Porcine epidemic diarrhea virus

Summary

Alias: porcine epidemic diarrhoea virus, PEDV

Top Publications

  1. Kocherhans R, Bridgen A, Ackermann M, Tobler K. Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence. Virus Genes. 2001;23:137-44 pubmed
    The sequence of the replicase gene of porcine epidemic diarrhoea virus (PEDV) has been determined...
  2. Duarte M, Tobler K, Bridgen A, Rasschaert D, Ackermann M, Laude H. Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF. Virology. 1994;198:466-76 pubmed
    In order to investigate the genome organization of the porcine epidemic diarrhea virus (PEDV) further, cDNA clones covering the region between the nucleocapsid and the spike (S) protein genes were independently constructed and sequenced ..
  3. Tobler K, Ackermann M. PEDV leader sequence and junction sites. Adv Exp Med Biol. 1995;380:541-2 pubmed
  4. Bridgen A, Kocherhans R, Tobler K, Carvajal A, Ackermann M. Further analysis of the genome of porcine epidemic diarrhoea virus. Adv Exp Med Biol. 1998;440:781-6 pubmed
    ..nucleotide sequence of both wild type (wt) and cell culture adapted (ca) porcine epidemic diarrhoea coronavirus (PEDV)...
  5. Junwei G, Baoxian L, Lijie T, Yijing L. Cloning and sequence analysis of the N gene of porcine epidemic diarrhea virus LJB/03. Virus Genes. 2006;33:215-9 pubmed
    The nucleocapsid (N) gene of the porcine epidemic diarrhea virus (PEDV) strain LJB/03 which was previously isolated in Heilongjiang province, China, was cloned, sequenced and compared with published sequences of other avian and mammalian ..
  6. Wang K, Lu W, Chen J, Xie S, Shi H, Hsu H, et al. PEDV ORF3 encodes an ion channel protein and regulates virus production. FEBS Lett. 2012;586:384-91 pubmed publisher
    Several studies suggest that the open reading frame 3 (ORF3) gene of porcine epidemic diarrhea virus (PEDV) is related to viral infectivity and pathogenicity, but its function remains unknown...
  7. Li Z, Chen F, Yuan Y, Zeng X, Wei Z, Zhu L, et al. Sequence and phylogenetic analysis of nucleocapsid genes of porcine epidemic diarrhea virus (PEDV) strains in China. Arch Virol. 2013;158:1267-73 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) causes acute diarrhea and dehydration with high mortality rates in swine. It has become increasingly problematic in China...
  8. Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, et al. Origin, evolution, and virulence of porcine deltacoronaviruses in the United States. MBio. 2015;6:e00064 pubmed publisher
    ..Polyclonal immune serum against PdCV but not immune serum against porcine epidemic diarrhea virus (PEDV) reacted with PdCV-infected small-intestinal epithelial cells, indicating that PdCV is ..
  9. Yang Y, Shi R, She R, Mao J, Zhao Y, Du F, et al. Fatal disease associated with Swine Hepatitis E virus and Porcine circovirus 2 co-infection in four weaned pigs in China. BMC Vet Res. 2015;11:77 pubmed publisher
    ..viruses (HEV, Porcine reproductive and respiratory syndrome virus, PCV2, Classical swine fever virus, Porcine epidemic diarrhea virus, Transmissible gastroenteritis coronavirus, Porcine parvovirus and Pseudorabies virus) that are ..

More Information

Publications208 found, 100 shown here

  1. Thimmasandra Narayanappa A, Sooryanarain H, Deventhiran J, Cao D, Ammayappan Venkatachalam B, Kambiranda D, et al. A novel pathogenic Mammalian orthoreovirus from diarrheic pigs and Swine blood meal in the United States. MBio. 2015;6:e00593-15 pubmed publisher
    ..S. swine industry, causing immense economic losses. Two different swine enteric coronaviruses (porcine epidemic diarrhea virus and Delta coronavirus) have been isolated from the affected swine population...
  2. Jung K, Hu H, Saif L. Porcine deltacoronavirus infection: Etiology, cell culture for virus isolation and propagation, molecular epidemiology and pathogenesis. Virus Res. 2016;226:50-59 pubmed publisher
    ..PDCoV diarrhea was first reported in the US in early 2014, concurrently with co-circulation of porcine epidemic diarrhea virus (PEDV) (family Coronaviridae, genus Alphacoronavirus)...
  3. Irigoyen N, Firth A, Jones J, Chung B, Siddell S, Brierley I. High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling. PLoS Pathog. 2016;12:e1005473 pubmed publisher
    ..Other coronaviruses, such as Porcine epidemic diarrhea virus and Avian coronavirus, are important livestock pathogens...
  4. Moutelikova R, Dufkova L, Kamler J, Drimaj J, Plhal R, Prodělalová J. Epidemiological survey of enteric viruses in wild boars in the Czech Republic: First evidence of close relationship between wild boar and human rotavirus A strains. Vet Microbiol. 2016;193:28-35 pubmed publisher
    ..virus (PRRSV), and members of family Coronaviridae (transmissible gastroenteritis virus - TGEV, porcine epidemic diarrhea virus - PEDV, porcine respiratory coronavirus - PRCV, and porcine hemagglutination encephalomyelitis virus -..
  5. Luo S, Fan J, Opriessnig T, Di J, Liu B, Zuo Y. Development and application of a recombinant M protein-based indirect ELISA for the detection of porcine deltacoronavirus IgG antibodies. J Virol Methods. 2017;249:76-78 pubmed publisher
    ..ELISA showed no cross-reaction with antisera against transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine rotavirus (PRV), porcine circovirus 2 (PCV2), classical swine fever virus (CSFV) or ..
  6. Wang H, Cong F, Zeng F, Lian Y, Liu X, Luo M, et al. Development of a real time reverse transcription loop-mediated isothermal amplification method (RT-LAMP) for detection of a novel swine acute diarrhea syndrome coronavirus (SADS-CoV). J Virol Methods. 2018;260:45-48 pubmed publisher
    ..syndrome virus EU, transmissible gastroenteritis coronavirus, foot and mouth disease virus, porcine epidemic diarrhea virus (S-INDEL and non-S-INDEL), swine influenza virus subtype H1N1, porcine circovirus type 2, seneca ..
  7. Jung K, Eyerly B, Annamalai T, Lu Z, Saif L. Structural alteration of tight and adherens junctions in villous and crypt epithelium of the small and large intestine of conventional nursing piglets infected with porcine epidemic diarrhea virus. Vet Microbiol. 2015;177:373-8 pubmed publisher
    ..for AJ in the small and large intestinal villous and crypt epithelium of nursing pigs infected with porcine epidemic diarrhea virus (PEDV)...
  8. Zhang F, Ye Y, Song D, Guo N, Peng Q, Li A, et al. A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification. Biol Res. 2017;50:30 pubmed publisher
    ..This assay could specifically amplify PDCoV and had no cross amplification with porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine kobuvirus (PKoV), porcine astrovirus (..
  9. Sun M, Ma J, Yu Z, Pan Z, Lu C, Yao H. Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways. Vet Res. 2017;48:44 pubmed publisher
    Entry of the α-coronavirus porcine epidemic diarrhea virus (PEDV) requires specific proteases to activate spike (S) protein for the membrane fusion of the virion to the host cell following receptor binding...
  10. Zhang J. Porcine deltacoronavirus: Overview of infection dynamics, diagnostic methods, prevalence and genetic evolution. Virus Res. 2016;226:71-84 pubmed publisher
    ..confirmed to cause diarrhea in inoculated pigs and need to be differentially diagnosed from porcine epidemic diarrhea virus and transmissible gastroenteritis virus in the field...
  11. Li J, Shen Q, Zhang W, Zhao T, Li Y, Jiang J, et al. Genomic organization and recombination analysis of a porcine sapovirus identified from a piglet with diarrhea in China. Virol J. 2017;14:57 pubmed publisher
    ..porcine rotavirus, porcine transmissible gastroenteritis virus, porcine SaV, porcine norovirus, and porcine epidemic diarrhea virus were detected by RT-PCR or PCR method...
  12. Mai K, Feng J, Chen G, Li D, Zhou L, Bai Y, et al. The detection and phylogenetic analysis of porcine deltacoronavirus from Guangdong Province in Southern China. Transbound Emerg Dis. 2018;65:166-173 pubmed publisher
    ..We found a prevalence of PDCoV (21.8%), porcine epidemic diarrhoea virus (65.5%), transmissible gastroenteritis virus (0%), rotavirus group A (25...
  13. Plotzki E, Heinrichs G, Kubícková B, Ulrich R, Denner J. Microbiological characterization of a newly established pig breed, Aachen Minipigs. Xenotransplantation. 2016;23:159-67 pubmed publisher
    ..for porcine circovirus 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and porcine epidemic diarrhea virus (PEDV)...
  14. Hsu T, Liu H, Chin C, Wang C, Zhu W, Wu B, et al. Detection, sequence analysis, and antibody prevalence of porcine deltacoronavirus in Taiwan. Arch Virol. 2018;163:3113-3117 pubmed publisher
    ..To investigate if PDCoV is also present in Taiwan, three swine coronaviruses-PDCoV, porcine epidemic diarrhea virus (PEDV), and transmissible gastroenteritis coronavirus (TGEV)-were tested using real-time reverse ..
  15. Wang W, Lin X, Liao Y, Guan X, Guo W, Xing J, et al. Discovery of a Highly Divergent Coronavirus in the Asian House Shrew from China Illuminates the Origin of the Alphacoronaviruses. J Virol. 2017;91: pubmed publisher
    ..severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, and porcine epidemic diarrhea virus. Because of their genetic diversity and phylogenetic relationships, it has been proposed that the ..
  16. Zeng Z, Deng F, Shi K, Ye G, Wang G, Fang L, et al. Dimerization of Coronavirus nsp9 with Diverse Modes Enhances Its Nucleic Acid Binding Affinity. J Virol. 2018;92: pubmed publisher
    ..porcine delta coronavirus (PDCoV) nsp9, PDCoV nsp9-ΔN7 (N-terminal 7 amino acids deleted), wild-type porcine epidemic diarrhea virus (PEDV) nsp9, and PEDV nsp9-C59A mutant...
  17. Pan Y, Tian X, Qin P, Wang B, Zhao P, Yang Y, et al. Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China. Vet Microbiol. 2017;211:15-21 pubmed publisher
    ..of diarrhea in newborn piglets without detection of transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), have been recorded in a pig farm in southern China since ..
  18. Dvorak C, Akkutay Yoldar Z, Stone S, Tousignant S, Vannucci F, Murtaugh M. An indirect enzyme-linked immunosorbent assay for the identification of antibodies to Senecavirus A in swine. BMC Vet Res. 2017;13:50 pubmed publisher
    ..Immune sera positive for FMDV, encephalomyocarditis virus, and porcine epidemic diarrhea virus antibodies did not cross-react...
  19. Chang Y, Chang C, Tsai P, Chiou H, Jeng C, Pang V, et al. Efficacy of heat-labile enterotoxin B subunit-adjuvanted parenteral porcine epidemic diarrhea virus trimeric spike subunit vaccine in piglets. Appl Microbiol Biotechnol. 2018;102:7499-7507 pubmed publisher
    ..diarrhea and high mortality in neonatal piglets, indicating that a new generation of vaccine against porcine epidemic diarrhea virus (PEDV) is urgently needed...
  20. Wang X, Chen J, Shi D, Shi H, Zhang X, Yuan J, et al. Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2. Arch Virol. 2016;161:537-47 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a coronavirus that infects cells lining the small intestine of swine, resulting in vomiting, diarrhea, and dehydration...
  21. Lee C. Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus. Virol J. 2015;12:193 pubmed publisher
    ..The coronavirus referred to as PED virus (PEDV) was determined to be the etiologic agent of this disease in the late 1970s...
  22. Zhu Y, Wang G, Cui Y, Cui S. Establishment of a nanoparticle-assisted RT-PCR assay to distinguish field strains and attenuated strains of porcine epidemic diarrhea virus. Arch Virol. 2016;161:2543-7 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) can cause serious disease and even death in neonatal piglets, resulting in serious damage to the swine industry worldwide. Open reading frame 3 (ORF3) is the only accessory gene in the PEDV genome...
  23. Wang X, Wang L, Huang X, Ma S, Yu M, Shi W, et al. Oral Delivery of Probiotics Expressing Dendritic Cell-Targeting Peptide Fused with Porcine Epidemic Diarrhea Virus COE Antigen: A Promising Vaccine Strategy against PEDV. Viruses. 2017;9: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is the causative agent of porcine epidemic diarrhea (PED) that damages intestinal epithelial cells and results in severe diarrhea and dehydration in neonatal suckling pigs ..
  24. Liu J, Li L, Han J, Sun T, Zhao X, Xu R, et al. A TaqMan probe-based real-time PCR to differentiate porcine epidemic diarrhea virus virulent strains from attenuated vaccine strains. Mol Cell Probes. 2019;: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is an important pathogen causing severe watery diarrhea, vomiting, dehydration, and death in sucking piglets...
  25. Grunewald M, Fehr A, Athmer J, Perlman S. The coronavirus nucleocapsid protein is ADP-ribosylated. Virology. 2018;517:62-68 pubmed publisher
    ..The N proteins of porcine epidemic diarrhea virus (PEDV), severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV ..
  26. Zhao Y, Liu F, Li Q, Wu M, Lei L, Pan Z. A multiplex RT-PCR assay for rapid and simultaneous detection of four RNA viruses in swine. J Virol Methods. 2019;269:38-42 pubmed publisher
    ..to classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis coronavirus (TGEV) were selected based on alignments of ..
  27. Alonso C, Raynor P, Davies P, Torremorell M. Concentration, Size Distribution, and Infectivity of Airborne Particles Carrying Swine Viruses. PLoS ONE. 2015;10:e0135675 pubmed publisher
    ..transport influenza A virus (IAV), porcine reproductive and respiratory syndrome virus (PRRSV), and porcine epidemic diarrhea virus (PEDV) generated by acutely infected pigs and assessed virus viability for each particle size range...
  28. Yuan P, Yang Z, Song H, Wang K, Yang Y, Xie L, et al. Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH. Intervirology. 2018;61:53-63 pubmed publisher
    Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are similar coronaviruses, causing diseases characterized by vomiting, diarrhea, and death from severe dehydration in piglets...
  29. Wen Z, Xu Z, Zhou Q, Li W, Wu Y, Du Y, et al. Oral administration of coated PEDV-loaded microspheres elicited PEDV-specific immunity in weaned piglets. Vaccine. 2018;36:6803-6809 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) infects pigs of all ages by invading villous epithelial cells of the small intestine causing severe diarrhea with high mortality rate in suckling piglets...
  30. Zhai S, Wei W, Li X, Wen X, Zhou X, Zhang H, et al. Occurrence and sequence analysis of porcine deltacoronaviruses in southern China. Virol J. 2016;13:136 pubmed publisher
    ..of PDCoV in this region and compare its activity to other enteric disease of swine caused by porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis coronavirus (TGEV), and porcine rotavirus group C (Rota C), 390 ..
  31. Li Z, Chen F, Ye S, Guo X, Muhanmmad Memon A, Wu M, et al. Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated Strain. Viruses. 2016;8: pubmed
    b>Porcine epidemic diarrhea virus (PEDV), a predominant cause of acute enteric infection, leads to severe dehydrating diarrhea and mortality in piglets all over the world...
  32. Song D, Huang D, Peng Q, Huang T, Chen Y, Zhang T, et al. Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea viruses associated with outbreaks of severe diarrhea in piglets in Jiangxi, China 2013. PLoS ONE. 2015;10:e0120310 pubmed publisher
    Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious, acute enteric viral disease of swine characterized by vomiting, watery diarrhea, dehydration and death...
  33. Langel S, Paim F, Lager K, Vlasova A, Saif L. Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts. Virus Res. 2016;226:93-107 pubmed publisher
    ..In 2013-2014, the porcine epidemic diarrhea virus (PEDV) outbreak led to $900 million to $1.8 billion in annual losses to US swine producers...
  34. Sun J, Li Q, Shao C, Ma Y, He H, Jiang S, et al. Isolation and characterization of Chinese porcine epidemic diarrhea virus with novel mutations and deletions in the S gene. Vet Microbiol. 2018;221:81-89 pubmed publisher
    Porcine epidemic diarrhea (PEDV) has raised growing concerns in the pig-breeding industry because it has caused significant economic losses...
  35. Gerber P, Xiao C, Chen Q, Zhang J, Halbur P, Opriessnig T. The spray-drying process is sufficient to inactivate infectious porcine epidemic diarrhea virus in plasma. Vet Microbiol. 2014;174:86-92 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is considered an emergent pathogen associated with high economic losses in many pig rearing areas...
  36. Paudel S, Park J, Jang H, Hyun B, Yang D, Shin H. Evaluation of antibody response of killed and live vaccines against porcine epidemic diarrhea virus in a field study. Vet Q. 2014;34:194-200 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is an infectious, highly contagious virus, and is an etiological agent of acute entero-pathogenic diarrhea in swine...
  37. Song D, Chen Y, Peng Q, Huang D, Zhang T, Huang T, et al. Full-Length Genome Sequence of a Variant Porcine Epidemic Diarrhea Virus Strain, CH/GDZQ/2014, Responsible for a Severe Outbreak of Diarrhea in Piglets in Guangdong, China, 2014. Genome Announc. 2014;2: pubmed publisher
    The full-length genome sequence of a variant porcine epidemic diarrhea virus (PEDV) strain, CH/GDZQ/2014, was determined...
  38. Bowman A, Krogwold R, Price T, Davis M, Moeller S. Investigating the introduction of porcine epidemic diarrhea virus into an Ohio swine operation. BMC Vet Res. 2015;11:38 pubmed publisher
    b>Porcine Epidemic Diarrhea virus (PEDV) is a highly transmissible coronavirus that causes a severe enteric disease that is particularly deadly for neonatal piglets...
  39. Lavazza A, Tittarelli C, Cerioli M. The use of convalescent sera in immune-electron microscopy to detect non-suspected/new viral agents. Viruses. 2015;7:2683-703 pubmed publisher
    ..of the following four diagnostic veterinary cases: (I) enteric viruses of pigs: Porcine Rotavirus, Porcine Epidemic Diarrhea Virus, Porcine Circovirus and Porcine Torovirus; (II) Rotavirus and astrovirus in young turkeys with ..
  40. Madson D, Arruda P, Magstadt D, Burrough E, Hoang H, Sun D, et al. Characterization of Porcine Epidemic Diarrhea Virus Isolate US/Iowa/18984/2013 Infection in 1-Day-Old Cesarean-Derived Colostrum-Deprived Piglets. Vet Pathol. 2016;53:44-52 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) was first recognized in North America in April 2013 and has since caused devastating disease...
  41. Ma Y, Zhang Y, Liang X, Oglesbee M, Krakowka S, Niehaus A, et al. Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus. Vet Microbiol. 2016;186:90-6 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV...
  42. Liu X, Wang Q. Reverse transcription-PCR assays for the differentiation of various US porcine epidemic diarrhea virus strains. J Virol Methods. 2016;234:137-41 pubmed publisher
    Concurrently, several porcine epidemic diarrhea virus (PEDV) variants are circulating in US swine farms, including the original US and the spike insertion-deletion (S-INDEL) strains...
  43. Yamane I, Yamazaki H, Ishizeki S, Watanabe Y, Okumura H, Okubo M, et al. Impact of a porcine epidemic diarrhea outbreak on swine productivity in Japan: a retrospective cohort study. J Vet Med Sci. 2016;78:1385-1389 pubmed
    ..1 April to 30 June 2014 (PED epidemic), any herds with clinical signs of PED and feces positive for porcine epidemic diarrhea virus (PEDV) on polymerase chain reaction analysis and/or immunohistochemical staining were defined as PED-..
  44. Suzuki T, Shibahara T, Yamaguchi R, Nakade K, Yamamoto T, Miyazaki A, et al. Pig epidemic diarrhoea virus S gene variant with a large deletion non-lethal to colostrum-deprived newborn piglets. J Gen Virol. 2016;97:1823-8 pubmed publisher
    We previously identified a third porcine epidemic diarrhoea virus (PEDV) S variant with a large deletion of 582 nucleotides in the 5' terminal region of the S gene, in addition to the North American type and the S INDELs type...
  45. Wang D, Fang L, Xiao S. Porcine epidemic diarrhea in China. Virus Res. 2016;226:7-13 pubmed publisher
    Porcine epidemic diarrhea (PED) is a contagious intestinal disease caused by Porcine epidemic diarrhea virus (PEDV) that characterized by vomiting, diarrhea, and dehydration...
  46. Shirato K, Maejima M, Islam M, Miyazaki A, Kawase M, Matsuyama S, et al. Porcine aminopeptidase N is not a cellular receptor of porcine epidemic diarrhea virus, but promotes its infectivity via aminopeptidase activity. J Gen Virol. 2016;97:2528-2539 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV), a causative agent of pig diarrhoea, has recently caused significant economic damage worldwide...
  47. Zhao X, Li Z, Zeng X, Zhang G, Niu J, Sun B, et al. Sequence analysis of the spike gene of Porcine epidemic diarrhea virus isolated from South China during 2011-2015. J Vet Sci. 2017;18:237-243 pubmed publisher
    The spike gene of porcine epidemic diarrhea virus (PEDV) was sequenced from 55 South China field strains isolated from pigs with symptoms of diarrhea...
  48. Kong N, Wu Y, Meng Q, Wang Z, Zuo Y, Pan X, et al. Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway. PLoS ONE. 2016;11:e0161508 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) has recently caused high mortality in suckling piglets with subsequent large economic losses to the swine industry...
  49. Lin C, Hou Y, Marthaler D, Gao X, Liu X, Zheng L, et al. Attenuation of an original US porcine epidemic diarrhea virus strain PC22A via serial cell culture passage. Vet Microbiol. 2017;201:62-71 pubmed publisher
    ..In this study, an original US, highly virulent PED virus (PEDV) strain PC22A was serially passaged in Vero CCL81 and Vero BI cells...
  50. Huang K, Yang G, Jin Y, Liu J, Chen H, Wang P, et al. Construction and immunogenicity analysis of Lactobacillus plantarum expressing a porcine epidemic diarrhea virus S gene fused to a DC-targeting peptide. Virus Res. 2018;247:84-93 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is one of the most important causative pathogens of swine diarrhea, which is widely prevalent throughout the world and is responsible for significant economic losses in the commercial pig industry, ..
  51. Yang L, Xu J, Guo L, Guo T, Zhang L, Feng L, et al. Porcine Epidemic Diarrhea Virus-Induced Epidermal Growth Factor Receptor Activation Impairs the Antiviral Activity of Type I Interferon. J Virol. 2018;92: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) causes acute and devastating enteric disease in suckling piglets and results in huge economic losses in the pig industry worldwide...
  52. Gillam F, Zhang C. Epitope selection and their placement for increased virus neutralization in a novel vaccination strategy for porcine epidemic diarrhea virus utilizing the Hepatitis B virus core antigen. Vaccine. 2018;36:4507-4516 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a member of the Alphacoronaviridae genus within the Coronaviridae family...
  53. Tian P, Jin Y, Xing G, Qv L, Huang Y, Zhou J. Evidence of recombinant strains of porcine epidemic diarrhea virus, United States, 2013. Emerg Infect Dis. 2014;20:1735-8 pubmed publisher
    To investigate the evolutionary process by which porcine epidemic diarrhea virus (PEDV) in the United States hypothetically descended from strains in China, we analyzed PEDV-positive samples collected in China during January 2012-July ..
  54. Park J, Park E, Yu J, Rho J, Paudel S, Hyun B, et al. Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus. Virus Res. 2015;197:108-15 pubmed publisher
    ..We confirmed the susceptibility to porcine epidemic diarrhea virus, one of the porcine coronaviruses...
  55. Huan C, Wang Y, Ni B, Wang R, Huang L, Ren X, et al. Porcine epidemic diarrhea virus uses cell-surface heparan sulfate as an attachment factor. Arch Virol. 2015;160:1621-8 pubmed publisher
    ..In the present study, we determined whether porcine epidemic diarrhea virus (PEDV), an emerging veterinary virus, infects Vero cells by attaching to heparan sulfate...
  56. Okda F, Liu X, Singrey A, Clement T, Nelson J, Christopher Hennings J, et al. Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of Porcine Epidemic Diarrhea Virus. BMC Vet Res. 2015;11:180 pubmed publisher
    Recent, severe outbreaks of porcine epidemic diarrhea virus (PEDV) in Asia and North America highlight the need for well-validated diagnostic tests for the identification of PEDV infected animals and evaluation of their immune status to ..
  57. Fan J, Zuo Y, Shen X, Gu W, Di J. Development of an enzyme-linked immunosorbent assay for the monitoring and surveillance of antibodies to porcine epidemic diarrhea virus based on a recombinant membrane protein. J Virol Methods. 2015;225:90-4 pubmed publisher
    ..diagnosis, serological monitoring, and surveillance of specific antibodies in pigs resulting from porcine epidemic diarrhea virus (PEDV) infection or vaccination would be essential in helping to control the spread of PED...
  58. Murakami S, Miyazaki A, Takahashi O, Hashizume W, Hase Y, Ohashi S, et al. Complete Genome Sequence of the Porcine Epidemic Diarrhea Virus Variant Tottori2/JPN/2014. Genome Announc. 2015;3: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a cause of diarrhea outbreaks at swine farms, causing vomiting, severe diarrhea, and mortality in piglets. We sequenced and analyzed the complete genome of recently isolated strains...
  59. Li Y, Zheng F, Fan B, Muhammad H, Zou Y, Jiang P. Development of an indirect ELISA based on a truncated S protein of the porcine epidemic diarrhea virus. Can J Microbiol. 2015;61:811-7 pubmed publisher
    Porcine epidemic diarrhea (PED) is a highly contagious, enteric disease of swine caused by the porcine epidemic diarrhea virus (PEDV)...
  60. Song Q, Stone S, Drebes D, Greiner L, Dvorak C, Murtaugh M. Characterization of anti-porcine epidemic diarrhea virus neutralizing activity in mammary secretions. Virus Res. 2016;226:85-92 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) causes a severe clinical enteric disease in suckling neonates with up to 100% mortality, resulting in devastating economic losses to the pork industry in recent years...
  61. Li W, van Kuppeveld F, He Q, Rottier P, Bosch B. Cellular entry of the porcine epidemic diarrhea virus. Virus Res. 2016;226:117-127 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV), a coronavirus discovered more than 40 years ago, regained notoriety recently by its devastating outbreaks in East Asia and the Americas, causing substantial economic losses to the swine husbandry...
  62. Shen H, Zhang C, Guo P, Liu Z, Sun M, Sun J, et al. Short communication: antiviral activity of porcine IFN-?3 against porcine epidemic diarrhea virus in vitro. Virus Genes. 2016;52:877-882 pubmed
    ..In this study, the molecular cloning, expression, and antiporcine epidemic diarrhea virus (PEDV) activity of porcine IFN-?3 (poIFN-?3) were reported...
  63. Huss A, Schumacher L, Cochrane R, Poulsen E, Bai J, Woodworth J, et al. Elimination of Porcine Epidemic Diarrhea Virus in an Animal Feed Manufacturing Facility. PLoS ONE. 2017;12:e0169612 pubmed publisher
    b>Porcine Epidemic Diarrhea Virus (PEDV) was the first virus of wide scale concern to be linked to possible transmission by livestock feed or ingredients...
  64. Zhang Y, Tian Y, Lin S, Sun S, Chen J, Wang G, et al. Two Distinct Genotypes of Porcine Epidemic Diarrhoea Virus in Vaccinated Pig Flocks in Shandong Province of China, 2012-2015. Transbound Emerg Dis. 2017;64:1549-1556 pubmed publisher
    As one of the top pork producers in China, Shandong Province suffered frequent outbreaks of porcine epidemic diarrhoea virus (PEDV) on pig farms from January 2012 to July 2015, resulting in significant economic losses...
  65. Luo X, Guo L, Zhang J, Xu Y, Gu W, Feng L, et al. Tight Junction Protein Occludin Is a Porcine Epidemic Diarrhea Virus Entry Factor. J Virol. 2017;91: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea, has caused huge economic losses in pig-producing countries...
  66. Wang F, Chen C, Yang K, Xu Y, Liu X, Gao F, et al. Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus. J Med Chem. 2017;60:3212-3216 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication...
  67. Cochrane R, Schumacher L, Dritz S, Woodworth J, Huss A, Stark C, et al. Effect of pelleting on survival of porcine epidemic diarrhea virus-contaminated feed. J Anim Sci. 2017;95:1170-1178 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a heat-sensitive virus that has devastated the U.S. swine industry...
  68. Tao J, Xiong N, Zhang C, Li B, Meng L, Liu H. [Identification and Characterzation of the Porcine Epidemic Diarrhea Virus (PEDV) Isolates]. Bing Du Xue Bao. 2016;32:603-9 pubmed
    To explore the porcine epidemic diarrhea virus(PEDV)epidemiology in domestic pigs, virus isolation and identification were carried out in pig herds in Shanghai and Jiangsu province...
  69. Yamamoto T, Suzuki T, Ohashi S, Miyazaki A, Tsutsui T. Genomic Motifs as a Novel Indicator of the Relationship between Strains Isolated from the Epidemic of Porcine Epidemic Diarrhea in 2013-2014. PLoS ONE. 2016;11:e0147994 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a positive-sense RNA virus that causes infectious gastroenteritis in pigs...
  70. Davies P. The dilemma of rare events: Porcine epidemic diarrhea virus in North America. Prev Vet Med. 2015;122:235-41 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) has been recognized as a swine pathogen for 40 years, but until 2013 had not been detected in the Western Hemisphere...
  71. Jarvis M, Lam H, Zhang Y, Wang L, Hesse R, Hause B, et al. Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus. Prev Vet Med. 2016;123:175-184 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) has caused severe economic losses both recently in the United States (US) and historically throughout Europe and Asia...
  72. Zhang X, Pan Y, Wang D, Tian X, Song Y, Cao Y. Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulence. Virol J. 2015;12:88 pubmed publisher
    Since 2010, a variant Porcine epidemic diarrhea virus (PEDV), which causes an acute, highly contagious, and devastating viral enteric disease with a high mortality rate in suckling pigs, broke out in China and spread rapidly to ..
  73. Trudeau M, Verma H, Sampedro F, Urriola P, Shurson G, McKelvey J, et al. Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV). PLoS ONE. 2016;11:e0158128 pubmed publisher
    Infection with porcine epidemic diarrhea virus (PEDV) causes diarrhea, vomiting, and high mortality in suckling pigs. Contaminated feed has been suggested as a vehicle of transmission for PEDV...
  74. Lee S, Kim Y, Lee C. Isolation and characterization of a Korean porcine epidemic diarrhea virus strain KNU-141112. Virus Res. 2015;208:215-24 pubmed publisher
    Severe outbreaks of porcine epidemic diarrhea virus (PEDV) have re-emerged in Korea and rapidly swept across the country, causing tremendous economic losses to producers and customers...
  75. Huang M, Wang H, Wang S, Cui D, Tuo X, Liu Y. Molecular characterization and phylogenetic analysis of porcine epidemic diarrhea virus samples obtained from farms in Gansu, China. Genet Mol Res. 2016;15: pubmed publisher
    ..The molecular diversity and phylogenetic relationships between porcine epidemic diarrhea viruses (PEDV) prevalent in Gansu were probed, and the resultant proteins were characterized...
  76. Kim S, Lee J, Jung J, Kim I, Hyun B, Kim H, et al. Genetic characterization of porcine epidemic diarrhea virus in Korea from 1998 to 2013. Arch Virol. 2015;160:1055-64 pubmed publisher
    ..Analysis of the selection patterns of PEDV isolated in Korea indicated positive selection of nine nonsynonymous sites in the S and N proteins and negative ..
  77. Gerber P, Xiao C, Lager K, Crawford K, Kulshreshtha V, Cao D, et al. Increased frequency of porcine epidemic diarrhea virus shedding and lesions in suckling pigs compared to nursery pigs and protective immunity in nursery pigs after homologous re-challenge. Vet Res. 2016;47:118 pubmed
    b>Porcine epidemic diarrhea virus (PEDV) causes enteric disease in pigs and spreads rapidly after entering naïve pig populations...
  78. Kim Y, Krishna V, Torremorell M, Goyal S, Cheeran M. Stability of Porcine Epidemic Diarrhea Virus on Fomite Materials at Different Temperatures. Vet Sci. 2018;5: pubmed publisher
    Indirect transmission of porcine epidemic diarrhea virus (PEDV) ensues when susceptible animals contact PEDV-contaminated fomite materials...
  79. Wang Z, Jiyuan Y, Su C, Xinyuan Q, Lijie T, Yijing L. Development of an antigen capture enzyme-linked immunosorbent assay for virus detection based on porcine epidemic diarrhea virus monoclonal antibodies. Viral Immunol. 2015;28:184-9 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV), a coronavirus, can cause acute diarrhea and dehydration in pigs...
  80. Stadler J, Zoels S, Fux R, Hanke D, Pohlmann A, Blome S, et al. Emergence of porcine epidemic diarrhea virus in southern Germany. BMC Vet Res. 2015;11:142 pubmed publisher
    Over the last years, porcine epidemic diarrhea virus (PEDV) has caused devastating enteric diseases in the US and several countries in Asia, while outbreaks in Europe have only been reported sporadically since the 1980s...
  81. Kim Y, Lim S, Lim J, Cho I, Park E, Le V, et al. A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs. Arch Virol. 2015;160:1573-7 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and dehydration in suckling pigs and has caused high rates of death among piglets and substantial economic loss in Vietnam since 2009...
  82. Liu X, Lin C, Annamalai T, Gao X, Lu Z, Esseili M, et al. Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain. Vet Res. 2015;46:109 pubmed publisher
    The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD50) of the virus pool was determined as 7...
  83. Sung M, Deng M, Chung Y, Huang Y, Chang C, Lan Y, et al. Evolutionary characterization of the emerging porcine epidemic diarrhea virus worldwide and 2014 epidemic in Taiwan. Infect Genet Evol. 2015;36:108-115 pubmed publisher
    Since 2010, a new variant of PEDV belonging to Genogroup 2 has been transmitting in China and further spreading to the Unites States and other Asian countries including Taiwan...
  84. Yang T, Li R, Peng W, Ge M, Luo B, Qu T, et al. First isolation and genetic characteristics of porcine sapeloviruses in Hunan, China. Arch Virol. 2017;162:1589-1597 pubmed publisher
    ..Diarrhetic fecal samples from 20 Hunan farm piglets were tested and found to be positive for porcine epidemic diarrhea virus (PEDV) by RT-PCR, although incubation with porcine kidney (PK-15) cells failed to produce infectious ..
  85. Sun D, Shi H, Guo D, Chen J, Shi D, Zhu Q, et al. Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique. J Virol Methods. 2015;218:27-39 pubmed publisher
    Recent outbreaks of porcine epidemic diarrhea virus (PEDV) have caused widespread concern...
  86. Gao Q, Zhao S, Qin T, Yin Y, Yang Q. Effects of porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cells. Vet Microbiol. 2015;179:131-41 pubmed publisher
    Infection with porcine epidemic diarrhea virus (PEDV) causes damage to intestinal epithelial cells and results in acute diarrhea and dehydration with high mortality rates in swine...
  87. Chen F, Zhu Y, Wu M, Ku X, Ye S, Li Z, et al. Comparative Genomic Analysis of Classical and Variant Virulent Parental/Attenuated Strains of Porcine Epidemic Diarrhea Virus. Viruses. 2015;7:5525-38 pubmed publisher
    Since 2010, the variant porcine epidemic diarrhea virus (PEDV) has been the etiological agent responsible for the outbreak of porcine epidemic diarrhea (PED) worldwide...
  88. Ye S, Shao K, Li Z, Guo N, Zuo Y, Li Q, et al. Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and Charge Matter. ACS Appl Mater Interfaces. 2015;7:21571-9 pubmed publisher
    ..report the broad-spectrum antiviral activity of GO against pseudorabies virus (PRV, a DNA virus) and porcine epidemic diarrhea virus (PEDV, an RNA virus)...
  89. Dastjerdi A, Carr J, Ellis R, Steinbach F, Williamson S. Porcine Epidemic Diarrhea Virus among Farmed Pigs, Ukraine. Emerg Infect Dis. 2015;21:2235-7 pubmed publisher
    ..Full genome sequencing showed the virus to be closely related to strains reported from North America, showing a sequence identity of up to 99.8%. ..
  90. Theuns S, Conceição Neto N, Christiaens I, Zeller M, Desmarets L, Roukaerts I, et al. Complete genome sequence of a porcine epidemic diarrhea virus from a novel outbreak in belgium, january 2015. Genome Announc. 2015;3: pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is a member of the family Coronaviridae and can cause severe outbreaks of diarrhea in piglets from different age groups...
  91. Li W, Luo R, He Q, van Kuppeveld F, Rottier P, Bosch B. Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus Res. 2017;235:6-13 pubmed publisher
    b>Porcine epidemic diarrhea virus (PEDV) is an emerging pathogenic coronavirus that causes a significant economic burden to the swine industry...
  92. Shi W, Fan W, Bai J, Tang Y, Wang L, Jiang Y, et al. TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells. Viruses. 2017;9: pubmed publisher
    ..whether TTSPs play a role in the progression of animal coronavirus infections, such as that by porcine epidemic diarrhea virus (PEDV)...