Human immunodeficiency virus 1

Summary

Alias: human immunodeficiency virus 1 HIV-1, human immunodeficiency virus-1 HIV-1, human immunodeficiency virus type-1 HIV-1, human immunodeficiency virus type I HIV-1, human immunodeficiency virus type 1, HIV-1, human immunodeficiency virus type 1 HIV1, human immunodeficiency virus type 1 HIV-1, human immunodeficiency virus type 1 HIV 1, human immunodeficiency virus HIV-1, Human immunodeficiency virus type 1, HIV-1, LAV-1, HIV1, HIV, human immunodeficiency virus type 1 ,HIV-1, Human immunodeficiencey virus type 1, Human immundeficiency virus type 1, AIDS virus

Top Publications

  1. Goujon C, Moncorgé O, Bauby H, Doyle T, Ward C, Schaller T, et al. Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature. 2013;502:559-62 pubmed publisher
    ..For the pathogenic retrovirus human immunodeficiency virus type 1 (HIV-1), these include widely expressed restriction factors, such as APOBEC3 proteins, TRIM5-α, ..
  2. Jafari M, Guatelli J, Lewinski M. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014;88:5062-78 pubmed publisher
    ..is associated with the evolution of simian immunodeficiency virus (SIVcpz) into pandemic group M human immunodeficiency virus type 1 (HIV-1)...
  3. Shingai M, Nishimura Y, Klein F, Mouquet H, Donau O, Plishka R, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature. 2013;503:277-80 pubmed publisher
    ..However, earlier studies of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies administered to infected individuals or humanized mice reported ..
  4. Pancera M, Zhou T, Druz A, Georgiev I, Soto C, Gorman J, et al. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014;514:455-61 pubmed publisher
    The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by rearranging from a mature unliganded state, through ..
  5. Lin D, Zimmermann S, Stuwe T, Stuwe E, Hoelz A. Structural and functional analysis of the C-terminal domain of Nup358/RanBP2. J Mol Biol. 2013;425:1318-29 pubmed publisher
    ..However, we demonstrate that the CTD is dispensable for nuclear envelope localization of Nup358, suggesting that the CTD does not interact with other nucleoporins. ..
  6. Lindqvist M, van Lunzen J, Soghoian D, Kuhl B, Ranasinghe S, Kranias G, et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012;122:3271-80 pubmed publisher
    b>HIV targets CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell memory...
  7. Wilson S, Schoggins J, Zang T, Kutluay S, Jouvenet N, Alim M, et al. Inhibition of HIV-1 particle assembly by 2',3'-cyclic-nucleotide 3'-phosphodiesterase. Cell Host Microbe. 2012;12:585-97 pubmed publisher
    ..genes (ISGs) causes the cellular "antiviral state" in which the replication of many viruses, including HIV-1, is attenuated...
  8. Sharifi H, Furuya A, Jellinger R, Nekorchuk M, de Noronha C. Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex. J Virol. 2014;88:6944-58 pubmed publisher
    Human immunodeficiency virus (HIV) seizes control of cellular cullin-RING E3 ubiquitin ligases (CRLs) to promote viral replication...
  9. Kogan M, Deshmane S, Sawaya B, Gracely E, Khalili K, Rappaport J. Inhibition of NF-?B activity by HIV-1 Vpr is dependent on Vpr binding protein. J Cell Physiol. 2013;228:781-90 pubmed publisher
    ..We did not identify such a role for HSP27, which instead seems to inhibit Vpr functions. Chronically HIV-1 infected U1 cells with knockdown constructs for Vpr were unexpectedly less responsive to TNF-? mediated viral ..

More Information

Publications292 found, 100 shown here

  1. Fricke T, Brandariz Nuñez A, Wang X, Smith A, Diaz Griffero F. Human cytosolic extracts stabilize the HIV-1 core. J Virol. 2013;87:10587-97 pubmed publisher
    The stability of the HIV-1 core in the cytoplasm is crucial for productive HIV-1 infection. Mutations that stabilize or destabilize the core showed defects on HIV-1 reverse transcription and infection...
  2. Bichel K, Price A, Schaller T, Towers G, Freund S, James L. HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358. Retrovirology. 2013;10:81 pubmed publisher
    Lentiviruses such as HIV-1 can be distinguished from other retroviruses by the cyclophilin A-binding loop in their capsid and their ability to infect non-dividing cells...
  3. Kane M, Yadav S, Bitzegeio J, Kutluay S, Zang T, Wilson S, et al. MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature. 2013;502:563-6 pubmed publisher
    b>HIV-1 replication can be inhibited by type I interferon (IFN), and the expression of a number of gene products with anti-HIV-1 activity is induced by type I IFN...
  4. Arias J, Heyer L, von Bredow B, Weisgrau K, Moldt B, Burton D, et al. Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2014;111:6425-30 pubmed publisher
    ..b>HIV-1 overcomes this restriction factor by expressing HIV-1 viral protein U (Vpu), which down-regulates and degrades ..
  5. Morrison J, Guevara R, Marcano A, Saenz D, Fadel H, Rogstad D, et al. Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation. J Virol. 2014;88:3255-72 pubmed publisher
    ..Budding of bald FIV and HIV particles was blocked by carnivore tetherins...
  6. Duncan C, Williams J, Schiffner T, Gärtner K, Ochsenbauer C, Kappes J, et al. High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse. J Virol. 2014;88:2025-34 pubmed publisher
    Macrophage infection is considered to play an important role in HIV-1 pathogenesis and persistence...
  7. Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist W, Schoehn G, et al. ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol. 2013;15:213-26 pubmed publisher
    ..Combinatorial siRNA knockdown experiments indicate that CHMP3 contributes synergistically to HIV-1 budding, and the CHMP3 contribution is ~ 10-fold more pronounced in concert with CHMP2A than with CHMP2B...
  8. Li Z, Guo J, Wu Y, Zhou Q. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res. 2013;41:277-87 pubmed publisher
    Latent HIV reservoirs are the primary hurdle to eradication of infection...
  9. Varadarajan J, McWilliams M, Hughes S. Treatment with suboptimal doses of raltegravir leads to aberrant HIV-1 integrations. Proc Natl Acad Sci U S A. 2013;110:14747-52 pubmed publisher
    Integration of the DNA copy of the HIV-1 genome into a host chromosome is required for viral replication and is thus an important target for antiviral therapy...
  10. Tran K, Poulsen C, Guenaga J, de Val N, de Val Alda N, Wilson R, et al. Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign. Proc Natl Acad Sci U S A. 2014;111:E738-47 pubmed publisher
    b>HIV-1 neutralization requires Ab accessibility to the functional envelope glycoprotein (Env) spike...
  11. Ooms M, Letko M, Binka M, Simon V. The resistance of human APOBEC3H to HIV-1 NL4-3 molecular clone is determined by a single amino acid in Vif. PLoS ONE. 2013;8:e57744 pubmed publisher
    Some human APOBEC3 cytidine deaminases have antiviral activity against HIV-1 and other retroviruses. The single deaminase domain APOBEC3H (A3H) enzyme is highly polymorphic and multiple A3H haplotypes have been identified...
  12. Crespillo S, Casares S, Mateo P, Conejero Lara F. Thermodynamic analysis of the binding of 2F5 (Fab and immunoglobulin G forms) to its gp41 epitope reveals a strong influence of the immunoglobulin Fc region on affinity. J Biol Chem. 2014;289:594-9 pubmed publisher
    ..on the induction of broadly neutralizing monoclonal antibodies (bNAbs) have become outstanding strategies against HIV-1. Diverse bNAbs recognizing different regions of the HIV-1 envelope have been identified and extensively studied...
  13. Hu G, Li X, Zhang X, Li Y, Ma L, Yang L, et al. Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. J Med Chem. 2012;55:10108-17 pubmed publisher
    This study aims to identify inhibitors that bind at the interface of HIV-1 integrase (IN) and human LEDGF/p75, which represents a novel target for anti-HIV therapy. To date, only a few such inhibitors have been reported...
  14. Yasuda Inoue M, Kuroki M, Ariumi Y. DDX3 RNA helicase is required for HIV-1 Tat function. Biochem Biophys Res Commun. 2013;441:607-11 pubmed publisher
    Host RNA helicase has been involved in human immunodeficiency virus type 1 (HIV-1) replication, since HIV-1 does not encode an RNA helicase...
  15. Acharya P, Luongo T, Georgiev I, Matz J, Schmidt S, Louder M, et al. Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites. J Virol. 2013;87:10173-81 pubmed publisher
    The conserved HIV-1 site of coreceptor binding is protected from antibody-directed neutralization by conformational and steric restrictions...
  16. Xiang S, Pacheco B, Bowder D, Yuan W, Sodroski J. Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2. Virology. 2013;438:5-13 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1) coreceptor usage and tropism can be modulated by the V3 loop sequence of the gp120 exterior envelope glycoprotein...
  17. Barouch D, Whitney J, Moldt B, Klein F, Oliveira T, Liu J, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013;503:224-8 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described...
  18. Phalora P, Sherer N, Wolinsky S, Swanson C, Malim M. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J Virol. 2012;86:11712-24 pubmed publisher
    ..role in host-mediated defense against exogenous viruses, most notably, human immunodeficiency virus type-1 (HIV-1) and endogenous transposable elements...
  19. Munro J, Nath A, Farber M, Datta S, Rein A, Rhoades E, et al. A conformational transition observed in single HIV-1 Gag molecules during in vitro assembly of virus-like particles. J Virol. 2014;88:3577-85 pubmed publisher
    The conformational changes within single HIV-1 Gag molecules that occur during assembly into immature viruses are poorly understood...
  20. Chakrabarti B, Feng Y, Sharma S, McKee K, Karlsson Hedestam G, LaBranche C, et al. Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates. J Virol. 2013;87:13239-51 pubmed publisher
    Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes...
  21. Padhi S, Khan N, Jameel S, Priyakumar U. Molecular dynamics simulations reveal the HIV-1 Vpu transmembrane protein to form stable pentamers. PLoS ONE. 2013;8:e79779 pubmed publisher
    The human immunodeficiency virus type I (HIV-1) Vpu protein is 81 residues long and has two cytoplasmic and one transmembrane (TM) helical domains...
  22. Qi M, Williams J, Chu H, Chen X, Wang J, Ding L, et al. Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex. PLoS Pathog. 2013;9:e1003278 pubmed publisher
    The incorporation of the envelope glycoprotein complex (Env) onto the developing particle is a crucial step in the HIV-1 lifecycle...
  23. Narayan K, Agrawal N, Du S, Muranaka J, Bauer K, Leaman D, et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate. PLoS ONE. 2013;8:e52732 pubmed publisher
    Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to difficult-to-neutralize primary isolates...
  24. Serra Moreno R, Zimmermann K, Stern L, Evans D. Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis. PLoS Pathog. 2013;9:e1003487 pubmed publisher
    ..Although the mechanisms of tetherin antagonism by HIV-1 Vpu and HIV-2 Env have been investigated in detail, comparatively little is known about tetherin antagonism by ..
  25. Joshi P, Sloan B, Torbett B, Stoddart C. Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores. Virology. 2013;436:162-72 pubmed publisher
    We previously showed that reduced infectivity of HIV with incompletely processed capsid-spacer protein 1 (CA-SP1) is rescued by cellular activation or increased expression of HSP90AB1, a member of the cytosolic heat shock protein 90 ..
  26. Erkelenz S, Poschmann G, Theiss S, Stefanski A, Hillebrand F, Otte M, et al. Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA. J Virol. 2013;87:2721-34 pubmed publisher
    Small noncoding HIV-1 leader exon 3 is defined by its splice sites A2 and D3...
  27. Shah A, Silverstein P, Kumar S, Singh D, Kumar A. Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. PLoS ONE. 2012;7:e52060 pubmed publisher
    b>HIV-1 envelope protein gp120 has been extensively studied for neurotoxic effects that have been attributed to the increased expression of various proinflammatory cytokines in the CNS...
  28. Jurado K, Wang H, Slaughter A, Feng L, Kessl J, Koh Y, et al. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A. 2013;110:8690-5 pubmed publisher
    Integration is essential for HIV-1 replication, and the viral integrase (IN) protein is an important therapeutic target...
  29. D ORSO I, Jang G, Pastuszak A, Faust T, Quezada E, Booth D, et al. Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA. Mol Cell Biol. 2012;32:4780-93 pubmed publisher
    ..In HIV, we previously proposed a two-step model where the viral Tat protein first preassembles at the promoter with an ..
  30. Medjahed H, Pacheco B, Desormeaux A, Sodroski J, Finzi A. The HIV-1 gp120 major variable regions modulate cold inactivation. J Virol. 2013;87:4103-11 pubmed publisher
    b>HIV-1 entry involves the viral envelope glycoproteins (Env gps) and receptors on the target cell. Receptor binding channels the intrinsic high potential energy of Env into the force required to fuse the membranes of virus and target cell...
  31. Li Z, Wu S, Wang J, Li W, Lin Y, Ji C, et al. Evaluation of the interactions of HIV-1 integrase with small ubiquitin-like modifiers and their conjugation enzyme Ubc9. Int J Mol Med. 2012;30:1053-60 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1) integrase mediates the integration of reverse-transcribed viral cDNA into the genome of the host for the stable maintenance of the viral genome and the persistence of HIV-1 infection...
  32. Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, et al. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2013;288:15813-20 pubmed publisher
    Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a very promising new class of anti-HIV-1 agents that exhibit a multimodal mechanism of action by allosterically modulating IN multimerization and interfering with IN-lens ..
  33. Alvarez R, Hamlin R, Monroe A, Moldt B, Hotta M, Rodriguez Caprio G, et al. HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells. J Virol. 2014;88:6031-46 pubmed publisher
    ..factor tetherin retains virus particles on the surfaces of cells infected with vpu-deficient human immunodeficiency virus type 1 (HIV-1)...
  34. Shah V, Shi J, Hout D, Oztop I, Krishnan L, Ahn J, et al. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol. 2013;87:422-32 pubmed publisher
    Following entry of the HIV-1 core into target cells, productive infection depends on the proper disassembly of the viral capsid (uncoating)...
  35. Pham T, Lukhele S, Hajjar F, Routy J, Cohen E. HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2. Retrovirology. 2014;11:15 pubmed publisher
    b>HIV proteins Nef and Vpu down-modulate various host factors to evade immune defenses. Indeed, the CD4 receptor is down-regulated by Nef and Vpu, whereas virion-tethering BST2 is depleted by Vpu...
  36. Götz N, Sauter D, Usmani S, Fritz J, Goffinet C, Heigele A, et al. Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host. Cell Host Microbe. 2012;12:373-80 pubmed publisher
    ..After cross-species transmission, the chimpanzee precursor of pandemic HIV-1 switched from the accessory protein Nef to Vpu to effectively counteract human tetherin...
  37. Tedbury P, Ablan S, Freed E. Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure. PLoS Pathog. 2013;9:e1003739 pubmed publisher
    The matrix (MA) domain of HIV-1 Gag plays key roles in membrane targeting of Gag, and envelope (Env) glycoprotein incorporation into virions...
  38. Doitsh G, Galloway N, Geng X, Yang Z, Monroe K, Zepeda O, et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014;505:509-14 pubmed publisher
    The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism...
  39. Fricke T, White T, Schulte B, de Souza Aranha Vieira D, Dharan A, Campbell E, et al. MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1. Retrovirology. 2014;11:68 pubmed publisher
    The IFN-α-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Genetic evidence suggested that capsid is the viral determinant for restriction by MxB...
  40. Maudet C, Sourisce A, Dragin L, Lahouassa H, Rain J, Bouaziz S, et al. HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP. PLoS ONE. 2013;8:e77320 pubmed publisher
    The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase...
  41. Pace M, Graf E, Agosto L, Mexas A, Male F, Brady T, et al. Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency. PLoS Pathog. 2012;8:e1002818 pubmed publisher
    Despite the effectiveness of highly active antiretroviral therapy (HAART) in treating individuals infected with HIV, HAART is not a cure...
  42. Lochmann T, Bann D, Ryan E, Beyer A, Mao A, Cochrane A, et al. NC-mediated nucleolar localization of retroviral gag proteins. Virus Res. 2013;171:304-18 pubmed publisher
    ..targeted to nucleoli by a nucleolar localization signal (NoLS) in the NC domain, and similarly, the human immunodeficiency virus type 1 (HIV-1) NC protein also contains an NoLS consisting of basic residues...
  43. Radestock B, Morales I, Rahman S, Radau S, Glass B, Zahedi R, et al. Comprehensive mutational analysis reveals p6Gag phosphorylation to be dispensable for HIV-1 morphogenesis and replication. J Virol. 2013;87:724-34 pubmed publisher
    The structural polyprotein Gag of human immunodeficiency virus type 1 (HIV-1) is necessary and sufficient for formation of virus-like particles...
  44. El Far M, Isabelle C, Chomont N, Bourbonnière M, Fonseca S, Ancuta P, et al. Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS ONE. 2013;8:e54295 pubmed publisher
    b>HIV-1 Nef protein down-regulates several cell surface receptors through its interference with the cell sorting and trafficking machinery...
  45. Chamanian M, Purzycka K, Wille P, Ha J, McDonald D, Gao Y, et al. A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation. Cell Host Microbe. 2013;13:181-92 pubmed publisher
    ..Packaging involves a cis-acting packaging element (?) within the 5' untranslated region of unspliced HIV-1 RNA genome. However, the mechanism(s) that selects and limits gRNAs for packaging remains uncertain...
  46. Nazli A, Kafka J, Ferreira V, Anipindi V, Mueller K, Osborne B, et al. HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. J Immunol. 2013;191:4246-58 pubmed publisher
    Although women constitute half of all HIV-1-infected people worldwide (UNAIDS World AIDS Day Report, 2011), the earliest events in the female reproductive tract (FRT) during heterosexual HIV-1 transmission are poorly understood...
  47. Flegler A, Cianci G, Hope T. CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS ONE. 2014;9:e89056 pubmed publisher
    CCR5 acts as the principal coreceptor during HIV-1 transmission and early stages of infection...
  48. Chou S, Upton H, Bao K, Schulze Gahmen U, Samelson A, He N, et al. HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A. 2013;110:E123-31 pubmed publisher
    The HIV-1 Tat protein stimulates viral gene expression by recruiting human transcription elongation complexes containing P-TEFb, AFF4, ELL2, and ENL or AF9 to the viral promoter, but the molecular organization of these complexes remains ..
  49. Ping L, Joseph S, Anderson J, Abrahams M, Salazar Gonzalez J, Kincer L, et al. Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. J Virol. 2013;87:7218-33 pubmed publisher
    Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine...
  50. Chandrasekaran P, Buckley M, Moore V, Wang L, Kehrl J, Venkatesan S. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting G?(i2) for degradation through ubiquitination. J Biol Chem. 2012;287:41481-98 pubmed publisher
    The HIV Nef protein is an important pathogenic factor that modulates cell surface receptor trafficking and impairs cell motility, presumably by interfering at multiple steps with chemotactic receptor signaling...
  51. Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, et al. Defining HIV-1 Vif residues that interact with CBF? by site-directed mutagenesis. Virology. 2014;449:82-7 pubmed publisher
    Vif is essential for HIV-1 replication in T cells and macrophages. Vif recruits a host ubiquitin ligase complex to promote proteasomal degradation of the APOBEC3 restriction factors by poly-ubiquitination...
  52. Ku P, Bendjennat M, Ballew J, Landesman M, Saffarian S. ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly. PLoS ONE. 2014;9:e96950 pubmed publisher
    Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of Human Immunodeficiency Virus 1 (HIV-1)...
  53. Ashkenazi A, Faingold O, Kaushansky N, Ben Nun A, Shai Y. A highly conserved sequence associated with the HIV gp41 loop region is an immunomodulator of antigen-specific T cells in mice. Blood. 2013;121:2244-52 pubmed publisher
    Modulation of T-cell responses by HIV occurs via distinct mechanisms, 1 of which involves inactivation of T cells already at the stage of virus-cell fusion...
  54. Akgun B, Satija S, Nanda H, Pirrone G, Shi X, Engen J, et al. Conformational transition of membrane-associated terminally acylated HIV-1 Nef. Structure. 2013;21:1822-33 pubmed publisher
    ..We used neutron and X-ray reflection methods to measure the displacement of the core domain of HIV Nef from lipid membranes upon insertion of the N-terminal myristate group...
  55. Ramirez P, Famiglietti M, Sowrirajan B, DePaula Silva A, RODESCH C, Barker E, et al. Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4? T cells. Cell Rep. 2014;7:2019-30 pubmed publisher
    ..Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells...
  56. Valiente Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi I, Bernard N, et al. eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection. Nat Commun. 2014;5:4819 pubmed publisher
    ..Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by ..
  57. Casey Klockow L, Sharifi H, Wen X, Flagg M, Furuya A, Nekorchuk M, et al. The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. Virology. 2013;444:191-202 pubmed publisher
    The HIV-1 protein Vpr enhances macrophage infection, triggers G2 cell cycle arrest, and targets cells for NK-cell killing. Vpr acts through the CRL4(DCAF1) ubiquitin ligase complex to cause G2 arrest and trigger expression of NK ligands...
  58. Zhou F, Xue M, Qin D, Zhu X, Wang C, Zhu J, et al. HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3? signaling pathway. PLoS ONE. 2013;8:e53145 pubmed publisher
    ..KS is characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation and accelerate Kaposin A-induced tumorigenesis...
  59. Yufenyuy E, Aiken C. The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid. Retrovirology. 2013;10:29 pubmed publisher
    ..The intrinsic stability of the capsid is critical for HIV-1 infection, since both stabilizing and destabilizing mutations compromise viral infectivity...
  60. Lu Z, Bergeron J, Atkinson R, Schaller T, Veselkov D, Oregioni A, et al. Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. Open Biol. 2013;3:130100 pubmed publisher
    The HIV-1 viral infectivity factor (Vif) neutralizes cell-encoded antiviral APOBEC3 proteins by recruiting a cellular ElonginB (EloB)/ElonginC (EloC)/Cullin5-containing ubiquitin ligase complex, resulting in APOBEC3 ubiquitination and ..
  61. Doria Rose N, Schramm C, Gorman J, Moore P, Bhiman J, DeKosky B, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 2014;509:55-62 pubmed publisher
    Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, but the mechanism of their elicitation has been unclear...
  62. Fassati A. Multiple roles of the capsid protein in the early steps of HIV-1 infection. Virus Res. 2012;170:15-24 pubmed publisher
    The early steps of HIV-1 infection starting after virus entry into cells up to integration of its genome into host chromosomes are poorly understood...
  63. Zhou X, Han X, Zhao K, Du J, Evans S, Wang H, et al. Dispersed and conserved hydrophobic residues of HIV-1 Vif are essential for CBF? recruitment and A3G suppression. J Virol. 2014;88:2555-63 pubmed publisher
    CBF? was recently found to be a key regulator of the ability of human immunodeficiency virus type 1 (HIV-1) Vif to overcome host antiviral APOBEC3 proteins...
  64. Dick R, Goh S, Feigenson G, Vogt V. HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes. Proc Natl Acad Sci U S A. 2012;109:18761-6 pubmed publisher
    Membrane binding of the HIV-1 group-specific antigen (Gag) structural protein, a critical step in viral assembly at the plasma membrane, is mediated by the myristoylated, highly basic matrix (MA) domain, which interacts with negatively ..
  65. Matz J, Kessler P, Bouchet J, Combes O, Ramos O, Barin F, et al. Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. J Virol. 2013;87:1137-49 pubmed publisher
    Few broadly neutralizing antibodies targeting determinants of the HIV-1 surface envelope glycoprotein (gp120) involved in sequential binding to host CD4 and chemokine receptors have been characterized...
  66. Fregoso O, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M. Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1. PLoS Pathog. 2013;9:e1003496 pubmed publisher
    SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells...
  67. Liu Z, Pan Q, Ding S, Qian J, Xu F, Zhou J, et al. The interferon-inducible MxB protein inhibits HIV-1 infection. Cell Host Microbe. 2013;14:398-410 pubmed publisher
    ..We find that human MxB inhibits HIV-1 infection by reducing the level of integrated viral DNA...
  68. Chompré G, Cruz E, Maldonado L, Rivera Amill V, Porter J, Noel R. Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory. Neurobiol Dis. 2013;49:128-36 pubmed publisher
    ..use of antiretroviral therapy that effectively limits viral replication, memory impairment remains a dilemma for HIV infected people...
  69. McNatt M, Zang T, Bieniasz P. Vpu binds directly to tetherin and displaces it from nascent virions. PLoS Pathog. 2013;9:e1003299 pubmed publisher
    ..The HIV-1 accessory protein, Vpu, antagonizes Tetherin through a variety of proposed mechanisms, including surface ..
  70. Blanchet F, Stalder R, Czubala M, Lehmann M, Rio L, Mangeat B, et al. TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse. Retrovirology. 2013;10:6 pubmed publisher
    ..The cellular restriction factor BST-2/tetherin (also known as CD317 or HM1.24) potently restricts HIV-1 release by retaining viral particles at the cell surface in many cell types, including primary cells such as ..
  71. Price A, Jacques D, McEwan W, Fletcher A, Essig S, Chin J, et al. Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathog. 2014;10:e1004459 pubmed publisher
    The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands...
  72. Furci L, Tolazzi M, Sironi F, Vassena L, Lusso P. Inhibition of HIV-1 infection by human ?-defensin-5, a natural antimicrobial peptide expressed in the genital and intestinal mucosae. PLoS ONE. 2012;7:e45208 pubmed publisher
    ..cells secrete HD5 in the genital and gastrointestinal mucosae, two anatomical sites that are critically involved in HIV-1 transmission and pathogenesis...
  73. Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, et al. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression. Nat Immunol. 2013;14:1256-65 pubmed publisher
    The humoral immune response after acute infection with HIV-1 is delayed and ineffective. The HIV-1 envelope protein gp120 binds to and signals through integrin α4β7 on T cells...
  74. Bai Y, Tambe A, Zhou K, Doudna J. RNA-guided assembly of Rev-RRE nuclear export complexes. elife. 2014;3:e03656 pubmed publisher
    b>HIV replication requires nuclear export of unspliced and singly spliced viral transcripts...
  75. Tan Q, Zhu Y, Li J, Chen Z, Han G, Kufareva I, et al. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science. 2013;341:1387-90 pubmed publisher
    The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc...
  76. Schwefel D, Groom H, Boucherit V, Christodoulou E, Walker P, Stoye J, et al. Structural basis of lentiviral subversion of a cellular protein degradation pathway. Nature. 2014;505:234-8 pubmed publisher
    ..One such restriction factor, SAMHD1, inhibits human immunodeficiency virus (HIV)-1 infection of myeloid-lineage cells as well as resting CD4(+) T cells by reducing the cellular deoxynucleoside 5'-..
  77. Cashin K, Gray L, Jakobsen M, Sterjovski J, Churchill M, Gorry P. CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm. Retrovirology. 2013;10:24 pubmed publisher
    The majority of HIV-1 subjects worldwide are infected with HIV-1 subtype C (C-HIV)...
  78. Ku P, Miller A, Ballew J, Sandrin V, Adler F, Saffarian S. Identification of pauses during formation of HIV-1 virus like particles. Biophys J. 2013;105:2262-72 pubmed publisher
    b>HIV Gag polymerizes on the plasma membrane to form virus like particles (VLPs) that have similar diameters to wild-type viruses...
  79. Murakami T, Aida Y. Visualizing Vpr-induced G2 arrest and apoptosis. PLoS ONE. 2014;9:e86840 pubmed publisher
    Vpr is an accessory protein of human immunodeficiency virus type 1 (HIV-1) with multiple functions...
  80. Fenton May A, Dibben O, Emmerich T, Ding H, Pfafferott K, Aasa Chapman M, et al. Relative resistance of HIV-1 founder viruses to control by interferon-alpha. Retrovirology. 2013;10:146 pubmed publisher
    Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication in the mucosa and draining lymph nodes...
  81. Meehan A, Saenz D, Guevera R, Morrison J, Peretz M, Fadel H, et al. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014;10:e1003969 pubmed publisher
    ..RNAi screens have implicated Nup358 in the HIV-1 life cycle...
  82. Madsen J, Gaiha G, Palaniyar N, Dong T, Mitchell D, Clark H. Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells. PLoS ONE. 2013;8:e59047 pubmed publisher
    ..SP-D has been shown to bind to HIV via the HIV envelope protein gp120 and inhibit infectivity in vitro...
  83. De Iaco A, Luban J. Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA. Retrovirology. 2014;11:11 pubmed publisher
    The human peptidyl-prolyl isomerase Cyclophilin A (CypA) binds HIV-1 capsid (CA) and influences early steps in the HIV-1 replication cycle. The mechanism by which CypA regulates HIV-1 transduction efficiency is unknown...
  84. Cocka L, Bates P. Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. PLoS Pathog. 2012;8:e1002931 pubmed publisher
    ..s-Tetherin), which lacks 12 residues present in the long isoform (l-Tetherin), is significantly more resistant to HIV-1 Vpu-mediated downregulation and consequently more effectively restricts HIV-1 viral budding in the presence of ..
  85. Nakagawa S, Castro V, Toborek M. Infection of human pericytes by HIV-1 disrupts the integrity of the blood-brain barrier. J Cell Mol Med. 2012;16:2950-7 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) affects cross-talk between the individual cell types of the neurovascular unit, which then contributes to disruption of the blood-brain barrier (..
  86. Zhu J, Gaiha G, John S, Pertel T, Chin C, Gao G, et al. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012;2:807-16 pubmed publisher
    b>HIV-1 depends on many host factors for propagation. Other host factors, however, antagonize HIV-1 and may have profound effects on viral activation...
  87. Yasuda Inoue M, Kuroki M, Ariumi Y. Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function. Biochem Biophys Res Commun. 2013;434:803-8 pubmed publisher
    ..Many viruses utilize RNA helicases in their life cycle, while human immunodeficiency virus type 1 (HIV-1) does not encode an RNA helicase...
  88. Widera M, Erkelenz S, Hillebrand F, Krikoni A, Widera D, Kaisers W, et al. An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA. J Virol. 2013;87:2707-20 pubmed publisher
    Within target T lymphocytes, human immunodeficiency virus type I (HIV-1) encounters the retroviral restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G; A3G), which is counteracted by the HIV-1 ..
  89. De Iaco A, Santoni F, Vannier A, Guipponi M, Antonarakis S, Luban J. TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. Retrovirology. 2013;10:20 pubmed publisher
    Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity...
  90. Colin P, Benureau Y, Staropoli I, Wang Y, González N, Alcami J, et al. HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines. Proc Natl Acad Sci U S A. 2013;110:9475-80 pubmed publisher
    CC chemokine receptor 5 (CCR5) is a receptor for chemokines and the coreceptor for R5 HIV-1 entry into CD4(+) T lymphocytes...
  91. Yin X, Hu Z, Gu Q, Wu X, Zheng Y, Wei P, et al. Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol. 2014;88:1259-70 pubmed publisher
    ..Equine tetherin is localized on the cell surface and strongly blocks human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIV), and equine infectious anemia virus (EIAV) release ..
  92. Kudoh A, Takahama S, Sawasaki T, Ode H, Yokoyama M, Okayama A, et al. The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions. Retrovirology. 2014;11:9 pubmed publisher
    b>Human immunodeficiency virus type 1 (HIV-1) Gag is the main structural protein that mediates the assembly and release of virus-like particles (VLPs) from an infected cell membrane...