Influenza A virus (A/California/07/2009(H1N1))
Garten R, Davis C, Russell C, Shu B, Lindstrom S, Balish A, et al
. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009;325:197-201 pubmed publisher
..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
Seidel N, Sauerbrei A, Wutzler P, Schmidtke M. Hemagglutinin 222D/G polymorphism facilitates fast intra-host evolution of pandemic (H1N1) 2009 influenza A viruses. PLoS ONE. 2014;9:e104233 pubmed publisher
Wang W, DEFEO C, Alvarado Facundo E, Vassell R, Weiss C. Intermonomer Interactions in Hemagglutinin Subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity. J Virol. 2015;89:10602-11 pubmed publisher
..These findings contribute to our understanding of the molecular mechanisms controlling HA function and antigen stability. ..
Yoon S, Chen N, Ducatez M, McBride R, Barman S, Fabrizio T, et al
. Changes to the dynamic nature of hemagglutinin and the emergence of the 2009 pandemic H1N1 influenza virus. Sci Rep. 2015;5:12828 pubmed publisher
..Receptor affinity should be considered as a factor limiting swine virus spread in humans. ..
Liu J, Huang F, Zhang J, Tan L, Lu G, Zhang X, et al
. Characteristic amino acid changes of influenza A(H1N1)pdm09 virus PA protein enhance A(H7N9) viral polymerase activity. Virus Genes. 2016;52:346-53 pubmed publisher
..Our results suggest that the novel H7N9 virus has more effective PB1, PB2, and NP genes than H1N1pdm09, and that H1N1pdm09-like PA mutations enhance the novel H7N9 polymerase function. ..
Zhang S, Wang R, Su H, Wang B, Sizhu S, Lei Z, et al
. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS, Respectively. Int J Mol Sci. 2017;18: pubmed publisher
..In summary, this work will provide us some important clues for controlling the prevalence of SIV-H1N1/2009 in pig populations. ..
Łepek K, Pajak B, Siedlecki P, Niemcewicz M, Kocik J, Wu H, et al
. Genetic diversity of hemagglutinin gene of A(H1N1)pdm09 influenza strains isolated in Taiwan and its potential impact on HA-neutralizing epitope interaction. Hum Vaccin Immunother. 2014;10:577-85 pubmed
Wang J, Li J, Zhao L, Cao M, Deng T. Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter. J Virol. 2017;91: pubmed
..This work has implications for the development of attenuated vaccine strains and for elucidation the mechanisms of the virus genome packaging. ..
Dawood F, Jain S, Finelli L, Shaw M, Lindstrom S, Garten R, et al
. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605-15 pubmed publisher
..It is likely that the number of confirmed cases underestimates the number of cases that have occurred...