FIPV

Summary

Alias: Feline infectious peritonitis virus

Top Publications

  1. de Groot R, Andeweg A, Horzinek M, Spaan W. Sequence analysis of the 3'-end of the feline coronavirus FIPV 79-1146 genome: comparison with the genome of porcine coronavirus TGEV reveals large insertions. Virology. 1988;167:370-6 pubmed
    The genetic information, carried on mRNA 6 of feline infectious peritonitis virus (FIPV) strain 79-1146, was determined by sequence analysis of cDNA clones derived from the 3' end of the FIPV genome...
  2. Chang H, Egberink H, Halpin R, Spiro D, Rottier P. Spike protein fusion peptide and feline coronavirus virulence. Emerg Infect Dis. 2012;18:1089-95 pubmed publisher
    ..Evidence indicates that FIPV originates from FECV by mutation, but consistent distinguishing differences have not been established...
  3. Doki T, Yabe M, Takano T, Hohdatsu T. Differential induction of type I interferon by type I and type II feline coronaviruses in vitro. Res Vet Sci. 2018;120:57-62 pubmed publisher
    ..were infected with FCoV, the virus titer of type II FCoV in the culture supernatant was higher than that of type I FIPV. When the IFNβ expression level in FCoV-infected fcwf-4 cells was semi-quantitatively analyzed, infection with ..
  4. O Brien A, Mettelman R, Volk A, Andre N, Whittaker G, Baker S. Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines. Virology. 2018;525:1-9 pubmed publisher
    ..Here we characterize replication kinetics and plaque formation of a model type I strain FIPV Black in Fcwf-4 cells established at Cornell University (Fcwf-4 CU)...
  5. Watanabe R, Eckstrand C, Liu H, Pedersen N. Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq. Vet Res. 2018;49:81 pubmed publisher
    Laboratory cats were infected with a serotype I cat-passaged field strain of FIP virus (FIPV) and peritoneal cells harvested 2-3 weeks later at onset of lymphopenia, fever and serositis...
  6. Shirato K, Chang H, Rottier P. Differential susceptibility of macrophages to serotype II feline coronaviruses correlates with differences in the viral spike protein. Virus Res. 2018;255:14-23 pubmed publisher
    ..the two feline coronavirus (FCoV) pathotypes: feline enteric coronavirus (FECV; low-virulent) and feline infectious peritonitis virus (FIPV; lethal)...
  7. Ehmann R, Kristen Burmann C, Bank Wolf B, König M, Herden C, Hain T, et al. Reverse Genetics for Type I Feline Coronavirus Field Isolate To Study the Molecular Pathogenesis of Feline Infectious Peritonitis. MBio. 2018;9: pubmed publisher
    ..infectious peritonitis (FIP), one of the most important lethal infections of cats, is caused by feline infectious peritonitis virus (FIPV), the high-virulence biotype of feline coronaviruses (FCoVs)...
  8. Pedersen N, Liu H, Gandolfi B, Lyons L. The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. Vet Immunol Immunopathol. 2014;162:33-40 pubmed publisher
    ..feline infectious peritonitis (FIP) is usually fatal, giving the impression that immunity to the FIP virus (FIPV) is extremely poor...
  9. McDonagh P, Sheehy P, Norris J. Combination siRNA therapy against feline coronavirus can delay the emergence of antiviral resistance in vitro. Vet Microbiol. 2015;176:10-8 pubmed publisher
    Virulent biotypes of feline coronavirus (FCoV), commonly referred to as feline infectious peritonitis virus (FIPV), can result in the development of feline infectious peritonitis (FIP), a typically fatal immune mediated disease for which ..

More Information

Publications41

  1. Murphy B, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018;219:226-233 pubmed publisher
    ..that GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low ..
  2. Resik S, Tejeda A, Mach O, Fonseca M, Diaz M, Alemany N, et al. Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: a randomized controlled trial in Cuba. Vaccine. 2015;33:307-13 pubmed publisher
    ..Administration of fractional dose (1/5th of full dose) IPV (fIPV) intradermally may reduce costs, but its administration is cumbersome with BCG needle and syringe...
  3. Pedersen N, Eckstrand C, Liu H, Leutenegger C, Murphy B. Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Vet Microbiol. 2015;175:157-66 pubmed publisher
    Twenty specific pathogen free cats were experimentally infected with a virulent cat-passaged type I field strain of FIPV. Eighteen cats succumbed within 2-4 weeks to effusive abdominal FIP, one survived for 6 weeks, and one seroconverted ..
  4. Miyamoto R, Kurita S, Tani H, Kobayashi M, Sugiura S, Shigihara K, et al. Establishment and characterization of a cell line from a feline histiocytic sarcoma. Vet Immunol Immunopathol. 2018;201:72-76 pubmed publisher
    ..Moreover, FHS-1 cells were tested for susceptibility to feline infectious peritonitis virus (FIPV) strain 79-1146; however, this cell line was not susceptible to this viral strain...
  5. Kim Y, Shivanna V, Narayanan S, Prior A, Weerasekara S, Hua D, et al. Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses. J Virol. 2015;89:4942-50 pubmed publisher
    ..b>Feline infectious peritonitis virus (FIPV) is the leading cause of death in young cats, and virulent, systemic feline calicivirus (vs-..
  6. Doki T, Takano T, Kawagoe K, Kito A, Hohdatsu T. Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis. Res Vet Sci. 2016;104:17-23 pubmed publisher
    b>Feline infectious peritonitis virus (FIPV) replication in macrophages/monocytes induced tumor necrosis factor (TNF)-alpha production, and that the TNF-alpha produced was involved in aggravating the pathology of FIP...
  7. St John S, Therkelsen M, Nyalapatla P, Osswald H, Ghosh A, Mesecar A. X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design. Bioorg Med Chem Lett. 2015;25:5072-7 pubmed publisher
    ..FIP for the treatment of cats, we screened a small set of designed peptidomimetic inhibitors for inhibition of FIPV-3CL(pro), identifying two compounds with low to sub-micromolar inhibition, compound 6 (IC50=0.59±0...
  8. Pedersen N, Liu H, Durden M, Lyons L. Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection. Vet Immunol Immunopathol. 2016;171:17-20 pubmed publisher
    A previous study demonstrated the existence of a natural resistance to feline infectious peritonitis virus (FIPV) among 36% of randomly bred laboratory cats...
  9. Wang F, Chen C, Liu X, Yang K, Xu X, Yang H. Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors. J Virol. 2016;90:1910-7 pubmed publisher
    Coronaviruses (CoVs) can cause highly prevalent diseases in humans and animals. Feline infectious peritonitis virus (FIPV) belongs to the genus Alphacoronavirus, resulting in a lethal systemic granulomatous disease called feline ..
  10. Shuid A, Safi N, Haghani A, Mehrbod P, Haron M, Tan S, et al. Apoptosis transcriptional mechanism of feline infectious peritonitis virus infected cells. Apoptosis. 2015;20:1457-70 pubmed publisher
    Apoptosis has been postulated to play an important role during feline infectious peritonitis virus (FIPV) infection; however, its mechanism is not well characterized...
  11. Resik S, Tejeda A, Mach O, Sein C, Molodecky N, Jarrahian C, et al. Needle-free jet injector intradermal delivery of fractional dose inactivated poliovirus vaccine: Association between injection quality and immunogenicity. Vaccine. 2015;33:5873-7 pubmed publisher
    ..Administration of fractional dose (1/5 of full dose) IPV (fIPV) by intradermal (ID) injection may reduce costs, but its conventional administration is with Bacillus Calmette-..
  12. Doki T, Takano T, Koyama Y, Hohdatsu T. Identification of the peptide derived from S1 domain that inhibits type I and type II feline infectious peritonitis virus infection. Virus Res. 2015;204:13-20 pubmed publisher
    b>Feline infectious peritonitis virus (FIPV) can cause a lethal disease in cats, feline infectious peritonitis (FIP). A therapeutic drug that is effective against FIP has not yet been developed...
  13. Burkard C, Verheije M, Haagmans B, van Kuppeveld F, Rottier P, Bosch B, et al. ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol. 2015;89:4434-48 pubmed publisher
    ..ATP1A1 protein was shown to be critical for infection of cells with murine hepatitis virus (MHV), feline infectious peritonitis virus (FIPV), and VSV but not with IAV...
  14. Tian J, Hu X, Liu D, Wu H, Qu L. Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. Int J Biol Macromol. 2017;95:160-167 pubmed publisher
    ..the feline herpesvirus 1, feline influenza virus H3N2 and H5N6, feline panleukopenia virus and feline infectious peritonitis virus that can contribute to respiratory and gastrointestinal diseases in cats...
  15. Safi N, Haghani A, Ng S, Selvarajah G, Mustaffa Kamal F, Omar A. Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats. BMC Vet Res. 2017;13:92 pubmed publisher
    ..biotypes of feline coronavirus (FCoV): the self-limiting feline enteric coronavirus (FECV) and the feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP), a fatal disease associated with cats ..
  16. Phillips J, Hilt D, Jackwood M. Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels. Virus Genes. 2013;47:490-7 pubmed publisher
    b>Feline infectious peritonitis virus (FIPV), an alpha Coronavirus, is the causative agent of a fatal immune mediated disease in cats...
  17. de Groot R, Maduro J, Lenstra J, Horzinek M, van der Zeijst B, Spaan W. cDNA cloning and sequence analysis of the gene encoding the peplomer protein of feline infectious peritonitis virus. J Gen Virol. 1987;68 ( Pt 10):2639-46 pubmed
    The peplomer gene of feline infectious peritonitis virus (FIPV) strain 79-1146 was isolated from a genomic cDNA library by differential hybridization with RNA 2 and 3 as probes...
  18. Saleem A, Mach O, Yousafzai M, Khan A, Weldon W, Oberste M, et al. Needle adapters for intradermal administration of fractional dose of inactivated poliovirus vaccine: Evaluation of immunogenicity and programmatic feasibility in Pakistan. Vaccine. 2017;35:3209-3214 pubmed publisher
    Administration of 1/5th dose of Inactivated poliovirus vaccine intradermally (fIPV) provides similar immune response as full-dose intramuscular IPV, however, fIPV administration with BCG needle and syringe (BCG NS) is technically ..
  19. Takano T, Nakaguchi M, Doki T, Hohdatsu T. Antibody-dependent enhancement of serotype II feline enteric coronavirus infection in primary feline monocytes. Arch Virol. 2017;162:3339-3345 pubmed publisher
    ..avirulent feline coronavirus (feline enteric coronavirus: FECV) and virulent feline coronavirus (feline infectious peritonitis virus: FIPV)...
  20. Florek D, Ehmann R, Kristen Burmann C, Lemmermeyer T, Lochnit G, Ziebuhr J, et al. Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7b. J Gen Virol. 2017;98:2017-2029 pubmed publisher
    ..called 7b (206 residues), was investigated using a reverse genetic approach established for feline infectious peritonitis virus (FIPV) strain 79-1146...
  21. Dedeurwaerder A, Olyslaegers D, Desmarets L, Roukaerts I, Theuns S, Nauwynck H. ORF7-encoded accessory protein 7a of feline infectious peritonitis virus as a counteragent against IFN-?-induced antiviral response. J Gen Virol. 2014;95:393-402 pubmed publisher
    ..previously that ORF7 is essential for efficient replication in vitro and virulence in vivo of feline infectious peritonitis virus (FIPV), the role of this ORF in the evasion of the IFN-? antiviral response was investigated...
  22. Tekes G, Thiel H. Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis. Adv Virus Res. 2016;96:193-218 pubmed publisher
    ..The causative agent of this deadly disease, feline infectious peritonitis virus (FIPV), arises from feline enteric coronavirus (FECV)...
  23. Felten S, Leutenegger C, Balzer H, Pantchev N, Matiasek K, Wess G, et al. Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis. BMC Vet Res. 2017;13:228 pubmed publisher
    ..It was hypothesized that this test would correctly discriminate feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV)...
  24. Porter E, Tasker S, Day M, Harley R, Kipar A, Siddell S, et al. Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis. Vet Res. 2014;45:49 pubmed publisher
    ..These results suggest that the methionine to leucine substitution at position 1058 in the FCoV spike protein is indicative of systemic spread of FCoV from the intestine, rather than a virus with the potential to cause FIP. ..
  25. Yamanaka M, Crisp T, Brown R, Dale B. Nucleotide sequence of the inter-structural gene region of feline infectious peritonitis virus. Virus Genes. 1998;16:317-8 pubmed
    The sequence of the region located between the S and M glycoprotein genes of the 79-1146 strain of feline infectious peritonitis virus (FIPV) is presented...
  26. Anand A, Molodecky N, Pallansch M, Sutter R. Immunogenicity to poliovirus type 2 following two doses of fractional intradermal inactivated poliovirus vaccine: A novel dose sparing immunization schedule. Vaccine. 2017;35:2993-2998 pubmed publisher
    ..We conducted a literature review and contacted corresponding authors of recent studies with fractional-dose IPV (fIPV), one-fifth of intramuscular dose administered intradermally, to conduct additional type 2 immunogenicity analyses ..
  27. Bank Wolf B, Stallkamp I, Wiese S, Moritz A, Tekes G, Thiel H. Mutations of 3c and spike protein genes correlate with the occurrence of feline infectious peritonitis. Vet Microbiol. 2014;173:177-88 pubmed publisher
    ..3b, 3c, 7a and 7b, the S2 domain of the spike (S) protein gene and the membrane (M) protein gene of feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV) samples were amplified, cloned and sequenced...
  28. Vennema H, de Groot R, Harbour D, Horzinek M, Spaan W. Primary structure of the membrane and nucleocapsid protein genes of feline infectious peritonitis virus and immunogenicity of recombinant vaccinia viruses in kittens. Virology. 1991;181:327-35 pubmed
    b>Feline infectious peritonitis virus (FIPV) causes a mostly fatal, immunologically mediated disease in cats...
  29. Pervaiz A, Mbaeyi C, Baig M, Burman A, Ahmed J, Akter S, et al. Fractional-Dose Inactivated Poliovirus Vaccine Campaign - Sindh Province, Pakistan, 2016. MMWR Morb Mortal Wkly Rep. 2017;66:1295-1299 pubmed publisher
    ..Fractional-dose, intradermal IPV (fIPV), one fifth of the standard intramuscular dose, has been developed to more efficiently manage limited IPV supplies...
  30. Terada Y, Shiozaki Y, Shimoda H, Mahmoud H, Noguchi K, Nagao Y, et al. Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats. J Gen Virol. 2012;93:1930-4 pubmed publisher
    In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal ..
  31. B lint d, Farsang A, Z dori Z, Horny k k, Dencso L, Almaz n F, et al. Molecular characterization of feline infectious peritonitis virus strain DF-2 and studies of the role of ORF3abc in viral cell tropism. J Virol. 2012;86:6258-67 pubmed publisher
    The full-length genome of the highly lethal feline infectious peritonitis virus (FIPV) strain DF-2 was sequenced and cloned into a bacterial artificial chromosome (BAC) to study the role of ORF3abc in the FIPV-feline enteric coronavirus (..
  32. Hu C, Chang W, Fang Z, Chen Y, Wang W, Tsai H, et al. Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Sci Rep. 2017;7:13043 pubmed publisher
    ..and its nanoformulation are herein investigated for their antiviral activity against the type II feline infectious peritonitis virus (FIPV)...