Respiratory syncytial virus

Summary

Alias: respiratory syncytial virus RS, respiratory syncytial virus RS virus, respiratory syncytial virus RSV

Top Publications

  1. Tolley K, Marriott A, Simpson A, Plows D, Matthews D, Longhurst S, et al. Identification of mutations contributing to the reduced virulence of a modified strain of respiratory syncytial virus. Vaccine. 1996;14:1637-46 pubmed
    ..The data suggest also that a mutation in the F gene may contribute to the attenuated phenotype. ..
  2. Harcourt J, Alvarez R, Jones L, Henderson C, Anderson L, Tripp R. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. J Immunol. 2006;176:1600-8 pubmed
    ..The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 and modify CXCL1-mediated responses...
  3. Ling Z, Tran K, Arnold J, Teng M. Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1. Protein Expr Purif. 2008;57:261-70 pubmed
    We report here the first biochemical and structural characterization of the respiratory syncytial virus (RSV) NS1 protein. We have used a pET-ubiquitin expression system to produce respiratory syncytial virus (RSV) NS1 protein in E...
  4. Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, et al. Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction. Int Immunol. 2008;20:1169-80 pubmed publisher
    ..When mDCs were treated with live or UV-irradiated respiratory syncytial virus (RSV), early ( approximately 4 h) induction of IFN-beta usually occurs in other virus infections was ..
  5. Kwilas S, Liesman R, Zhang L, Walsh E, Pickles R, Peeples M. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans. J Virol. 2009;83:10710-8 pubmed publisher
    Human respiratory syncytial virus (RSV) contains a heavily glycosylated 90-kDa attachment glycoprotein (G)...
  6. Zhu Q, Patel N, McAuliffe J, Zhu W, Wachter L, McCarthy M, et al. Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumab. J Infect Dis. 2012;205:635-8 pubmed publisher
    Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance...
  7. Nguyen T, Power U, Robert A, Haeuw J, Helffer K, Perez A, et al. The respiratory syncytial virus G protein conserved domain induces a persistent and protective antibody response in rodents. PLoS ONE. 2012;7:e34331 pubmed publisher
    b>Respiratory syncytial virus (RSV) is an important cause of severe upper and lower respiratory disease in infants and in the elderly. There are 2 main RSV subtypes A and B...
  8. Slack M, Easton A. Characterization of the interaction of the human respiratory syncytial virus phosphoprotein and nucleocapsid protein using the two-hybrid system. Virus Res. 1998;55:167-76 pubmed
    The interaction between the human respiratory syncytial virus phosphoprotein (P) and nucleocapsid (N) protein has been investigated using the two hybrid system in yeast and in tissue culture cells...
  9. Gould P, Easton A. Coupled translation of the respiratory syncytial virus M2 open reading frames requires upstream sequences. J Biol Chem. 2005;280:21972-80 pubmed publisher
    We have investigated the mechanism of the translation of the second open reading frame (ORF) of the respiratory syncytial virus M2 transcript that uses a novel coupled translation process requiring prior translation of the upstream ORF...

More Information

Publications212 found, 100 shown here

  1. Ghildyal R, Li D, Peroulis I, Shields B, Bardin P, Teng M, et al. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol. 2005;86:1879-84 pubmed publisher
    ..The specific protein interactions during assembly of respiratory syncytial virus (RSV) are unknown...
  2. Ghildyal R, Ho A, Wagstaff K, Dias M, Barton C, Jans P, et al. Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. Biochemistry. 2005;44:12887-95 pubmed
    The matrix (M) protein of respiratory syncytial virus (RSV) plays an important role in virus assembly through specific interactions with RSV nucleocapsids and envelope glycoproteins in the cytoplasm as well as with the host cell membrane...
  3. Bukreyev A, Serra M, Laham F, Melendi G, Kleeberger S, Collins P, et al. The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopes. J Virol. 2006;80:5854-61 pubmed publisher
    The cytotoxic T-lymphocyte (CTL) response is important for the control of viral replication during respiratory syncytial virus (RSV) infection...
  4. Fleming E, Kolokoltsov A, Davey R, Nichols J, Roberts N. Respiratory syncytial virus F envelope protein associates with lipid rafts without a requirement for other virus proteins. J Virol. 2006;80:12160-70 pubmed publisher
    Like many enveloped viruses, human respiratory syncytial virus (RSV) assembles at and buds from lipid rafts...
  5. Kim Y, Choi E, Lee H. Genetic variability of the fusion protein and circulation patterns of genotypes of the respiratory syncytial virus. J Med Virol. 2007;79:820-8 pubmed publisher
    Although antigenic and genetic variations were shown to occur both in the G and F protein of respiratory syncytial virus (RSV), few studies looked at the variation of F gene...
  6. Avadhanula V, Wang Y, Portner A, Adderson E. Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein. J Med Microbiol. 2007;56:1133-7 pubmed publisher
    b>Respiratory syncytial virus (RSV) infection is associated with secondary bacterial infections caused by nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae...
  7. Eckardt Michel J, Lorek M, Baxmann D, Grunwald T, Keil G, Zimmer G. The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis. J Virol. 2008;82:3236-49 pubmed publisher
    Infection with respiratory syncytial virus (RSV) frequently causes inflammation and obstruction of the small airways, leading to severe pulmonary disease in infants...
  8. Ghildyal R, Ho A, Dias M, Soegiyono L, Bardin P, Tran K, et al. The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism. J Virol. 2009;83:5353-62 pubmed publisher
    The respiratory syncytial virus (RSV) matrix (M) protein is localized in the nucleus of infected cells early in infection but is mostly cytoplasmic late in infection...
  9. Tran T, Castagn N, Dubosclard V, Noinville S, Koch E, Moudjou M, et al. The respiratory syncytial virus M2-1 protein forms tetramers and interacts with RNA and P in a competitive manner. J Virol. 2009;83:6363-74 pubmed publisher
    The respiratory syncytial virus (RSV) M2-1 protein is an essential cofactor of the viral RNA polymerase complex and functions as a transcriptional processivity and antitermination factor...
  10. Tawar R, Duquerroy S, Vonrhein C, Varela P, Damier Piolle L, Castagné N, et al. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science. 2009;326:1279-83 pubmed publisher
    The respiratory syncytial virus (RSV) is an important human pathogen, yet neither a vaccine nor effective therapies are available to treat infection...
  11. Swanson K, Settembre E, Shaw C, Dey A, Rappuoli R, Mandl C, et al. Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A. 2011;108:9619-24 pubmed publisher
    b>Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major unmet vaccine need despite more than 40 years of vaccine research...
  12. Ren J, Liu T, Pang L, Li K, Garofalo R, Casola A, et al. A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein. J Gen Virol. 2011;92:2153-9 pubmed publisher
    Human respiratory syncytial virus (RSV), a leading cause of respiratory tract infections in infants, inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis...
  13. Boyapalle S, Wong T, Garay J, TENG M, San Juan Vergara H, Mohapatra S, et al. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PLoS ONE. 2012;7:e29386 pubmed publisher
    b>Respiratory syncytial virus (RSV) nonstructural protein 1(NS1) attenuates type-I interferon (IFN) production during RSV infection; however the precise role of RSV NS1 protein in orchestrating the early host-virus interaction during ..
  14. Arnold R, K nig B, Werchau H, K nig W. Respiratory syncytial virus deficient in soluble G protein induced an increased proinflammatory response in human lung epithelial cells. Virology. 2004;330:384-97 pubmed publisher
    b>Respiratory syncytial virus (RSV) is worldwide the single most important respiratory pathogen in infancy and early childhood...
  15. Brock S, Heck J, McGraw P, Crowe J. The transmembrane domain of the respiratory syncytial virus F protein is an orientation-independent apical plasma membrane sorting sequence. J Virol. 2005;79:12528-35 pubmed publisher
    ..The respiratory syncytial virus (RSV) fusion (F) protein is a type I integral membrane protein that is uniformly distributed on the ..
  16. Fuentes S, Tran K, Luthra P, Teng M, He B. Function of the respiratory syncytial virus small hydrophobic protein. J Virol. 2007;81:8361-6 pubmed publisher
    b>Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function...
  17. Li D, Jans D, Bardin P, Meanger J, Mills J, Ghildyal R. Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. J Virol. 2008;82:8863-70 pubmed publisher
    Cytoplasmic inclusions in respiratory syncytial virus-infected cells comprising viral nucleocapsid proteins (L, N, P, and M2-1) and the viral genome are sites of viral transcription...
  18. Bian T, Gibbs J, rvell C, Imani F. Respiratory syncytial virus matrix protein induces lung epithelial cell cycle arrest through a p53 dependent pathway. PLoS ONE. 2012;7:e38052 pubmed publisher
    b>Respiratory syncytial virus (RSV) is the major cause of viral respiratory infections in children. Our previous study showed that the RSV infection induced lung epithelial cell cycle arrest, which enhanced virus replication...
  19. Noton S, Deflub L, Tremaglio C, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog. 2012;8:e1002980 pubmed publisher
    b>Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined...
  20. Kushibuchi I, Kobayashi M, Kusaka T, Tsukagoshi H, Ryo A, Yoshida A, et al. Molecular evolution of attachment glycoprotein (G) gene in human respiratory syncytial virus detected in Japan 2008-2011. Infect Genet Evol. 2013;18:168-73 pubmed publisher
    ..We investigated the evolution of the C-terminal 3rd hypervariable region of G gene in the prevalent human respiratory syncytial virus (RSV) subgroups A (RSV-A) and B (RSV-B) in Japan in 2008-2011...
  21. Esperante S, Noval M, Altieri T, de Oliveira G, Silva J, de Prat Gay G. Fine modulation of the respiratory syncytial virus M2-1 protein quaternary structure by reversible zinc removal from its Cys(3)-His(1) motif. Biochemistry. 2013;52:6779-89 pubmed publisher
    Human respiratory syncytial virus (hRSV) is a worldwide distributed pathogen that causes respiratory disease mostly in infants and the elderly...
  22. Smith C, Sandrini S, Datta S, Freestone P, Shafeeq S, Radhakrishnan P, et al. Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. Am J Respir Crit Care Med. 2014;190:196-207 pubmed publisher
    b>Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Coinfection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. ..
  23. Caffarelli C, Santamaria F, Di Mauro D, Mastrorilli C, Mirra V, Bernasconi S. Progress in pediatrics in 2015: choices in allergy, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, nephrology, neurology, nutrition, oncology and pulmonology. Ital J Pediatr. 2016;42:75 pubmed publisher
    ..Control of risk factors for bronchiolitis and administration of pavilizumab for preventing respiratory syncytial virus infection may reduce hospitalization...
  24. Davis R, McGregor G, Enfield K. Humidity: A review and primer on atmospheric moisture and human health. Environ Res. 2016;144:106-116 pubmed publisher
    ..the importance of humidity variable selection, we correlate numerous hourly humidity variables to daily respiratory syncytial virus isolates in Singapore from 1992 to 1994...
  25. Giannakaki S, Politi L, Antonogiannaki E, Spanakis N, Arsenis G, Filaditaki V, et al. Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease. Respir Res. 2016;17:11 pubmed publisher
    Previous studies have reported very different rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) genome detection in nasal and sputum samples, but not in bronchoalveolar lavage (BAL) and bronchial biopsy samples...
  26. Hogan A, Glass K, Moore H, Anderssen R. Exploring the dynamics of respiratory syncytial virus (RSV) transmission in children. Theor Popul Biol. 2016;110:78-85 pubmed publisher
    b>Respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in children. Whilst highly seasonal, RSV dynamics can have either one-year (annual) or two-year (biennial) cycles...
  27. Xiang Z, Liang Z, Yanfeng H, Leitao K. Persistence of RSV promotes proliferation and epithelial-mesenchymal transition of bronchial epithelial cells through Nodal signaling. J Med Microbiol. 2017;66:1499-1505 pubmed publisher
    ..The present study was designed to determine the effects of Nodal induced by respiratory syncytial virus (RSV) infection on the occurrence and development of lung cancer and the underlying mechanisms...
  28. Kolawole O, Oguntoye M, Dam T, Chunara R. Etiology of respiratory tract infections in the community and clinic in Ilorin, Nigeria. BMC Res Notes. 2017;10:712 pubmed publisher
    ..Parainfluenza virus 4, respiratory syncytial virus B and enterovirus were the most common viruses in the clinical sample; present in 93...
  29. Culley F, Pollott J, Openshaw P. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J Exp Med. 2002;196:1381-6 pubmed
    Infants experiencing severe respiratory syncytial virus (RSV) bronchiolitis have an increased frequency of wheeze and asthma in later childhood...
  30. Mwambi H, Ramroop S, White L, Okiro E, Nokes D, Shkedy Z, et al. A frequentist approach to estimating the force of infection for a respiratory disease using repeated measurement data from a birth cohort. Stat Methods Med Res. 2011;20:551-70 pubmed publisher
    ..The current application is based on infection with respiratory syncytial virus. The force of infection and the recovery rate or per capita loss of infection are the parameters of ..
  31. Schulert G, Hain P, Williams D. Utilization of viral molecular diagnostics among children hospitalized with community acquired pneumonia. Hosp Pediatr. 2014;4:372-6 pubmed publisher
    ..course, although this was due largely to more severe disease seen in younger children and those with respiratory syncytial virus (n = 38, 30% of positive detections). Detection of a virus did not influence antibiotic therapy...
  32. Gross A, Bryson M. Oral Ribavirin for the Treatment of Noninfluenza Respiratory Viral Infections: A Systematic Review. Ann Pharmacother. 2015;49:1125-35 pubmed publisher
    ..to June 1, 2015) were queried with the following search term combinations: "Oral" AND "ribavirin" AND ("respiratory syncytial virus" OR "metapneumovirus" OR "parainfluenza" OR "coronavirus" OR "rhinovirus" OR "enterovirus" OR "..
  33. Valdez J, Bawage S, Gomez I, Singh S. Facile and rapid detection of respiratory syncytial virus using metallic nanoparticles. J Nanobiotechnology. 2016;14:13 pubmed publisher
    b>Respiratory syncytial virus (RSV) causes severe respiratory infection in infants, children and elderly. Currently, there is no effective vaccine or RSV specific drug for the treatment...
  34. McGill J, Rusk R, Guerra Maupome M, Briggs R, Sacco R. Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica. PLoS ONE. 2016;11:e0151083 pubmed publisher
    Human respiratory syncytial virus (HRSV) is a leading cause of severe lower respiratory tract infection in children under five years of age...
  35. Cervantes Ortiz S, Zamorano Cuervo N, Grandvaux N. Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology. Viruses. 2016;8: pubmed publisher
    Human respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, is a major cause of severe acute lower respiratory tract infection in infants, elderly and immunocompromised adults...
  36. Oren E, Frere J, Yom Tov E, Yom Tov E. Respiratory syncytial virus tracking using internet search engine data. BMC Public Health. 2018;18:445 pubmed publisher
    b>Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in children less than 1 year of age in the United States...
  37. Liikonen K, Ojalehto T, Elf S, Mäki M, Matero P, Eboigbodin K. Clinical evaluation of a novel and simple-to-use molecular platform for diagnosis of respiratory syncytial virus. Anal Biochem. 2018;551:4-6 pubmed publisher
    ..of Orion GenRead® RSV, a novel, rapid, and easy-to-use molecular test for the diagnosis of respiratory syncytial virus (RSV) infection. The sensitivity and specificity of Orion GenRead RSV were 99% and 100%, respectively...
  38. Loebbermann J, Schnoeller C, Thornton H, Durant L, Sweeney N, Schuijs M, et al. IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice. PLoS ONE. 2012;7:e32371 pubmed publisher
    ..Here we demonstrate that infection of BALB/c mice with respiratory syncytial virus (RSV) induced IL-10 production by CD4(+) and CD8(+) T cells in the airways at later time points (e.g...
  39. Ohuma E, Okiro E, Ochola R, Sande C, Cane P, Medley G, et al. The natural history of respiratory syncytial virus in a birth cohort: the influence of age and previous infection on reinfection and disease. Am J Epidemiol. 2012;176:794-802 pubmed publisher
    ..aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus ..
  40. Kidszun A, Klein L, Winter J, Schmeh I, Gröndahl B, Gehring S, et al. Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study. Am J Perinatol. 2017;34:1-7 pubmed publisher
    ..reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, ..
  41. Hogan A, Anderssen R, Davis S, Moore H, Lim F, Fathima P, et al. Time series analysis of RSV and bronchiolitis seasonality in temperate and tropical Western Australia. Epidemics. 2016;16:49-55 pubmed publisher
    b>Respiratory syncytial virus (RSV) causes respiratory illness in young children and is most commonly associated with bronchiolitis...
  42. Galleguillos C, Galleguillos B, Larios G, Menchaca G, Bont L, Castro Rodriguez J. Down's syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial virus. Acta Paediatr. 2016;105:e531-e535 pubmed publisher
    ..suggested that Down's syndrome is an independent risk factor for severe respiratory infection due to respiratory syncytial virus (RSV)...
  43. Shobugawa Y, Takeuchi T, Hibino A, Hassan M, Yagami R, Kondo H, et al. Occurrence of human respiratory syncytial virus in summer in Japan. Epidemiol Infect. 2017;145:272-284 pubmed
    In temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn...
  44. Fauroux B, Simoes E, Checchia P, Paes B, Figueras Aloy J, Manzoni P, et al. The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood. Infect Dis Ther. 2017;6:173-197 pubmed publisher
    ..of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years...
  45. Eichinger K, Resetar E, Orend J, Anderson K, Empey K. Age predicts cytokine kinetics and innate immune cell activation following intranasal delivery of IFN? and GM-CSF in a mouse model of RSV infection. Cytokine. 2017;97:25-37 pubmed publisher
    b>Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children and is further associated with increased healthcare utilization and cost of care in the first years of life...
  46. Resch B. Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection. Hum Vaccin Immunother. 2017;13:2138-2149 pubmed publisher
    b>Respiratory syncytial virus (RSV) accounts for about 20% of all respiratory infections in children below the age of 5 y...
  47. Ma Y, Jiao Y, Yu Y, Jiang N, Hua Y, Zhang X, et al. A Built-In CpG Adjuvant in RSV F Protein DNA Vaccine Drives a Th1 Polarized and Enhanced Protective Immune Response. Viruses. 2018;10: pubmed publisher
    Human respiratory syncytial virus (RSV) is the most significant cause of acute lower respiratory infection in children. However, there is no licensed vaccine available...
  48. Dodd J, Clark D, Muir R, Korpis C, Openshaw P. Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice. Mucosal Immunol. 2013;6:704-17 pubmed publisher
    ..In BALB/c mice infected with respiratory syncytial virus (RSV), IL-21 depletion had little effect in primary infection...
  49. Friedman D, Domachowske J, Wong P, Parimi P, Garcia D, Marcus M, et al. Perceived Risk of Severe Respiratory Syncytial Virus Disease and Immunoprophylaxis Use Among US Pediatric Specialists. Clin Pediatr (Phila). 2016;55:724-37 pubmed publisher
    This study was conducted to assess the perception of US pediatric specialists of respiratory syncytial virus (RSV) disease risk and determine their clinical practices regarding immunoprophylaxis for high-risk children...
  50. Bilawchuk L, Griffiths C, Jensen L, Elawar F, Marchant D. The Susceptibilities of Respiratory Syncytial Virus to Nucleolin Receptor Blocking and Antibody Neutralization are Dependent upon the Method of Virus Purification. Viruses. 2017;9: pubmed publisher
    b>Respiratory Syncytial Virus (RSV) that is propagated in cell culture is purified from cellular contaminants that can confound experimental results...
  51. Cai H, Zhang Y, Ma Y, Sun J, Liang X, Li J. Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo. J Virol. 2015;89:6391-405 pubmed publisher
    ..The pneumoviruses include many important human and animal pathogens, such as human respiratory syncytial virus (hRSV), hMPV, bovine RSV, and avian metapneumovirus (aMPV)...
  52. Bhattacharyya S, Gesteland P, Korgenski K, Bjørnstad O, Adler F. Cross-immunity between strains explains the dynamical pattern of paramyxoviruses. Proc Natl Acad Sci U S A. 2015;112:13396-400 pubmed publisher
    ..To untangle the complex out-of-phase annual and biennial pattern of three common paramyxoviruses, Respiratory Syncytial Virus (RSV), Human Parainfluenza Virus (HPIV), and Human Metapneumovirus (hMPV), we adopt a theoretical ..
  53. Alan S, Erdeve O, Cakir U, Akduman H, Zenciroglu A, Akcakus M, et al. Outcome of the Respiratory Syncytial Virus related acute lower respiratory tract infection among hospitalized newborns: a prospective multicenter study. J Matern Fetal Neonatal Med. 2016;29:2186-93 pubmed publisher
    To determine the incidence and outcomes of respiratory syncytial virus (RSV)-related acute lower respiratory tract infection (ALRI) including morbidity, nosocomial infection and mortality among newborn infants who were admitted to the ..
  54. O Brien K, Chandran A, Weatherholtz R, Jafri H, Griffin M, Bellamy T, et al. Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial. Lancet Infect Dis. 2015;15:1398-408 pubmed publisher
    b>Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections in children...
  55. Shao H, Hsu H, Yu S, Wu S, Hu K, Chang C, et al. Immunogenicity of an adeno-vector vaccine expressing the F protein of a respiratory syncytial virus manufactured from serum-free suspension culture. Antiviral Res. 2016;130:27-35 pubmed publisher
    ..up the production of a recombinant adenovirus that expresses the membrane-trunked fusion protein of respiratory syncytial virus (RSV; Ad-F0ΔTM)...
  56. Fretzayas A, Moustaki M. Etiology and clinical features of viral bronchiolitis in infancy. World J Pediatr. 2017;13:293-299 pubmed publisher
    ..The most common viral pathogen that causes bronchiolitis is respiratory syncytial virus which was identified in 1955; now many other viruses have been implicated in the etiology of ..
  57. Guimarães G, Piva H, Araújo G, Lima C, Regasini L, de Melo F, et al. Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: 1H NMR, fluorescence spectroscopy, and molecular docking. Int J Biol Macromol. 2018;111:33-38 pubmed publisher
    The human Respiratory Syncytial Virus (hRSV) is the main responsible for occurrences of respiratory diseases as pneumonia and bronchiolitis in children and elderly...
  58. Karppinen S, Toivonen L, Schuez Havupalo L, Waris M, Peltola V. Interference between respiratory syncytial virus and rhinovirus in respiratory tract infections in children. Clin Microbiol Infect. 2016;22:208.e1-208.e6 pubmed publisher
    ..We analysed the effect of respiratory syncytial virus (RSV) infection on the occurrence of simultaneous rhinovirus (RV) infection in children within a birth ..
  59. Ganesan S, Pham D, Jing Y, Farazuddin M, Hudy M, Unger B, et al. TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1-Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells. J Immunol. 2016;197:2409-20 pubmed publisher
    ..Finally, influenza- and respiratory syncytial virus-induced CXCL-10 was also found to be partially dependent on IL-33/ST2/IRAK-1 signaling in airway ..
  60. Ellis J. How efficacious are vaccines against bovine respiratory syncytial virus in cattle?. Vet Microbiol. 2017;206:59-68 pubmed publisher
    Bovine respiratory syncytial virus (BRSV) is a paramyxovirus that is the major cause of pneumonia in calves. Vaccines for this important pathogen have been available since the late 1970's...
  61. Marom T, Israel O, Gavriel H, Pitaro J, Baker A, Eviatar E. Comparison of first year of life acute otitis media admissions before and after the 13-valent pneumococcal conjugate vaccine. Int J Pediatr Otorhinolaryngol. 2017;97:251-256 pubmed publisher
    ..b>Respiratory syncytial virus was detected in ?20% of collected respiratory samples, and influenza A/B viruses in ?8%...
  62. Falloon J, Talbot H, Curtis C, Ervin J, Krieger D, Dubovsky F, et al. Dose Selection for an Adjuvanted Respiratory Syncytial Virus F Protein Vaccine for Older Adults Based on Humoral and Cellular Immune Responses. Clin Vaccine Immunol. 2017;24: pubmed publisher
    This is the second phase 1 study of a respiratory syncytial virus (RSV) vaccine containing RSV fusion protein (sF) adjuvanted with glucopyranosyl lipid A (GLA) in a squalene-based 2% stable emulsion (GLA-SE)...
  63. Simões E, Bont L, Manzoni P, Fauroux B, Paes B, Figueras Aloy J, et al. Past, Present and Future Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children. Infect Dis Ther. 2018;7:87-120 pubmed publisher
    ..of the Literature) series has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years...
  64. Larkin E, Gebretsadik T, Moore M, Anderson L, Dupont W, Chappell J, et al. Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med. 2015;15:45 pubmed publisher
    b>Respiratory syncytial virus (RSV) lower respiratory tract infection (LRI) during infancy has been consistently associated with an increased risk of childhood asthma. In addition, evidence supports that this relationship is causal...
  65. Luo X, Liu T, Wang Y, Jia H, Zhang Y, Caballero D, et al. An Epitope-Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold. Angew Chem Int Ed Engl. 2015;54:14531-4 pubmed publisher
    b>Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children...
  66. Grandin C, Hourani M, Janin Y, Dauzonne D, Munier Lehmann H, Paturet A, et al. Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors. Antiviral Res. 2016;125:58-62 pubmed publisher
    ..against ubiquitous and life-threatening respiratory viruses, foremost among them being the human respiratory syncytial virus (hRSV)...
  67. Purtle L, Mattick D, Schneider C, Smith L, Xue W, Trigo E. One year duration of immunity of the modified live bovine viral diarrhea virus type 1 and type 2 and bovine herpesvirus-1 fractions of Vista® Once SQ vaccine. Vaccine. 2016;34:1582-1588 pubmed publisher
    ..Once SQ (Vista®) vaccine contains five modified-live viruses, BVDV-1, BVDV-2, BHV-1, bovine respiratory syncytial virus, and bovine parainfluenza 3 virus, and two modified-live bacteria, Pasteurella multocida and Mannheimia ..
  68. Heylen E, Neyts J, Jochmans D. Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery. Biochem Pharmacol. 2017;127:1-12 pubmed publisher
    The development of antiviral strategies to prevent or treat respiratory syncytial virus (RSV) infections is of great importance, especially considering the fact that RSV is one of the most important causes of pediatric respiratory ..
  69. van Mechelen L, Luytjes W, de Haan C, Wicht O. RSV neutralization by palivizumab, but not by monoclonal antibodies targeting other epitopes, is augmented by Fc gamma receptors. Antiviral Res. 2016;132:1-5 pubmed publisher
    Palivizumab efficiently blocks respiratory syncytial virus (RSV) infection in vitro. However, virus neutralization assays generally omit Fc region-mediated effects...
  70. Piedra P, Hause A, Aideyan L. Respiratory Syncytial Virus (RSV): Neutralizing Antibody, a Correlate of Immune Protection. Methods Mol Biol. 2016;1442:77-91 pubmed publisher
    ..This chapter discusses important elements in standardization of the RSV-specific microneutralization assay for use in the laboratory. ..
  71. Isakova Sivak I, Korenkov D, Fedorova E, Tretiak T, Matyushenko V, Smolonogina T, et al. Analysis of Immune Epitopes of Respiratory Syncytial Virus for Designing of Vectored Vaccines Based on Influenza Virus Platform. Bull Exp Biol Med. 2016;161:533-7 pubmed publisher
    The immunoepitope database was used for analysis of experimentally detected epitopes of the respiratory syncytial virus (RSV) proteins and for selection of the epitope combinations for subsequent designing of recombinant vectored anti-..
  72. Gumpper R, Li W, Castañeda C, Scuderi M, Bashkin J, Luo M. A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid. J Virol. 2018;92: pubmed publisher
    ..polyamides may be optimized to target the specific RNA genome of a negative-strand RNA virus, such as respiratory syncytial virus and Ebola virus...
  73. Green M, Petroff N, La Perle K, Niewiesk S. Characterization of Cotton Rat (Sigmodon hispidus) Eosinophils, Including Their Response to Respiratory Syncytial Virus Infection. Comp Med. 2018;68:31-40 pubmed
    Eosinophils have been postulated to play a protective role against infection with respiratory syncytial virus (RSV), increase the severity of allergic asthma during respiratory viral infection, and drive vaccine-enhanced disease...
  74. Glatthaar Saalmüller B, Fal A, Schönknecht K, Conrad F, Sievers H, Saalmüller A. Antiviral activity of an aqueous extract derived from Aloe arborescens Mill. against a broad panel of viruses causing infections of the upper respiratory tract. Phytomedicine. 2015;22:911-20 pubmed publisher
    ..In vitro infections with respiratory syncytial virus and parainfluenza virus, both belonging to the paramyxoviridae, were only poorly blocked by the test ..
  75. Lu Y, Xu J, Zhang X, Zhao X. Gu-Ben-Fang-Xiao decoction attenuates sustained airway inflammation by suppressing ER stress response in a murine asthma remission model of respiratory syncytial virus infection. J Ethnopharmacol. 2016;192:496-509 pubmed publisher
    ..To investigate the involvement of ER stress and UPR in the anti-inflammatory effects of GBFXD in Respiratory Syncytial Virus (RSV)-OVA-induced asthma remission mice...
  76. Granbom E, Fernlund E, Sunnegårdh J, Lundell B, Naumburg E. Respiratory Tract Infection and Risk of Hospitalization in Children with Congenital Heart Defects During Season and Off-Season: A Swedish National Study. Pediatr Cardiol. 2016;37:1098-105 pubmed publisher
    ..Heart defects were grouped according to type. Hospitalization rates for respiratory syncytial virus (RSV) infection and RTI in general were retrieved from the national inpatient registry...
  77. Viegas M, Goya S, Mistchenko A. Sixteen years of evolution of human respiratory syncytial virus subgroup A in Buenos Aires, Argentina: GA2 the prevalent genotype through the years. Infect Genet Evol. 2016;43:213-21 pubmed publisher
    Human respiratory syncytial virus (HRSV) is the main viral cause of acute lower respiratory tract infections (LRTI) in children worldwide. In recent years, several preclinical trials with vaccine candidates have been reported...
  78. Van Heeke G, Allosery K, De Brabandere V, De Smedt T, Detalle L, de Fougerolles A. Nanobodies® as inhaled biotherapeutics for lung diseases. Pharmacol Ther. 2017;169:47-56 pubmed publisher
    ..The latter is illustrated by the specific example of ALX-0171, a Nanobody in clinical development for the treatment of respiratory syncytial virus (RSV) infections.
  79. Loubet P, Lenzi N, Valette M, Foulongne V, Krivine A, Houhou N, et al. Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France. Clin Microbiol Infect. 2017;23:253-259 pubmed publisher
    The aim of this study was to analyse characteristics and outcome of respiratory syncytial virus (RSV) infection in adults hospitalized with influenza-like illness (ILI)...
  80. Vandini S, Calamelli E, Faldella G, Lanari M. Immune and inflammatory response in bronchiolitis due to respiratory Syncytial Virus and Rhinovirus infections in infants. Paediatr Respir Rev. 2017;24:60-64 pubmed publisher
    Bronchiolitis is a common disease in infancy, mostly due to Respiratory Syncytial Virus and Rhinovirus. In addition to acute infection, viral bronchiolitis is responsible for sequelae including recurrent wheezing and asthma...
  81. van Erp E, van Kasteren P, Guichelaar T, Ahout I, de Haan C, Luytjes W, et al. In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants. J Virol. 2017;91: pubmed publisher
    b>Respiratory syncytial virus (RSV) is the leading cause of severe respiratory illness in infants...
  82. Oma V, Klem T, Tråvén M, Alenius S, Gjerset B, Myrmel M, et al. Temporary carriage of bovine coronavirus and bovine respiratory syncytial virus by fomites and human nasal mucosa after exposure to infected calves. BMC Vet Res. 2018;14:22 pubmed publisher
    In order to prevent spread of the endemic pathogens bovine coronavirus (BCoV) and bovine respiratory syncytial virus (BRSV) between herds, knowledge of indirect transmission by personnel and fomites is fundamental...
  83. Moesker F, van Kampen J, Aron G, Schutten M, van de Vijver D, Koopmans M, et al. Diagnostic performance of influenza viruses and RSV rapid antigen detection tests in children in tertiary care. J Clin Virol. 2016;79:12-17 pubmed publisher
    Rapid antigen detection tests (RADTs) are increasingly used to detect influenza viruses and respiratory syncytial virus (RSV). However, their sensitivity and specificity are a matter of debate, challenging their clinical usefulness.
  84. Calvo C, Garcia Garcia M, Pozo F, Carballo D, Martínez Monteserín E, Casas I. Infections and coinfections by respiratory human bocavirus during eight seasons in hospitalized children. J Med Virol. 2016;88:2052-2058 pubmed publisher
    ..The HBoV was the fourth most common virus detected, behind respiratory syncytial virus (39.8%), rhinovirus (30.6%), and adenovirus (15%)...
  85. Ye Q, Fu J, Mao J, Shang S. Haze is a risk factor contributing to the rapid spread of respiratory syncytial virus in children. Environ Sci Pollut Res Int. 2016;23:20178-20185 pubmed
    This study investigated whether respiratory syncytial virus (RSV) infection in children was associated with ambient temperature and air pollutants in Hangzhou, China...
  86. Anderson E, Carosone Link P, Yogev R, Yi J, Simoes E. Effectiveness of Palivizumab in High-risk Infants and Children: A Propensity Score Weighted Regression Analysis. Pediatr Infect Dis J. 2017;36:699-704 pubmed publisher
    ..heart disease are at an increased risk for lower respiratory tract infections and hospitalization from respiratory syncytial virus (RSV), which has been shown in randomized trials to be prevented by palivizumab...
  87. Liu X, Liang B, Ngwuta J, Liu X, Surman S, Lingemann M, et al. Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F. J Virol. 2017;91: pubmed publisher
    Human respiratory syncytial virus (RSV) is the most prevalent worldwide cause of severe respiratory tract infection in infants and young children...
  88. Bucher H, Duechs M, Tilp C, Jung B, Erb K. Tiotropium Attenuates Virus-Induced Pulmonary Inflammation in Cigarette Smoke-Exposed Mice. J Pharmacol Exp Ther. 2016;357:606-18 pubmed publisher
    ..effects in mice exposed to cigarette smoke (CS) and infected with influenza virus A/PR/8/34 (H1N1) or respiratory syncytial virus (RSV) and compared these effects with those of steroid fluticasone and PDE4-inhibitor roflumilast...
  89. Huong T, Tan B, Sugrue R. A Proteomic-Based Workflow Using Purified Respiratory Syncytial Virus Particles to Identify Cellular Factors as Drug Targets. Methods Mol Biol. 2016;1442:175-94 pubmed publisher
    The identification of cellular factors that play a role in respiratory syncytial virus (RSV) replication is an alternative strategy in the identification of druggable cellular protein that are essential for RSV replication...
  90. Kerstein A, Schüler S, Cabral Marques O, Fazio J, Häsler R, Muller A, et al. Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis. J Autoimmun. 2017;78:79-91 pubmed publisher
    ..T-cells specific for other viruses (influenza A virus, metapneumovirus, respiratory syncytial virus) and the autoantigen proteinase 3 (PR3) were infrequently detected in GPA...
  91. Marimón J, Navarro Marí J. [Rapid diagnostic test for respiratory infections]. Enferm Infecc Microbiol Clin. 2017;35:108-115 pubmed publisher
    ..Legionella pneumophila serogroup O1 infections from urine, Streptococcus pyogenes from throat swabs and respiratory syncytial virus from nasopharyngeal aspirates...
  92. Openshaw P, Chiu C, Culley F, Johansson C. Protective and Harmful Immunity to RSV Infection. Annu Rev Immunol. 2017;35:501-532 pubmed publisher
    b>Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects...