Simian immunodeficiency virus

Summary

Alias: Chimpanzee immunodeficiency virus, Chimpanzee immunodeficiency virus (SIV(CPZ)), Simian immunodeficiency virus SIVcpz, simian immunodeficiency virus SIV, simian immunodeficiency virus, SIV, simian immunodeficiency viruses SIV, CIV, SIV

Top Publications

  1. Sharova N, Wu Y, Zhu X, Stranska R, Kaushik R, Sharkey M, et al. Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. PLoS Pathog. 2008;4:e1000057 pubmed publisher
    ..We present evidence that the Vpx proteins of HIV-2/SIV(SM) promote virus infection by antagonizing an antiviral restriction in macrophages...
  2. Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, et al. Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. J Virol. 2008;82:12335-45 pubmed publisher
    Human immunodeficiency virus type 2 (HIV-2)/simian immunodeficiency virus SIV(SM) Vpx is incorporated into virion particles and is thus present during the early steps of infection, when it has been reported to influence the nuclear ..
  3. Jia B, Serra Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana I, et al. Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog. 2009;5:e1000429 pubmed publisher
    ..Since lentiviruses of the SIV(smm/mac)/HIV-2 lineage do not have a vpu gene, this activity has likely been assumed by other viral gene products...
  4. Zhang F, Landford W, Ng M, McNatt M, Bieniasz P, Hatziioannou T. SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release. PLoS Pathog. 2011;7:e1002039 pubmed publisher
    ..Accordingly, depletion of AP-2 using RNA interference impairs the ability of Nef to antagonize Tetherin, demonstrating that AP-2 recruitment is required for Nef proteins to counteract this antiviral protein. ..
  5. Breed M, Jordan A, Aye P, Lichtveld C, Midkiff C, Schiro F, et al. Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression. J Virol. 2013;87:1528-43 pubmed publisher
    A hallmark of pathogenic simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections is the rapid and near-complete depletion of mucosal CD4(+) T lymphocytes from the gastrointestinal tract...
  6. Delucia M, Mehrens J, Wu Y, Ahn J. HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation. J Biol Chem. 2013;288:19116-26 pubmed publisher
    ..HIV-2 and simian immunodeficiency virus (SIV) counteract this restriction via a virion-associated virulence accessory factor, Vpx (Vpr in some ..
  7. Chen B, Vogan E, Gong H, Skehel J, Wiley D, Harrison S. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature. 2005;433:834-41 pubmed
    Envelope glycoproteins of human and simian immunodeficiency virus (HIV and SIV) undergo a series of conformational changes when they interact with receptor (CD4) and co-receptor on the surface of a potential host cell, leading ultimately ..
  8. Brenner M, Munch J, Schindler M, Wildum S, Stolte N, Stahl Hennig C, et al. Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. J Virol. 2006;80:4469-81 pubmed
    ..developed moderate to high viral loads and developed disease, whereas the remaining animals efficiently controlled SIV replication and showed a more attenuated clinical course of infection...
  9. Takeuchi H, Buckler White A, Goila Gaur R, Miyagi E, Khan M, Opi S, et al. Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells. J Virol. 2007;81:8080-90 pubmed
    ..We now report a novel function of African green monkey simian immunodeficiency virus (SIVagm) Vif that promotes replication of SIVagm in human cells lacking detectable deaminase activity...

More Information

Publications259 found, 100 shown here

  1. Srivastava S, Swanson S, Manel N, Florens L, Washburn M, Skowronski J. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog. 2008;4:e1000059 pubmed publisher
  2. Sigalov A, Kim W, Saline M, Stern L. The intrinsically disordered cytoplasmic domain of the T cell receptor zeta chain binds to the nef protein of simian immunodeficiency virus without a disorder-to-order transition. Biochemistry. 2008;47:12942-4 pubmed publisher
    ..binding of the intrinsically disordered T cell receptor zeta cytoplasmic tail to the well-folded simian immunodeficiency virus Nef core domain is accompanied by a disorder-to-order transition...
  3. Schüle S, Kloke B, Kaiser J, Heidmeier S, Panitz S, Wolfrum N, et al. Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj. PLoS ONE. 2009;4:e7098 pubmed publisher
    ..In contrast, efficient single round transduction of monocytes is mediated by vectors derived from simian immunodeficiency virus of sooty mangabeys (SIVsmmPBj), depending on the presence of the viral accessory protein Vpx.
  4. Berger A, Munk C, Schweizer M, Cichutek K, Schüle S, Flory E. Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. J Biol Chem. 2010;285:12248-54 pubmed publisher
    ..A single-point mutation in Vpx (H82A) abrogated binding to A3A and single-round infection of monocytes by HIV-1. Taken together, our data indicate that lentiviral Vpx counteracts A3A in human monocytes. ..
  5. Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable Bessia C, Segeral E, et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 2011;474:654-7 pubmed publisher
    ..Our results demonstrate that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle...
  6. Pertel T, Reinhard C, Luban J. Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon. Retrovirology. 2011;8:49 pubmed publisher
    ..Vpx provides a tool for the characterization of a potent, new HIV-1 restriction activity, which acts in the nucleus of type 1 IFN-treated dendritic cells. ..
  7. Hrecka K, Hao C, Gierszewska M, Swanson S, Kesik Brodacka M, Srivastava S, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature. 2011;474:658-61 pubmed publisher
  8. Ahn J, Hao C, Yan J, Delucia M, Mehrens J, Wang C, et al. HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1. J Biol Chem. 2012;287:12550-8 pubmed publisher
    ..SAMHD1) inhibits infection of myeloid cells by human and related primate immunodeficiency viruses (HIV and SIV)...
  9. Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, et al. A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest. Cell Microbiol. 2012;14:1745-56 pubmed publisher
    HIV-2 and closely related SIV Vpx proteins are essential for viral replication in macrophages and dendritic cells. Vpx hijacks DCAF1-DDB1-Cul4 E3 ubiquitin ligase to promote viral replication...
  10. Guo H, Wei W, Wei Z, Liu X, Evans S, Yang W, et al. Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation. PLoS ONE. 2013;8:e66201 pubmed publisher
    ..infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV)...
  11. Bissa M, Forlani G, Zanotto C, Tosi G, De Giuli Morghen C, Accolla R, et al. Fowlpoxvirus recombinants coding for the CIITA gene increase the expression of endogenous MHC-II and Fowlpox Gag/Pro and Env SIV transgenes. PLoS ONE. 2018;13:e0190869 pubmed publisher
    ..Here, we report on construction of novel FPgp and FPenv recombinants that express the highly immunogenic SIV Gag-pro and Env structural antigens...
  12. Muthusamy S, Dalal M, Chinnusamy V, Bansal K. Genome-wide identification and analysis of biotic and abiotic stress regulation of small heat shock protein (HSP20) family genes in bread wheat. J Plant Physiol. 2017;211:100-113 pubmed publisher
    ..4-CI, TaHSP17.7A-CI, TaHSP19.1-CIII, TaACD20.0B-CII and TaACD20.6C-CIV, while TaHSP23.7-MTI was specifically induced only under heat stress...
  13. Zhang M, Xie Z, Xie L, Deng X, Xie Z, Luo S, et al. Simultaneous detection of eight swine reproductive and respiratory pathogens using a novel GeXP analyser-based multiplex PCR assay. J Virol Methods. 2015;224:9-15 pubmed publisher
    ..syndrome virus (PRRSV-NA), classical swine fever virus (CSFV), porcine circovirus 2 (PCV-2), swine influenza virus (SIV) (including H1 and H3 subtypes), porcine parvovirus (PPV), pseudorabies virus (PRV) and Japanese encephalitis virus ..
  14. Wang Q, Dai X, Yang W, Wang H, Zhao H, Yang F, et al. Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells. Int Immunopharmacol. 2015;25:340-52 pubmed publisher
    ..hyaluronic acid (HA), laminin (LN), N-terminal peptide of type III procollagen (PIIINP) and type IV collagen (CIV). Then liver tissues were obtained for hematoxylin-eosin staining and Sirius-red staining...
  15. Fan H, Chen N, Shen W, Zhao X, Zhang J. Endogenous hydrogen sulfide is associated with angiotensin II type 1 receptor in a rat model of carbon tetrachloride-induced hepatic fibrosis. Mol Med Rep. 2015;12:3351-3358 pubmed publisher
    ..The serum levels of hyaluronidase (HA), laminin protein (LN), procollagen III (PcIII), and collagen IV (cIV) were detected using ELISA...
  16. Novosel D, Cadar D, Tuboly T, Jungić A, Stadejek T, Ait Ali T, et al. Investigating porcine parvoviruses genogroup 2 infection using in situ polymerase chain reaction. BMC Vet Res. 2018;14:163 pubmed publisher
    ..class II DQ (SLAIIDQ), lysozyme, porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza (SIV), Mycoplasma hyopneumoniae (Mhyo); and by in situ hybridization (ISH) to detect ssDNA and dsDNA of PCV2...
  17. Zhang P, Li H, Cheng J, Sun A, Wang L, Mirchevska G, et al. Respiratory stress in mitochondrial electron transport chain complex mutants of Candida albicans activates Snf1 kinase response. Fungal Genet Biol. 2018;111:73-84 pubmed publisher
    ..In comparison, over the same time period, electron transport complex mutants (CI, CIII and CIV) have heightened activities in both oxygen consumption and glycolysis upon glucose uptake...
  18. Sappal R, Fast M, Purcell S, MacDonald N, Stevens D, Kibenge F, et al. Copper and hypoxia modulate transcriptional and mitochondrial functional-biochemical responses in warm acclimated rainbow trout (Oncorhynchus mykiss). Environ Pollut. 2016;211:291-306 pubmed publisher
    ..Activities of ETS enzyme complexes I-IV (CI-CIV) were measured in liver and gill mitochondria...
  19. Wren M, Caskey J, Liu D, Embers M. Septic arthritis due to moraxella osloensis in a rhesus macaque (Macaca mulatta). Comp Med. 2013;63:521-7 pubmed
    ..The primate had been group-reared in an SPF breeding colony and was seronegative for Macacine herpesvirus 1, SIV, simian retrovirus type D, and simian T-lymphotropic virus...
  20. Jiménez L, Ramírez Nieto G, Alfonso V, Correa J. Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia. Virol Sin. 2014;29:242-9 pubmed publisher
    ..and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinobacillus pleuropneumoniae (APP), Pasteurella multocida and Porcine ..
  21. Periyasamy P, Thangaraj A, Guo M, Hu G, Callen S, Buch S. Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci. 2018;38:5367-5383 pubmed publisher
    ..i>In vitro findings were also confirmed in the basal ganglia of SIV-infected rhesus macaques (both sexes)...
  22. Keating S, Heitman J, Wu S, Deng X, Stacey A, Zahn R, et al. Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates. J Virol. 2016;90:10339-10350 pubmed publisher
    ..Here we studied progressive and nonprogressive simian immunodeficiency virus (SIV) infection models in both natural and nonnatural host NHP species...
  23. She X, Zhang P, Gao Y, Zhang L, Wang Q, Chen H, et al. A mitochondrial proteomics view of complex I deficiency in Candida albicans. Mitochondrion. 2018;38:48-57 pubmed publisher
    ..subunit proteins as well as phospholipid, ergosterol and cell wall mannan synthesis, and up-regulated proteins in CIV and the alternative oxidase (AOX2)...
  24. Minang J, Trivett M, Coren L, Barsov E, Piatak M, Ott D, et al. Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responses. Virology. 2009;391:130-9 pubmed publisher
    CD8(+) T lymphocytes (CTL) play a role in controlling HIV/SIV infection...
  25. Shingai M, Donau O, Plishka R, Buckler White A, Mascola J, Nabel G, et al. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med. 2014;211:2061-74 pubmed publisher
    ..the plasma neutralization titers, which must be present at the time of exposure, to prevent acquisition of SIV/HIV chimeric virus (SHIV) infections...
  26. Mir K, Mavigner M, Wang C, Paiardini M, Sodora D, Chahroudi A, et al. Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors. J Virol. 2015;89:10136-44 pubmed publisher
    Macrophages are target cells of HIV/SIV infection that may play a role in AIDS pathogenesis and contribute to the long-lived reservoir of latently infected cells during antiretroviral therapy (ART)...
  27. Vujkovic Cvijin I, Swainson L, Chu S, Ortiz A, Santee C, Petriello A, et al. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Rep. 2015;13:1589-97 pubmed publisher
    ..A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the ..
  28. Rahmberg A, Rajakumar P, Billingsley J, Johnson R. Dynamic Modulation of Expression of Lentiviral Restriction Factors in Primary CD4+ T Cells following Simian Immunodeficiency Virus Infection. J Virol. 2017;91: pubmed publisher
    ..HIV and simian immunodeficiency virus (SIV) target CD4+ T cells...
  29. Marno K, O Sullivan E, Jones C, Díaz Delfín J, Pardieu C, Sloan R, et al. RNA-Associated Early-Stage Antiviral Factor Is a Major Component of Lv2 Restriction. J Virol. 2017;91: pubmed publisher
    Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication in human cells is restricted at early postentry steps by host inhibitory factors...
  30. Veazey R, Ling B. Short Communication: Comparative Susceptibility of Rhesus Macaques of Indian and Chinese Origin to Vaginal Simian-Human Immunodeficiency Virus Transmission as Models for HIV Prevention Research. AIDS Res Hum Retroviruses. 2017;33:1199-1201 pubmed publisher
    Historically, Indian rhesus macaques (iRMs) have been preferred for simian immunodeficiency virus (SIV)/HIV prevention, pathogenesis, and treatment studies, yet their supply is limited...
  31. Thitilertdecha P, Suwannachod P, Poungpairoj P, Tantithavorn V, Khowawisetsut L, Ammaranond P, et al. A closed-culture system using a GMP-grade culture bag and anti-CD3/28 coated bead stimulation for CD4+ T cell expansion from healthy and HIV-infected donors. J Immunol Methods. 2018;460:17-25 pubmed publisher
    ..Transfusion of anti-CD3/28 expanded CD4+ T cells is also proved to be safe and effective in both SIV-infected macaques and HIV-infected patients...
  32. Bowder D, Hollingsead H, Durst K, Hu D, Wei W, Wiggins J, et al. Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses. Virology. 2018;521:158-168 pubmed publisher
    ..patch (amino acid residues 307, 309 and 317) contributes to gp120-trimer association in HIV-1 subtype C, HIV-2 and SIV. Changes that reduced the hydrophobicity of these V3 residues resulted in increased gp120 shedding and decreased ..
  33. Schreiber Stainthorp W, Sinharay S, Srinivasula S, Shah S, Wang J, Dodd L, et al. Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation. J Neuroinflammation. 2018;15:207 pubmed publisher
    ..Our study investigates how treatment initiation and interruption alter brain glucose metabolism in SIV-infected macaques, using 18F-FDG PET in correlation with plasma and CSF viral loads (VL) and cytokine ..
  34. Maloveste S, Chen D, Gostick E, Vivian J, Plishka R, Iyengar R, et al. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. J Immunol. 2012;189:4338-48 pubmed publisher
    ..In HIV infection, survival is linked to host KIR and MHC-I genotypes. In the SIV macaque model, however, the role of NK cells is unclear due to the lack of information on KIR-MHC interactions...
  35. Miles L, Greiner H, Mangano F, Horn P, Leach J, Miles M. Cytochrome c oxidase deficit is associated with the seizure onset zone in young patients with focal cortical dysplasia Type II. Metab Brain Dis. 2015;30:1151-60 pubmed publisher
    ..The current study tests the hypothesis that mitochondrial Complex IV (CIV) or cytochrome c oxidase dysfunction is associated with the seizure onset zone (SOZ) in patients with focal ..
  36. Barouch D, Alter G, Broge T, Linde C, Ackerman M, Brown E, et al. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. 2015;349:320-4 pubmed publisher
    ..These data demonstrate robust protection by Ad/Env vaccines against acquisition of neutralization-resistant virus challenges in rhesus monkeys. ..
  37. Demberg T, Mohanram V, Musich T, Brocca Cofano E, McKinnon K, Venzon D, et al. Loss of marginal zone B-cells in SHIVSF162P4 challenged rhesus macaques despite control of viremia to low or undetectable levels in chronic infection. Virology. 2015;484:323-33 pubmed publisher
    ..They have been identified in cynomolgus monkeys and monitored during acute SIV infection, yet have not been well-studied in rhesus macaques...
  38. Beswick J. DEVO-(WO) MAN? A MOVE IN RESPECT OF PERSONAL SOVEREIGNTY AND DECISION-MAKING IN HEALTH CARE? Anita Border v Lewisham and Greenwich NHS Trust [2015] EWCA Civ 8. Med Law Rev. 2015;23:683-93 pubmed publisher
    ..It concludes by examining the possibility that the courts in England and Wales might be entering an era of judicial assertiveness in the regulation of clinical practice. ..
  39. Lu X, Li Z, Li Q, Jiao Y, Ji Y, Zhang H, et al. Preferential loss of gut-homing ?4?7 CD4+ T cells and their circulating functional subsets in acute HIV-1 infection. Cell Mol Immunol. 2016;13:776-784 pubmed publisher
    ..infection and depletion of gut-homing ?4?7 CD4+ T cells in the blood are observed in chronic HIV/SIV infection...
  40. Beck S, Queen S, Viscidi R, Johnson D, Kent S, Adams R, et al. Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control. J Neurovirol. 2016;22:498-507 pubmed publisher
    ..Using a simian immunodeficiency virus (SIV)/macaque model, we examined CNS outcomes in pigtailed macaques expressing the MHC class I allele ..
  41. Deléage C, Turkbey B, Estes J. Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence. Curr Opin Virol. 2016;19:77-84 pubmed publisher
    ..research has provided a vital bridge between basic and preclinical research and clinical studies, with experimental SIV infection of NHP models offering unique opportunities to understand key processes of HIV-1 infection and disease ..
  42. Ploquin M, Madec Y, Casrouge A, Huot N, Passaes C, Lécuroux C, et al. Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset. PLoS Pathog. 2016;12:e1005774 pubmed publisher
    ..IP-10 was increased in SIV-exposed aviremic macaques with detectable SIV DNA in tissues...
  43. Byrareddy S, Arthos J, Cicala C, Villinger F, Ortiz K, Little D, et al. Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy. Science. 2016;354:197-202 pubmed
    ..drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn...
  44. Orrico Sanchez A, Lopez Lacort M, Pérez Vilar S, Diez Domingo J. Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain. BMC Infect Dis. 2017;17:267 pubmed publisher
    ..ecological study using the hospital discharge registry's Minimum Basic Data Set (MBDS) and the vaccine register (SIV) was performed, among Valencia Region's children <5 years old, during 2002 - 2015...
  45. Jiang G, Santos Rocha C, Hirao L, Mendes E, Tang Y, Thompson G, et al. HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. MBio. 2017;8: pubmed publisher
    ..infection and viral evasion by utilizing human CD4+ T cell cultures in vitro and a simian immunodeficiency virus (SIV) model of AIDS in vivo Our data showed that early host innate defense against the viral ..
  46. Krimmling T, Schwegmann Weßels C. Comparison of mono- and co-infection by swine influenza A viruses and porcine respiratory coronavirus in porcine precision-cut lung slices. Res Vet Sci. 2017;115:470-477 pubmed publisher
    ..This is in accordance with in vivo experiments, revealing cell innate immune answers to both PRCoV and SIV that are able to restrict the virulence and pathogenicity of the viruses.
  47. Liu Y, Li H, Xue Y, Zhao S, Li C, Qu L, et al. Characterization of Monoclonal Antibodies against HA Protein of H1N1 Swine Influenza Virus and Protective Efficacy against H1 Viruses in Mice. Viruses. 2017;9: pubmed publisher
    H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats...
  48. Paparisto E, Woods M, Coleman M, Moghadasi S, Kochar D, Tom S, et al. Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. J Virol. 2018;92: pubmed publisher
    ..Notably, coelacanth HERC5 inhibited simian immunodeficiency virus (SIV), but not HIV-1, particle production, suggesting that the antiviral activity of HERC5 emerged ..
  49. Li G, Wang R, Zhang C, Wang S, He W, Zhang J, et al. Genetic and evolutionary analysis of emerging H3N2 canine influenza virus. Emerg Microbes Infect. 2018;7:73 pubmed publisher
    The H3N2 canine influenza virus (CIV) originated from an avian species...
  50. Gama L, Abreu C, Shirk E, Queen S, Beck S, Metcalf Pate K, et al. SIV Latency in Macrophages in the CNS. Curr Top Microbiol Immunol. 2018;417:111-130 pubmed publisher
    ..HIV and SIV are lentiviruses that infect CD4+ lymphocytes in addition to myeloid cells in blood and tissues...
  51. Al Hakim R, Kaufman J, Farsad K. Iliac Vein Stent Placement: Acute Venographic Changes and Relevance to Venous Biomechanics. J Vasc Interv Radiol. 2018;29:1023-1027 pubmed publisher
    To describe acute venographic changes of external iliac vein (EIV) after ipsilateral common iliac vein (CIV) stent placement. Retrospective review was performed of 17 cases with placement of a single CIV stent...
  52. Luo J, Lu G, Ye S, Ou J, Fu C, Zhang X, et al. Comparative pathogenesis of H3N2 canine influenza virus in beagle dogs challenged by intranasal and intratracheal inoculation. Virus Res. 2018;255:147-153 pubmed publisher
    ..However, knowledge regarding H3N2 canine influenza virus (CIV) pathogenicity is not comprehensive, which directly affects the animal models of pathogenicity in H3N2 CIV vaccine ..
  53. Leitner M, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, et al. A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. Cell Mol Life Sci. 2018;75:4235-4250 pubmed publisher
    ..of VSPs and studied phosphatase activity in living cells utilizing engineered, voltage switchable PTENCiV, a Ci-VSP/PTEN chimera that retains D3 site activity of the native enzyme...
  54. Murphey Corb M, Rajakumar P, Michael H, Nyaundi J, Didier P, Reeve A, et al. Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo. Antimicrob Agents Chemother. 2012;56:4707-12 pubmed publisher
    ..In this report, we describe the response of a primary isolate of simian immunodeficiency virus (SIV) to 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) both in vitro and in vivo...
  55. Swaminathan S, Hu X, Zheng X, Kriga Y, Shetty J, Zhao Y, et al. Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties. Biochem Biophys Res Commun. 2013;434:228-34 pubmed publisher
    ..We have previously demonstrated that IL-27 induces potent anti-viral effects against HIV-1, HIV-2, SIV, HSV-2, KSHV and influenza viruses in macrophages...
  56. Wu F, Kirmaier A, White E, Ourmanov I, Whitted S, Matsuda K, et al. TRIM5? Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains. J Virol. 2016;90:11087-11095 pubmed
    TRIM5? polymorphism limits and complicates the use of simian immunodeficiency virus (SIV) for evaluation of human immunodeficiency virus (HIV) vaccine strategies in rhesus macaques...
  57. Pahar B, Kenway Lynch C, Marx P, Srivastav S, Labranche C, Montefiori D, et al. Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. Virol J. 2016;13:200 pubmed
    ..We therefore explored the role of antigen-specific immune responses in controlling plasma viremia in SIV infected rhesus macaques...
  58. Brown E, Weiner J, Lin S, Natarajan H, Normandin E, Barouch D, et al. Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1/SIV. J Immunol Methods. 2018;455:24-33 pubmed publisher
    ..Assay conditions were optimized for performance and reproducibility, and the final version of the assay was then evaluated for specificity, accuracy, precision, limits of detection and quantitation, linearity, range and robustness. ..
  59. McNamara R, Costantini L, Myers T, Schouest B, Maness N, Griffith J, et al. Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses. MBio. 2018;9: pubmed publisher
    ..The negative regulatory factor (Nef) encoded by simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) plays a critical role in the progression to AIDS and ..
  60. Cai M, Huang J, Bu D, Yu Z, Fu X, Ji C, et al. Molecular evolution of H1N1 swine influenza in Guangdong, China, 2016-2017. Infect Genet Evol. 2018;60:103-108 pubmed publisher
    Swine are the main host of the H1N1 swine influenza virus (SIV), however, H1N1 can also infect humans and occasionally cause serious respiratory disease...
  61. Ohmori T, Mizukami H, Katakai Y, Kawai S, Nakamura H, Inoue M, et al. Safety of intra-articular transplantation of lentivirally transduced mesenchymal stromal cells for haemophilic arthropathy in a non-human primate. Int J Hematol. 2018;108:239-245 pubmed publisher
    ..The proviral sequence of the simian immunodeficiency virus lentiviral vector was not detected in the heart, lungs, spleen, liver, testis, or bone marrow by real-..
  62. Fernandez C, Reece J, Saepuloh U, De Rose R, Ishkandriati D, O Connor D, et al. Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques. Immunogenetics. 2011;63:511-21 pubmed publisher
    ..The Mane-A1*084:01 MHC class I allele (previously named Mane-A*10) is important for the control of SIV infection by CD8+ T cells in this model...
  63. Etienne L, Hahn B, Sharp P, Matsen F, Emerman M. Gene loss and adaptation to hominids underlie the ancient origin of HIV-1. Cell Host Microbe. 2013;14:85-92 pubmed publisher
    HIV-1 resulted from cross-species transmission of SIVcpz, a simian immunodeficiency virus that naturally infects chimpanzees. SIVcpz, in turn, is a recombinant between two SIV lineages from Old World monkeys...
  64. Dickerson M, Astorga N, Astorga N, Lewis A. Chagas disease in 2 geriatric rhesus macaques (Macaca mulatta) housed in the Pacific Northwest. Comp Med. 2014;64:323-8 pubmed
    ..The second case affected a geriatric female macaque experimentally infected with SIV. She was euthanized for a protocol-related time point...
  65. Harada K, Takamune N, Shoji S, Misumi S. Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1. Virol J. 2014;11:222 pubmed publisher
    ..functions of Nef is in the enhancement of the infectivity of the human and simian immunodeficiency viruses (HIV and SIV, respectively). However, the detailed mechanism of the enhancement of viral infectivity by Nef remains unclear...
  66. Wares M, Hassounah S, Mesplède T, Sandstrom P, Wainberg M. Simian-tropic HIV as a model to study drug resistance against integrase inhibitors. Antimicrob Agents Chemother. 2015;59:1942-9 pubmed publisher
    ..However, relatively little work has been conducted using either simian immunodeficiency virus (SIV) or SIV/HIV recombinant viruses for studying resistance against integrase strand transfer ..
  67. Coren L, Trivett M, Jain S, Ayala V, Del Prete G, Ohlen C, et al. Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α. Retrovirology. 2015;12:11 pubmed publisher
    ..Furthermore, AgmTRIM5α was able to potently restrict both HIV-1 and SIV replication in a cell-to-cell infection challenge...
  68. Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, et al. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. J Virol. 2015;89:8643-50 pubmed publisher
    To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes ..
  69. Xu H, Wang X, Malam N, Lackner A, Veazey R. Persistent Simian Immunodeficiency Virus Infection Causes Ultimate Depletion of Follicular Th Cells in AIDS. J Immunol. 2015;195:4351-7 pubmed publisher
    ..Although CD4(+) Tfh cells are reported to accumulate in HIV or SIV infection, we found that germinal center Tfh cells, defined in this study as CXCR5(+)PD-1(HIGH)CD4(+) T cells, did ..
  70. Killick M, Grant M, Cerutti N, Capovilla A, Papathanasopoulos M. Env-2dCD4 S60C complexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1). Vaccine. 2015;33:6298-306 pubmed publisher
    ..ability of the unique Env-2dCD4(S60C) complexes to elicit potent bNAb responses has not been described previously, reinforcing that further investigation for their utility in preventing and controlling HIV-1/SIV infection is warranted.
  71. Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed publisher
    Human and simian immunodeficiency viruses (HIV and SIV) exploit follicular lymphoid regions by establishing high levels of viral replication and dysregulating humoral immunity...
  72. Javed A, Leuchte N, Neumann B, Sopper S, Sauermann U. Noncytolytic CD8+ Cell Mediated Antiviral Response Represents a Strong Element in the Immune Response of Simian Immunodeficiency Virus-Infected Long-Term Non-Progressing Rhesus Macaques. PLoS ONE. 2015;10:e0142086 pubmed publisher
    The ability of long term non progressors to maintain very low levels of HIV/SIV and a healthy state, involves various host genetic and immunological factors...
  73. Fackler O. Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor. Viruses. 2015;7:6730-8 pubmed publisher
    ..is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression...
  74. Veazey R, Pilch Cooper H, Hope T, Alter G, Carias A, Sips M, et al. Prevention of SHIV transmission by topical IFN-β treatment. Mucosal Immunol. 2016;9:1528-1536 pubmed publisher
    ..More recent studies suggest that systemically administered type 1 interferon protects against simian immunodeficiency virus infection of macaques...
  75. Daugherty S, Gillespie D. Venous angioplasty and stenting improve pelvic congestion syndrome caused by venous outflow obstruction. J Vasc Surg Venous Lymphat Disord. 2015;3:283-9 pubmed publisher
    ..This report of a retrospective review of treatment of nonthrombotic common iliac vein (CIV) or inferior vena cava (IVC) obstruction with relief of symptoms demonstrates an often overlooked pathologic ..
  76. Zhao L, Gao J, Li Y, Liu L, Yang Y, Guo B, et al. Disrupted Homeostatic Cytokines Expression in Secondary Lymph Organs during HIV Infection. Int J Mol Sci. 2016;17:413 pubmed publisher
    ..disruption in secondary lymph organs (SLOs) and that IL-7 expression by SLOs is downregulated in simian immunodeficiency virus (SIV)-infected rhesus macaques...
  77. Montoya S, Motoike S, Kuki K, Couto A. Fruit development, growth, and stored reserves in macauba palm (Acrocomia aculeata), an alternative bioenergy crop. Planta. 2016;244:927-38 pubmed publisher
    ..differentiation of the inner parts; SIII-growth slowed down and all structures attained differentiation; and SIV-second growth spurt and fruit maturation...
  78. Bertero T, Oldham W, Cottrill K, Pisano S, Vanderpool R, Yu Q, et al. Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J Clin Invest. 2016;126:3313-35 pubmed publisher
    ..Notably, evaluation of simian immunodeficiency virus-infected nonhuman primates and HIV-infected subjects revealed a correlation between YAP/TAZ-GLS ..
  79. Vargas Inchaustegui D, Ying O, Demberg T, Robert Guroff M. Evaluation of Functional NK Cell Responses in Vaccinated and SIV-Infected Rhesus Macaques. Front Immunol. 2016;7:340 pubmed publisher
    ..In this study, we examined the effects of a simian immunodeficiency virus (SIV) vaccine regimen and subsequent SIV infection on the cytotoxic and immunomodulatory functions of ..
  80. Wrensch F, Hoffmann M, Gärtner S, Nehlmeier I, Winkler M, Pohlmann S. Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins. J Virol. 2017;91: pubmed publisher
    ..transmembrane proteins (IFITMs) can inhibit the cellular entry of several enveloped viruses, including simian immunodeficiency virus (SIV)...
  81. Dubruc E, Lebreton F, Giannoli C, Rabilloud M, Huissoud C, Devouassoux Shisheboran M, et al. Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases. Placenta. 2016;48:104-109 pubmed publisher
    ..7-113.8), basal chronic villitis (BCV) (OR 17, 95%CI 2-145.6) and chronic intervillositis (CIV). Chronic villitis (CV) (OR 3.7, 95%CI 0.9-15.2) and chronic deciduitis (CD) (OR 4.7, 95%CI 0.79-28...
  82. Xue J, Fu C, Cong Z, Peng L, Peng Z, Chen T, et al. Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages. FEBS J. 2017;284:97-113 pubmed publisher
    ..These findings suggest that galectin-3 may potentially aid in the eradication of HIV-1/SIV-infected macrophages.
  83. Mallard J, Papazian E, Soulas C, Nolan D, Salemi M, Williams K. A method for obtaining simian immunodeficiency virus RNA sequences from laser capture microdissected and immune captured CD68+ and CD163+ macrophages from frozen tissue sections of bone marrow and brain. J Immunol Methods. 2017;442:59-63 pubmed publisher
    ..In this study we sought to obtain simian immunodeficiency virus (SIV) RNA from SIV gp120+ and CD68+ monocyte/macrophages in bone marrow (BM) and CD163+ perivascular ..
  84. Mylvaganam G, Rios D, Abdelaal H, Iyer S, Tharp G, Mavigner M, et al. Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection. Proc Natl Acad Sci U S A. 2017;114:1976-1981 pubmed publisher
    ..Here, we show a population of simian immunodeficiency virus (SIV)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor ..
  85. Cao S, Yang Q, Guo L, Mai H, Mo H, Cao K, et al. Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: A phase III multicentre randomised controlled trial. Eur J Cancer. 2017;75:14-23 pubmed publisher
    ..The investigational arm received cisplatin (80 mg/m2 d1) and fluorouracil (800 mg/m2 civ d1-5) every 3 weeks for two cycles before CCRT...
  86. Pomorska Mól M, Dors A, Kwit K, Kowalczyk A, Stasiak E, Pejsak Z. Kinetics of single and dual infection of pigs with swine influenza virus and Actinobacillus pleuropneumoniae. Vet Microbiol. 2017;201:113-120 pubmed publisher
    ..Pathogens that are amongst other pathogens frequently involved in PRDC etiology are swine influenza virus (SIV) and A. pleuropneumoniae. The effect of dual infection with mentioned pathogens has not been investigated to date...
  87. Lakritz J, Yalamanchili S, Polydefkis M, Miller A, McGrath M, Williams K, et al. An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy. J Neurovirol. 2017;23:568-576 pubmed publisher
    ..Here, MGBG was administered to nine SIV-infected, CD8-depleted rhesus macaques at 21 days post-infection (dpi)...
  88. Chebli K, Papon L, Paul C, Garcel A, Campos N, Scherrer D, et al. The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages. Sci Rep. 2017;7:4860 pubmed publisher
    ..colitis that was recently shown to recapitulate the link between GI-tract damage and pathogenic features of SIV infection...
  89. Colović M, Medic B, Cetković M, Kravic Stevovic T, Stojanovic M, Ayass W, et al. Toxicity evaluation of two polyoxotungstates with anti-acetylcholinesterase activity. Toxicol Appl Pharmacol. 2017;333:68-75 pubmed publisher
    ..K7[Ti2PW10O40]·6H2O and K6H[SiV3W9O40]·3H2O, with different inhibitory potencies toward ..
  90. Sato K, Misawa N, Takeuchi J, Kobayashi T, Izumi T, Aso H, et al. Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model. J Virol. 2018;92: pubmed publisher
    Human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, originated from simian immunodeficiency virus from chimpanzees (SIVcpz), the precursor of the human virus, approximately 100 years ago...
  91. Zhu Y, Zhang X, Ding X, Chong H, Cui S, He J, et al. Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus. J Biol Chem. 2018;293:5323-5334 pubmed publisher
    ..has been designed as a 39-mer peptide composed of amino acid sequences derived from HIV-1, HIV-2, and simian immunodeficiency virus (SIV); however, its development has been suspended due to formulation difficulties...
  92. Autissier E, Li H, Goepfert P, Reeves R. Apoptotic membrane microparticles quantified by fluorescent bead-based assay are elevated in HIV and SIV infections. AIDS Res Hum Retroviruses. 2018;: pubmed publisher
    ..However, MMP increased 2-to-3 fold during HIV and SIV infections and were positively associated with T cell immune activation...