Moloney murine leukemia virus


Alias: Moloney murine leukemia virus M-MuLV, rat Moloney murine leukemia virus MoMuLV, MMLV, MoMLV

Top Publications

  1. Chen Y, Tsai Y, Tseng S. Selenite Stimulates the Proliferation of Intestinal Stem Cells With Elevated Antioxidative Activity. Transplant Proc. 2016;48:507-11 pubmed publisher
    ..with elevated expression of leucine-rich repeat-containing G-protein-coupled receptor 5, B lymphoma Moloney murine leukemia virus insertion region homolog-1, and Musashi-1, compared with the ISCs from control samples treated with ..
  2. Kuiper M, Sanches R, Gaken J, Bignon Y. Cloning and characterization of a retroviral plasmid, pCC1, for combination suicide gene therapy. Biotechniques. 2000;28:572-4, 576 pubmed
    ..MCS) allows the introduction of a second therapeutic gene under the transcriptional control of the Moloney murine leukemia virus 5' long terminal repeat...
  3. Codony Servat J, Codony Servat C, Cardona A, Gimenez Capitan A, Drozdowskyj A, Berenguer J, et al. Cancer Stem Cell Biomarkers in EGFR-Mutation-Positive Non-Small-Cell Lung Cancer. Clin Lung Cancer. 2019;: pubmed publisher
    ..The gene expression of B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) that maintains the self-renewal of stem cells was also related to treatment ..
  4. Soni P, Ghufran M, Kanade S. Aflatoxin B1 induced multiple epigenetic modulators in human epithelial cell lines. Toxicon. 2018;151:119-128 pubmed publisher
    ..The gene and protein expression of polycomb repressor proteins B cell specific moloney murine leukemia virus integration site 1 (BMI-1) and enhancer of zeste homolog 2 (EZH2) was significantly over expressed ..
  5. Sharapova T, Ivanova O, Prasolov V, Romanova E, Sashchenko L, Yashin D. Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells. IUBMB Life. 2017;69:971-977 pubmed publisher
    ..populations-natural killer (NK) cells and CD8+ NKG2D+ T lymphocytes-that kill Moloney murine leukemia virus (MMLV) infected SC-1 cells using different mechanisms of cell death induction...
  6. Lee D, Na J, Ryu J, Kim H, Nam S, Kang M, et al. Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. Hepatology. 2015;61:1978-97 pubmed publisher
    ..transducer and activator of transcription 3 (STAT3)/Twist-related protein 1 (Twist1)/B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) signaling for spheroid formation, whereas disturbing the interaction, ..
  7. Qiu M, Liang Z, Chen L, Tan G, Liu L, Wang K, et al. MicroRNA-200c suppresses cell growth and metastasis by targeting Bmi-1 and E2F3 in renal cancer cells. Exp Ther Med. 2017;13:1329-1336 pubmed publisher
    ..revealed that miR-200c directly targeted the 3' untranslated regions of the oncogenes B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) and E2F transcription factor 3 (E2F3) mRNAs, reduced the expression of Bmi-1 ..
  8. Nie Q, Lin Y, Yang X, Shen L, Guo L, Que S, et al. IDH1R¹³²H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. Mol Med Rep. 2015;12:6695-701 pubmed publisher
    ..Furthermore, miR‑128a negatively regulated the expression of B‑cell‑specific Moloney murine leukemia virus integration site 1 protein (Bmi‑1), which is involved in suppressing cell proliferation...
  9. Lai Y, Yu W, Kuo S, Ho C, Hung C, Way T, et al. CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma. J Cell Physiol. 2019;234:9118-9129 pubmed publisher
    ..Moreover, CSC-3436 exposure reduced B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) expression regulated by Twist and further suppressed the direct co-..

More Information

Publications138 found, 100 shown here

  1. Bognar Z, Fekete K, Antus C, Hocsak E, Bognar R, Tapodi A, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS ONE. 2017;12:e0189470 pubmed publisher
    ..DEA also inhibits the expression of B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) and reduces colony formation of T24 bladder carcinoma cells, indicating its ..
  2. Zhou L, Zhang W, Wang D, Tao K, Song W, Dou K. MicroRNA-183 is involved in cell proliferation, survival and poor prognosis in pancreatic ductal adenocarcinoma by regulating Bmi-1. Oncol Rep. 2014;32:1734-40 pubmed publisher
    ..The present study revealed that B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression was inversely correlated with miR-183...
  3. Serrao E, Ballandras Colas A, Cherepanov P, Maertens G, ENGELMAN A. Key determinants of target DNA recognition by retroviral intasomes. Retrovirology. 2015;12:39 pubmed publisher
    ..which yields a 5 bp TSD, revealed the targeting of global chromatin features most similar to those of Moloney murine leukemia virus, which yields a 4 bp duplication...
  4. Tiwari S, Hontz A, Terrell C, Arumugam P, Carmo M, Risma K, et al. High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis. Hum Gene Ther. 2016;27:847-859 pubmed publisher
    ..gene) is inadequate and thus engineered an LV vector using a viral promoter (MND; a modified Moloney murine leukemia virus long terminal repeat with myeloproliferative sarcoma virus enhancer) containing microRNA126 target ..
  5. Thenin Houssier S, de Vera I, Pedro Rosa L, Brady A, Richard A, Konnick B, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016;60:2195-208 pubmed publisher
    ..This compound also blocks infection of other retroviruses, such as Moloney murine leukemia virus and simian immunodeficiency virus, but displays no inhibitory activity against hepatitis C and ..
  6. Qiu M, Liang Z, Chen L, Tan G, Wang K, Liu L, et al. MicroRNA-429 suppresses cell proliferation, epithelial-mesenchymal transition, and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma. Urol Oncol. 2015;33:332.e9-18 pubmed publisher
    ..miR-429 was shown to directly target the 3' untranslated regions of B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) and E2F transcription factor 3 (E2F3) transcripts, regulating their expression,..
  7. Kim Y, Farrar W, Colburn N, Milner J. Cancer stem cells: potential target for bioactive food components. J Nutr Biochem. 2012;23:691-8 pubmed publisher
    ..the network including dickkopf 1 (DKK-1), secreted frizzled-related protein 2 (sFRP2), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and cyclin-dependent kinase 6 (CDK6) may account for their biological ..
  8. Döring J, Hurek T. Dual coding potential of a 2',5'-branched ribonucleotide in DNA. RNA. 2019;25:105-120 pubmed publisher
    ..Our sequence analysis of full-length nucleic acid generated by Taq DNA polymerase, Moloney murine leukemia virus reverse transcriptase, and T7 RNA polymerase from the 2'-arm of bDNA shows that the branched guanine ..
  9. Kang Y, McMillan I, Norris M, Hoang T. Single prokaryotic cell isolation and total transcript amplification protocol for transcriptomic analysis. Nat Protoc. 2015;10:974-84 pubmed publisher
    ..microdissection instrument for single-cell isolation, followed by reverse transcription via Moloney murine leukemia virus, degradation of chromosomal DNA with McrBC and DpnI restriction enzymes, single-stranded cDNA (ss-cDNA)..
  10. Okano H, Katano Y, Baba M, Fujiwara A, Hidese R, Fujiwara S, et al. Enhanced detection of RNA by MMLV reverse transcriptase coupled with thermostable DNA polymerase and DNA/RNA helicase. Enzyme Microb Technol. 2017;96:111-120 pubmed publisher
    ..engineered thermostable variant of reverse transcriptase (RT), MM4 (E286R/E302K/L435R/D524A) from Moloney murine leukemia virus (MMLV), the genetically engineered variant of family A DNA polymerase with RT activity, K4pol..
  11. Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
    ..this process through expression of the NFκB-dependent kinase proviral integration site for Moloney murine leukemia virus-1 (PIM-1), which in turn regulates NFκB and Eomes...
  12. Wang G, Wang Y, Goff S. Histones Are Rapidly Loaded onto Unintegrated Retroviral DNAs Soon after Nuclear Entry. Cell Host Microbe. 2016;20:798-809 pubmed publisher
    ..Here, we show that core histones are rapidly loaded onto unintegrated Moloney murine leukemia virus DNAs. Loading of nucleosomes requires nuclear entry, but does not require viral DNA integration...
  13. Nitta T, Ha D, Galvez F, Miyazawa T, Fan H. Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms. Retrovirology. 2015;12:68 pubmed publisher
    ..Since glyco-gag mediates resistance of Moloney murine leukemia virus to the restriction factor APOBEC3, the sensitivity of KoRV (wt or putatively mutant for glyco-gag) to ..
  14. Yasukawa K, Iida K, Okano H, Hidese R, Baba M, Yanagihara I, et al. Next-generation sequencing-based analysis of reverse transcriptase fidelity. Biochem Biophys Res Commun. 2017;492:147-153 pubmed publisher
    ..The error rates in cDNA synthesis with Moloney murine leukemia virus (MMLV) RT thermostable variant MM4 or the recently developed 16-tuple variant of family B DNA ..
  15. Oyallon B, Brachet Botineau M, Loge C, Bonnet P, Souab M, Robert T, et al. Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. Eur J Med Chem. 2018;154:101-109 pubmed publisher
    ..series of quinoxaline-2-carboxylic acid derivatives, targeting the human proviral integration site for Moloney murine leukemia virus-1 (HsPim-1) kinase...
  16. Zhang X, Wei C, Li J, Liu J, Qu J. MicroRNA-194 represses glioma cell epithelial?to?mesenchymal transition by targeting Bmi1. Oncol Rep. 2017;37:1593-1600 pubmed publisher
    ..Bioinformatics analysis showed that the B cell-specific moloney murine leukemia virus insertion site 1 (Bmi1) was a direct target of miR-194, which was validated by dual-luciferase ..
  17. Taniguchi N, Murakami H. Multiple Site-Directed and Saturation Mutagenesis by the Patch Cloning Method. Methods Mol Biol. 2017;1498:339-347 pubmed
    ..used to introduce multiple site-directed mutations in the green fluorescent protein gene and in the moloney murine leukemia virus reverse transcriptase gene...
  18. Espersen M, Olsen J, Linnemann D, Høgdall E, Troelsen J. Clinical implications of intestinal stem cell markers in colorectal cancer. Clin Colorectal Cancer. 2015;14:63-71 pubmed publisher
    ..stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their ..
  19. Shahi M, Farheen S, Mariyath M, Castresana J. Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance. Tumour Biol. 2016;37:15107-15114 pubmed
    ..found that Shh-Gli1 signaling regulates the expression of one stem cell marker, BMI1 (B cell-specific Moloney murine leukemia virus), in glioma...
  20. Quercioli V, Di Primio C, Casini A, Mulder L, Vranckx L, Borrenberghs D, et al. Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions. J Virol. 2016;90:5205-5209 pubmed publisher
    ..To extend this investigation to gammaretroviruses, we engineered a fluorescent Moloney murine leukemia virus (MLV) system consisting of MLV-integrase fused to enhanced green fluorescent protein (MLV-IN-EGFP)...
  21. Ohtaka M, Itoh M, Tohda S. BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells. Anticancer Res. 2017;37:6047-6053 pubmed
    B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is up-regulated in several cancers; therefore, we investigated the effects of BMI1 inhibitors on leukemia cells.
  22. Kesari A, Sharkey C, Sanders D. Role of heparan sulfate in entry and exit of Ross River virus glycoprotein-pseudotyped retroviral vectors. Virology. 2019;529:177-185 pubmed publisher
    ..To explore the effects of mutations that convey HS utilization, we pseudotyped Moloney murine leukemia virus (MoMLV), with the RRV envelope...
  23. Datta S, Zuo X, Clark P, Campbell S, Wang Y, Rein A. Solution properties of murine leukemia virus gag protein: differences from HIV-1 gag. J Virol. 2011;85:12733-41 pubmed publisher
    ..We now describe the properties of the Gag protein of Moloney murine leukemia virus (MLV), a gammaretrovirus...
  24. Aiyer S, Rossi P, Malani N, Schneider W, Chandar A, Bushman F, et al. Structural and sequencing analysis of local target DNA recognition by MLV integrase. Nucleic Acids Res. 2015;43:5647-63 pubmed publisher
    ..We describe the solution nuclear magnetic resonance structure of the Moloney murine leukemia virus IN (M-MLV) C-terminal domain (CTD) and a structural homology model of the catalytic core domain (CCD)...
  25. Zhu K, Li K, Yuan D, Xu G, Kang L, Dang C, et al. Clinicopathological and Prognostic Significance of Expression of B-Cell-Specific Moloney Murine Leukemia Virus Insertion Site 1 (BMI-1) Gene and Protein in Gastrointestinal Stromal Tumors. Med Sci Monit. 2018;24:6414-6421 pubmed publisher traditional therapy, the aim of the present study was to explore the correlation of B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI-1) mRNA and BMI-1 protein levels with the clinicopathological characteristics ..
  26. Miyazaki Y, Irobalieva R, Tolbert B, Smalls Mantey A, Iyalla K, Loeliger K, et al. Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. J Mol Biol. 2010;404:751-72 pubmed publisher
    ..We have determined the three-dimensional structure of the double hairpin from the Moloney murine leukemia virus ([Ψ(CD)](2), 132 nt, 42.8 kDa) using a (2)H-edited NMR-spectroscopy-based approach...
  27. Zhang X, Wang C, Zhu C, Zhang J, Kan S, Du L, et al. Overexpression of Bmi-1 in uterine cervical cancer: correlation with clinicopathology and prognosis. Int J Gynecol Cancer. 2010;20:1597-603 pubmed
    B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a member of polycomb group, which participates in axial patterning, hematopoiesis, cell cycle regulation, and senescence...
  28. Sun W, Qiao W, Zhou B, Hu Z, Yan Q, Wu J, et al. Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition. Metabolism. 2018;88:61-71 pubmed publisher
    B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) deficiency (Bmi-1-/-) leads to an osteoporotic phenotype with a significant downregulation of Sirt1 protein expression...
  29. Remy J, Linder B, Weirauch U, Konovalova J, Marschalek R, Aigner A, et al. Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis. Biochim Biophys Acta Mol Cell Res. 2019;1866:175-189 pubmed publisher
    ..The constitutively active serine/threonine kinase proviral integration site for moloney murine leukemia virus 1 (PIM1) was recently found to be overexpressed in GB patient samples and to maintain cell survival in ..
  30. Pektor S, Hilscher L, Walzer K, Miederer I, Bausbacher N, Loquai C, et al. In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET. EJNMMI Res. 2018;8:80 pubmed publisher
    ..this purpose, we employed systemic administration of RNA-lipoplexes encoding the endogenous antigen of Moloney murine leukemia virus (gp70) which have been previously shown to induce potent innate as well as adaptive immune mechanisms ..
  31. Quan J, Zhou L, Qu J. Knockdown of Pim-3 suppresses the tumorigenicity of glioblastoma by regulating cell cycle and apoptosis. Cell Mol Biol (Noisy-le-grand). 2015;61:42-50 pubmed
    Products of the Pim (the proviral integration site for the Moloney murine leukemia virus) family of proto—oncogenes possess serine/threonine kinase activity and belong to the Ca2+/calmodulin—dependent protein kinase ..
  32. Chen S, Chen Y, Zeng L, Zhang Q, Lian G, Li J, et al. Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro. Tumour Biol. 2016;37:11299-309 pubmed publisher
    ..The polycomb group family member B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi1) is overexpressed and involved in cancer progression in PDAC; however, its ..
  33. Qiu G, Mao X, Ma Y, Gao X, Wang Z, Jin M, et al. Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization. Cancer Sci. 2018;109:2199-2210 pubmed publisher
    ..With a cell-penetrating TAT-tag protein, B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a robust glioma stem-cell marker, is found to mediate the effect of USP22 ..
  34. Schenone S, Tintori C, Botta M. Using insights into Pim1 structure to design new anticancer drugs. Curr Pharm Des. 2010;16:3964-78 pubmed
    Human Pim1 (proviral integration site for Moloney murine leukemia virus) kinase is a 313-amino acid serine-threonine kinase that possesses several biological functions in cell survival, proliferation and differentiation, and its ..
  35. Nishida Y, Maeda A, Chachad D, Ishizawa J, Qiu Y, Kornblau S, et al. Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy. Cancer Sci. 2015;106:1705-13 pubmed publisher
    ..The polycomb complex protein B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) is required for the self-renewal and maintenance of leukemia stem cells...
  36. Swords R, Kelly K, Carew J, Nawrocki S, Mahalingam D, Sarantopoulos J, et al. The Pim kinases: new targets for drug development. Curr Drug Targets. 2011;12:2059-66 pubmed
    ..They were first recognized as pro-viral integration sites for the Moloney Murine Leukemia virus. Unlike other kinases, they possess a hinge region which creates a unique binding pocket for ATP...
  37. Lee A, Cingoz O, Sabo Y, Goff S. Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology. 2018;516:165-175 pubmed publisher
    b>Moloney Murine Leukemia Virus (M-MLV) proviral DNA is transcriptionally silenced in embryonic cells by a large repressor complex tethered to the provirus by two sequence-specific DNA binding proteins, ZFP809 and YY1...
  38. Yuan B, Zhao H, Xue X, Zhou J, Wang X, Han Y, et al. Prognostic Value and Clinicopathological Differences of Bmi1 in Gastric Cancer: A Meta-analysis. Anticancer Agents Med Chem. 2016;16:407-13 pubmed
    B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) was identified as a biomarker of cancer stem cells, and over-expression of Bmi1 might enhance tumor aggressive clinical behavior in gastric cancer (GC)...
  39. Park Y, Lee T, Choi J, Hong V, Lee J, Park J, et al. Inhibition of adipogenesis and leptin production in 3T3-L1 adipocytes by a derivative of meridianin C. Biochem Biophys Res Commun. 2014;452:1078-83 pubmed publisher
    ..a series of meridianin C derivatives (compound 7a-7j) and reported their proviral integration Moloney Murine Leukemia Virus (pim) kinases' inhibitory and anti-proliferative effects on human leukemia cells...
  40. Li A, Dunham C, Tabori U, Carret A, McNeely P, Johnston D, et al. EZH2 expression is a prognostic factor in childhood intracranial ependymoma: a Canadian Pediatric Brain Tumor Consortium study. Cancer. 2015;121:1499-507 pubmed publisher
    ..EZH2, pAKT, and P16 are potential therapeutic targets, particularly for patients who have tumors in which standard gross total resection plus fractionated radiotherapy is not feasible. ..
  41. Nishimura K, Yokokawa K, Hisayoshi T, Fukatsu K, Kuze I, Konishi A, et al. Preparation and characterization of the RNase H domain of Moloney murine leukemia virus reverse transcriptase. Protein Expr Purif. 2015;113:44-50 pubmed publisher
    b>Moloney murine leukemia virus reverse transcriptase (MMLV RT) contains fingers, palm, thumb, and connection subdomains as well as an RNase H domain...
  42. Harada M, Benito J, Yamamoto S, Kaur S, Arslan D, Ramirez S, et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015;6:37930-47 pubmed publisher
    ..Proviral integration site for moloney murine leukemia virus (PIM) serine/threonine kinase signaling takes part in various pathways exerting tumorigenic properties...
  43. Fukuda K, Okuda A, Yusa K, Shinkai Y. A CRISPR knockout screen Identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Genome Res. 2018;: pubmed publisher
    ..The Moloney murine leukemia virus (MLV)-based retroviral vector MSCV-GFP, which is repressed by the SETDB1/KAP1 pathway in mESCs was ..
  44. Shinnick T, Lerner R, Sutcliffe J. Nucleotide sequence of Moloney murine leukaemia virus. Nature. 1981;293:543-8 pubmed
  45. Ferrarone J, Knoper R, Li R, Kozak C. Second site mutation in the virus envelope expands the host range of a cytopathic variant of Moloney murine leukemia virus. Virology. 2012;433:7-11 pubmed publisher
    Spl574 MLV (murine leukemia virus) is a variant of Moloney ecotropic MLV (MoMLV) that is cytopathic in Mus dunni cells and restricted by other mouse cells...
  46. Kim S, Wong P. p53 as a retrovirus-induced oxidative stress modulator. J Gen Virol. 2015;96:144-9 pubmed publisher
    Infection of astrocytes by the neuropathogenic mutant of Moloney murine leukemia virus, ts1, exhibits increased levels of reactive oxygen species (ROS) and signs of oxidative stress compared with uninfected astrocytes...
  47. Zhao Q, Qian Q, Cao D, Yang J, Gui T, Shen K. Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing. J Ovarian Res. 2018;11:31 pubmed publisher
    B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) might be an appropriate biomarker in the management of epithelial ovarian cancer (EOC)...
  48. Takami M, Katayama K, Noguchi K, Sugimoto Y. Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells. Biochem Biophys Res Commun. 2018;503:1364-1371 pubmed publisher
    ..FLT3-ITD upregulates the proviral integration site for Moloney murine leukemia virus 1 (PIM-1) expression and promotes the proliferation of AML cells...
  49. He Q, Liu Z, Zhao T, Zhao L, Zhou X, Wang A. Bmi1 drives stem-like properties and is associated with migration, invasion, and poor prognosis in tongue squamous cell carcinoma. Int J Biol Sci. 2015;11:1-10 pubmed publisher
    Bmi1 (B-cell-specific Moloney murine leukemia virus insertion site 1) had been found to involve in self -renewal of stem cells and tumorigenesis in various malignancies...
  50. Anizon F, Shtil A, Danilenko V, Moreau P. Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors. Curr Med Chem. 2010;17:4114-33 pubmed
    The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the fundamental characteristics critical for the biology of eukaryotes, in particular, survival and malignant ..
  51. Hwang C, Nieh S, Lai C, Tsai C, Chang L, Hua C, et al. A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma. PLoS ONE. 2014;9:e105676 pubmed publisher
    ..the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues...
  52. Kvaratskhelia M, Sharma A, Larue R, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res. 2014;42:10209-25 pubmed publisher
    ..preferentially integrate within the bodies of active genes, whereas the prototypical gammaretrovirus Moloney murine leukemia virus (MoMLV) favors strong enhancers and active gene promoter regions...
  53. Ma M, Zhao L, Sun G, Zhang C, Liu L, Du Y, et al. Mda-7/IL-24 enhances sensitivity of B cell lymphoma to chemotherapy drugs. Oncol Rep. 2016;35:3122-30 pubmed publisher
    ..The expression of multidrug resistance gene 1 (MDR1), B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), topoisomerase II (Topo II) and multidrug resistance-related protein 1 (MRP1) ..
  54. Zhu X, Xu J, Hu S, Feng J, Jiang L, Hou X, et al. Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma. J Exp Clin Cancer Res. 2014;33:114 pubmed publisher
    Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis...
  55. Crea F, Duhagon Serrat M, Hurt E, Thomas S, Danesi R, Farrar W. BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer. Int J Cancer. 2011;128:1946-54 pubmed publisher
    The BMI1 oncogene promotes prostate cancer (PC) progression. High B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) expression predicts poor prognosis in PC patients...
  56. Moreau P, Dezhenkova L, Anizon F, Nauton L, Thery V, Liang S, et al. New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin. Anticancer Agents Med Chem. 2014;14:1228-36 pubmed
    The Pim protein kinases (provirus insertion site of Moloney murine leukemia virus) have been identified as important actors involved in tumor cell survival, proliferation, migration and invasion...
  57. Konishi A, Hisayoshi T, Yokokawa K, Barrioluengo V, Menéndez Arias L, Yasukawa K. Amino acid substitutions away from the RNase H catalytic site increase the thermal stability of Moloney murine leukemia virus reverse transcriptase through RNase H inactivation. Biochem Biophys Res Commun. 2014;454:269-74 pubmed publisher
    ..e., Arg; Lys) in the nucleic acid binding cleft of the Moloney murine leukemia virus reverse transcriptase (MMLV RT) in order to increase its template-primer (T/P) binding affinity...
  58. Hwang Y, Yoo N, Yang H, Choi S. RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences. Biochem Biophys Res Commun. 2015;456:110-5 pubmed publisher
    ..RNA leukemia viruses induce T-cell lymphoblastic lymphomas or myeloid leukemias. Infection of cells with Moloney murine leukemia virus (M-MuLV) up-regulates the expression of a number of cellular genes, including those involved in T-..
  59. Picó S, Ortiz Marchena M, Merini W, Calonje M. Deciphering the Role of POLYCOMB REPRESSIVE COMPLEX1 Variants in Regulating the Acquisition of Flowering Competence in Arabidopsis. Plant Physiol. 2015;168:1286-97 pubmed publisher
    ..Here, we show that Arabidopsis (Arabidopsis thaliana) B lymphoma Moloney murine leukemia virus insertion region1 homolog (BMI1) POLYCOMB REPRESSIVE COMPLEX1 (PRC1) components participate in the ..
  60. Yang Q, Chen L, Gandhi V. Mechanism-based combinations with Pim kinase inhibitors in cancer treatments. Curr Pharm Des. 2014;20:6670-81 pubmed
    Proviral integration site for Moloney murine leukemia virus (Pim) kinases is a potential therapeutic target in both hematological and solid tumors, and is up-regulated in various cancer types...
  61. Hacein Bey Abina S, Pai S, Gaspar H, Armant M, Berry C, Blanche S, et al. A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med. 2014;371:1407-17 pubmed publisher
    ..clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA ..
  62. Ichida Y, Utsunomiya Y, Onodera M. Effect of the linkers between the zinc fingers in zinc finger protein 809 on gene silencing and nuclear localization. Biochem Biophys Res Commun. 2016;471:533-8 pubmed publisher zinc finger protein (KRAB-ZFP) family and functions in repressing the expression of Moloney murine leukemia virus (MoMLV)...
  63. Hiraki M, Maeda T, Bouillez A, Alam M, Tagde A, Hinohara K, et al. MUC1-C activates BMI1 in human cancer cells. Oncogene. 2017;36:2791-2801 pubmed publisher
    B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is a component of the polycomb repressive complex 1 (PRC1) complex that is overexpressed in breast and other cancers, and promotes self-renewal of cancer stem-like ..
  64. Usami Y, Popov S, Gottlinger H. The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. J Virol. 2014;88:3443-54 pubmed publisher
    ..In the case of the ecotropic Moloney murine leukemia virus (M-MLV), the Nef-like effect is mediated by the glycosylated Gag (glycoGag) protein...
  65. Albertson D, Schmidt R, Bearss J, Tripp S, Bearss D, Liu T. Patterns and Significance of PIM Kinases in Urothelial Carcinoma. Appl Immunohistochem Mol Morphol. 2015;23:717-23 pubmed publisher
    The Provirus integrating site Moloney murine leukemia virus (Pim) family are proteins with serine/threonine kinase activity. Studies have demonstrated overexpression of Pims in cancer...
  66. Ichida Y, Utsunomiya Y, Onodera M. The third to fifth zinc fingers play an essential role in the binding of ZFP809 to the MLV-derived PBS. Biochem Biophys Res Commun. 2016;469:490-4 pubmed publisher
    ..protein 809 (ZFP809) belongs to the KRAB-ZFP family and functions in repressing the expression of Moloney murine leukemia virus (MoMLV) via sequence-specific binding to the primer-binding site (PBS) located downstream of the MoMLV-..
  67. Aouidate A, Ghaleb A, Ghamali M, Ousaa A, Choukrad M, Sbai A, et al. 3D QSAR studies, molecular docking and ADMET evaluation, using thiazolidine derivatives as template to obtain new inhibitors of PIM1 kinase. Comput Biol Chem. 2018;74:201-211 pubmed publisher
    Proviral Integration site for Moloney murine leukemia virus-1 (PIM1) belongs to the serine/threonine kinase family of Ca2+-calmodulin-dependent protein kinase (CAMK) group, which is involved in cell survival and proliferation ..
  68. Wang M, Okamoto M, Domenico J, Han J, Ashino S, Shin Y, et al. Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation. J Allergy Clin Immunol. 2012;130:932-44.e12 pubmed publisher
    The provirus integration site for Moloney murine leukemia virus (Pim) 1 kinase is an oncogenic serine/threonine kinase implicated in cytokine-induced cell signaling, whereas Runt-related transcription factor (Runx) has been implicated in ..
  69. Keswani R, Lazebnik M, Pack D. Intracellular trafficking of hybrid gene delivery vectors. J Control Release. 2015;207:120-30 pubmed publisher
    ..b>Moloney murine leukemia virus-like particles (M-VLPs) were complexed with chitosan (Chi) or liposomes (Lip) comprising DOTAP, DOPE ..
  70. Chen Y, Lian G, Ou G, Yang K, Chen J, Li H, et al. Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor metastasis and chemotherapy resistance. Gastric Cancer. 2016;19:392-402 pubmed publisher
    B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and Raf kinase inhibitory protein (RKIP) are involved in cancer metastasis and chemotherapeutic resistance, respectively...
  71. Ul Haq Z, Gul S, Usmani S, Wadood A, Khan W. Binding site identification and role of permanent water molecule of PIM-3 kinase: A molecular dynamics study. J Mol Graph Model. 2015;62:276-282 pubmed publisher
    ..Proviral Integration Site for Moloney Murine Leukemia Virus (PIM) kinase encodes serine/threonine protein kinases that recognized as proto-oncogene, responsible ..
  72. La J, Latham C, Tinetti R, Johnson A, Tyssen D, Huber K, et al. Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening. Proc Natl Acad Sci U S A. 2015;112:6979-84 pubmed publisher
    ..These compounds also inhibit Moloney murine leukemia virus RT but not the Klenow fragment of Escherichia coli DNA polymerase I...
  73. Ichida Y, Utsunomiya Y, Yasuda T, Nakabayashi K, Sato T, Onodera M. Functional Domains of ZFP809 Essential for Nuclear Localization and Gene Silencing. PLoS ONE. 2015;10:e0139274 pubmed publisher
    ..ZFP809 is known to inhibit the expression of transduced genes driven by Moloney murine leukemia virus (MoMLV)-typed retroviral vectors by binding to the primer binding site (PBS) located downstream of the ..
  74. Kim S, Singh S. The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate. Breast Cancer Res Treat. 2015;149:681-92 pubmed publisher
    ..BITC treatment resulted in a marked decrease in protein level of polycomb group protein B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) in cultured human breast cancer cells (MCF-7, SUM159, MDA-MB-231, and MDA-..
  75. Hofmann A, Takahashi T, Duess J, Gosemann J, Puri P. Increased expression of activated pSTAT3 and PIM-1 in the pulmonary vasculature of experimental congenital diaphragmatic hernia. J Pediatr Surg. 2015;50:908-11 pubmed publisher
    ..activated STAT3 (pSTAT3) was shown to directly trigger expression of the provirus integration site for Moloney murine leukemia virus (Pim-1), which promotes proliferation and resistance to apoptosis in SMCs...
  76. Xu X, Liu Y, Su J, Li D, Hu J, Huang Q, et al. Downregulation of Bmi-1 is associated with suppressed tumorigenesis and induced apoptosis in CD44⁺ nasopharyngeal carcinoma cancer stem-like cells. Oncol Rep. 2016;35:923-31 pubmed publisher
    Bmi-1 (B-cell-specific Moloney murine leukemia virus insertion site 1) is a member of the Polycomb group gene (PcG) family, which is involved in the proliferation, migration and tumorigenesis of several types of cancer stem cells (CSCs)...
  77. Bai X, Ouyang L, Li B, Zhou Y, Wen X. Expression of B cell-specific Moloney murine leukemia virus integration site 1 in vulvar squamous cell carcinoma and its effect on the biological behavior of A-431 cells. Oncol Lett. 2015;10:3369-3376 pubmed
    The aim of the present study was to investigate the expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in vulvar squamous cell carcinoma (VSCC) and vulvar intraepithelial neoplasia (VIN)...
  78. Li X, Wang Z, Chen R, Fu H, Gao C, Yan H, et al. LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling. Int J Mol Sci. 2018;19: pubmed publisher
    Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) are markers of fast-cycling and quiescent intestinal stem cells, respectively...
  79. Darwish N, Sudha T, Godugu K, Elbaz O, Abdelghaffar H, Hassan E, et al. Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1. Oncotarget. 2016;7:57811-57820 pubmed publisher
    ..LSCs might rely on the B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) in promoting cellular proliferation and survival...
  80. Brzezinski J, Modi A, Liu M, Roth M. Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12. J Virol. 2016;90:11197-11207 pubmed
    ..A model for how this conformational change regulates early versus late functions is presented. ..
  81. Brzezinski J, Felkner R, Modi A, Liu M, Roth M. Phosphorylation Requirement of Murine Leukemia Virus p12. J Virol. 2016;90:11208-11219 pubmed
    ..Mass spectrometry and mutagenesis studies suggest that phosphorylation of both the repression domain and the chromatin binding domain acts to temporally regulate this process at the appropriate stages during infection. ..
  82. Wu S, Niu W, Li Y, Huang H, Zhan R. miR-203 inhibits cell growth and regulates G1/S transition by targeting Bmi-1 in myeloma cells. Mol Med Rep. 2016;14:4795-4801 pubmed publisher
    The oncogene B-cell-specific Moloney murine leukemia virus insertion site?1 (Bmi?1) is overexpressed in multiple myeloma (MM). Our previous study demonstrated that Bmi?1 silencing sensitized MM cells to bortezomib...
  83. Guan R, Aiyer S, Coté M, Xiao R, Jiang M, Acton T, et al. X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition. Proteins. 2017;85:647-656 pubmed publisher
    ..Two crystal structures of Moloney murine leukemia virus (M-MuLV) IN N-terminal region (NTR) constructs that both include an N-terminal extension domain (NED, ..
  84. Kim H, Han S, Jung Y. Mouse tetherin enhances moloney murine leukemia virus-induced syncytium formation. Acta Virol. 2016;60:372-378 pubmed
    ..However, it is unclear whether mouse tetherin restricts cell-to-cell spread of moloney murine leukemia virus (Mo-MLV) or whether is the mouse tetherin involved in syncytium formation...
  85. Yi C, Rosenberg N. Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV. J Virol. 2008;82:5307-15 pubmed publisher
    ..These results indicate that MA sequences within the Gag moiety of the v-Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule. ..
  86. Katano Y, Hisayoshi T, Kuze I, Okano H, Ito M, Nishigaki K, et al. Expression of moloney murine leukemia virus reverse transcriptase in a cell-free protein expression system. Biotechnol Lett. 2016;38:1203-11 pubmed publisher
    To characterize Moloney murine leukemia virus (MMLV) reverse transcriptases (RTs) expressed in a cell-free system and in Escherichia coli. We previously expressed MMLV RT using an E...
  87. Warfel N, Sainz A, Song J, Kraft A. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016;15:1637-47 pubmed publisher
    ..The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases represent a prosurvival pathway that is upregulated in response to hypoxia, in a HIF-1-..
  88. Mou S, Wang G, Ding D, Yu D, Pei Y, Teng S, et al. Expression and function of PIM kinases in osteosarcoma. Int J Oncol. 2016;49:2116-2126 pubmed publisher
    The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies...
  89. Liu Y, Chu Z, Li Q, Peng B, Xu S, Lian C, et al. Downregulation of Bmi-1 suppresses epithelial?mesenchymal transition in melanoma. Oncol Rep. 2017;37:139-146 pubmed publisher
    ..A significant higher expression of B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) has been reported in cell lines from metastatic melanoma compared to cell ..
  90. Chu W, Weerasekera A, Kim C. On the conformational stability of the smallest RNA kissing complexes maintained through two G·C base pairs. Biochem Biophys Res Commun. 2017;483:39-44 pubmed publisher
    ..tetra-loop motifs with different stem sequences (called H2 and H3) are found in the 5' end region of Moloney Murine Leukemia Virus (MMLV) genomic RNA...
  91. Döring J, Hurek T. Arm-specific cleavage and mutation during reverse transcription of 2?,5?-branched RNA by Moloney murine leukemia virus reverse transcriptase. Nucleic Acids Res. 2017;45:3967-3984 pubmed publisher
    ..the effects of the two arms of bRNA on branchpoint-directed RNA cleavage and mutation produced by Moloney murine leukemia virus (M-MLV) RT during DNA polymerization. We constructed a long-chained bRNA template by splinted-ligation...
  92. Aziz A, Farid S, Qin K, Wang H, Liu B. PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer. Biomolecules. 2018;8: pubmed publisher
    ..In addition, this review suggests a connection between the PIM kinases and the PI3K/AKT/mTOR pathway and their parallel mechanism in the regulation of ovarian cancer. ..