Feline leukemia virus

Summary

Alias: feline leukemia virus FeLV, Feline leukemia provirus

Top Publications

  1. Munhoz A, Hage S, Cruz R, Calazans A, Silva F, Albuquerque G, et al. Toxoplasmosis in cats in northeastern Brazil: Frequency, associated factors and coinfection with Neospora caninum, feline immunodeficiency virus and feline leukemia virus. Vet Parasitol Reg Stud Reports. 2017;8:35-38 pubmed publisher
    ..demonstrate occurrences of coinfection with Neospora caninum, the feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in cats in the state of Bahia, Brazil...
  2. Miyake A, Kawasaki J, Ngo H, Makundi I, Muto Y, Khan A, et al. The reduced folate carrier: an entry receptor for a novel feline leukemia virus variant. J Virol. 2019;: pubmed publisher
    b>Feline leukemia virus (FeLV) is horizontally transmitted among cats and causes a variety of hematopoietic disorders. Five subgroups of FeLV, A-D and T, each with distinct receptor usage, have been described...
  3. Biezus G, Machado G, Ferian P, da Costa U, Pereira L, Withoeft J, et al. Prevalence of and factors associated with feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) in cats of the state of Santa Catarina, Brazil. Comp Immunol Microbiol Infect Dis. 2019;63:17-21 pubmed publisher
    ..Most of the animals were adopted from shelters or rescued from streets, living with multiple cats that had access to outdoors. The high prevalence of FeLV suggests a need for better control strategies against this disease. ..
  4. Russo V, Roperto F, Taulescu M, De Falco F, Urraro C, Corrado F, et al. Expression of the feline leukemia virus subgroup C receptors in normal and neoplastic urothelium of the urinary bladder of cattle associated with bovine papillomavirus infection. Vet Microbiol. 2019;229:147-152 pubmed publisher
    The feline leukemia virus subgroup C receptors (FLVCRs) were originally cloned as virus receptors, but are now believed to function also as heme transporters and are expressed in a broad range of tissues in a wide range of mammalian ..
  5. Helfer Hungerbuehler A, Cattori V, Boretti F, Ossent P, Grest P, Reinacher M, et al. Dominance of highly divergent feline leukemia virus A progeny variants in a cat with recurrent viremia and fatal lymphoma. Retrovirology. 2010;7:14 pubmed publisher
    In a cat that had ostensibly recovered from feline leukemia virus (FeLV) infection, we observed the reappearance of the virus and the development of fatal lymphoma 8.5 years after the initial experimental exposure to FeLV-A/Glasgow-1...
  6. Cavalcante L, Muniz C, Jia H, Augusto A, Troccoli F, Medeiros S, et al. Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats. Viruses. 2018;10: pubmed publisher
    Feline foamy virus (FFV) and feline leukemia virus (FeLV) belong to the Retroviridae family. While disease has not been reported for FFV infection, FeLV infection can cause anemia and immunosuppression (progressive infection)...
  7. Hartmann K. Clinical aspects of feline retroviruses: a review. Viruses. 2012;4:2684-710 pubmed publisher
    b>Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are retroviruses with global impact on the health of domestic cats. The two viruses differ in their potential to cause disease...
  8. Powers J, Chiu E, Kraberger S, Roelke Parker M, Lowery I, Erbeck K, et al. Feline Leukemia Virus (FeLV) Disease Outcomes in a Domestic Cat Breeding Colony: Relationship to Endogenous FeLV and Other Chronic Viral Infections. J Virol. 2018;92: pubmed publisher
    Exogenous feline leukemia virus (FeLV) is a feline gammaretrovirus that results in a variety of disease outcomes...
  9. Boesch A, Cattori V, Riond B, Willi B, Meli M, Rentsch K, et al. Evaluation of the effect of short-term treatment with the integrase inhibitor raltegravir (Isentress) on the course of progressive feline leukemia virus infection. Vet Microbiol. 2015;175:167-78 pubmed publisher
    Cats persistently infected with the gammaretrovirus feline leukemia virus (FeLV) are at risk to die within months to years from FeLV-associated disease, such as immunosuppression, anemia or lymphoma/leukemia...

More Information

Publications71

  1. Helfer Hungerbuehler A, Widmer S, Kessler Y, Riond B, Boretti F, Grest P, et al. Long-term follow up of feline leukemia virus infection and characterization of viral RNA loads using molecular methods in tissues of cats with different infection outcomes. Virus Res. 2015;197:137-50 pubmed publisher
    It is a remarkable feature for a retrovirus that an infection with feline leukemia virus (FeLV) can result in various outcomes...
  2. Makundi I, Koshida Y, Endo Y, Nishigaki K. Identification of Felis catus Gammaherpesvirus 1 in Tsushima Leopard Cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan. Viruses. 2018;10: pubmed publisher
    ..080) or feline leukemia virus-infected (p = 0...
  3. de Castro F, Junqueira D, de Medeiros R, da Silva T, Costenaro J, Knak M, et al. Analysis of single-nucleotide polymorphisms in the APOBEC3H gene of domestic cats (Felis catus) and their association with the susceptibility to feline immunodeficiency virus and feline leukemia virus infections. Infect Genet Evol. 2014;27:389-94 pubmed publisher
    Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are widely distributed retroviruses that infect domestic cats (Felis catus)...
  4. Chatzis M, Leontides L, Athanasiou L, Papadopoulos E, Kasabalis D, Mylonakis M, et al. Evaluation of indirect immunofluorescence antibody test and enzyme-linked immunosorbent assay for the diagnosis of infection by Leishmania infantum in clinically normal and sick cats. Exp Parasitol. 2014;147:54-9 pubmed publisher
    ..signalment, living conditions, season of sampling and health status of the cats or with seropositivity to feline leukemia virus, feline immunodeficiency virus, feline coronavirus, Toxoplasma gondii and Bartonella henselae...
  5. Sakaguchi S, Shojima T, Fukui D, Miyazawa T. A soluble envelope protein of endogenous retrovirus (FeLIX) present in serum of domestic cats mediates infection of a pathogenic variant of feline leukemia virus. J Gen Virol. 2015;96:681-7 pubmed publisher
    T-lymphotropic feline leukemia virus (FeLV-T), a highly pathogenic variant of FeLV, induces severe immunosuppression in cats...
  6. Philip M, Funkhouser S, Chiu E, Phelps S, Delrow J, Cox J, et al. Heme exporter FLVCR is required for T cell development and peripheral survival. J Immunol. 2015;194:1677-85 pubmed publisher
    ..The feline leukemia virus subgroup C receptor (FLVCR) is a 12-transmembrane domain surface protein that exports heme from cells, and ..
  7. Saba C. Vaccine-associated feline sarcoma: current perspectives. Vet Med (Auckl). 2017;8:13-20 pubmed publisher
    ..Although uncommon, these tumors are iatrogenic, and vaccination against rabies and feline leukemia virus is perhaps the most common inciting cause...
  8. Heddergott M, Steeb S, Osten Sacken N, Steinbach P, Schneider S, Pir J, et al. Serological survey of feline viral pathogens in free-living European wildcats (Felis s. silvestris) from Luxembourg. Arch Virol. 2018;163:3131-3134 pubmed publisher
    ..The values for feline leukemia virus (FeLV; 52.9%) and feline coronavirus (FCoV; 47.1%) were amongst the highest reported for wildcats...
  9. Cong W, Meng Q, Blaga R, Villena I, Zhu X, Qian A. Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats (Felis catus) in northwest China: co-infections and risk factors. Parasitol Res. 2016;115:217-23 pubmed publisher
    ..the prevalence of Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections among stray and pet cats in Lanzhou, northwest China, and to identify the influence of ..
  10. Kawasaki J, Nishigaki K. Tracking the Continuous Evolutionary Processes of an Endogenous Retrovirus of the Domestic Cat: ERV-DC. Viruses. 2018;10: pubmed publisher
    ..their capacity to produce infectious viruses; their recombination with other retroviruses, such as feline leukemia virus or RD-114; and their biological functions as host antiviral factors...
  11. Nesina S, Katrin Helfer Hungerbuehler A, Riond B, Boretti F, Willi B, Meli M, et al. Retroviral DNA--the silent winner: blood transfusion containing latent feline leukemia provirus causes infection and disease in naïve recipient cats. Retrovirology. 2015;12:105 pubmed publisher
    The feline leukemia virus (FeLV) is a gamma-retrovirus of domestic cats that was discovered half a century ago...
  12. Kawamura M, Watanabe S, Odahara Y, Nakagawa S, Endo Y, Tsujimoto H, et al. Genetic diversity in the feline leukemia virus gag gene. Virus Res. 2015;204:74-81 pubmed publisher
    b>Feline leukemia virus (FeLV) belongs to the Gammaretrovirus genus and is horizontally transmitted among cats...
  13. Mercurio S, Petrillo S, Chiabrando D, Bassi Z, Gays D, Camporeale A, et al. The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica. 2015;100:720-9 pubmed publisher
    b>Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria...
  14. Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E. Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis. Antioxid Redox Signal. 2015;23:1410-23 pubmed publisher
    ..The feline leukemia virus, subgroup C, receptor 1a (FLVCR1a) is a heme exporter expressed in almost all cell types, including ..
  15. Valdivieso Torres L, Sarangi A, Whidby J, Marcotrigiano J, Roth M. Role of Cysteines in Stabilizing the Randomized Receptor Binding Domains within Feline Leukemia Virus Envelope Proteins. J Virol. 2015;90:2971-80 pubmed publisher
    ..These studies facilitate the screening of Env libraries for functional entry into target cells, allowing the identification of novel gammaretroviral Envs targeting alternative host cell receptors for gene and protein delivery. ..
  16. Paşa S, Tetik Vardarlı A, Erol N, Karakuş M, Töz S, Atasoy A, et al. Detection of Leishmania major and Leishmania tropica in domestic cats in the Ege Region of Turkey. Vet Parasitol. 2015;212:389-92 pubmed publisher
    ..ELISA assays for feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) were also carried out for 145 of the 147 samples. Overall, 13/147 (8...
  17. Krunić M, Ertl R, Hagen B, Sedlazeck F, Hofmann Lehmann R, von Haeseler A, et al. Decreased expression of endogenous feline leukemia virus in cat lymphomas: a case control study. BMC Vet Res. 2015;11:90 pubmed publisher
    Cats infected with exogenous feline leukemia virus (exFeLV) have a higher chance of lymphoma development than uninfected cats...
  18. Miyake A, Watanabe S, Hiratsuka T, Ito J, Ngo M, Makundi I, et al. Novel Feline Leukemia Virus Interference Group Based on the env Gene. J Virol. 2016;90:4832-4837 pubmed publisher
    b>Feline leukemia virus (FeLV) subgroups have emerged in infected cats via the mutation or recombination of the env gene of subgroup A FeLV (FeLV-A), the primary virus...
  19. Mercurio S, Aspesi A, Silengo L, Altruda F, Dianzani I, Chiabrando D. Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia. Eur J Haematol. 2016;96:367-74 pubmed publisher
    ..Alternative spliced isoforms of FLVCR1 (feline leukemia virus subgroup C receptor 1) transcript coding for non-functional proteins have been reported in some DBA ..
  20. Bergmann M, Englert T, Stuetzer B, Hawley J, Lappin M, Hartmann K. Prevalence of selected rickettsial infections in cats in Southern Germany. Comp Immunol Microbiol Infect Dis. 2015;42:33-6 pubmed publisher
    ..Associations between rickettsial infections, and feline immunodeficiency virus (FIV), as well as feline leukemia virus (FeLV) status were evaluated. Rickettsial prevalence was 0.4% (2/479; CI: 0.01-1.62%)...
  21. Chhetri B, Berke O, Pearl D, Bienzle D. Comparison of risk factors for seropositivity to feline immunodeficiency virus and feline leukemia virus among cats: a case-case study. BMC Vet Res. 2015;11:30 pubmed publisher
    Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are reported to have similar risk factors and similar recommendations apply to manage infected cats...
  22. Koba R, Oguma K, Sentsui H. Overexpression of feline tripartite motif-containing 25 interferes with the late stage of feline leukemia virus replication. Virus Res. 2015;204:88-94 pubmed publisher
    ..Because feline TRIM25 is expected to modulate the infection of feline leukemia virus (FeLV), we investigated its effects on early- and late-stage FeLV replication...
  23. Hashimoto Gotoh A, Yoshikawa R, Miyazawa T. Comparison between S+L- assay and LacZ marker rescue assay for detecting replication-competent gammaretroviruses. Biologicals. 2015;43:363-8 pubmed publisher
    ..Further, S+L- mink cells could not detect feline leukemia virus subgroups B in addition to PERV-A/B...
  24. Helfer Hungerbuehler A, Spiri A, Riond B, Grest P, Boretti F, Hofmann Lehmann R. No benefit of therapeutic vaccination in clinically healthy cats persistently infected with feline leukemia virus. Vaccine. 2015;33:1578-85 pubmed publisher
    ..In contrast to HIV, efficacious vaccines for a cat retrovirus, feline leukemia virus (FeLV), are commercially available...
  25. Tekelioglu B, Berriatua E, Turan N, Helps C, Kocak M, Yilmaz H. A retrospective clinical and epidemiological study on feline coronavirus (FCoV) in cats in Istanbul, Turkey. Prev Vet Med. 2015;119:41-7 pubmed publisher
    ..presence of antibodies to feline coronavirus (FCoV) and feline immunodeficiency virus (FIV), together with feline leukemia virus (FeLV) antigen was investigated in 169 ill household and stray cats attending a veterinary surgery in ..
  26. Ramírez H, Autran M, García M, Carmona M, Rodríguez C, Martínez H. Genotyping of feline leukemia virus in Mexican housecats. Arch Virol. 2016;161:1039-45 pubmed publisher
    b>Feline leukemia virus (FeLV) is a retrovirus with variable rates of infection globally. DNA was obtained from cats' peripheral blood mononuclear cells, and proviral DNA of pol and env genes was detected using PCR...
  27. Wilkes R, Kania S, Tsai Y, Lee P, Chang H, Ma L, et al. Rapid and sensitive detection of Feline immunodeficiency virus using an insulated isothermal PCR-based assay with a point-of-need PCR detection platform. J Vet Diagn Invest. 2015;27:510-5 pubmed publisher
    ..any nontargeted feline pathogens, including Felid herpesvirus 1, feline coronavirus, Feline calicivirus, Feline leukemia virus, Mycoplasma haemofelis, and Chlamydophila felis...
  28. Furtado M, Taniwaki S, de Barros I, Brandão P, Catão Dias J, Cavalcanti S, et al. Molecular detection of viral agents in free-ranging and captive neotropical felids in Brazil. J Vet Diagn Invest. 2017;29:660-668 pubmed publisher
    ..protoparvovirus 1 (CPPV-1), feline calicivirus (FCV), alphacoronavirus 1 (feline coronavirus [FCoV]), feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and canine distemper virus (CDV) in whole blood samples of ..
  29. Willi B, Spiri A, Meli M, Samman A, Hoffmann K, Sydler T, et al. Molecular characterization and virus neutralization patterns of severe, non-epizootic forms of feline calicivirus infections resembling virulent systemic disease in cats in Switzerland and in Liechtenstein. Vet Microbiol. 2016;182:202-12 pubmed publisher
    ..with no contact with symptomatic cats were collected and tested for FCV, feline herpesvirus-1 (FHV-1), feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV)...
  30. Ito J, Baba T, Kawasaki J, Nishigaki K. Ancestral Mutations Acquired in Refrex-1, a Restriction Factor against Feline Retroviruses, during its Cooption and Domestication. J Virol. 2016;90:1470-85 pubmed publisher
    ..of Refrex-1, a soluble antiretroviral factor in domestic cats that specifically inhibits infection by feline leukemia virus subgroup D (FeLV-D), a chimeric virus of FeLV, and a feline ERV, ERV-DC...
  31. Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1. Biochim Biophys Acta. 2014;1839:259-64 pubmed publisher
    ..The Feline Leukemia Virus, subgroup C, Receptor 1 (Flvcr1) gene encodes for two isoforms, Flvcr1a and 1b, involved in the export of ..
  32. Spada E, Canzi I, Baggiani L, Perego R, Vitale F, Migliazzo A, et al. Prevalence of Leishmania infantum and co-infections in stray cats in northern Italy. Comp Immunol Microbiol Infect Dis. 2016;45:53-8 pubmed publisher
    ..Feline immunodeficiency virus, feline leukemia virus, and feline coronavirus (FCoV) seroprevalence determined by enzyme-linked immunosorbent assay was 6.1, 6...
  33. Krengel A, Cattori V, Meli M, Wachter B, Böni J, Bisset L, et al. Gammaretrovirus-specific antibodies in free-ranging and captive Namibian cheetahs. Clin Vaccine Immunol. 2015;22:611-7 pubmed publisher
    ..and quantitative real-time PCR to test free-ranging and captive Namibian cheetahs for the presence of feline leukemia virus (FeLV), a gammaretrovirus that can be highly aggressive in populations with low genetic diversity, such as ..
  34. Marcondes M, Hirata K, Vides J, Sobrinho L, Azevedo J, Vieira T, et al. Infection by Mycoplasma spp., feline immunodeficiency virus and feline leukemia virus in cats from an area endemic for visceral leishmaniasis. Parasit Vectors. 2018;11:131 pubmed publisher
    ..and Anaplasma platys. A low prevalence of co-infection in Leishmania-infected and non-infected cats was found. Co-infections with Leishmania and vector-borne diseases in cats are not common in this area endemic for VL in Brazil. ..
  35. Patel M, Carritt K, Lane J, Jayappa H, Stahl M, Bourgeois M. Comparative Efficacy of Feline Leukemia Virus (FeLV) Inactivated Whole-Virus Vaccine and Canarypox Virus-Vectored Vaccine during Virulent FeLV Challenge and Immunosuppression. Clin Vaccine Immunol. 2015;22:798-805 pubmed publisher
    Four vaccines for feline leukemia virus (FeLV) are available in the United States...
  36. Meli M, Cattori V, Martínez F, López G, Vargas A, Simón M, et al. Feline leukemia virus and other pathogens as important threats to the survival of the critically endangered Iberian lynx (Lynx pardinus). PLoS ONE. 2009;4:e4744 pubmed publisher
    ..Fourteen lynxes were feline leukemia virus (FeLV) provirus-positive; eleven of these were antigenemic (FeLV p27 positive)...
  37. Galdo Novo S, Bucafusco D, Diaz L, Bratanich A. Viral diagnostic criteria for Feline immunodeficiency virus and Feline leukemia virus infections in domestic cats from Buenos Aires, Argentina. Rev Argent Microbiol. 2016;48:293-297 pubmed publisher
    ..Aires to assess the prevalence and associated risk factors of Feline immunodeficiency virus (FIV) and Feline leukemia virus (FeLV) in the city of Buenos Aires, Argentina...
  38. Sumi R, Miyake A, Endo T, Ohsato Y, Ngo M, Nishigaki K. Polymerase chain reaction-based detection of myc transduction in feline leukemia virus-infected cats. Arch Virol. 2018;163:1073-1077 pubmed publisher
    ..are associated with the transduction and activation of cellular proto-oncogenes, such as c-myc, by feline leukemia virus (FeLV)...
  39. Díaz Regañón D, Villaescusa A, Ayllon T, Rodriguez Franco F, Baneth G, Calleja Bueno L, et al. Molecular detection of Hepatozoon spp. and Cytauxzoon sp. in domestic and stray cats from Madrid, Spain. Parasit Vectors. 2017;10:112 pubmed publisher
    ..treatment, previous blood transfusion, previous tetracycline administration in the last 60 days, Feline Leukemia virus (FeLV) and Feline Immunodeficiency virus (FIV) status, positivity to other vector-borne diseases, the ..
  40. Lacerda L, Silva A, Freitas J, Cruz R, Said R, Munhoz A. Feline immunodeficiency virus and feline leukemia virus: frequency and associated factors in cats in northeastern Brazil. Genet Mol Res. 2017;16: pubmed publisher
    Our aims were to determine the frequencies of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in owned and stray cats in the northeastern region of Brazil, ascertain the status of FeLV infection, and investigate ..
  41. Kawasaki J, Kawamura M, Ohsato Y, Ito J, Nishigaki K. Presence of a Shared 5'-Leader Sequence in Ancestral Human and Mammalian Retroviruses and Its Transduction into Feline Leukemia Virus. J Virol. 2017;91: pubmed publisher
    ..We discovered a new recombinant feline leukemia virus (FeLV) gag gene harboring an unrelated insertion, termed the X region, which was derived from ..
  42. Kawamura M, Umehara D, Odahara Y, Miyake A, Ngo M, Ohsato Y, et al. AKT capture by feline leukemia virus. Arch Virol. 2017;162:1031-1036 pubmed publisher
    ..We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma...
  43. Spada E, Perego R, Sgamma E, Proverbio D. Survival time and effect of selected predictor variables on survival in owned pet cats seropositive for feline immunodeficiency and leukemia virus attending a referral clinic in northern Italy. Prev Vet Med. 2018;150:38-46 pubmed publisher
    Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are among the most important feline infectious diseases worldwide...
  44. Roccabianca P, Avallone G, Rodriguez A, Crippa L, Lepri E, Giudice C, et al. Cutaneous Lymphoma at Injection Sites: Pathological, Immunophenotypical, and Molecular Characterization in 17 Cats. Vet Pathol. 2016;53:823-32 pubmed publisher
    ..Emergence of FPCL seems unrelated to feline leukemia virus (FeLV) serological positivity or to skin inflammation...
  45. Chiu E, Hoover E, Vandewoude S. A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep Sequencing. Viruses. 2018;10: pubmed publisher
    b>Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma...
  46. Philip M, Chiu E, Hajjar A, Abkowitz J. TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages. J Immunol Res. 2016;2016:4039038 pubmed publisher
    ..The feline leukemia virus, subgroup C (FeLV-C) receptor, FLVCR, exports heme from cells...
  47. Terry A, Kilbey A, Naseer A, Levy L, Ahmad S, Watts C, et al. Barriers to Infection of Human Cells by Feline Leukemia Virus: Insights into Resistance to Zoonosis. J Virol. 2017;91: pubmed publisher
    ..Since cells derived from other normal human cell types are fully supportive of FeLV replication, innate resistance of blood cells could be critical in protecting against cross-species infection. ..
  48. Chiabrando D, Castori M, Di Rocco M, Ungelenk M, Gießelmann S, di Capua M, et al. Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception. PLoS Genet. 2016;12:e1006461 pubmed publisher
    ..in patients with congenital loss of pain perception, we here identify bi-allelic mutations in the FLVCR1 (Feline Leukemia Virus subgroup C Receptor 1) gene, which encodes a broadly expressed heme exporter...
  49. Bergmann M, Englert T, Stuetzer B, Hawley J, Lappin M, Hartmann K. Risk factors of different hemoplasma species infections in cats. BMC Vet Res. 2017;13:52 pubmed publisher
    ..Results were evaluated in relation to the age, sex, housing conditions, feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) status of the cats...
  50. Noorbakhsh F, Tang Q, Liu S, Silva C, van Marle G, Power C. Lentivirus envelope protein exerts differential neuropathogenic effects depending on the site of expression and target cell. Virology. 2006;348:260-76 pubmed publisher
    ..01). Thus, lentivirus envelope proteins exert differential neuropathogenic effects through mechanisms that depend on the infected or exposed cell type...
  51. Schlecht Louf G, Mangeney M, El Garch H, Lacombe V, Poulet H, Heidmann T. A targeted mutation within the feline leukemia virus (FeLV) envelope protein immunosuppressive domain to improve a canarypox virus-vectored FeLV vaccine. J Virol. 2014;88:992-1001 pubmed publisher
    ..The objective of this work was to study the immunosuppressive activity of the envelope protein (p15E) of feline leukemia virus (FeLV) and evaluate the effect of its abolition on the efficacy of a vaccine against FeLV...
  52. Best C, Pressman E, Cao C, Cooper E, Guillet R, Yost O, et al. Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans. FASEB J. 2016;30:3541-3550 pubmed
    ..46; P < 0.0001). Neonatal SF was also related to mRNA expression of the heme exporter feline leukemia virus subgroup C receptor 1 (? = -0.30; P = 0.004)...
  53. Klotz D, Baumgartner W, Gerhauser I. Type I interferons in the pathogenesis and treatment of canine diseases. Vet Immunol Immunopathol. 2017;191:80-93 pubmed publisher
    ..In addition, recombinant feline IFN-? has been approved for the treatment of canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections...
  54. Yusuf I, Shanks M, Clouston P, MacLaren R. A splice-site variant in FLVCR1 produces retinitis pigmentosa without posterior column ataxia. Ophthalmic Genet. 2017;:1-5 pubmed publisher
    FLVCR1 (feline leukemia virus subgroup c receptor 1) is a transmembrane protein involved in the trafficking of intracellular heme...
  55. Li S, Zhao F, Shao J, Xie Y, Chang H, Zhang Y. Interferon-omega: Current status in clinical applications. Int Immunopharmacol. 2017;52:253-260 pubmed publisher
    ..While recombinant feline IFN-? has been licensed in several countries for treating canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections, it also exhibits a certain efficacy when used to treat ..
  56. Bolin L, Chandhasin C, Lobelle Rich P, Albritton L, Levy L. Distinctive receptor binding properties of the surface glycoprotein of a natural feline leukemia virus isolate with unusual disease spectrum. Retrovirology. 2011;8:35 pubmed publisher
    b>Feline leukemia virus (FeLV)-945, a member of the FeLV-A subgroup, was previously isolated from a cohort of naturally infected cats...
  57. Shalev Z, Duffy S, Adema K, Prasad R, Hussain N, Willett B, et al. Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection. J Virol. 2009;83:6706-16 pubmed publisher
    The pathogenic subgroup C feline leukemia virus (FeLV-C) arises in infected cats as a result of mutations in the envelope (Env) of the subgroup A FeLV (FeLV-A)...
  58. Chen H, Bechtel M, Shi Y, Phipps A, Mathes L, Hayes K, et al. Pathogenicity induced by feline leukemia virus, Rickard strain, subgroup A plasmid DNA (pFRA). J Virol. 1998;72:7048-56 pubmed
    A new provirus clone of feline leukemia virus (FeLV), which we named FeLV-A (Rickard) or FRA, was characterized with respect to viral interference group, host range, complete genome sequence, and in vivo pathogenicity in specific-..
  59. Khan A, Ng S, Vandeputte O, Aljanahi A, Deyati A, Cassart J, et al. A Multicenter Study To Evaluate the Performance of High-Throughput Sequencing for Virus Detection. mSphere. 2017;2: pubmed publisher
    ..properties and commercial availability: human respiratory syncytial virus (RSV), Epstein-Barr virus (EBV), feline leukemia virus (FeLV), and human reovirus (REO). Additionally, porcine circovirus (PCV) was tested by one laboratory...
  60. Filoni C, Helfer Hungerbuehler A, Catão Dias J, Marques M, Torres L, Reinacher M, et al. Putative progressive and abortive feline leukemia virus infection outcomes in captive jaguarundis (Puma yagouaroundi). Virol J. 2017;14:226 pubmed publisher
    b>Feline leukemia virus (FeLV) is an exogenous gammaretrovirus of domestic cats (Felis catus) and some wild felids...
  61. McLuckie A, Barrs V, Wilson B, Westman M, Beatty J. Felis Catus Gammaherpesvirus 1 DNAemia in Whole Blood from Therapeutically Immunosuppressed or Retrovirus-Infected Cats. Vet Sci. 2017;4: pubmed publisher
    ..in the frequency of DNAemia or DNA load in therapeutically immunosuppressed (P1, n = 18) or feline leukemia virus (FeLV)-infected (P2, n = 57) patients compared with age- and sex-matched controls (C1, n = ..
  62. Jaacks L, Young M, Essley B, McNanley T, Cooper E, Pressman E, et al. Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents. J Nutr. 2011;141:1267-72 pubmed publisher
    ..To address this area of research, relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein (BCRP), was assessed using Western-..