Porcine reproductive and respiratory syndrome virus

Summary

Alias: Porcine reproductive and respiratory syndrome virus (PRRSV), Porcine respiratory and reproductive syndrome virus, porcine reproductive and respiratory syndrome virus PRRSV, porcine reproductive and respiratory syndrome virus, PRRSV, PRRSV

Top Publications

  1. Van Breedam W, Van Gorp H, Zhang J, Crocker P, Delputte P, Nauwynck H. The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. PLoS Pathog. 2010;6:e1000730 pubmed publisher
    The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today...
  2. Allende R, Lewis T, Lu Z, Rock D, Kutish G, Ali A, et al. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J Gen Virol. 1999;80 ( Pt 2):307-15 pubmed
    Although North American and European serotypes of porcine reproductive and respiratory syndrome virus (PRRSV) are recognized, only the genome of the European Lelystad strain (LV) has been sequenced completely...
  3. Ziebuhr J, Snijder E, Gorbalenya A. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J Gen Virol. 2000;81:853-79 pubmed publisher
  4. Wang M, Li G, Yin J, Ren X. Phylogenetic characterization of genes encoding for glycoprotein 5 and membrane protein of PRRSV isolate HH08. J Vet Sci. 2009;10:309-15 pubmed
    A porcine reproductive and respiratory syndrome virus (PRRSV) was obtained from clinic samples...
  5. Song C, Krell P, Yoo D. Nonstructural protein 1? subunit-based inhibition of NF-?B activation and suppression of interferon-? production by porcine reproductive and respiratory syndrome virus. Virology. 2010;407:268-80 pubmed publisher
    Induction of type I interferon (IFN-?/?) is an early antiviral response of the host, and porcine reproductive and respiratory syndrome virus (PRRSV) has been reported to downregulate the IFN response during infection in cells and pigs...
  6. Johnson C, Griggs T, Gnanandarajah J, Murtaugh M. Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J Gen Virol. 2011;92:1107-16 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus that emerged in the late 1980s in both Europe and North America as the causative agent of porcine reproductive and respiratory syndrome (PRRS), now the most ..
  7. Wang R, Nan Y, Yu Y, Zhang Y. Porcine reproductive and respiratory syndrome virus Nsp1? inhibits interferon-activated JAK/STAT signal transduction by inducing karyopherin-?1 degradation. J Virol. 2013;87:5219-28 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the interferon-mediated antiviral response...
  8. Wu W, Fang Y, Farwell R, Steffen Bien M, Rowland R, Christopher Hennings J, et al. A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology. 2001;287:183-91 pubmed
    The major structural proteins of porcine reproductive and respiratory syndrome virus (PRRSV) are derived from ORFs 5, 6, and 7...
  9. Wissink E, Kroese M, Maneschijn Bonsing J, Meulenberg J, van Rijn P, Rijsewijk F, et al. Significance of the oligosaccharides of the porcine reproductive and respiratory syndrome virus glycoproteins GP2a and GP5 for infectious virus production. J Gen Virol. 2004;85:3715-23 pubmed
    The arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) contains four glycoproteins, GP(2a), GP(3), GP(4) and GP(5), the functions of which are still largely unresolved...

More Information

Publications305 found, 100 shown here

  1. Wissink E, Kroese M, van Wijk H, Rijsewijk F, Meulenberg J, Rottier P. Envelope protein requirements for the assembly of infectious virions of porcine reproductive and respiratory syndrome virus. J Virol. 2005;79:12495-506 pubmed
    Virions of porcine reproductive and respiratory syndrome virus (PRRSV) contain six membrane proteins: the major proteins GP5 and M and the minor proteins GP2a, E, GP3, and GP4...
  2. Das P, Vu H, Dinh P, Cooney J, Kwon B, Osorio F, et al. Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response. Virology. 2011;410:385-94 pubmed publisher
    The role of N-glycosylation of the three minor envelope glycoproteins (GP2, GP3, and GP4) of porcine reproductive and respiratory syndrome virus (PRRSV) on infectious virus production, interactions with the receptor CD163, and ..
  3. Vu H, Kwon B, Yoon K, Laegreid W, Pattnaik A, Osorio F. Immune evasion of porcine reproductive and respiratory syndrome virus through glycan shielding involves both glycoprotein 5 as well as glycoprotein 3. J Virol. 2011;85:5555-64 pubmed publisher
    Passive administration of porcine reproductive and respiratory syndrome virus (PRRSV) neutralizing antibodies (NAbs) can effectively protect pigs against PRRSV infection...
  4. Shi X, Wang L, Li X, Zhang G, Guo J, Zhao D, et al. Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-? induction. Mol Immunol. 2011;48:1568-72 pubmed publisher
    Previous studies have shown that PRRSV nsp11, which was an endoribonuclease, was an interferon antagonist, however, the mechanism that nsp11 inhibited IFN-? production was unclear...
  5. Eck M, Durán M, Ricklin M, Locher S, Sarraseca J, Rodríguez M, et al. Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs. Vet Res. 2016;47:33 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of one of the most devastating and economically significant viral disease of pigs worldwide...
  6. Liu L, Lear Z, Hughes D, Wu W, Zhou E, Whitehouse A, et al. Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. Vet Microbiol. 2015;176:109-19 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to the swine industry and food security worldwide. The nucleocapsid (N) protein is a major structural protein of PRRSV...
  7. Zhao Y, Cheng G, Hao H, Pan Y, Liu Z, Dai M, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016;12:186 pubmed publisher
    ..compounds were also submitted to antiviral assay against infectious bursal disease virus, porcine reproductive and respiratory syndrome virus, porcine parvovirus and classical swine fever virus...
  8. Yang Y, Shi R, She R, Mao J, Zhao Y, Du F, et al. Fatal disease associated with Swine Hepatitis E virus and Porcine circovirus 2 co-infection in four weaned pigs in China. BMC Vet Res. 2015;11:77 pubmed publisher
    ..PCR was used to identify the pathogen and we tested for eight viruses (HEV, Porcine reproductive and respiratory syndrome virus, PCV2, Classical swine fever virus, Porcine epidemic diarrhea virus, Transmissible ..
  9. Zhang M, Xie Z, Xie L, Deng X, Xie Z, Luo S, et al. Simultaneous detection of eight swine reproductive and respiratory pathogens using a novel GeXP analyser-based multiplex PCR assay. J Virol Methods. 2015;224:9-15 pubmed publisher
    ..The reproductive and respiratory pathogens include North American porcine reproductive and respiratory syndrome virus (PRRSV-NA), classical swine fever virus (CSFV), porcine circovirus 2 (PCV-2), swine ..
  10. Hu L, Lin X, Nie F, ZexiaoYang -, Yao X, Li G, et al. Simultaneous typing of seven porcine pathogens by multiplex PCR with a GeXP analyser. J Virol Methods. 2016;232:21-8 pubmed publisher
    ..virus (PRV), classical swine fever virus (CSFV), African swine fever virus (ASFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), porcine circovirus type 2 (PCV-2) and Japanese ..
  11. Wilkinson J, Bao H, Ladinig A, Hong L, Stothard P, Lunney J, et al. Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus. BMC Genomics. 2016;17:383 pubmed publisher
    b>Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result in congenital infection and ultimately fetal death...
  12. Sookhoo J, Brown Jordan A, Blake L, Holder R, Brookes S, Essen S, et al. Seroprevalence of economically important viral pathogens in swine populations of Trinidad and Tobago, West Indies. Trop Anim Health Prod. 2017;49:1117-1124 pubmed publisher
    ..the seroprevalence of porcine parvovirus (PPV), transmissible gastroenteritis virus (TGEV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine respiratory coronavirus (PRCV), porcine circovirus type 2 (PCV-2), and ..
  13. Novosel D, Cadar D, Tuboly T, Jungić A, Stadejek T, Ait Ali T, et al. Investigating porcine parvoviruses genogroup 2 infection using in situ polymerase chain reaction. BMC Vet Res. 2018;14:163 pubmed publisher
    ..IHC) to detect CD3, Swine leukocyte antigen class II DQ (SLAIIDQ), lysozyme, porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza (SIV), Mycoplasma hyopneumoniae (Mhyo); and by in situ ..
  14. Huong Giang N, Lan N, Nam N, Hirai T, Yamaguchi R. Pathological Characterization of an Outbreak of Porcine Reproductive and Respiratory Syndrome in Northern Vietnam. J Comp Pathol. 2016;154:135-49 pubmed publisher
    In 2007, a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) emerged in Vietnam and spread to nearly all regions of the country by 2010...
  15. Jiménez L, Ramírez Nieto G, Alfonso V, Correa J. Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia. Virol Sin. 2014;29:242-9 pubmed publisher
    ..PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinobacillus ..
  16. Jiang N, Liu H, Wang P, Huang J, Han H, Wang Q. Illumina MiSeq Sequencing Investigation of Microbiota in Bronchoalveolar Lavage Fluid and Cecum of the Swine Infected with PRRSV. Curr Microbiol. 2019;76:222-230 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide...
  17. Zeng Z, Liu Z, Wang W, Tang D, Liang H, Liu Z. Establishment and application of a multiplex PCR for rapid and simultaneous detection of six viruses in swine. J Virol Methods. 2014;208:102-6 pubmed publisher
    ..parvovirus (PPV), and porcine circovirus type 2 (PCV2); three common RNA viruses, including porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), and Japanese encephalitis virus (JEV)...
  18. Caì Y, Postnikova E, Bernbaum J, Yú S, Mazur S, Deiuliis N, et al. Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway. J Virol. 2015;89:844-56 pubmed publisher
    ..targeting CD163, a cell surface molecule identified as an entry factor for the SHFV-related porcine reproductive and respiratory syndrome virus, diminished SHFV replication, identifying CD163 as an important SHFV entry component...
  19. Liu L, Wang J, Zhang R, Lin M, Shi R, Han Q, et al. Visual and equipment-free reverse transcription recombinase polymerase amplification method for rapid detection of foot-and-mouth disease virus. BMC Vet Res. 2018;14:263 pubmed publisher
    ..virus (VSV), encephalomyocarditis virus (EMCV), classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus 2 (PCV2) and pseudorabies virus (PRV)...
  20. Li Y, Shyu D, Shang P, Bai J, Ouyang K, Dhakal S, et al. Mutations in a Highly Conserved Motif of nsp1β Protein Attenuate the Innate Immune Suppression Function of Porcine Reproductive and Respiratory Syndrome Virus. J Virol. 2016;90:3584-99 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 1β (nsp1β) is a multifunctional viral protein, which is involved in suppressing the host innate immune response and activating a unique -2/-1 ..
  21. Fertey J, Bayer L, Grunwald T, Pohl A, Beckmann J, Gotzmann G, et al. Pathogens Inactivated by Low-Energy-Electron Irradiation Maintain Antigenic Properties and Induce Protective Immune Responses. Viruses. 2016;8: pubmed
    ..We show that LEEI efficiently inactivates different viruses (influenza A (H3N8), porcine reproductive and respiratory syndrome virus (PRRSV), equine herpesvirus 1 (EHV-1)) and bacteria (Escherichia coli) and maintains ..
  22. Cano Manuel F, López Olvera J, Fandos P, Soriguer R, Pérez J, Granados J. Long-term monitoring of 10 selected pathogens in wild boar (Sus scrofa) in Sierra Nevada National Park, southern Spain. Vet Microbiol. 2014;174:148-54 pubmed publisher
    ..In this study, the epidemiology of 10 selected pathogens (Aujeszky's disease virus - ADV, porcine reproductive and respiratory syndrome virus - PRRSV, porcine influenza virus, porcine circovirus, porcine parvovirus, Erysipelotrix ..
  23. Salogni C, Lazzaro M, Giacomini E, Giovannini S, Zanoni M, Giuliani M, et al. Infectious agents identified in aborted swine fetuses in a high-density breeding area: a three-year study. J Vet Diagn Invest. 2016;28:550-4 pubmed publisher
    ..8%). These included viral agents (Porcine circovirus-2, 138/323; Porcine reproductive and respiratory syndrome virus, 108/323; porcine parvovirus, 20/323; pseudorabies virus, 6/323; and Encephalomyocarditis ..
  24. Moutelikova R, Dufkova L, Kamler J, Drimaj J, Plhal R, Prodělalová J. Epidemiological survey of enteric viruses in wild boars in the Czech Republic: First evidence of close relationship between wild boar and human rotavirus A strains. Vet Microbiol. 2016;193:28-35 pubmed publisher
    ..the prevalence of enteric viral pathogens, namely rotavirus groups A and C (RVA and RVC), porcine reproductive and respiratory syndrome virus (PRRSV), and members of family Coronaviridae (transmissible gastroenteritis virus - TGEV, ..
  25. Zhang M, Li X, Deng Z, Chen Z, Liu Y, Gao Y, et al. Structural Biology of the Arterivirus nsp11 Endoribonucleases. J Virol. 2017;91: pubmed publisher
    ..Here, we report three crystal structures of porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus (EAV) nsp11 mutants...
  26. Gulyaeva A, Dunowska M, Hoogendoorn E, Giles J, Samborskiy D, Gorbalenya A. Domain Organization and Evolution of the Highly Divergent 5' Coding Region of Genomes of Arteriviruses, Including the Novel Possum Nidovirus. J Virol. 2017;91: pubmed publisher
    ..i>Simian hemorrhagic fever virus, Lactate dehydrogenase-elevating virus, Porcine respiratory and reproductive syndrome virus 1, and Porcine respiratory and reproductive syndrome virus 2 Here we present the ..
  27. Lee Y, Lin C, Jeng C, Chang H, Chang C, Pang V. The pathogenic role of torque teno sus virus 1 and 2 and their correlations with various viral pathogens and host immunocytes in wasting pigs. Vet Microbiol. 2015;180:186-95 pubmed publisher
    ..common concurrently infected viral pathogens including porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and porcine parvovirus (PPV), as well as changes in the distribution and ..
  28. Escobar J, Van Alstine W, Baker D, Johnson R. Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle. J Nutr. 2004;134:3047-53 pubmed
    ..Mycoplasma hyopneumoniae (Mh) or medium was given intratracheally at 4 wk of age, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) or medium was given intranasally at 6 wk of age, and pigs were killed 7 or 14 d ..
  29. Suhardiman M, Kramyu J, Narkpuk J, Jongkaewwattana A, Wanasen N. Generation of porcine reproductive and respiratory syndrome virus by in vitro assembly of viral genomic cDNA fragments. Virus Res. 2015;195:1-8 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent for a swine disease affecting the pig industry worldwide...
  30. Yu Y, Wang G, Li Q, Du Y, Du T, Mu Y, et al. Single-chain anti-idiotypic antibody retains its specificity to porcine reproductive and respiratory syndrome virus GP5. Immunol Lett. 2015;163:8-13 pubmed publisher
    ..antibody (Mab2-5G2) raised against idiotypic antibodies to membrane glycoprotein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV)...
  31. Murthy A, Ni Y, Meng X, Zhang C. Production and evaluation of virus-like particles displaying immunogenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV). Int J Mol Sci. 2015;16:8382-96 pubmed publisher
    ..Several inactivated and modified live vaccines (MLV) have been developed to curb PRRSV infections...
  32. Suradhat S, Wongyanin P, Kesdangsakonwut S, Teankum K, Lumyai M, Triyarach S, et al. A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept. Vaccine. 2015;33:3997-4003 pubmed publisher
    ..believed to play a major role in shaping the immunological and clinical outcomes following Porcine Reproductive and Respiratory Syndrome virus (PRRSV) infection...
  33. Zhou L, Kang R, Xie B, Tian Y, Yang X, Yu J, et al. Complete Genome Sequence of a Recombinant NADC30-Like Strain, SCnj16, of Porcine Reproductive and Respiratory Syndrome Virus in Southwestern China. Genome Announc. 2018;6: pubmed publisher
    The NADC30-like strains of porcine reproductive and respiratory syndrome virus (PRRSV) are characterized by a 131-amino-acid deletion in nonstructural protein 2 (NSP2)...
  34. Xie J, Christiaens I, Yang B, Trus I, Devriendt B, Cui T, et al. Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1-CD163 and PK15S10-CD163 cells. Vet Res. 2018;49:67 pubmed publisher
    Cellular entry mediators define whether the cell is permissive to PRRSV infection. Porcine sialoadhesin (pSn, Siglec-1) and CD163 are main entry mediators facilitating infection of porcine macrophages by PRRSV...
  35. Zhou L, Zhang J, Zeng J, Yin S, Li Y, Zheng L, et al. The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence. J Virol. 2009;83:5156-67 pubmed publisher
    During the past 2 years, an atypical clinical outbreak, caused by a highly pathogenic porcine reproductive and respiratory syndrome virus (PRRSV) with a unique 30-amino-acid deletion in its Nsp2-coding region, was pandemic in China...
  36. Pujhari S, Kryworuchko M, Zakhartchouk A. Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) signalling pathways in porcine reproductive and respiratory syndrome virus (PRRSV) replication. Virus Res. 2014;194:138-44 pubmed publisher
    b>Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a positive sense, single-stranded RNA genome virus that has become a major infection in swine, exerting huge economic losses to the industry worldwide...
  37. Lu Z, Archibald A, Ait Ali T. Beyond the whole genome consensus: unravelling of PRRSV phylogenomics using next generation sequencing technologies. Virus Res. 2014;194:167-74 pubmed publisher
    The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows ..
  38. Pileri E, Gibert E, Soldevila F, García Saenz A, Pujols J, Diaz I, et al. Vaccination with a genotype 1 modified live vaccine against porcine reproductive and respiratory syndrome virus significantly reduces viremia, viral shedding and transmission of the virus in a quasi-natural experimental model. Vet Microbiol. 2015;175:7-16 pubmed publisher
    The present study assessed the efficacy of vaccination against genotype 1 porcine reproductive and respiratory syndrome virus (PRRSV) in terms of reduction of the transmission...
  39. Subramaniam S, Piñeyro P, Tian D, Overend C, Yugo D, Matzinger S, et al. In vivo targeting of porcine reproductive and respiratory syndrome virus antigen through porcine DC-SIGN to dendritic cells elicits antigen-specific CD4T cell immunity in pigs. Vaccine. 2014;32:6768-75 pubmed publisher
    ..In this study, we demonstrate that porcine reproductive and respiratory syndrome virus (PRRSV) antigen was targeted efficiently to dendritic cells through antibodies specific to ..
  40. Li J, Murtaugh M. Functional analysis of porcine reproductive and respiratory syndrome virus N-glycans in infection of permissive cells. Virology. 2015;477:82-88 pubmed publisher
    The role of envelope protein-linked N-glycans in porcine reproductive and respiratory syndrome virus (PRRSV) infection of permissive cells was examined...
  41. Niederwerder M, Jaing C, Thissen J, Cino Ozuna A, McLoughlin K, Rowland R. Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2). Vet Microbiol. 2016;188:1-11 pubmed publisher
    On a world-wide basis, co-infections involving porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are common and contribute to a range of polymicrobial disease syndromes in swine...
  42. Chen Z, Collin E, Peddireddi L, Clement T, Gauger P, Hause B. Genetic diversity in envelope genes of contemporary U.S. porcine reproductive and respiratory syndrome virus strains influences viral antigenicity. Res Vet Sci. 2017;115:432-441 pubmed publisher
    ..syndrome (PRRS) is one of the most economically important diseases in swine caused by porcine reproductive and respiratory syndrome virus (PRRSV)...
  43. Spear A, Wang F, Kappes M, Das P, Faaberg K. Progress toward an enhanced vaccine: Eight marked attenuated viruses to porcine reproductive and respiratory disease virus. Virology. 2018;516:30-37 pubmed publisher
    Recombinant viruses of strain Ingelvac® PRRS porcine reproductive and respiratory syndrome virus (PRRSV) modified live virus vaccine were produced with two individual small in-frame deletions in nonstructural protein 2 (nsp2; ?23 and ?..
  44. Burkard C, Opriessnig T, Mileham A, Stadejek T, Ait Ali T, Lillico S, et al. Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection. J Virol. 2018;92: pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) has a narrow host cell tropism, limited to cells of the monocyte/macrophage lineage...
  45. Bordet E, Maisonnasse P, Renson P, Bouguyon E, Crisci E, Tiret M, et al. Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus. Sci Rep. 2018;8:10172 pubmed publisher
    ..We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen...
  46. Zhou F, Zhao J, Chen L, Chang H, Li Y, Liu H, et al. Complete Genome Sequence of a Novel Porcine Reproductive and Respiratory Syndrome Virus That Emerged in China. Genome Announc. 2015;3: pubmed publisher
    A novel porcine reproductive and respiratory syndrome virus (PRRSV) strain with 393 nucleotide deletions in the nonstructural protein 2 (Nsp2) region was examined in this study...
  47. Li Z, Wang G, Wang Y, Zhang C, Huang B, Li Q, et al. Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol. 2015;168:40-8 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) has spread worldwide, causing huge economic losses to the swine industry. The current PRRSV vaccines have failed to provide broad protection against various strains...
  48. Wang C, Shi X, Zhang X, Wang A, Wang L, Chen J, et al. The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1β Induction. DNA Cell Biol. 2015;34:728-35 pubmed publisher
    ..It has been shown that porcine reproductive and respiratory syndrome virus (PRRSV) could activate the NLRP3 inflammasome but induce the host's immunosuppression...
  49. Du Y, Du T, Shi Y, Zhang A, Zhang C, Diao Y, et al. Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages. Antiviral Res. 2016;131:9-18 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV), a common viral pathogen, causes huge annual economic losses to the swine industry worldwide...
  50. Yuan S, Zhang N, Xu L, Zhou L, Ge X, Guo X, et al. Induction of Apoptosis by the Nonstructural Protein 4 and 10 of Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE. 2016;11:e0156518 pubmed publisher
    ..b>Porcine reproductive and respiratory syndrome virus (PRRSV) has been shown to induce apoptosis both in vitro and in vivo, while the regulatory ..
  51. Fan B, Zhang H, Bai J, Liu X, Li Y, Wang X, et al. Pathogenesis of highly pathogenic porcine reproductive and respiratory syndrome virus in Chinese Tibetan swine. Res Vet Sci. 2016;108:33-7 pubmed publisher
    Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) was first characterized in 2006 in China, and it causes great economic losses to the Chinese swine production industry...
  52. Lee K, Polson D, Lowe E, Main R, Holtkamp D, Martinez Lopez B. Unraveling the contact patterns and network structure of pig shipments in the United States and its association with porcine reproductive and respiratory syndrome virus (PRRSV) outbreaks. Prev Vet Med. 2017;138:113-123 pubmed publisher
    ..We also aimed to evaluate the association between network properties and porcine respiratory and reproductive syndrome virus (PRRSV) transmission between production sites...
  53. Alkhamis M, Arruda A, Morrison R, Perez A. Novel approaches for Spatial and Molecular Surveillance of Porcine Reproductive and Respiratory Syndrome Virus (PRRSv) in the United States. Sci Rep. 2017;7:4343 pubmed publisher
  54. Luo S, Fan J, Opriessnig T, Di J, Liu B, Zuo Y. Development and application of a recombinant M protein-based indirect ELISA for the detection of porcine deltacoronavirus IgG antibodies. J Virol Methods. 2017;249:76-78 pubmed publisher
    ..porcine rotavirus (PRV), porcine circovirus 2 (PCV2), classical swine fever virus (CSFV) or porcine reproductive and respiratory syndrome virus (PRRSV). The diagnostic sensitivity was 90.6% and the diagnostic specificity was 93.3%...
  55. Wenke C, Pospiech J, Reutter T, Altmann B, Truyen U, Speck S. Impact of different supply air and recirculating air filtration systems on stable climate, animal health, and performance of fattening pigs in a commercial pig farm. PLoS ONE. 2018;13:e0194641 pubmed publisher
    ..Animal data regarding respiratory diseases, presence of antibodies against influenza A viruses, PRRSV, and Actinobacillus pleuropneumoniae and lung health score at slaughter were recorded, additionally...
  56. Das P, Dinh P, Ansari I, de Lima M, Osorio F, Pattnaik A. The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163. J Virol. 2010;84:1731-40 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) contains the major glycoprotein, GP5, as well as three other minor glycoproteins, namely, GP2a, GP3, and GP4, on the virion envelope, all of which are required for generation of ..
  57. Sun W, Xie Z, Zhang S, Nan W, Chen J. Identification of the porcine sialoadhesin gene promoter region and its cell-specific expression in porcine alveolar macrophage cells. Genet Mol Res. 2014;13:9615-21 pubmed publisher
    Porcine reproductive and respiratory syndrome (PRRS), which is caused by the PRRS virus (PRRSV), is a communicable disease. PRRS caused huge economic losses to swine breeding...
  58. Jaing C, Thissen J, Gardner S, McLoughlin K, Hullinger P, Monday N, et al. Application of a pathogen microarray for the analysis of viruses and bacteria in clinical diagnostic samples from pigs. J Vet Diagn Invest. 2015;27:313-25 pubmed publisher
    ..unknown microbes in serum, oral fluid, and tonsil from pigs experimentally coinfected with Porcine reproductive and respiratory syndrome virus (PRRSV) and Porcine circovirus-2 (PCV-2)...
  59. Trible B, Popescu L, Monday N, Calvert J, Rowland R. A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity. J Virol. 2015;89:6515-20 pubmed publisher
    Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity...
  60. Vu H, Pattnaik A, Osorio F. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017;206:29-34 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens currently affecting swine production worldwide...
  61. Liang W, Ji L, Zhang Y, Zhen Y, Zhang Q, Xu X, et al. Transcriptome Differences in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs in Response to Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection. Int J Mol Sci. 2017;18: pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded positive-sense RNA virus that can cause devastating reproductive failure and respiratory tract lesions, which has led to serious damage to the swine ..
  62. Zhang F, Ye Y, Song D, Guo N, Peng Q, Li A, et al. A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification. Biol Res. 2017;50:30 pubmed publisher
    ..gastroenteritis virus (TGEV), porcine kobuvirus (PKoV), porcine astrovirus (PAstV), porcine reproductive and respiratory syndrome virus (PRRSV), classic swine fever virus (CSFV), and porcine circovirus type 2 (PCV2)...
  63. Zhu L, Bi J, Zheng L, Zhao Q, Shu X, Guo G, et al. In vitro inhibition of porcine reproductive and respiratory syndrome virus replication by short antisense oligonucleotides with locked nucleic acid modification. BMC Vet Res. 2018;14:109 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS), which is currently insufficiently controlled...
  64. Han M, Yoo D. Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae. Virus Res. 2014;194:100-9 pubmed publisher
    ..For porcine reproductive and respiratory syndrome virus (PRRSV), individual subunits (nsp1α and nsp1β) of nsp1 suppress type I IFN production...
  65. Li Y, Sun Y, Xing F, Kang L, Wang P, Wang L, et al. Identification of a single nucleotide promoter polymorphism regulating the transcription of ubiquitin specific protease 18 gene related to the resistance to porcine reproductive and respiratory syndrome virus infection. Vet Immunol Immunopathol. 2014;162:65-71 pubmed publisher
    ..Previous studies revealed that the overexpression of porcine ubiquitin specific protease 18 (USP18) gene inhibits PRRSV replication in vitro...
  66. Guo C, Chen L, Mo D, Chen Y, Liu X. DRACO inhibits porcine reproductive and respiratory syndrome virus replication in vitro. Arch Virol. 2015;160:1239-47 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses to the pig industry worldwide. Current vaccination strategies and antiviral drugs against PRRSV are still inadequate...
  67. Richmond O, Cecere T, Erdogan E, Meng X, Piñeyro P, Subramaniam S, et al. The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-c. Vet Microbiol. 2015;180:223-9 pubmed publisher
    Porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) continue to have a negative economic impact on global swine production operations...
  68. Wang T, Wang X, Li X, Nie L, Zhang M, Liu S, et al. Intranasal inoculation of sows with highly pathogenic porcine reproductive and respiratory syndrome virus at mid-gestation causes transplacental infection of fetuses. Vet Res. 2015;46:142 pubmed publisher
    Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respiratory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure ..
  69. Ge M, Zhang Y, Liu Y, Liu T, Zeng F. Propagation of field highly pathogenic porcine reproductive and respiratory syndrome virus in MARC-145 cells is promoted by cell apoptosis. Virus Res. 2016;213:322-331 pubmed publisher
    Infection of porcine reproductive and respiratory syndrome virus (PRRSV) induces cell apoptosis both in vivo and in vitro. However, the correlation between host cell apoptosis and PRRSV replication is unclear...
  70. Lv F, Lu Y, Hao Z, Zhao Y, Zhang L, Feng L, et al. Preparation and heat resistance study of porcine reproductive and respiratory syndrome virus sugar glass vaccine. Vaccine. 2016;34:3746-50 pubmed publisher
    ..composed of trehalose, tryptone and other protectants were dried by vacuum foam drying (VFD) along with PRRSV solutions...
  71. Zhang A, Zhao L, Li N, Duan H, Liu H, Pu F, et al. Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-κB Signaling Pathway. J Virol. 2017;91: pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the pork industry worldwide each year...
  72. Do H, Trinh D, Nguyen T, Vu T, Than D, Van Lo T, et al. Molecular evolution of type 2 porcine reproductive and respiratory syndrome viruses circulating in Vietnam from 2007 to 2015. BMC Vet Res. 2016;12:256 pubmed
    ..Knowing of molecular evolution of PRRSV fields strains might contribute to PRRS control in Vietnam...
  73. Yang K, Tian Y, Zhou D, Duan Z, Guo R, Liu Z, et al. A Multiplex RT-PCR Assay to Detect and Discriminate Porcine Reproductive and Respiratory Syndrome Viruses in Clinical Specimens. Viruses. 2017;9: pubmed publisher
    Outbreaks of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) have led to large economic losses in China. The attenuated vaccine (HP-PRRSV JXA1-R) was used to control HP-PRRSV...
  74. Guo Z, Chen X, Li R, Qiao S, Zhang G. The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective. Virol J. 2018;15:2 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) has been epidemic more than 30 years in America and 20 years in China. It is still one of the most important causative agents to the worldwide swine industry...
  75. Li Y, Fang L, Zhou Y, Tao R, Wang D, Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces both eIF2α Phosphorylation-Dependent and -Independent Host Translation Shutoff. J Virol. 2018;92: pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has caused tremendous economic losses in the global swine industry since it was discovered in the late 1980s...
  76. Duan E, Wang D, Fang L, Ma J, Luo J, Chen H, et al. Suppression of porcine reproductive and respiratory syndrome virus proliferation by glycyrrhizin. Antiviral Res. 2015;120:122-5 pubmed publisher
    ..In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the ..
  77. Richmond O, Cecere T, Erdogan E, Meng X, Piñeyro P, Subramaniam S, et al. PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections. Vet Immunol Immunopathol. 2015;168:24-9 pubmed publisher
    ..derived dendritic cells (MoDC) were infected with different combinations of PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV) and evaluated for expression levels of PD-L1, as well as the expression levels of ..
  78. Weesendorp E, Stockhofe Zurwieden N, Nauwynck H, Popma De Graaf D, Rebel J. Characterization of immune responses following homologous reinfection of pigs with European subtype 1 and 3 porcine reproductive and respiratory syndrome virus strains that differ in virulence. Vet Microbiol. 2016;182:64-74 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the pork industry worldwide. Vaccination results often in limited protection...
  79. Liang W, Li Z, Wang P, Fan P, Zhang Y, Zhang Q, et al. Differences of immune responses between Tongcheng (Chinese local breed) and Large White pigs after artificial infection with highly pathogenic porcine reproductive and respiratory syndrome virus. Virus Res. 2016;215:84-93 pubmed publisher
    ..Here, the differences of immune responses to highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) were investigated by artificially infecting Tongcheng (TC) pigs (a Chinese ..
  80. Yang L, Wang R, Ma Z, Xiao Y, Nan Y, Wang Y, et al. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation. J Virol. 2017;91: pubmed publisher
    ..The objective of this study was to determine the effect of porcine reproductive and respiratory syndrome virus (PRRSV) infection on the STAT3 signaling since PRRSV induces a weak protective immune ..
  81. Wang L, Xie W, Chen X, Qiao S, Zhao M, Gu Y, et al. Molecular epidemiology of porcine reproductive and respiratory syndrome virus in Central China since 2014: The prevalence of NADC30-like PRRSVs. Microb Pathog. 2017;109:20-28 pubmed publisher
    ..Our data suggested that the NADC30-like PRRSV strains spread quickly and are now circulating and prevalent in Central China as well as the classical HP-PRRSV ..
  82. Renson P, Touzain F, Lebret A, Le Dimna M, Quenault H, Normand V, et al. Complete Genome Sequence of a Recombinant Porcine Reproductive and Respiratory Syndrome Virus Strain from Two Genotype 1 Modified Live Virus Vaccine Strains. Genome Announc. 2017;5: pubmed publisher
    This paper provides information on the complete genome sequence of a porcine reproductive and respiratory syndrome virus (PRRSV) strain isolated on a French pig farm which was identified as a recombinant strain from two commercial ..
  83. Wang T, Fang L, Zhao F, Wang D, Xiao S. Exosomes Mediate Intercellular Transmission of Porcine Reproductive and Respiratory Syndrome Virus. J Virol. 2018;92: pubmed publisher
    ..b>Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the global swine industry since ..
  84. Rappe J, de Wilde A, Di H, Müller C, Stalder H, V kovski P, et al. Antiviral activity of K22 against members of the order Nidovirales. Virus Res. 2018;246:28-34 pubmed publisher
    ..of viruses representing two (sub)families of the order Nidovirales, the Arteriviridae (porcine reproductive and respiratory syndrome virus [PRRSV], equine arteritis virus [EAV] and simian hemorrhagic fever virus [SHFV]), and the ..
  85. Fan B, Liu X, Bai J, Zhang T, Zhang Q, Jiang P. The amino acid residues at 102 and 104 in GP5 of porcine reproductive and respiratory syndrome virus regulate viral neutralization susceptibility to the porcine serum neutralizing antibody. Virus Res. 2015;204:21-30 pubmed publisher
    b>Porcine reproductive and respiratory syndrome virus (PRRSV) is mainly responsible for the heavy economic losses in pig industry in the world...
  86. Savard C, Gagnon C, Chorfi Y. Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine. Vaccine. 2015;33:3881-6 pubmed publisher
    ..Recently, DON naturally contaminated feed has been shown to decrease porcine reproductive and respiratory syndrome virus (PRRSV) specific antibody responses following experimental infection...
  87. Renukaradhya G, Meng X, Calvert J, Roof M, Lager K. Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction. Vaccine. 2015;33:4069-80 pubmed publisher
    Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) was reported in the late 1980s...
  88. Thakur K, Sanchez J, Hurnik D, Poljak Z, Opps S, Revie C. Development of a network based model to simulate the between-farm transmission of the porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2015;180:212-22 pubmed publisher
    ..this study was to develop a network based simulation model for the between-farm spread of porcine reproductive and respiratory syndrome virus to assess the impact of contact structure on between-farm transmission of PRRS virus...
  89. Lee J, Lee N, Lee J, Park S, Song C, Choi I, et al. Genetic diversity of the Korean field strains of porcine reproductive and respiratory syndrome virus. Infect Genet Evol. 2016;40:288-294 pubmed publisher
    ..The PRRS virus (PRRSV) has genetically diverse populations, like other RNA viruses, and various field strains continue to be reported ..
  90. Fablet C, Marois Créhan C, Grasland B, Simon G, Rose N. Factors associated with herd-level PRRSV infection and age-time to seroconversion in farrow-to-finish herds. Vet Microbiol. 2016;192:10-20 pubmed publisher
    Factors associated with porcine reproductive and respiratory syndrome virus (PRRSV) infection were investigated in 109 herds...
  91. Antonson A, Radlowski E, Lawson M, Rytych J, Johnson R. Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation. Brain Behav Immun. 2017;59:300-312 pubmed publisher
    ..Pregnant gilts were inoculated with porcine reproductive and respiratory syndrome virus (PRRSV; 5×105 TCID50 of live PRRSV) or saline at gestational day 76...
  92. Sun Y, Zhou L, Bian T, Tian X, Ren W, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018;216:176-182 pubmed publisher
    NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) causing clinical disease outbreaks has been recently reported in China...