Equine infectious anemia virus

Summary

Alias: equine infectious anemia virus EIAV, EIAV

Top Publications

  1. Martin Serrano J, Yarovoy A, Perez Caballero D, Bieniasz P, Yaravoy A. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:12414-9 pubmed
    ..Notably, the prototype YPDL-type L domain encoded by equine infectious anemia virus (EIAV) acts by recruiting AIP-1/ALIX and expression of a truncated form of AIP-1/ALIX or small ..
  2. Strack B, Calistri A, Craig S, Popova E, Gottlinger H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003;114:689-99 pubmed
    ..AIP1 also binds to the L domain in EIAV p9, and this binding correlates perfectly with L domain function...
  3. Ahmad I, Li S, Li R, Chai Q, Zhang L, Wang B, et al. The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5. J Biol Chem. 2019;294:7013-7024 pubmed publisher
    ..The S2 protein from equine infectious anemia virus (EIAV) has been reported to reduce SERINC5 expression at steady-state levels likely via the endocytic ..
  4. Li M, Waheed A, Yu J, Zeng C, Chen H, Zheng Y, et al. TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins. Proc Natl Acad Sci U S A. 2019;116:5705-5714 pubmed publisher
    ..Consistent with a role for SERINC protein in potentiating TIM-1 restriction, we find that MLV glycoGag and EIAV S2 proteins, which, like Nef, antagonize SERINC-mediated diminishment of HIV-1 infectivity, also effectively ..
  5. Wang J, Wang Q, Hao S, Guo C, An J, Zhang Q, et al. Thermostable properties of the equine infectious anemia virus nucleocapsid protein NCp11. Biochem Biophys Res Commun. 2019;510:472-478 pubmed publisher
    ..In this study, we report for the first time, to our knowledge, the thermostable property of equine infectious anemia virus (EIAV) NCp11...
  6. Scicluna M, Autorino G, Cook S, Issel C, Cook R, Nardini R. Validation of an immunoblot assay employing an objective reading system and used as a confirmatory test in equine infectious anaemia surveillance programs. J Virol Methods. 2019;266:77-88 pubmed publisher
    ..according to the OIE guidelines, employing eight panels containing positive sera, including those from EIA virus (EIAV) proven infected horses, and negative horse, mule and donkey sera collected from different geographical areas...
  7. Du J, Wang X, Ma J, Wang J, Qin Y, Zhu C, et al. Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain. Retrovirology. 2014;11:26 pubmed publisher
    The equine infectious anemia virus (EIAV) is a lentivirus of the Retrovirus family, which causes persistent infection in horses often characterized by recurrent episodes of high fever...
  8. Naves J, Oliveira F, Bicalho J, Santos P, Machado de Avila R, Chavez Olortegui C, et al. Serological diagnosis of equine infectious anemia in horses, donkeys and mules using an ELISA with a gp45 synthetic peptide as antigen. J Virol Methods. 2019;266:49-57 pubmed publisher
    ..synthetic peptide pools to map and identify a consensus, widely recognised antibody epitope within env encoding the EIAV envelope proteins...
  9. Schmalen A, Karius Fischer J, Rauch P, Setz C, Korn K, Henklein P, et al. The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE. Viruses. 2018;10: pubmed publisher
    ..This phenomenon appears to be specific for HIV-1, since p6 homologs of HIV-2, SIV and EIAV were IDE-insensitive...

More Information

Publications71

  1. Fontes K, Silva Júnior L, Nascimento S, Chaves D, Pinheiro Junior J, Freitas A, et al. Enzyme-linked immunosorbent assay and agar gel immunodiffusion assay for diagnosis of equine infectious anemia employing p26 protein fused to the maltose-binding protein. Arch Virol. 2018;163:2871-2875 pubmed publisher
    A codon-optimized equine infectious anemia virus p26 gene was fused to a maltose-binding protein (MBP) and expressed in Escherichia coli for use as an antigen in agar gel immunodiffusion (AGID) and enzyme-linked immunosorbent assay (ELISA)..
  2. Meier K, Jaguva Vasudevan A, Zhang Z, Bähr A, Kochs G, Haussinger D, et al. Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV). Virology. 2018;523:52-63 pubmed publisher
    ..However, hMXB is not antiviral against equine infectious anemia virus (EIAV). We show here that equine MX2 (eMX2) potently restricts EIAV in vitro...
  3. Tang Y, Na L, Fu L, Yang F, Zhu C, Tang L, et al. Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity. Virology. 2015;476:364-371 pubmed publisher
    ..In this study, we demonstrated that equine ADAR1 (eADAR1) was a positive regulator of equine infectious anemia virus (EIAV), another lentivirus of the Retroviridae family...
  4. Zhang J, Wu J, Wang W, Wu H, Yu B, Wang J, et al. Role of cullin-elonginB-elonginC E3 complex in bovine immunodeficiency virus and maedi-visna virus Vif-mediated degradation of host A3Z2-Z3 proteins. Retrovirology. 2014;11:77 pubmed publisher
    All lentiviruses except equine infectious anemia virus (EIVA) antagonize antiviral family APOBEC3 (A3) proteins of the host through viral Vif proteins...
  5. de Pablo Maiso L, Domenech A, Echeverría I, Gómez Arrebola C, de Andrés D, Rosati S, et al. Prospects in Innate Immune Responses as Potential Control Strategies against Non-Primate Lentiviruses. Viruses. 2018;10: pubmed publisher
    ..related to the infection by animal lentiviruses, centered on small ruminant lentiviruses (SRLV), equine infectious anemia virus (EIAV), and feline (FIV) and bovine immunodeficiency viruses (BIV), specifically focusing on the ..
  6. Umunnakwe C, Loyd H, Cornick K, Chavez J, Dobbs D, Carpenter S. Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding. Retrovirology. 2014;11:115 pubmed publisher
    ..b>Equine infectious anemia virus (EIAV) Rev is functionally homologous to HIV-1 Rev, but shares very little sequence similarity and ..
  7. Cursino A, Vilela A, Franco Luiz A, de Oliveira J, Nogueira M, Júnior J, et al. Equine infectious anemia virus in naturally infected horses from the Brazilian Pantanal. Arch Virol. 2018;163:2385-2394 pubmed publisher
    ..Considering the limited number of equine infectious anemia virus (EIAV) sequences which are available in public databases and the great genome variability, studies of ..
  8. Tang Y, Na L, Zhu C, Shen N, Yang F, Fu X, et al. Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum. J Virol. 2014;88:12296-310 pubmed publisher
    ..The lentivirus equine infectious anemia virus (EIAV) has been studied extensively...
  9. Liu C, Cook S, Craigo J, Cook F, Issel C, Montelaro R, et al. Epitope shifting of gp90-specific cellular immune responses in EIAV-infected ponies. Vet Immunol Immunopathol. 2014;161:161-9 pubmed publisher
    Unlike other lentiviruses, EIAV replication can be controlled in most infected horses leading to an inapparent carrier state free of overt clinical signs which lasts for many years...
  10. Ji S, Na L, Ren H, Wang Y, Wang X. Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein. J Virol. 2018;92: pubmed publisher
    ..In this study, we examined the restrictive effect of equine Mx2 (eqMx2) on both equine infectious anemia virus (EIAV) and HIV-1 and investigated possible mechanisms for its specific function...
  11. Yin X, Guo M, Gu Q, Wu X, Wei P, Wang X. Antiviral potency and functional analysis of tetherin orthologues encoded by horse and donkey. Virol J. 2014;11:151 pubmed publisher
    ..However, much less is known about the functional roles of tetherin on other lentiviruses. Equine infectious anemia virus (EIAV) is an important macrophage-tropic lentivirus that has been widely used as a practical model for ..
  12. Wang X, Wang S, Liu Q, Lin Y, Du C, Tang Y, et al. A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses. Viruses. 2014;6:4265-79 pubmed publisher
    b>Equine infectious anemia virus (EIAV) is a member of the Lentivirus genus in the Retroviridae family that exhibits a genomic structure similar to that of HIV-1...
  13. Voronin N, Herzig E, Hizi A. The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein. Retrovirology. 2014;11:60 pubmed publisher
    ..Controls of recombinant dUTPase from equine infectious anemia virus (EIAV) or of EIAV virions showed substantial dUTPase activities...
  14. Ai Y, Zhu D, Wang C, Su C, Ma J, Ma J, et al. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. J Virol. 2014;88:12112-22 pubmed publisher
    Viral infectivity factor (Vif) is required for lentivirus fitness and pathogenicity, except in equine infectious anemia virus (EIAV)...
  15. Goh G, Dunker A, Uversky V. Shell disorder, immune evasion and transmission behaviors among human and animal retroviruses. Mol Biosyst. 2015;11:2312-23 pubmed publisher
    ..most unique pattern of disorder distribution with generally high levels of disorder in all three proteins, while EIAV (PIDs:: 26, 29, 13) is diametrically different from HIV-1 (N C M PIDs: 39.5 ± 3.0, 44.5 ± 2.6, 56.5 ± 10...
  16. Schwartz E, Smith R. Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus. Vaccines (Basel). 2014;2:397-421 pubmed publisher
    ..vaccine protection has been shown via passive transfer of neutralizing antibodies before equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID)...
  17. Nardini R, Autorino G, Ricci I, Frontoso R, Rosone F, Simula M, et al. Validation according to OIE criteria of a monoclonal, recombinant p26-based, serologic competitive enzyme-linked immunosorbent assay as screening method in surveillance programs for the detection of Equine infectious anemia virus antibodies. J Vet Diagn Invest. 2016;28:88-97 pubmed publisher
    ..8%, which was more than the diagnostic Sp (80.2%) estimated from validation. The high Se and Sp of the cELISA confirm its fit for purpose as a screening test. ..
  18. Schwartz E, Nanda S, Mealey R. Antibody escape kinetics of equine infectious anemia virus infection of horses. J Virol. 2015;89:6945-51 pubmed publisher
    ..we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth ..
  19. Alvarez I, Cipolini F, Wigdorovitz A, Trono K, Barrandeguy M. The efficacy of ELISA commercial kits for the screening of equine infectious anemia virus infection. Rev Argent Microbiol. 2015;47:25-8 pubmed publisher
    The most used and reliable indicator of Equine infectious anemia virus (EIAV) infection is the detection of its specific antibodies in horse serum...
  20. Duan L, Du J, Wang X, Zhou J, Wang X, Liu X. Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer. Virology. 2016;491:64-72 pubmed publisher
    Equine infectious anaemia virus (EIAV) and human immunodeficiency virus (HIV) are members of the lentiviral genus...
  21. Yao S, Liu J, Qi J, Chen R, Zhang N, Liu Y, et al. Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles. J Immunol. 2016;196:1943-54 pubmed publisher
    ..occurring lentivirus and in the protective immune response to the successfully applied attenuated equine infectious anemia virus vaccine in the horse...
  22. Liu Q, Ma J, Wang X, Xiao F, Li L, Zhang J, et al. Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response. Vet Immunol Immunopathol. 2016;170:30-40 pubmed publisher
    The live equine infectious anemia virus (EIAV) vaccine strain EIAVDLV121 was developed by in vitro attenuation of a virulent strain, EIAVLN40, in the 1970s, and it has been demonstrated to induce protective immunity under laboratory and ..
  23. Liu Q, Wang X, Ma J, He X, Wang X, Zhou J. Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome. Viruses. 2015;7:3241-60 pubmed publisher
    ..b>Equine infectious anemia virus (EIAV) is another well-studied lentivirus that can also be used as a promising retro-transfection ..
  24. Allen L, Schwartz E. Free-virus and cell-to-cell transmission in models of equine infectious anemia virus infection. Math Biosci. 2015;270:237-48 pubmed publisher
    b>Equine infectious anemia virus (EIAV) is a lentivirus in the retrovirus family that infects horses and ponies...
  25. Wang X, Lin Y, Li Q, Liu Q, Zhao W, Du C, et al. Genetic Evolution during the development of an attenuated EIAV vaccine. Retrovirology. 2016;13:9 pubmed publisher
    The equine infectious anemia virus (EIAV) vaccine is the only attenuated lentiviral vaccine applied on a large scale that has been shown to be effective in controlling the prevalence of EIA in China...
  26. Senova S, Poupon C, Dauguet J, Stewart H, Dugué G, Jan C, et al. Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates. Sci Rep. 2018;8:3362 pubmed publisher
    ..Rabies-G-pseudotyped and Rabies-G-VSVg-pseudotyped EIAV lentiviral vectors encoding the opsin ChR2 gene were stereotaxically injected into the subthalamic nucleus (STN) ..
  27. Dufour C, Claudel A, Joubarne N, Merindol N, Maisonnet T, Masroori N, et al. Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1. PLoS ONE. 2018;13:e0191709 pubmed publisher
    ..factor TRIM5α inhibits the infection of human cells by specific nonhuman retroviruses, such as N-MLV and EIAV, but does not generally target HIV-1...
  28. Cervantes D, Ball J, Edwards J, Payne S. Horses naturally infected with EIAV harbor 2 distinct SU populations but are monophyletic with respect to IN. Virus Genes. 2016;52:71-80 pubmed publisher
    b>Equine infectious anemia virus (EIAV) causes lifelong infections ranging from acutely fatal, to chronic, to asymptomatic. Within infected animals, EIAV is found as a quasispecies. Many experimental studies on EIAV, carried out in the U.S...
  29. Du C, Ma J, Liu Q, Li Y, He X, Lin Y, et al. Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection. Retrovirology. 2015;12:36 pubmed publisher
    ..receptor 1 (ELR1) has been shown to be expressed in various equine cells that are permissive for equine infectious anemia virus (EIAV) replication...
  30. Corbi Botto C, Sadaba S, Zappa M, Peral Garcia P, Diaz S. Nonsynonymous changes of equine lentivirus receptor-1 (ELR1) gene in amino acids involved in the interaction with equine infectious anemia virus (EIAV). Res Vet Sci. 2017;112:185-191 pubmed publisher
    ..lentivirus receptor-1 (ELR1) has been characterized as the specific functional receptor that mediates equine infectious anemia virus (EIAV) entrance to horse macrophages...
  31. Ai Y, Ma J, Wang X. Clues for two-step virion infectivity factor regulation by core binding factor beta. J Gen Virol. 2017;98:1113-1121 pubmed publisher
    ..factor (Vif) is essential for the infectivity of most lentiviruses, except for the equine infectious anaemia virus (EIAV)...
  32. Nagarajan M, Simard C. Gag genetic heterogeneity of equine infectious anemia virus (EIAV) in naturally infected horses in Canada. Virus Res. 2007;129:228-35 pubmed
    Gag genetic heterogeneity of equine infectious anemia virus (EIAV) variants in naturally infected horses in Canada was studied since very limited information is available on the variability of EIAV Gag sequences in public database...
  33. Han X, Zhang P, Yu W, Xiang W, Li X. Amino acid mutations in the env gp90 protein that modify N-linked glycosylation of the Chinese EIAV vaccine strain enhance resistance to neutralizing antibodies. Virus Genes. 2016;52:814-822 pubmed
    The Chinese EIAV vaccine is an attenuated live virus vaccine obtained by serial passage of a virulent horse isolate (EIAVL) in donkeys (EIAVD) and, subsequently, in donkey cells in vitro...
  34. Hu Z, Chang H, Chu X, Li S, Wang M, Wang X. Identification and characterization of a common B-cell epitope on EIAV capsid proteins. Appl Microbiol Biotechnol. 2016;100:10531-10542 pubmed
    The equine infectious anemia virus (EIAV) capsid protein (p26) is one of the major immunogenic proteins during EIAV infection and is widely used for the detection of EIAV antibodies in horses...
  35. Sharma A, Bruns K, Röder R, Henklein P, Votteler J, Wray V, et al. Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein. BMC Struct Biol. 2009;9:74 pubmed publisher
    The equine infection anemia virus (EIAV) p9 Gag protein contains the late (L-) domain required for efficient virus release of nascent virions from the cell membrane of infected cell...
  36. Oliveira F, Cook R, Naves J, Oliveira C, Diniz R, Freitas F, et al. Equine infectious anemia prevalence in feral donkeys from Northeast Brazil. Prev Vet Med. 2017;140:30-37 pubmed publisher
    b>Equine infectious anemia virus (EIAV) is an important cause of morbidity and mortality throughout the world...
  37. Yao Q, Ma J, Wang X, Guo M, Li Y, Wang X. A pilot study on interaction between donkey tetherin and EIAV stains with different virulent and replication characteristics. Microb Pathog. 2017;106:65-68 pubmed publisher
    ..During the development of an attenuated equine infectious anemia virus (EIAV) vaccine in our laboratory, we found that serial passage of a field-isolated virulent EIAV ..
  38. Ahi Y, Zhang S, Thappeta Y, Denman A, Feizpour A, Gummuluru S, et al. Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins. MBio. 2016;7: pubmed publisher
    ..Glycogag could be replaced, with respect to viral infectivity, by the unrelated S2 protein of equine infectious anemia virus. We devised an assay for viral entry in which virus particles deliver the Cre recombinase into cells, ..
  39. Tigre D, Brandão C, de Paula F, Chinalia F, Campos G, Sardi S. Characterization of isolates of equine infectious anemia virus in Brazil. Arch Virol. 2017;162:873-877 pubmed publisher
    ..Control of the disease is currently based on detection of anti-p26 EIAV by Agar Gel Immunodiffusion (AGID)...
  40. Bolfa P, Jeon I, Loftis A, Leslie T, Marchi S, Sithole F, et al. Detection of West Nile Virus and other common equine viruses in three locations from the Leeward Islands, West Indies. Acta Trop. 2017;174:24-28 pubmed publisher
    ..Equine Herpes Virus-1 and 4 (EHV-1 and EHV-4), Equine Influenza (EI), Equine Viral Arteritis (EVA) and Equine Infectious Anemia Virus (EIAV) using a retrospective serological convenience study...
  41. Ricotti S, Garcia M, Veaute C, Bailat A, Lucca E, Cook R, et al. Serologically silent, occult equine infectious anemia virus (EIAV) infections in horses. Vet Microbiol. 2016;187:41-49 pubmed publisher
    Molecular and serological techniques for Equine Infectious Anemia Virus (EIAV) diagnosis were compared using samples from 59 clinically normal horses stabled on five farms in the Santa Fe Province of Argentina. Of these 26 (44...
  42. Parreira D, Jansen A, Abreu U, Macedo G, Silva A, Mazur C, et al. Health and epidemiological approaches of Trypanosoma evansi and equine infectious anemia virus in naturally infected horses at southern Pantanal. Acta Trop. 2016;163:98-102 pubmed publisher
    b>Equine infectious anemia virus (EIAV) and Trypanossoma evansi are endemic in Brazilian Pantanal Biome, an important area for livestock production. In this sense, we evaluated the epidemiological single and co-infection effects of T...
  43. Autorino G, Eleni C, Manna G, Frontoso R, Nardini R, Cocumelli C, et al. Evolution of equine infectious anaemia in naturally infected mules with different serological reactivity patterns prior and after immune suppression. Vet Microbiol. 2016;189:15-23 pubmed publisher
    ..On the basis of the above results, even mules with an equivocal/negative AGIDT reaction may act as EIAV reservoirs...
  44. Yoshikawa R, Takeuchi J, Yamada E, Nakano Y, Misawa N, Kimura Y, et al. Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3. J Virol. 2017;91: pubmed publisher
    ..All pathogenic lentiviruses, excluding equine infectious anemia virus, have acquired the vif gene via evolution to combat APOBEC3 proteins, which are intrinsic ..
  45. Pluta A, Rola Łuszczak M, Kubis P, Balov S, Moskalik R, Choudhury B, et al. Molecular characterization of bovine leukemia virus from Moldovan dairy cattle. Arch Virol. 2017;162:1563-1576 pubmed publisher
    ..human immunodeficiency virus (HIV) (20-38%) Mason IL (Trudy vologod moloch Inst 146-164, 1970) and equine infectious anemia virus (EIAV) (~40%) Willems L et al (AIDS Res Hum Retroviruses 16(16):1787-1795, 2000), where the envelope ..
  46. Zhang Z, Ma J, Zhang X, Su C, Yao Q, Wang X. Equine Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix Protein through trans-Golgi Networks and Cellular Vesicles. J Virol. 2016;90:1824-38 pubmed publisher
    ..Previous studies have demonstrated that equine infectious anemia virus (EIAV) matrix (MA) possesses distinct phosphoinositide affinity compared with HIV-1 MA and that ..
  47. Liu J, Ren L, Ju B, Song W, Ge X, Hong K, et al. Comparison of Antibody Immune responses to different HIV-1 Envelope Glycoprotein Mutants. Curr HIV Res. 2016;: pubmed
    ..In our previous study, we demonstrated that HIV-1 envelope glycoprotein mutants based on the equine infectious anemia virus (EIAV)attenuated vaccine enhance immunogenicity, both for DNA immunization alone and as a combined DNA ..
  48. Chande A, Cuccurullo E, Rosa A, Ziglio S, Carpenter S, Pizzato M. S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3. Proc Natl Acad Sci U S A. 2016;113:13197-13202 pubmed
    The lentivirus equine infectious anemia virus (EIAV) encodes the small protein S2, a pathogenic determinant that is important for virus replication and disease progression in horses...
  49. Fouladi N, Parker M, Kennedy V, Binley K, MCCLOSKEY L, Loader J, et al. Safety and efficacy of OXB-202, a Genetically-Engineered Tissue Therapy for the Prevention of Rejection In High Risk Corneal Transplant Patients. Hum Gene Ther. 2018;: pubmed publisher
    ..This is achieved using a lentiviral vector derived from the Equine Infectious Anaemia Virus (EIAV) called pONYK1EiA, which subsequently prevents rejection by suppressing neovascularisation...
  50. Costa S, Sastre P, Perez T, Tapia I, Barrandeguy M, Sanchez Vizcaino J, et al. Development and evaluation of a new lateral flow assay for simultaneous detection of antibodies against African Horse Sickness and Equine Infectious Anemia viruses. J Virol Methods. 2016;237:127-131 pubmed publisher
    ..LFA) for simultaneous detection and differentiation of specific antibodies against AHS virus (AHSV) and EIA virus (EIAV) was developed and evaluated with experimental and field serum samples...
  51. Tang Y, Zhang X, Na L, Wang X, Fu L, Zhu C, et al. Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys. Arch Virol. 2016;161:2667-72 pubmed publisher
    b>Equine infectious anemia virus (EIAV) is a member of the genus Lentivirus of the family Retroviridae. Horses are the most susceptible equids to EIAV infection and are therefore the primary hosts of this virus...
  52. Sun C, Zhang B, Jin J, Montelaro R. Binding of equine infectious anemia virus to the equine lentivirus receptor-1 is mediated by complex discontinuous sequences in the viral envelope gp90 protein. J Gen Virol. 2008;89:2011-9 pubmed publisher
    The identification and characterization of a functional cellular receptor for equine infectious anemia virus (EIAV), designated equine lentivirus receptor-1 (ELR1), a member of the tumour necrosis factor receptor protein family, has been ..
  53. Wang X, Liu Q, Wang Y, Wang S, Chen J, Lin Y, et al. Characterization of Equine Infectious Anemia Virus Long Terminal Repeat Quasispecies In Vitro and In Vivo. J Virol. 2018;92: pubmed publisher
    The equine infectious anemia virus (EIAV) attenuated vaccine was developed by long-term passaging of a field-isolated virulent strain in cross-species hosts, followed by successive cultivation in cells in vitro To explore the ..
  54. Jin J, Sturgeon T, Chen C, Watkins S, Weisz O, Montelaro R. Distinct intracellular trafficking of equine infectious anemia virus and human immunodeficiency virus type 1 Gag during viral assembly and budding revealed by bimolecular fluorescence complementation assays. J Virol. 2007;81:11226-35 pubmed publisher
    ..While there may be a general assumption that lentiviruses share common assembly mechanisms, studies of equine infectious anemia virus (EIAV) have indicated alternative cellular pathways and cofactors employed among lentiviruses for ..
  55. Scicluna M, Autorino G, Nogarol C, Ricci I, Frontoso R, Rosone F, et al. Validation of an indirect ELISA employing a chimeric recombinant gag and env peptide for the serological diagnosis of equine infectious anemia. J Virol Methods. 2018;251:111-117 pubmed publisher
    The National Reference Center for equine infectious anemia (EIA) validated a commercial ELISA (Eradikit® EIAV Indirect ELISA, In3diagnostic®, Turin, Italy) employing a chimeric recombinant gag and env peptide for ..
  56. Wang J, Wen S, Zhao R, Qi J, Liu Z, Li W, et al. Covalent conjugation of the equine infectious anemia virus Gag with SUMO. Biochem Biophys Res Commun. 2017;486:712-719 pubmed publisher
    ..In this study, we report for the first time, to our knowledge, the covalent conjugation of equine infectious anemia virus (EIAV) Gag with SUMO...
  57. Schwartz E, Vaidya N, Dorman K, Carpenter S, Mealey R. Dynamics of lentiviral infection in vivo in the absence of adaptive immune responses. Virology. 2018;513:108-113 pubmed publisher
    ..effect of neutralizing antibodies in preventing infection, using mathematical modeling of data from equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID)...
  58. Sharav T, Konnai S, Ochirkhuu N, Ts E, Mekata H, Sakoda Y, et al. Detection and molecular characterization of equine infectious anemia virus in Mongolian horses. J Vet Med Sci. 2017;79:1884-1888 pubmed publisher
    The genetic characterization and actual prevalence of EIAV in Mongolian horse in the disease endemic region is currently unknown...
  59. Lin Y, Sun L, Zhu D, Hu Z, Wang X, Du C, et al. Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology. 2016;495:112-21 pubmed publisher
    ..of equine schlafen11 (eSLFN11) and the characteristics of its role in restricting the production of equine infectious anemia virus (EIAV), a retrovirus similar to HIV-1...
  60. Dang Y, Loewen R, Parikh H, Roy P, Loewen N. Gene transfer to the outflow tract. Exp Eye Res. 2017;158:73-84 pubmed publisher
    ..The most prominent long-term expressing vector systems are based on lentiviruses that are derived from HIV, FIV, or EIAV. Safety considerations make non-primate lentiviral vector systems easier to work with as they are not derived from ..
  61. Binley K, Widdowson P, Loader J, Kelleher M, Iqball S, Ferrige G, et al. Transduction of photoreceptors with equine infectious anemia virus lentiviral vectors: safety and biodistribution of StarGen for Stargardt disease. Invest Ophthalmol Vis Sci. 2013;54:4061-71 pubmed publisher
    StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), ..
  62. Kong J, Kim S, Binley K, Pata I, Doi K, Mannik J, et al. Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy. Gene Ther. 2008;15:1311-20 pubmed publisher
    ..b>Equine infectious anemia virus (EIAV)-derived lentiviral vectors were constructed expressing either the human ABCA4 gene or the LacZ ..