K, Courtney D, Cullen B. Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. PLoS Pathog. 2018;14:e1006919 pubmed publisher
    ..tumor viruses that includes several pathogenic human members, including Merkel cell polyomavirus, BK virus and JC virus. As is characteristic of DNA tumor viruses, gene expression in polyomaviruses is temporally regulated into an ..
  25. Fernandez Cassi X, Timoneda N, Martínez Puchol S, Rusinol M, Rodriguez Manzano J, Figuerola N, et al. Metagenomics for the study of viruses in urban sewage as a tool for public health surveillance. Sci Total Environ. 2018;618:870-880 pubmed publisher
    ..In experimental infections with sewage in a rhesus macaque model, infective human hepatitis E and JC polyomavirus were identified...
  26. Hegen H, Auer M, Deisenhammer F. Predictors of Response to Multiple Sclerosis Therapeutics in Individual Patients. Drugs. 2016;76:1421-1445 pubmed
    ..interferon (IFN)-? and natalizumab that are associated with abolished drug levels and treatment failure; anti-JC virus (JCV) antibody index that allows risk stratification for the development of progressive multifocal ..
  27. Kamae C, Imai K, Kato T, Okano T, Honma K, Nakagawa N, et al. Clinical and Immunological Characterization of ICF Syndrome in Japan. J Clin Immunol. 2018;38:927-937 pubmed publisher
    ..three patients died of influenza virus, fatal viral infection with persistent Epstein-Barr virus infection, or JC virus infection. One of three dead patients showed normal intelligence with mild facial anomaly...
  28. Rusinol M, Fernandez Cassi X, Timoneda N, Carratala A, Abril J, Silvera C, et al. Evidence of viral dissemination and seasonality in a Mediterranean river catchment: Implications for water pollution management. J Environ Manage. 2015;159:58-67 pubmed publisher
    ..Five viruses were analysed in the study. Human adenovirus (HAdV) and JC polyomavirus (JCPyV) were analysed as indicators of human faecal contamination of human pathogens; both were reported in ..
  29. Day Williams A, Sun C, Jelcic I, McLaughlin H, Harris T, Martin R, et al. Whole Genome Sequencing Reveals a Chromosome 9p Deletion Causing DOCK8 Deficiency in an Adult Diagnosed with Hyper IgE Syndrome Who Developed Progressive Multifocal Leukoencephalopathy. J Clin Immunol. 2015;35:92-6 pubmed publisher
    ..The immune symptoms were attributed to Hyper IgE syndrome (HIES) and the neurological symptoms with presence of JC virus in cerebrospinal fluid were diagnosed as Progressive Multifocal Leukoencephalopathy (PML)...
  30. Nishiyama Fujita Y, Kawana Tachikawa A, Ono T, Tanaka Y, Kato T, Heslop H, et al. Generation of multivirus-specific T cells by a single stimulation of peripheral blood mononuclear cells with a peptide mixture using serum-free medium. Cytotherapy. 2018;20:1182-1190 pubmed publisher
    ..cytomegalovirus [CMV], Epstein-Barr virus [EBV], adenovirus [AdV], human herpesvirus 6 [HHV-6], BK virus [BKV], JC virus [JCV] and Varicella Zoster virus [VZV]) in a single line...
  31. Kurmann R, Weisstanner C, Kardas P, Hirsch H, Wiest R, Lämmle B, et al. Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. J Neurovirol. 2015;21:694-701 pubmed publisher
    ..Laboratory diagnostics included complete blood count and JC virus (JCV) concentration in cerebrospinal fluid (CSF)...
  32. Landi D, de Rossi N, Zagaglia S, Scarpazza C, Prosperini L, Albanese M, et al. No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML. Neurology. 2017;88:1144-1152 pubmed publisher
    ..score, NTZ infusion number, prior immunosuppressant exposure, PML symptoms, PML lesion location at diagnosis, CSF JC virus status and copies, additional PML treatments and steroids, and PML immune reconstitution inflammatory syndrome (..
  33. Machova J, Reischig T. [Cytomegalovirus and polyomavirus infection after renal transplantation]. Vnitr Lek. 2017;63:488-497 pubmed
    ..Key words: BK virus - cytomegalovirus - ganciclovir - immunosuppressive therapy - JC virus - kidney transplantation - polyomavirus - polyomavirus-associated nephropathy - preemptive therapy - prophylaxis -..
  34. Gonzalez S, Escobar Serna D, Suarez O, Benavides X, Escobar Serna J, Lozano E. BK Virus Nephropathy in Kidney Transplantation: An Approach Proposal and Update on Risk Factors, Diagnosis, and Treatment. Transplant Proc. 2015;47:1777-85 pubmed publisher
    ..to Polyomaviridae family; it causes 95% of nephropathy cases related to polyomavirus, with the other 5% caused by JC virus. Nephropathy jeopardizes graft function, causing a premature failure of the graft in 1%-10% of patients with ..
  35. Mateen F, Muralidharan R, Carone M, van de Beek D, Harrison D, Aksamit A, et al. Progressive multifocal leukoencephalopathy in transplant recipients. Ann Neurol. 2011;70:305-22 pubmed publisher
    ..multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction by JC virus. Reports of PML following transplantation were found using PubMed Entrez (1958-July 2010)...
  36. Outteryck O, Zephir H, Salleron J, Ongagna J, Etxeberria A, Collongues N, et al. JC-virus seroconversion in multiple sclerosis patients receiving natalizumab. Mult Scler. 2014;20:822-9 pubmed publisher
    The objectives of this study were to evaluate the rate of JC virus (JCV) seroconversion/seroreversion in a French cohort of multiple sclerosis (MS) patients receiving natalizumab (NTZ), describe the characteristics of this population, ..
  37. Bellaguarda E, Keyashian K, Pekow J, Rubin D, Cohen R, Sakuraba A. Prevalence of Antibodies Against JC Virus in Patients With Refractory Crohn's Disease and Effects of Natalizumab Therapy. Clin Gastroenterol Hepatol. 2015;13:1919-25 pubmed publisher
    ..We assessed the prevalence of and risk factors for antibodies to JC virus in serum of patients with refractory CD who were candidates for, or already were receiving, natalizumab...
  38. Coric P, Saribas A, Abou Gharbia M, Childers W, Condra J, White M, et al. Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein. J Cell Biochem. 2017;118:3268-3280 pubmed publisher
    Agnoprotein is an important regulatory protein of the human polyoma JC virus (JCV) and plays critical roles during the viral replication cycle...
  39. Lagatie O, Van Loy T, Tritsmans L, Stuyver L. Antibodies reacting with JCPyV_VP2 _167-15mer as a novel serological marker for JC polyomavirus infection. Virol J. 2014;11:174 pubmed publisher
    b>JC polyomavirus (JCPyV) is a widespread human polyomavirus that usually resides latently in its host, but can be reactivated under immune-compromised conditions potentially causing Progressive Multifocal Leukoencephalopathy (PML)...
  40. Zerbe C, Marciano B, Katial R, Santos C, Adamo N, Hsu A, et al. Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature. Clin Infect Dis. 2016;62:986-94 pubmed publisher
    ..PML) is a rare, severe, otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically occurs only in immunocompromised patients...
  41. Pato Pato A, Costa Arpín E, Rodríguez Regal A, Rodríguez Constenla I, Cimas Hernando I, Muñoz Pousa I, et al. Progression of a series of patients with relapsing-remitting multiple sclerosis treated for 7 years with natalizumab using the "no evidence of disease activity" parameter. Neurologia. 2018;: pubmed publisher
    ..Fourteen of these patients (56%) dropped out due to the appearance of anti-JC virus antibodies, either in isolation or associated with another cause...
  42. White M, Kaminski R, Khalili K, Wollebo H. Rad51 activates polyomavirus JC early transcription. PLoS ONE. 2014;9:e110122 pubmed publisher
    The human neurotropic polyomavirus JC (JCV) causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML)...
  43. Van Loy T, Thys K, Ryschkewitsch C, Lagatie O, Monaco M, Major E, et al. JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route. J Virol. 2015;89:1340-7 pubmed publisher
    Opportunistic infection of oligodendrocytes by human JC polyomavirus may result in the development of progressive multifocal encephalopathy in immunocompromised individuals...
  44. Peterson L, Ostermann H, Fiegl M, Tischer J, Jaeger G, Rieger C. Reactivation of polyomavirus in the genitourinary tract is significantly associated with severe GvHD and oral mucositis following allogeneic stem cell transplantation. Infection. 2016;44:483-90 pubmed publisher
    ..Severe GvHD and oral mucositis are significantly associated with reactivation of polyomaviridae in the genitourinary-tract already at the level of asymptomatic viruria. ..
  45. Serana F, Chiarini M, Sottini A, Bertoli D, Giustini V, Tessitore M, et al. Immunological biomarkers identifying natalizumab-treated multiple sclerosis patients at risk of progressive multifocal leukoencephalopathy. J Neuroimmunol. 2014;277:6-12 pubmed publisher
    ..to be unleashed by complex interactions between viral and immunological host factors leading the latent form of JC virus to become pathogenic...
  46. Otlu O, De Simone F, Otalora Y, Khalili K, Sariyer I. The agnoprotein of polyomavirus JC is released by infected cells: evidence for its cellular uptake by uninfected neighboring cells. Virology. 2014;468-470:88-95 pubmed publisher
    ..The late leader sequence of JC virus contains an open reading frame encoding a small regulatory protein called agnoprotein...
  47. Lagatie O, Van Loy T, Tritsmans L, Stuyver L. Viral miRNAs in plasma and urine divulge JC polyomavirus infection. Virol J. 2014;11:158 pubmed publisher
    b>JC polyomavirus (JCPyV) is a widespread human polyomavirus that usually resides latently in its host, but can be reactivated under immune-compromised conditions potentially causing Progressive Multifocal Leukoencephalopathy (PML)...
  48. Saida T, Kira J, Kishida S, Yamamura T, Ohtsuka N, Ling Y, et al. Safety and Efficacy of Natalizumab in Japanese Patients with Relapsing-Remitting Multiple Sclerosis: Open-Label Extension Study of a Phase 2 Trial. Neurol Ther. 2017;6:39-55 pubmed publisher
    ..Anti-natalizumab and anti-JC virus (JCV) antibodies were measured...
  49. Jiang Z, Cohen J, Marshall L, Major E. Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures. Antimicrob Agents Chemother. 2010;54:4723-32 pubmed publisher
    b>JC virus (JCV) is a polyomavirus that infects human oligodendrocytes, leading to development of progressive multifocal leukoencephalopathy (PML), an often fatal demyelinating disease occurring in immunocompromised individuals...
  50. Fang C, Tsai Y, Lin M, Wang M, Chen P, Chao C, et al. Inhibition of human bladder cancer growth by a suicide gene delivered by JC polyomavirus virus-like particles in a mouse model. J Urol. 2015;193:2100-6 pubmed publisher
    ..Previous studies demonstrated that human urothelial carcinoma is susceptible to infection by JC polyomavirus. We used JC polyomavirus virus-like particles to deliver genes into human urothelial carcinoma cells for ..
  51. Smolle E, Trojan A, Schuster S, Haybaeck J. Progressive multifocal leukoencephalopathy--a case report and review of the literature. In Vivo. 2014;28:941-8 pubmed
    ..disease of the central nervous system which affects the white matter and is caused by reactivation of the JC polyomavirus. We report the case of a 63-year-old man with chronic lymphocytic leukemia who was treated with fludarabine; ..
  52. Verheyen J, Maizus K, Feist E, Tolman Z, Knops E, Saech J, et al. Increased frequency of JC-polyomavirus detection in rheumatoid arthritis patients treated with multiple biologics. Med Microbiol Immunol. 2015;204:613-8 pubmed publisher
    ..multifocal leukoencephalopathy (PML) represents a rare but potentially fatal reactivation of JC-polyomavirus (JCPyV) recently also reported in patients with autoimmune diseases such as systemic lupus erythematosus and rheumatoid ..
  53. Ryschkewitsch C, Jensen P, Major E. Multiplex qPCR assay for ultra sensitive detection of JCV DNA with simultaneous identification of genotypes that discriminates non-virulent from virulent variants. J Clin Virol. 2013;57:243-8 pubmed publisher
    b>JC virus (JCV) is the etiologic agent for progressive multifocal leukoencephalopathy (PML), a demyelinating disease occurring in the brain of patients with underlying immune compromised states...
  54. Giovannelli I, Ciccone N, Vaggelli G, Malva N, Torricelli F, Rossolini G, et al. Utility of droplet digital PCR for the quantitative detection of polyomavirus JC in clinical samples. J Clin Virol. 2016;82:70-75 pubmed publisher
    Quantitative PCR (qPCR) is the standard molecular method for detection of polyomavirus JC (JCPyV) DNA reactivation in serum and cerebrospinal fluid (CSF) in patients at risk of progressive multifocal leukoencephalopathy (PML)...
  55. Lamba S, Ravichandran V, Major E. Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism. Glia. 2009;57:971-7 pubmed publisher
    ..patient brains affected with progressive multifocal leukoencephalopathy (PML), a demylinating disease caused by JC virus (JCV). The possible involvement of 14-3-3 in JCV tropism, however, has never been examined...
  56. Kondo Y, Windrem M, Zou L, Chandler Militello D, Schanz S, Auvergne R, et al. Human glial chimeric mice reveal astrocytic dependence of JC virus infection. J Clin Invest. 2014;124:5323-36 pubmed publisher
    ..multifocal leukoencephalopathy (PML) is a demyelinating disease triggered by infection with the human gliotropic JC virus (JCV)...
  57. Felli V, Di Sibio A, Anselmi M, Gennarelli A, Sucapane P, Splendiani A, et al. Progressive Multifocal Leukoencephalopathy Following Treatment with Rituximab in an HIV-Negative Patient with Non-Hodgkin Lymphoma. A Case Report and Literature Review. Neuroradiol J. 2014;27:657-64 pubmed publisher
    ..CT and MRI findings were suggestive of PML, and JC virus DNA was detected by polymerase chain reaction assay of the cerebrospinal fluid and serum...
  58. Nelson C, Ströh L, Gee G, O Hara B, Stehle T, Atwood W. Modulation of a pore in the capsid of JC polyomavirus reduces infectivity and prevents exposure of the minor capsid proteins. J Virol. 2015;89:3910-21 pubmed publisher
    b>JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML)...
  59. Alroughani R, Akhtar S, Ahmed S, Khoury S, Al Hashel J, Sahraian M, et al. JC virus seroprevalence and seroconversion in multiple sclerosis cohort: A Middle-Eastern study. J Neurol Sci. 2016;360:61-5 pubmed publisher
    ..Risk of JCV seroconversion was higher than previously reported figures. Observed JCV sero-reversion or pseudo-conversion entail watchful period before embarking on a clinical decision. ..
  60. Pietropaolo V, Bellizzi A, Anzivino E, Iannetta M, Zingaropoli M, Rodio D, et al. Human polyomavirus JC replication and non-coding control region analysis in multiple sclerosis patients under natalizumab treatment. J Neurovirol. 2015;21:653-65 pubmed publisher
    ..has been associated with the occurrence of progressive multifocal leukoencephalopathy (PML) caused by human polyomavirus JC (JCV)...
  61. Soleimani Meigooni D, Schwetye K, Angeles M, Ryschkewitsch C, Major E, Dang X, et al. JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. J Neurovirol. 2017;23:141-146 pubmed publisher
    b>JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia...
  62. Mornese Pinna S, Scarvaglieri E, Milia M, Imperiale D, Ghisetti V, Audagnotto S, et al. Detectable cerebrospinal fluid JCV DNA in late-presenting HIV-positive patients: beyond progressive multifocal leukoencephalopathy?. J Neurovirol. 2017;23:763-767 pubmed publisher
    ..study (2009-2015) describing the outcome of 25 HIV-positive patients with detectable cerebrospinal fluid JC virus DNA: 14 had a probable PML while the others had evidence of other inflammatory central nervous system (CNS) ..
  63. Miyamura T, Furuno A, Yoshiike K. DNA rearrangement in the control region for early transcription in a human polyomavirus JC host range mutant capable of growing in human embryonic kidney cells. J Virol. 1985;54:750-6 pubmed
    A human polyomavirus JC virus (JCV) host range mutant (JC-HEK) can grow in human embryonic kidney cells, whereas the brain cell-tropic wild-type JCV strain (Mad-1) cannot; JC-HEK contains two complementing defective DNAs, JC-HEK-A and JC-..
  64. Lu M, Yin W, Liu S, Koo M, Tung C, Huang K, et al. Increased prevalence of JC polyomavirus viruria was associated with arthritis/arthralgia in patients with systemic lupus erythematosus. Lupus. 2015;24:687-94 pubmed publisher
    ..Both JCV viruria and urine JCV viral load were associated with the occurrence of arthritis/arthralgia in patients with SLE. High urine JCV viral load also was associated with the genetic variant in the VP1 gene. ..
  65. Dang X, Chalkias S, Koralnik I. JC virus-iLOV fluorescent strains enable the detection of early and late viral protein expression. J Virol Methods. 2015;223:25-9 pubmed publisher
    b>JC virus (JCV) is highly prevalent in humans, and may cause progressive multifocal leukoencephalopathy (PML), JCV granule cell neuronopathy (JCV GCN), JCV encephalopathy (JCVE) and JCV meningitis (JCVM) in immunocompromised individuals...
  66. Alstadhaug K, Fykse Halstensen R, Odeh F. Progressive multifocal leukoencephalopathy in a patient with systemic mastocytosis treated with cladribine. J Clin Virol. 2017;88:17-20 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic brain infection caused by the human polyomavirus JC (JCPyV)...
  67. Chao C, Yang Y, Wu M, Chou M, Fang C, Lin M, et al. Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector. Sci Rep. 2018;8:2213 pubmed publisher
    ..The neurotropic JC polyomavirus (JCPyV) infects glial cells and oligodendrocytes and causes fatal progressive multifocal leukoencephalopathy ..
  68. Clifford D. Progressive multifocal leukoencephalopathy therapy. J Neurovirol. 2015;21:632-6 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML) is caused by the JC virus in the setting of chronic immune deficiency...
  69. Wollebo H, Bellizzi A, Kaminski R, Hu W, White M, Khalili K. CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. PLoS ONE. 2015;10:e0136046 pubmed publisher
    ..PML) is a fatal demyelinating disease of the central nervous system (CNS) caused by reactivation of the human polyomavirus JCV gene expression and its replication in oligodendrocytes, the myelin producing cells in the brain...
  70. Warnke C, Wattjes M, Adams O, Hartung H, Martin R, Weber T, et al. [Progressive multifocal leukoencephalopathy]. Nervenarzt. 2016;87:1300-1304 pubmed
    Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV)...
  71. Alroughani R, Akhtar S, Ahmed S, Al Hashel J. A longitudinal study of JC virus serostatus stability among multiple sclerosis patients. Mult Scler Relat Disord. 2018;20:132-135 pubmed publisher
    Anti-JC virus (JCV) antibody testing has been used increasingly to stratify multiple sclerosis (MS) patients into different disease modifying therapies...
  72. Bahr N, Boulware D, Marais S, Scriven J, Wilkinson R, Meintjes G. Central nervous system immune reconstitution inflammatory syndrome. Curr Infect Dis Rep. 2013;15:583-93 pubmed publisher
    ..Common CNS-IRIS events occur in relation to Cryptococcus, tuberculosis (TB), and JC virus, but several other mycobacteria, fungi, and viruses have been associated with IRIS...
  73. Sariyer R, De Simone F, Gordon J, Sariyer I. Immune suppression of JC virus gene expression is mediated by SRSF1. J Neurovirol. 2016;22:597-606 pubmed
    Progressive multifocal leukoemcephalopathy (PML) is a fatal demyelinating disease caused by the human neurotropic JC virus (JCV)...
  74. Auer M, Borena W, Holm von Laer D, Deisenhammer F. Correlation between anti-JC-virus and anti-cytomegalovirus, -Epstein-Barr virus and -measles/-rubella/-varicella-zoster-virus antibodies. J Med Virol. 2017;89:3-9 pubmed publisher
    ..J. Med. Virol. 89:3-9, 2017. © 2016 Wiley Periodicals, Inc. ..
  75. Chao C, Huang Y, Lin M, Fang C, Shen C, Chen P, et al. Inhibition of human diffuse large B-cell lymphoma growth by JC polyomavirus-like particles delivering a suicide gene. J Transl Med. 2015;13:29 pubmed publisher
    ..Human B-lymphocytes are susceptible to JC polyomavirus (JCPyV) infection, and JCPyV virus-like particles (VLPs) can effectively deliver exogenous genes to ..
  76. Dammeier N, Schubert V, Hauser T, Bornemann A, Bischof F. Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate. BMC Neurol. 2015;15:108 pubmed publisher
    Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence...
  77. Simon Santamaria J, Rinaldo C, Kardas P, Li R, Malovic I, Elvevold K, et al. Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta. PLoS ONE. 2014;9:e111762 pubmed publisher
    ..in blood, we studied the fate of virus-like particles (VLPs) of two ubiquitous human DNA viruses, BK and JC polyomavirus, in mice...
  78. Barroso B, Miquel M, Marasescu R, Demasles S, Krim E, Bonnan M. Natalizumab is effective in controlling the inflammatory rebound after its discontinuation and failure of an alternative treatment. Mult Scler Relat Disord. 2015;4:380-2 pubmed publisher
    ..b>JC virus serologic status is a currently established risk factor for PML...
  79. Shin J, Phelan P, Chhum P, Bashkenova N, Yim S, Parker R, et al. Analysis of JC virus DNA replication using a quantitative and high-throughput assay. Virology. 2014;468-470:113-25 pubmed publisher
    Progressive Multifocal Leukoencephalopathy (PML) is caused by lytic replication of JC virus (JCV) in specific cells of the central nervous system...
  80. Chahin S, Berger J. A risk classification for immunosuppressive treatment-associated progressive multifocal leukoencephalopathy. J Neurovirol. 2015;21:623-31 pubmed publisher
    ..leukoencephalopathy (PML) is a rare, complex opportunistic infection of the central nervous system caused by the JC virus. This past decade, PML was increasingly recognized to be associated with the use of immunosuppressive and ..
  81. Pavlovic D, Patel M, Patera A, Peterson I. T cell deficiencies as a common risk factor for drug associated progressive multifocal leukoencephalopathy. Immunobiology. 2018;223:508-517 pubmed publisher
    ..is a disease of the central nervous system caused by neuropathogenic prototypes of ubiquitous community-acquired JC virus (JCV)...
  82. Koolaji S, Allahabadi N, Ahmadi A, Eskandarieh S, Moghadasi A, Azimi A, et al. Anti-JC virus antibody sera positivity and index value among patients with multiple sclerosis may be correlated with age, sex, and area of residence. J Neurovirol. 2018;24:570-576 pubmed publisher
    Anti-JC virus (JCV) antibody index is the predictive factor of progressive multifocal leukoencephalopathy (PML) for multiple sclerosis (MS) patients treating with natalizumab...
  83. Maginnis M, Ströh L, Gee G, O Hara B, Derdowski A, Stehle T, et al. Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding. MBio. 2013;4:e00247-13 pubmed publisher
    The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML)...
  84. Wollebo H, Bellizzi A, Cossari D, Safak M, Khalili K, White M. Epigenetic regulation of polyomavirus JC involves acetylation of specific lysine residues in NF-κB p65. J Neurovirol. 2015;21:679-87 pubmed publisher
    ..multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by neurotropic polyomavirus, JC virus (JCV), a virus that causes lytic infection of CNS glial cells...
  85. Henry C, Jouan F, de Broucker T. JC virus granule cell neuronopathy: A cause of infectious cerebellar degeneration. J Neurol Sci. 2015;354:86-90 pubmed publisher
    b>JC virus (JCV) infection of glial cells can lead to progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. A newly described phenotype of the infection is infection of neurons...
  86. Louthrenoo W. Treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases. Best Pract Res Clin Rheumatol. 2015;29:319-42 pubmed publisher
    ..It also covered the effect of interferon-α, which is used to treat chronic hepatitis infection, and the induction of autoimmunity. ..
  87. Gupta T, Robles M, Schowalter R, Buck C, Pipas J. Expression of the small T antigen of Lymphotropic Papovavirus is sufficient to transform primary mouse embryo fibroblasts. Virology. 2016;487:112-20 pubmed publisher
    ..For instance, the LTs of Simian virus 40 (SV40), BK and/or JC virus can induce transformation; but Merkel Cell Polyomavirus (MCPyV) requires expression of sT...
  88. Wollebo H, Bellizzi A, Cossari D, Salkind J, Safak M, White M. The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol. 2016;22:615-625 pubmed
    ..Brd4 specifically binds to acetylated transcription factor NF-κB p65 and coactivates transcription. Polyomavirus JC (JCV) is regulated by a noncoding control region (NCCR) containing promoter/enhancer elements for viral gene ..
  89. Prezioso C, Scribano D, Rodìo D, Ambrosi C, Trancassini M, Palamara A, et al. COS-7-based model: methodological approach to study John Cunningham virus replication cycle. Virol J. 2018;15:29 pubmed publisher
    ..Importantly, in this study we developed an improved culture system to obtain a large scale production of JC virus in order to study the genetic features, the biology and the pathogenic mechanisms of JC virus that induce PML.
  90. TAN C, Broge T, Ngo L, Gheuens S, Viscidi R, Bord E, et al. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is associated with selective control of JC virus reactivation. Biol Blood Marrow Transplant. 2014;20:992-9 pubmed publisher
    b>JC virus (JCV) causes progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. The mechanism of JCV reactivation and immunity in a transplanted immune system remains unclear...
  91. Basnyat P, Hagman S, Kolasa M, Koivisto K, Verkkoniemi Ahola A, Airas L, et al. Association between soluble L-selectin and anti-JCV antibodies in natalizumab-treated relapsing-remitting MS patients. Mult Scler Relat Disord. 2015;4:334-8 pubmed publisher
    ..The levels of soluble L-selectin (sL-selectin) in sera were measured by ELISA, and the anti-JC Virus (JCV) antibody index was determined by the second-generation ELISA (STRATIFY JCVâ„¢ DxSelectâ„¢) assay...
  92. Raffel J, Gafson A, Malik O, Nicholas R. Anti-JC virus antibody titres increase over time with natalizumab treatment. Mult Scler. 2015;21:1833-8 pubmed publisher
    Anti-JC virus antibody status is a risk factor for progressive multifocal leukoencephalopathy after natalizumab treatment in multiple sclerosis...