Enterobacteria phage P2

Summary

Alias: Bacteriophage P2, phage P2

Top Publications

  1. Hagg rd Ljungquist E, Halling C, Calendar R. DNA sequences of the tail fiber genes of bacteriophage P2: evidence for horizontal transfer of tail fiber genes among unrelated bacteriophages. J Bacteriol. 1992;174:1462-77 pubmed
    We have determined the DNA sequence of the bacteriophage P2 tail genes G and H, which code for polypeptides of 175 and 669 residues, respectively...
  2. Linderoth N, Ziermann R, Hagg rd Ljungquist E, Christie G, Calendar R. Nucleotide sequence of the DNA packaging and capsid synthesis genes of bacteriophage P2. Nucleic Acids Res. 1991;19:7207-14 pubmed
    Overlapping DNA fragments containing the DNA packaging and capsid synthesis gene region of bacteriophage P2 were cloned and sequenced. In this report we present the complete nucleotide sequence of this 6550 bp region...
  3. Christie G, Temple L, Bartlett B, Goodwin T. Programmed translational frameshift in the bacteriophage P2 FETUD tail gene operon. J Bacteriol. 2002;184:6522-31 pubmed
    ..The arrangement of these two genes within the tail gene cluster of phage P2 and their coupling via a translational frameshift appears to be conserved among P2-related phages...
  4. Yu A, Bertani L, Hagg rd Ljungquist E. Control of prophage integration and excision in bacteriophage P2: nucleotide sequences of the int gene and att sites. Gene. 1989;80:1-11 pubmed
    Integration of bacteriophage P2 into the Escherichia coli host genome involves recombination between two specific attachment sites, attP and attB, one on the phage and the other on the host genome, respectively...
  5. Rishovd S, Marvik O, Jacobsen E, Lindqvist B. Bacteriophage P2 and P4 morphogenesis: identification and characterization of the portal protein. Virology. 1994;200:744-51 pubmed publisher
    ..Previous work has demonstrated processing of the major capsid protein. Thus, all essential capsid proteins of P2 and P4 are proteolytically cleaved during the morphogenetic process...
  6. Saha S, Hagg rd Ljungquist E, Nordstr m K. The cox protein of bacteriophage P2 inhibits the formation of the repressor protein and autoregulates the early operon. EMBO J. 1987;6:3191-9 pubmed
    The cox gene is the first gene of the early operon of bacteriophage P2. The early promoter Pe and the repressor promoter Pc are located close to each other and in such a way that their transcripts have opposite polarity and show an ..
  7. Linderoth N, Julien B, Flick K, Calendar R, Christie G. Molecular cloning and characterization of bacteriophage P2 genes R and S involved in tail completion. Virology. 1994;200:347-59 pubmed
    The sequences of two previously known tail genes, R and S, of the temperate bacteriophage P2 and the sequence of an additional open reading frame (orf-30) located between S and V, were determined...
  8. Hagg rd Ljungquist E, Kockum K, Bertani L. DNA sequences of bacteriophage P2 early genes cox and B and their regulatory sites. Mol Gen Genet. 1987;208:52-6 pubmed
    Part of the early operon of the temperate phage P2 of Escherichia coli, including genes cox (involved in prophage excision) and B (required for phage specific DNA synthesis), was sequenced...
  9. Ziermann R, Bartlett B, Calendar R, Christie G. Functions involved in bacteriophage P2-induced host cell lysis and identification of a new tail gene. J Bacteriol. 1994;176:4974-84 pubmed
    Successful completion of the bacteriophage P2 lytic cycle requires phage-induced lysis of its Escherichia coli host, a process that is poorly understood...

More Information

Publications28

  1. Christie G, Calendar R. Bacteriophage P2 late promoters. II. Comparison of the four late promoter sequences. J Mol Biol. 1985;181:373-82 pubmed
    The late genes of bacteriophage P2 are clustered into four transcription units. We have reported the transcription initiation sites for two of the late messenger RNAs, encoding genes QP and ONMLKRS...
  2. Hagg rd Ljungquist E, Jacobsen E, Rishovd S, Six E, Nilssen O, Sunshine M, et al. Bacteriophage P2: genes involved in baseplate assembly. Virology. 1995;213:109-21 pubmed
    The sequences of two previously defined tail genes, V and J, of the temperate bacteriophage P2, and those of two new essential tail genes, W and I, were determined...
  3. Ljungquist E, Kockum K, Bertani L. DNA sequences of the repressor gene and operator region of bacteriophage P2. Proc Natl Acad Sci U S A. 1984;81:3988-92 pubmed
    The nucleotide sequence of the repressor gene C of the temperate phage P2 has been determined. It codes for a nonbasic polypeptide, 99 amino acids long. Twelve repressor-defective mutants have been mapped...
  4. Lemay M, Otto A, Maaß S, Plate K, Becher D, Moineau S. Investigating Lactococcus lactis MG1363 response to phage p2 infection at the proteome level. Mol Cell Proteomics. 2019;: pubmed publisher
    ..proteomics to reveal the proteotypes of Lactococcus lactis MG1363 during infection by the virulent phage p2, a model for studying the biology of phages infecting Gram-positive bacteria...
  5. Buth S, Shneider M, Scholl D, Leiman P. Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers. Viruses. 2018;10: pubmed publisher
    ..Structurally, the R-type pyocins are similar to "simple" contractile tails, such as those of phage P2 and Mu...
  6. Christie G, Calendar R. Bacteriophage P2 late promoters. Transcription initiation sites for two late mRNAs. J Mol Biol. 1983;167:773-90 pubmed
    Divergent transcription of two of the bacteriophage P2 late mRNAs, encoding genes QP and ONMLKRS, is initiated from opposite strands of the DNA in a region near the left end of the P2 genome...
  7. Haggård Ljungquist E, Barreiro V, Calendar R, Kurnit D, Cheng H. The P2 phage old gene: sequence, transcription and translational control. Gene. 1989;85:25-33 pubmed
    The old (overcoming lysogenization defect) gene product of bacteriophage P2 kills Escherichia coli recB and recC mutants and interferes with phage lambda growth [Sironi et al., Virology 46 (1971) 387-396; Lindahl et al., Proc. Natl. Acad...
  8. Six E, Sunshine M, Williams J, Haggård Ljungquist E, Lindqvist B. Morphopoietic switch mutations of bacteriophage P2. Virology. 1991;182:34-46 pubmed
    During the growth of bacteriophage P4, for which the genome of bacteriophage P2 is needed as helper, the decision whether to make large, P2 size, heads or small, P4 size, heads depends on the size-directing function of P4's sid gene and ..
  9. Maxwell K, Fatehi Hassanabad M, Chang T, Paul V, Pirani N, Bona D, et al. Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages. J Bacteriol. 2013;195:5461-8 pubmed publisher
    ..The well-characterized Escherichia coli phage P2 provides an excellent system for studies related to these systems, as its protein composition appears to ..
  10. Birkeland N, Lindquist B. Coliphage P2 late control gene ogr. DNA sequence and product identification. J Mol Biol. 1986;188:487-90 pubmed
    The bacteriophage P2 late control gene ogr was cloned and precisely localized by deletion analysis in vitro. The DNA sequence of the ogr gene containing the ogr1 mutation was determined...
  11. Christie G, Haggård Ljungquist E, Feiwell R, Calendar R. Regulation of bacteriophage P2 late-gene expression: the ogr gene. Proc Natl Acad Sci U S A. 1986;83:3238-42 pubmed
    The ogr gene product of bacteriophage P2 is a positive regulatory factor required for P2 late-gene transcription. We have determined the nucleotide sequence of the ogr gene, which encodes a basic polypeptide of 72 amino acids...
  12. Liu Y, Saha S, Haggård Ljungquist E. Studies of bacteriophage P2 DNA replication. The DNA sequence of the cis-acting gene A and ori region and construction of a P2 mini-chromosome. J Mol Biol. 1993;231:361-74 pubmed
    A self-replicating plasmid was constructed from the 76.7 to 91.6% region of bacteriophage P2, which contains the P2 origin or replication (ori) and the genetically defined replication genes B and A. The sequence of the 76.7 to 80...
  13. Doan D, Dokland T. The gpQ portal protein of bacteriophage P2 forms dodecameric connectors in crystals. J Struct Biol. 2007;157:432-6 pubmed
    ..The gpQ connector protein from bacteriophage P2 has been overexpressed in Escherichia coli and purified by sucrose gradient centrifugation...
  14. Skaar K, Claesson M, Odegrip R, Högbom M, Haggård Ljungquist E, Stenmark P. Crystal structure of the bacteriophage P2 integrase catalytic domain. FEBS Lett. 2015;589:3556-63 pubmed publisher
    b>Bacteriophage P2 is a temperate phage capable of integrating its DNA into the host genome by site-specific recombination upon lysogenization...
  15. Frykholm K, Berntsson R, Claesson M, de Battice L, Odegrip R, Stenmark P, et al. DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels. Nucleic Acids Res. 2016;44:7219-27 pubmed publisher
    The Cox protein from bacteriophage P2 forms oligomeric filaments and it has been proposed that DNA can be wound up around these filaments, similar to how histones condense DNA...
  16. Roszniowski B, Latka A, Maciejewska B, Vandenheuvel D, Olszak T, Briers Y, et al. The temperate Burkholderia phage AP3 of the Peduovirinae shows efficient antimicrobial activity against B. cenocepacia of the IIIA lineage. Appl Microbiol Biotechnol. 2017;101:1203-1216 pubmed publisher
    ..holin, endolysin, and spanins) and shows 29-98 % homology between specific lysis genes, in contrast to Enterobacteria phage P2, the hallmark phage of this genus...
  17. Lemay M, Tremblay D, Moineau S. Genome Engineering of Virulent Lactococcal Phages Using CRISPR-Cas9. ACS Synth Biol. 2017;6:1351-1358 pubmed publisher
    ..The lactococcal phage p2 is one of the best-studied models for these virulent phages...
  18. Temple L, Forsburg S, Calendar R, Christie G. Nucleotide sequence of the genes encoding the major tail sheath and tail tube proteins of bacteriophage P2. Virology. 1991;181:353-8 pubmed
    The major structural components of the contractile tail of bacteriophage P2 are proteins FI and FII, which are believed to be the tail sheath and tube proteins, respectively...
  19. Chang J, Spilman M, Dokland T. Assembly of bacteriophage P2 capsids from capsid protein fused to internal scaffolding protein. Virus Genes. 2010;40:298-306 pubmed publisher
    ..The gpO scaffolding protein of bacteriophage P2 also doubles as a maturation protease, while the scaffolding activity is confined to a 90 residue C-terminal &..