Sendai virus

Summary

Alias: murine parainfluenza virus 1

Top Publications

  1. Suzuki H, Kurooka M, Hiroaki Y, Fujiyoshi Y, Kaneda Y. Sendai virus F glycoprotein induces IL-6 production in dendritic cells in a fusion-independent manner. FEBS Lett. 2008;582:1325-9 pubmed publisher
    We previously reported that inactivated Sendai virus particle (hemagglutinating virus of Japan envelope; HVJ-E) has anti-tumor effects by eliciting IL-6 production in dendritic cells (DCs)...
  2. Horikami S, Smallwood S, Moyer S. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication. Virology. 1996;222:383-90 pubmed publisher
    The interactions of Sendai virus proteins required for viral RNA synthesis have been characterized both by the yeast two-hybrid system and through the use of glutathione S-transferase (gst)-viral fusion proteins synthesized in mammalian ..
  3. Itoh M, Isegawa Y, Hotta H, Homma M. Isolation of an avirulent mutant of Sendai virus with two amino acid mutations from a highly virulent field strain through adaptation to LLC-MK2 cells. J Gen Virol. 1997;78 ( Pt 12):3207-15 pubmed publisher
    A field strain of Sendai virus (SeV) Ohita-M1 (M1) was isolated from an epidemic in an animal laboratory by passaging in mice. A mutant strain, Ohita-MVC11 (MVC11), was then obtained by passaging M1 in rhesus monkey (LLC-MK2) cells...
  4. Cevik B, Kaesberg J, Smallwood S, Feller J, Moyer S. Mapping the phosphoprotein binding site on Sendai virus NP protein assembled into nucleocapsids. Virology. 2004;325:216-24 pubmed publisher
    To catalyze RNA synthesis, the Sendai virus P-L RNA polymerase complex first binds the viral nucleocapsid (NC) template through an interaction of the P subunit with NP assembled with the genome RNA...
  5. Ogino T, Kobayashi M, Iwama M, Mizumoto K. Sendai virus RNA-dependent RNA polymerase L protein catalyzes cap methylation of virus-specific mRNA. J Biol Chem. 2005;280:4429-35 pubmed publisher
    The Sendai virus (SeV) RNA-dependent RNA polymerase complex, which consists of L and P proteins, participates in the synthesis of viral mRNAs that possess a methylated cap structure...
  6. de Breyne S, Stalder R, Curran J. Intracellular processing of the Sendai virus C' protein leads to the generation of a Y protein module: structure-functional implications. FEBS Lett. 2005;579:5685-90 pubmed publisher
    The Sendai virus "C-proteins" (C', C, Y1 and Y2) are a nested set of non-structural proteins. The shorter Y proteins arise in vivo both by de novo translation initiation and by proteolytic processing of C'...
  7. Irie T, Shimazu Y, Yoshida T, Sakaguchi T. The YLDL sequence within Sendai virus M protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein. J Virol. 2007;81:2263-73 pubmed publisher
    ..Here we show that both Sendai virus (SeV) matrix protein M and accessory protein C contribute to virus budding by physically interacting with Alix/..
  8. Kato A, Kiyotani K, Kubota T, Yoshida T, Tashiro M, Nagai Y. Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice. J Virol. 2007;81:3264-71 pubmed
    The Sendai virus (SeV) C protein blocks signal transduction of interferon (IFN), thereby counteracting the antiviral actions of IFN...
  9. Marq J, Brini A, Kolakofsky D, Garcin D. Targeting of the Sendai virus C protein to the plasma membrane via a peptide-only membrane anchor. J Virol. 2007;81:3187-97 pubmed
    ..This paper reports that the apparently unmodified N-terminal sequence of the Sendai virus C protein (MPSFLKKILKLRGRR . . ...

More Information

Publications224 found, 100 shown here

  1. Wiegand M, Bossow S, Schlecht S, Neubert W. De novo synthesis of N and P proteins as a key step in Sendai virus gene expression. J Virol. 2007;81:13835-44 pubmed publisher
    ..Here, we reexamined the function of the viral RNA-dependent RNA polymerase through infection studies with Sendai virus (SeV) N and P deletion (Delta) mutants...
  2. Irie T, Nagata N, Yoshida T, Sakaguchi T. Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles. Virology. 2008;374:495-505 pubmed publisher
    The Sendai virus (SeV) C proteins are a nested set of four accessory proteins, C', C, Y1, and Y2, encoded on the P mRNA from an alternate reading frame...
  3. Takeuchi K, Komatsu T, Kitagawa Y, Sada K, Gotoh B. Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA. J Virol. 2008;82:10102-10 pubmed publisher
    b>Sendai virus (SeV) C protein is a multifunctional protein that plays important roles in regulating viral genome replication and transcription, antagonizing the host interferon system, suppressing virus-induced apoptosis, and facilitating ..
  4. Murphy A, Grdzelishvili V. Identification of sendai virus L protein amino acid residues affecting viral mRNA cap methylation. J Virol. 2009;83:1669-81 pubmed publisher
    ..critical amino acid residues have a similar function in other members of the Mononegavirales, we examined the Sendai virus (SeV) (family Paramyxoviridae) L protein by targeting homologous amino acid residues important for cap ..
  5. Luque L, Bridges O, Mason J, Boyd K, Portner A, Russell C. Residues in the heptad repeat a region of the fusion protein modulate the virulence of Sendai virus in mice. J Virol. 2010;84:810-21 pubmed publisher
    ..the results show that residues in the heptad repeat A region of the F protein modulate the virulence of Sendai virus in mice by influencing both the spread and clearance of the virus and the extent and severity of inflammation...
  6. Irie T, Nagata N, Igarashi T, Okamoto I, Sakaguchi T. Conserved charged amino acids within Sendai virus C protein play multiple roles in the evasion of innate immune responses. PLoS ONE. 2010;5:e10719 pubmed publisher
    One of the accessory proteins of Sendai virus (SeV), C, translated from an alternate reading frame of P/V mRNA has been shown to function at multiple stages of infection in cell cultures as well as in mice...
  7. Irie T, Inoue M, Sakaguchi T. Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection. Virology. 2010;405:334-41 pubmed publisher
    b>Sendai virus (SeV) M protein has a YLDL motif, which is essential for budding of virus-like particles (VLPs) by expression of the M protein. We investigated the importance of the YLDL motif for SeV budding...
  8. Murphy A, Moerdyk Schauwecker M, Mushegian A, Grdzelishvili V. Sequence-function analysis of the Sendai virus L protein domain VI. Virology. 2010;405:370-82 pubmed publisher
    ..In our recent study we analyzed four amino acid residues within domain VI of the Sendai virus L protein and our data indicated that there could be differences in L protein sequence requirements for cap ..
  9. Gosselin Grenet A, Mottet Osman G, Roux L. Sendai virus particle production: basic requirements and role of the SYWST motif present in HN cytoplasmic tail. Virology. 2010;405:439-47 pubmed publisher
    b>Sendai virus (SeV) HN protein is dispensable for virus particle production. HN incorporation into virions strictly depends on a cytoplasmic domain SYWST motif...
  10. Sakaguchi T, Irie T, Kuwayama M, Ueno T, Yoshida A, Kawabata R. Analysis of interaction of Sendai virus V protein and melanoma differentiation-associated gene 5. Microbiol Immunol. 2011;55:760-7 pubmed publisher
    b>Sendai virus (SeV), a pneumotropic virus of rodents, has an accessory protein, V, and the V protein has been shown to interact with MDA5, inhibiting IRF3 activation and interferon-? production...
  11. Irie T, Kiyotani K, Igarashi T, Yoshida A, Sakaguchi T. Inhibition of interferon regulatory factor 3 activation by paramyxovirus V protein. J Virol. 2012;86:7136-45 pubmed publisher
    The V protein of Sendai virus (SeV) suppresses innate immunity, resulting in enhancement of viral growth in mouse lungs and viral pathogenicity...
  12. Bampi C, Rasga L, Roux L. Antagonism to human BST-2/tetherin by Sendai virus glycoproteins. J Gen Virol. 2013;94:1211-9 pubmed publisher
    Tetherin is an interferon-inducible factor that restricts viral particle production. We show here that Sendai virus (SeV) induces a drastic decrease in tetherin levels in infected HeLa cells...
  13. Chen M, Aoki Utsubo C, Kameoka M, Deng L, Terada Y, Kamitani W, et al. Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane. Sci Rep. 2017;7:15931 pubmed publisher
    ..values of CM-II-sPLA2 against viruses that bud through the PM (Sindbis virus, influenza virus and Sendai virus) or trans-Golgi network (TGN) (herpes simplex virus) were >10,000 ng/ml...
  14. Layh Schmitt G, Lu S, Navid F, Brooks S, Lazowick E, Davis K, et al. Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors. Clin Rheumatol. 2017;36:143-154 pubmed publisher
    ..Dermal fibroblasts of two axSpA patients and one healthy control were reprogrammed into iPSCs using a Sendai virus vector encoding pluripotency genes...
  15. Luo F, Liu H, Yang S, Fang Y, Zhao Z, Hu Y, et al. Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production. J Immunol. 2019;202:2254-2265 pubmed publisher
    ..The inhibitor AMN107 inhibits IFN-β production induced by poly(dA:dT), poly(I:C), and Sendai virus in THP-1 and mouse bone marrow-derived macrophage cells...
  16. Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, et al. HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. J Immunol. 2017;199:3280-3292 pubmed publisher
    ..the expression of IFNs, which leads to a broad inhibition of the replication of RNA viruses, including EV71, Sendai virus, influenza A virus, and vesicular stomatitis virus...
  17. Chiu S, Fernandez R, Subramanian V, Sun H, Decamp M, Kreisel D, et al. Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity. J Immunol. 2016;197:51-7 pubmed publisher
    ..Intratracheal instillation of anti-MHC class I Abs, but not isotype control, followed by murine Sendai virus infection led to development of Abs against ColV and KAT, but not collagen type II (ColII), a cartilaginous ..
  18. Zhirnov O. Biochemical Variations in Cytolytic Activity of Ortho- and Paramyxoviruses in Human Lung Tumor Cell Culture. Biochemistry (Mosc). 2017;82:1048-1054 pubmed publisher
    ..Infection with Sendai virus caused moderate stimulation of autophagy, which suggests that the mechanism of the virus-induced cell death and ..
  19. Hu Y, Li W, Gao T, Cui Y, Jin Y, Li P, et al. The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. J Virol. 2017;91: pubmed publisher
    ..Type I IFN production induced by poly I·C or Sendai virus (SeV) was suppressed by the SARS-CoV N protein...
  20. Cohen T, Schwarz T, Vigant F, Gardner T, Hernandez R, Lee B, et al. The Microtubule Inhibitor Podofilox Inhibits an Early Entry Step of Human Cytomegalovirus. Viruses. 2016;8: pubmed
    ..of infection by viruses with single step binding processes prior to fusion-like Newcastle disease virus, Sendai virus, and influenza A virus or viruses that enter via endocytosis like vesicular stomatitis virus and a clinical-..
  21. Mouka A, Izard V, Tachdjian G, Brisset S, Yates F, Mayeur A, et al. Induced pluripotent stem cell generation from a man carrying a complex chromosomal rearrangement as a genetic model for infertility studies. Sci Rep. 2017;7:39760 pubmed publisher
    ..Erythroblasts from the patient were reprogrammed with Sendai virus vectors to generate iPSCs...
  22. Rybová J, Ledvinova J, Sikora J, Kuchar L, Dobrovolny R. Neural cells generated from human induced pluripotent stem cells as a model of CNS involvement in mucopolysaccharidosis type II. J Inherit Metab Dis. 2018;41:221-229 pubmed publisher
    ..white blood cells from male and female MPSII patients into iPSC using a non-integrating protocol based on the Sendai virus vector system...
  23. Khan K, Dô F, Marineau A, Doyon P, Clément J, Woodgett J, et al. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Mol Cell Biol. 2015;35:3029-43 pubmed publisher
    ..Mechanistically, GSK-3 isoform activation following Sendai virus infection results in phosphorylation of β-catenin at S33/S37/T41, promoting IRF3 DNA binding and activation ..
  24. Kim J, Kim M, Jeong H, Kang S, Park S, Lee Y, et al. Sendai viroplexes for epidermal growth factor receptor-directed delivery of interleukin-12 and salmosin genes to cancer cells. J Gene Med. 2016;18:112-23 pubmed publisher
    ..The system consists of a well-verified cationic O,O'-dimyristyl-N-lysyl glutamate (DMKE), Sendai virus fusion (F) protein and hemagglutinin-neuraminidase (HN) protein, referred to as cationic Sendai F/HN virosomes...
  25. Li F, Lang Y, Ji Z, Xia Z, Han Y, Cheng Y, et al. A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles. J Biol Chem. 2019;294:182-194 pubmed publisher
    ..1 (HSV-1) infections in a dose-dependent manner at noncytotoxic concentrations, but that it has no effect on Sendai virus (SeV) and adenovirus (AdV) infections in vitro Furthermore, rEv37 alkalized acidic organelles to prevent ..
  26. Piacentini S, La Frazia S, Riccio A, Pedersen J, Topai A, Nicolotti O, et al. Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57. Sci Rep. 2018;8:10425 pubmed publisher
    ..We show that nitazoxanide and its circulating-metabolite tizoxanide act at post-entry level by provoking Sendai virus and RSV F-protein aggregate formation, halting F-trafficking to the host plasma membrane...
  27. Nakai R, Ohnuki M, Kuroki K, Ito H, Hirai H, Kitajima R, et al. Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata). Sci Rep. 2018;8:12187 pubmed publisher
    ..Here we generated induced pluripotent stem cells (iPSCs) from skin fibroblasts of the Japanese macaque with Sendai virus or plasmid vectors...
  28. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, et al. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016;68:2086-2096 pubmed publisher
    ..We generated iPSCs from their skin fibroblasts by using integration-free Sendai virus. We used directed differentiation to create purified populations of iPSC-CMs...
  29. Liu G, Lu Y, Thulasi Raman S, Xu F, Wu Q, Li Z, et al. Nuclear-resident RIG-I senses viral replication inducing antiviral immunity. Nat Commun. 2018;9:3199 pubmed publisher
    ..specificity conferred by nuclear RIG-I is reinforced by its inability to sense cytoplasmic-replicating Sendai virus and appreciable sensing of hepatitis B virus pregenomic RNA in the nucleus...
  30. Hotz C, Roetzer L, Huber T, Sailer A, Oberson A, Treinies M, et al. TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection. J Immunol. 2015;195:4387-95 pubmed publisher
    ..receptor signaling also occurred after viral infection, because infection of host cells with Sendai virus or their exposure to supernatant from virus-infected cells induced the same changes in TLR and RLR sensitivity ..
  31. Suslov A, Boldanova T, Wang X, Wieland S, Heim M. Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver. Gastroenterology. 2018;154:1778-1790 pubmed publisher
    ..were incubated with toll-like receptor (TLR) ligands (polyinosinic-polycytidylic acid) or infected with Sendai virus and then analyzed...
  32. Maguire J, Gagne A, Jobaliya C, Gandre Babbe S, Gadue P, French D. Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells. Stem Cell Res. 2016;16:338-41 pubmed publisher
    ..Peripheral blood mononuclear cells (PBMCs) obtained from a healthy adult male were reprogrammed using the non-integrating Sendai virus expressing Oct3/4, Sox2, c-Myc, and Klf4.
  33. Marsoner F, Marcatili M, Karnavas T, Bottai D, D Agostino A, Scarone S, et al. Generation and characterization of an induced pluripotent stem cell (iPSC) line from a patient with clozapine-resistant Schizophrenia. Stem Cell Res. 2016;17:661-664 pubmed publisher
    ..iPSCs were established with a non-integrating Sendai virus-based reprogramming system...
  34. Cheng M, Niu Y, Fan J, Chi X, Liu X, Yang W. Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression. J Biol Chem. 2018;293:5975-5986 pubmed publisher
    ..endogenous miR-1225-3p inhibited infection by multiple IFN-susceptible viruses, including hepatitis C virus, Sendai virus, and Newcastle disease virus...
  35. Pisal R, Suchanek J, Siller R, Soukup T, Hrebíková H, Bezrouk A, et al. Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth. Sci Rep. 2018;8:6168 pubmed publisher
    ..nDPSC yielded hiPSC colonies upon transduction with Sendai virus expressing the pluripotency transcription factors POU5F1, SOX2, c-MYC and KLF4...
  36. Peng C, Huang K, Lu H, Syu S, Yarmishyn A, Lu J, et al. Generation of induced pluripotent stem cells from a patient with X-linked juvenile retinoschisis. Stem Cell Res. 2018;29:152-156 pubmed publisher
    ..We believe that XLRS patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease. ..
  37. Yeon S, Song M, Kang H, Lee J. Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1. Immunology. 2015;144:312-20 pubmed publisher
    ..Our results show that Sendai virus infection, which is recognized by RIG-I, led to IRF3 activation and IFN-β expression and these responses ..
  38. Cary W, Hori C, Pham M, Nacey C, McGee J, Hamou M, et al. Efficient Generation of Induced Pluripotent Stem and Neural Progenitor Cells From Acutely Harvested Dura Mater Obtained During Ventriculoperitoneal Shunt Surgery. World Neurosurg. 2015;84:1256-66.e1 pubmed publisher
    ..Fibroblasts were isolated from the dural matrix and transduced with nonintegrating Sendai virus for iPSC induction...
  39. Meliopoulos V, Van De Velde L, Van De Velde N, Karlsson E, Neale G, Vogel P, et al. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016;12:e1005804 pubmed publisher
    ..Protection extended to other respiratory pathogens such as Sendai virus and bacterial pneumonia...
  40. Zhu X, Fang L, Wang D, Yang Y, Chen J, Ye X, et al. Porcine deltacoronavirus nsp5 inhibits interferon-? production through the cleavage of NEMO. Virology. 2017;502:33-38 pubmed publisher
    ..Here, we demonstrate that nonstructural protein 5 (nsp5) of PDCoV, the 3C-like protease, significantly inhibits Sendai virus (SEV)-induced IFN-? production by targeting the NF-?B essential modulator (NEMO), confirmed by the diminished ..
  41. Trevisan M, Desole G, Costanzi G, Lavezzo E, Palu G, Barzon L. Reprogramming Methods Do Not Affect Gene Expression Profile of Human Induced Pluripotent Stem Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..In this study, three different strategies, based on retroviral vectors, episomal vectors, and Sendai virus vectors, were applied to derive iPSCs from human fibroblasts...
  42. Longhi S, Bloyet L, Gianni S, Gerlier D. How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication. Cell Mol Life Sci. 2017;74:3091-3118 pubmed publisher
    ..Nipah, and Hendra viruses and highlight both commonalities and differences with respect to the closely related Sendai virus. The molecular mechanisms that control the disorder-to-order transition undergone by the intrinsically ..
  43. Nishimura K, Ohtaka M, Takada H, Kurisaki A, Tran N, Tran Y, et al. Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302. Stem Cell Res. 2017;23:13-19 pubmed publisher
    ..We previously reported that a replication-defective and persistent Sendai virus (SeVdp) vector harboring four reprogramming factors (SeVdp-iPS) can efficiently induce generation of transgene-..
  44. Wang H, Zhao S, Finnell R, George T, Cooney A. Generation of integration-free induced pluripotent stem cells from a patient with spina bifida. Stem Cell Res. 2018;31:27-30 pubmed publisher
    ..Dermal fibroblasts were isolated and reprogrammed with Sendai virus (SeV) vectors encoding OCT3/4, SOX2, KLF4, and c-MYC...
  45. Jiang G, Herron T, Di Bernardo J, Walker K, O Shea K, Kunisaki S. Human Cardiomyocytes Prior to Birth by Integration-Free Reprogramming of Amniotic Fluid Cells. Stem Cells Transl Med. 2016;5:1595-1606 pubmed
    ..8-10 ml) at 20 weeks gestation were expanded and reprogrammed toward pluripotency using nonintegrating Sendai virus (SeV) expressing OCT4, SOX2, cMYC, and KLF4...
  46. Miere C, Devito L, Ilic D. Sendai Virus-Based Reprogramming of Mesenchymal Stromal/Stem Cells from Umbilical Cord Wharton's Jelly into Induced Pluripotent Stem Cells. Methods Mol Biol. 2016;1357:33-44 pubmed publisher
    ..The episomal modified Sendai virus-based vector has emerged as one of the most practical ones...
  47. Wu H, Zhang X, Liu C, Liu D, Liu J, Wang G, et al. Molecular cloning and functional characterization of feline MAVS. Immunol Res. 2016;64:82-92 pubmed publisher
    ..Additionally, Sendai virus-induced IFN-β promoter activation was significantly inhibited by siRNA targeting MAVS...
  48. Oda K, Matoba Y, Irie T, Kawabata R, Fukushi M, Sugiyama M, et al. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein. J Virol. 2015;89:11487-99 pubmed publisher
    b>Sendai virus (SeV) C protein inhibits the signal transduction pathways of interferon alpha/beta (IFN-α/β) and IFN-γ by binding to the N-terminal domain of STAT1 (STAT1ND), thereby allowing SeV to escape from host innate immunity...
  49. Wang J, Hao J, Bai D, Gu Q, Han W, Wang L, et al. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015;6:223 pubmed publisher
    ..Clinical-grade hiPSCs were derived by integration-free Sendai virus-based reprogramming kit in Xeno-free pluritonâ„¢ reprogramming medium or X medium...
  50. Saito H, Okita K, Fusaki N, Sabel M, Chang A, Ito F. Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells. Stem Cells Int. 2016;2016:8394960 pubmed publisher
    ..Here, we describe the derivation of human iPSCs from melanoma TILs expressing high level of PD-1 by Sendai virus-mediated transduction of the four transcription factors, OCT3/4, SOX2, KLF4, and c-MYC...
  51. Park A, Hong P, Won S, Thibault P, Vigant F, Oguntuyo K, et al. Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing. Mol Ther Methods Clin Dev. 2016;3:16057 pubmed publisher
    ..Here, we repurpose Sendai virus, an RNA virus with no viral DNA phase and that replicates solely in the cytoplasm, as a delivery system for ..
  52. Tancos Z, Varga E, Kovacs E, Dinnyes A, Kobolak J. Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:81-83 pubmed publisher
    ..Furthermore, the iPSC line showed normal karyotype. Our model might offer a good platform to further study the pathomechanism of sporadic AD, to identify early biomarkers and also for drug testing and gene therapy studies. ..
  53. Afzal M, Gartz M, Klyachko E, Khan S, Shah S, Gupta S, et al. Generation of human iPSCs from urine derived cells of a non-affected control subject. Stem Cell Res. 2017;18:33-36 pubmed publisher
    ..The Sendai Virus (SeV) vector encoding pluripotent Yamanaka transcription factors was used at a low multiplicity of infection to ..
  54. Varga E, Nemes C, Bock I, Táncos Z, Berzsenyi S, Lévay G, et al. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD). Stem Cell Res. 2017;21:19-22 pubmed publisher
    ..Furthermore, the iPSC line showed normal karyotype. Our model might offer a good platform to study the pathomechanism of ASD, also for drug testing, early biomarker discovery and gene therapy studies. ..
  55. Peitz M, Bechler T, Thiele C, Veltel M, Bloschies M, Fliessbach K, et al. Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype. Stem Cell Res. 2018;29:250-253 pubmed publisher
    ..Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC...
  56. Mizokami D, Araki K, Tanaka N, Suzuki H, Tomifuji M, Yamashita T, et al. Gene therapy of c-myc suppressor FUSE-binding protein-interacting repressor by Sendai virus delivery prevents tracheal stenosis. PLoS ONE. 2015;10:e0116279 pubmed publisher
    ..The objective of this study was to determine whether the Sendai virus (SeV)-mediated c-myc suppressor, a far upstream element (FUSE)-binding protein (FBP)-interacting repressor (FIR)..
  57. Katoh H, Nakatsu Y, Kubota T, Sakata M, Takeda M, Kidokoro M. Mumps Virus Is Released from the Apical Surface of Polarized Epithelial Cells, and the Release Is Facilitated by a Rab11-Mediated Transport System. J Virol. 2015;89:12026-34 pubmed publisher
    ..In addition, our data and previous studies on Sendai virus, respiratory syncytial virus, and measles virus suggested that selective apical release from epithelial cells ..
  58. Zhan X, Slobod K, Jones B, Sealy R, Takimoto T, Boyd K, et al. Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats. Int Immunol. 2015;27:229-36 pubmed publisher
    ..Currently, there is no standard treatment for RSV disease and no vaccine. Sendai virus (SeV) is an attractive pediatric vaccine candidate because it elicits robust and long-lasting virus-specific B ..
  59. Iskender B, Izgi K, Canatan H. Reprogramming bladder cancer cells for studying cancer initiation and progression. Tumour Biol. 2016;37:13237-13245 pubmed
    ..present study, we aimed at reprogramming two bladder cancer cell lines HTB-9 and T24 using a non-integrating Sendai virus (SeV) system...
  60. Wen W, Zhang J, Chen W, Arakaki C, Li X, Baylink D, et al. Generation of Integration-free Induced Pluripotent Stem Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors. J Vis Exp. 2017;: pubmed publisher
    ..Although the reprogramming efficiency is comparable to that of Sendai Virus (SV) vectors, EV plasmids are considerably more economical than the commercially available SV vectors...
  61. Matsumoto Y, Ohta K, Nishio M. Human parainfluenza virus type 2 polymerase complex recognizes leader promoters of other species belonging to the genus Rubulavirus. Med Microbiol Immunol. 2017;206:441-446 pubmed publisher
    ..mumps virus (MuV) and PIV5 as well as Newcastle disease virus (NDV), it cannot recognize measles virus, hPIV1, Sendai virus (SeV) or hPIV3...
  62. Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli K, Barrett B, et al. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways. Proc Natl Acad Sci U S A. 2018;115:E3798-E3807 pubmed publisher
    ..Compared with control cells, infection of SAMHD1-silenced human monocytic cells or primary macrophages with Sendai virus (SeV) or HIV-1, or treatment with inflammatory stimuli, induces significantly higher levels of NF-κB ..
  63. Hsu C, Lu H, Chuang J, Ko Y, Tsai Y, Tai H, et al. Generation of induced pluripotent stem cells from a patient with Best Dystrophy carrying 11q12.3 (BEST1 (VMD2)) mutation. Stem Cell Res. 2018;29:134-138 pubmed publisher
    ..line, TVGH-iPSC-012-04, from the peripheral blood mononuclear cells of a female patient with BD by using the Sendai virus delivery system...
  64. Flores M, Chew C, Tyan K, Huang W, SALEM A, Clynes R. FcγRIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response. J Immunol. 2015;194:4240-50 pubmed publisher
    ..Furthermore, FcγRIIB was required for Sendai virus immune complex uptake by splenic pDCs in vitro, and internalization via FcγRIIb prevented cargo from ..
  65. Devito L, Donne M, Kolundžić N, Khurana P, Hobbs C, Kaddour G, et al. Induced pluripotent stem cell line from an atopic dermatitis patient heterozygous for c.2282del4 mutation in filaggrin: KCLi001-A. Stem Cell Res. 2018;31:122-126 pubmed publisher
    ..2282del4 in the filaggrin gene (FLG). Epidermal keratinocytes were reprogrammed using non-integrating Sendai virus vectors...
  66. James S, Jiao H, Teh H, Takahashi H, Png C, Phoon M, et al. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015;10:1722-1734 pubmed publisher
    ..in MKP5-deficient cells and animals upon other RNA virus infection, including vesicular stomatitis virus and sendai virus. These observations were attributed to the ability of MKP5 to interact with and dephosphorylate IRF3...
  67. Harman A, Nasr N, Feetham A, Galoyan A, Alshehri A, Rambukwelle D, et al. HIV Blocks Interferon Induction in Human Dendritic Cells and Macrophages by Dysregulation of TBK1. J Virol. 2015;89:6575-84 pubmed publisher
    ..Here we show that HIV-1 (but not herpes simplex virus 2 [HSV-2] or Sendai virus)-exposed DCs and macrophages fail to induce the expression of all known type I and III IFN genes...
  68. Xu J, Mercado López X, Grier J, Kim W, Chun L, Irvine E, et al. Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I. MBio. 2015;6:e01265-15 pubmed publisher
    ..Immunostimulatory defective viral genomes (iDVGs) from Sendai virus (SeV) are among the most potent natural viral triggers of antiviral immunity...
  69. Stone R, Hayashi T, Bajimaya S, Hodges E, Takimoto T. Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology. 2016;487:11-8 pubmed publisher
    ..In this study, we analyzed the impact of the Rab11-mediated recycling pathway in Sendai virus (SeV) and human parainfluenza virus type 1 (hPIV1) vRNP transport...
  70. Li H, Zhai Y, Fan Y, Chen H, Zhang A, Jin H, et al. Molecular cloning and functional characterization of duck mitochondrial antiviral-signaling protein (MAVS). Dev Comp Immunol. 2016;56:1-6 pubmed publisher
    ..In addition, poly(I:C)- or Sendai virus (SeV)-induced IFN-β expression in DEFs were significantly decreased by knock-down of duMAVS with siRNA...
  71. Wen W, Zhang J, Xu J, Su R, Neises A, Ji G, et al. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports. 2016;6:873-884 pubmed publisher
    ..The combination of EV plasmids (OS + M + K + B) is comparable with Sendai virus in reprogramming efficiency but at a fraction of the cost...
  72. Rungsiwiwut R, Pavarajarn W, Numchaisrika P, Virutamasen P, Pruksananonda K. Transgene-free human induced pluripotent stem cell line (HS5-SV.hiPS) generated from cesarean scar-derived fibroblasts. Stem Cell Res. 2016;16:10-3 pubmed publisher
    ..hiPS line was generated from human cesarean scar-derived fibroblasts using temperature-sensitive Sendai virus vectors carrying Oct4, Sox2, cMyc and Klf4 exogenous transcriptional factors...
  73. Rim Y, Nam Y, Ju J. Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation. J Vis Exp. 2016;: pubmed publisher
    ..This method is also applicable to umbilical cord blood mononuclear cells (CBMCs). This study presents a simple and efficient protocol for the reprogramming of PBMCs and CBMCs. ..
  74. Gélinas J, Davies L, Gill D, Hyde S. Assessment of selected media supplements to improve F/HN lentiviral vector production yields. Sci Rep. 2017;7:10198 pubmed publisher
    ..Pluronic F-68) were assayed in order to improve production yields in a transient transfection production of a Sendai virus F/HN-pseudotyped HIV-1-based third generation lentiviral vector in FreeStyle 293 (serum-free media) in ..
  75. Ellwanger K, Becker E, Kienes I, Sowa A, Postma Y, Cardona Gloria Y, et al. The NLR family pyrin domain-containing 11 protein contributes to the regulation of inflammatory signaling. J Biol Chem. 2018;293:2701-2710 pubmed publisher
    ..of NLRP11 in human myeloid THP1 cells validated these findings and revealed enhanced lipopolysaccharide and Sendai virus-induced cytokine and interferon responses, respectively, in cells with reduced NLRP11 expression...
  76. Lu H, Yang Y, Chen Y, Wu Y, Wang C, Tsai F, et al. Generation of patient-specific induced pluripotent stem cells from Leber's hereditary optic neuropathy. Stem Cell Res. 2018;28:56-60 pubmed publisher
    ..We believe LHON patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease. ..
  77. Pars S, Cristo F, Inácio J, Rosas G, Carreira I, Melo J, et al. Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration. Stem Cell Res. 2018;29:202-206 pubmed publisher
    ..Exfoliated renal epithelial (RE) cells were collected and reprogrammed into iPSCs using Sendai virus reprogramming system...
  78. Xu C, Sun L, Liu W, Duan Z. Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway. Front Immunol. 2018;9:1446 pubmed publisher
    ..In this study, we have provided strong evidence that LMP1 inhibits Sendai virus mediated type I interferon production and downregulates RIG-I signaling pathway by promotion RIG-I degradation ..
  79. Boonkaew B, Tapeng L, Netsrithong R, Vatanashevanopakorn C, Pattanapanyasat K, Wattanapanitch M. Induced pluripotent stem cell line MUSIi006-A derived from hair follicle keratinocytes as a non-invasive somatic cell source. Stem Cell Res. 2018;31:79-82 pubmed publisher
    ..Reprogramming of keratinocytes was performed using Sendai virus. Further characterization of the keratinocyte-derived iPSC line (designated as MUSIi006-A) confirmed that the ..
  80. Zhang Q, Zhu H, Xu X, Li L, Tan H, Cai X. Inactivated Sendai virus induces apoptosis and autophagy via the PI3K/Akt/mTOR/p70S6K pathway in human non-small cell lung cancer cells. Biochem Biophys Res Commun. 2015;465:64-70 pubmed publisher
    Inactivated Sendai virus (HVJ-E) has shown potential anticancer efficacy in various cancer cells. However, the ability of HVJ-E to regulate cancer cell survival and death remains largely unknown...
  81. Nobre L, Wise D, Ron D, Volmer R. Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization. PLoS ONE. 2015;10:e0136883 pubmed publisher
    ..These events were mirrored by Sendai virus infection, which similarly induced lipid peroxidation and promoted lipid-dependent MAVS transmembrane domain ..
  82. Xu L, Yu D, Fan Y, Peng L, Wu Y, Yao Y. Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. Proc Natl Acad Sci U S A. 2016;113:10950-5 pubmed publisher
    ..tMDA5 or tMDA5/tLGP2 could sense Sendai virus (an RNA virus posed as a RIG-I agonist) for inducing type I IFN, although conventional RIG-I and MDA5 were ..
  83. Wu M, Zhu Y, Cong F, Rao D, Yuan W, Wang J, et al. Rapid detection of three rabbit pathogens by use of the Luminex x-TAG assay. BMC Vet Res. 2018;14:127 pubmed publisher
    ..Rabbit hemorrhagic disease virus, rabbit rotavirus and Sendai virus are the important pathogens that needed to be eliminated...
  84. Fang P, Fang L, Ren J, Hong Y, Liu X, Zhao Y, et al. Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA. J Virol. 2018;92: pubmed publisher
    ..Here, we found that ectopic expression of accessory protein NS6 significantly inhibits Sendai virus-induced interferon beta (IFN-β) production as well as the activation of transcription factors IRF3 and NF-κB...
  85. Chai W, Li J, Shangguan Q, Liu Q, Li X, Qi D, et al. Lnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression. J Virol. 2018;92: pubmed publisher
    ..levels, while knockdown of lnc-ISG20 reduces ISG20 protein levels in A549 cells induced with poly(I·C) and Sendai virus. We demonstrated that lnc-ISG20 inhibits IAV replication in an ISG20-dependent manner...
  86. Zhai Y, Luo F, Chen Y, Zhou S, Li Z, Liu M, et al. Molecular characterization and functional analysis of duck TRAF6. Dev Comp Immunol. 2015;49:1-6 pubmed publisher
    ..In addition, duTRAF6 knockdown by RNA interference significantly reduced poly(I:C)- and Sendai virus-induced NF-κB activation in DEFs...
  87. Gotoh E. Drug-induced premature chromosome condensation (PCC) protocols: cytogenetic approaches in mitotic chromosome and interphase chromatin. Methods Mol Biol. 2015;1288:53-66 pubmed publisher
    ..g., Sendai virus) or cell fusion chemicals (e.g., polyethylene glycol), but the cell fusion PCC has several drawbacks...
  88. Wu K, Byers D, Jin X, Agapov E, Alexander Brett J, Patel A, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med. 2015;212:681-97 pubmed publisher
    ..Here, we study a mouse model in which infection with a mouse parainfluenza virus known as Sendai virus (SeV) leads to long-term activation of innate immune cells that drive IL-13-dependent lung disease...
  89. Singh B, Hornick A, Krishnamurthy S, Locke A, Mendoza C, Mateo M, et al. The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia. J Virol. 2015;89:7089-96 pubmed publisher
    ..larger than those of other respiratory pathogens: human respiratory syncytial virus, parainfluenza virus 5, and Sendai virus. While visible syncytia do not form after MV infection of HAE, the cytoplasm of an infected cell suddenly flows ..
  90. Liang Y, Wu L, Zhang Q, Zhou P, Wang M, Yang X, et al. Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii. Virol Sin. 2015;30:425-32 pubmed publisher
    ..davidii after treatment with polyI:C or infection with Sendai virus. Furthermore, the recombinant IFNβ inhibited vesicular stomatitis virus and bat adenovirus replication in ..
  91. Zurita Díaz F, Galera Monge T, Moreno Izquierdo A, Fraga M, Ayuso C, Fernandez A, et al. Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene. Stem Cell Res. 2016;16:124-7 pubmed publisher
    ..Reprogramming factors OCT3/4, SOX2, CMYC and KLF4 were delivered using a non integrative methodology that involves the use of Sendai virus.
  92. Tremblay N, Baril M, Chatel Chaix L, Es Saad S, Park A, Koenekoop R, et al. Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response. PLoS Pathog. 2016;12:e1005772 pubmed publisher
    ..confirmed in peripheral blood cells of RP33 patients bearing missense mutation in SNRNP200 upon infection with Sendai virus (SeV)...