Human metapneumovirus

Summary

Alias: HMPV

Top Publications

  1. Biacchesi S, Skiadopoulos M, Boivin G, Hanson C, Murphy B, Collins P, et al. Genetic diversity between human metapneumovirus subgroups. Virology. 2003;315:1-9 pubmed
    Complete consensus nucleotide sequences were determined for human metapneumovirus (HMPV) isolates CAN97-83 and CAN98-75, representing the two proposed genotypes or genetic subgroups of HMPV...
  2. Buchholz U, Biacchesi S, Pham Q, Tran K, Yang L, Luongo C, et al. Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity. J Virol. 2005;79:6588-97 pubmed
    The M2 gene of human metapneumovirus (HMPV) contains two overlapping open reading frames (ORFs), M2-1 and M2-2...
  3. Biacchesi S, Pham Q, Skiadopoulos M, Murphy B, Collins P, Buchholz U. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J Virol. 2005;79:12608-13 pubmed
    Recombinant human metapneumovirus (HMPV) in which the SH, G, or M2 gene or open reading frame was deleted by reverse genetics was evaluated for replication and vaccine efficacy following topical administration to the respiratory tract of ..
  4. Biacchesi S, Pham Q, Skiadopoulos M, Murphy B, Collins P, Buchholz U. Modification of the trypsin-dependent cleavage activation site of the human metapneumovirus fusion protein to be trypsin independent does not increase replication or spread in rodents or nonhuman primates. J Virol. 2006;80:5798-806 pubmed
    The contribution of cleavage activation of the fusion F protein of human metapneumovirus (HMPV) to replication and pathogenicity in rodents and nonhuman primates was investigated...
  5. Williams J, Chen Z, Cseke G, Wright D, Keefer C, Tollefson S, et al. A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo. J Virol. 2007;81:8315-24 pubmed
    b>Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in infants and persons with underlying medical conditions...
  6. Liu L, Bastien N, Li Y. Intracellular processing, glycosylation, and cell surface expression of human metapneumovirus attachment glycoprotein. J Virol. 2007;81:13435-43 pubmed
    The biosynthesis and posttranslational processing of human metapneumovirus attachment G glycoprotein were investigated...
  7. Thammawat S, Sadlon T, Hallsworth P, Gordon D. Role of cellular glycosaminoglycans and charged regions of viral G protein in human metapneumovirus infection. J Virol. 2008;82:11767-74 pubmed publisher
    b>Human metapneumovirus (hMPV) is an important cause of lower respiratory tract disease, particularly in infants and young children...
  8. Kitagawa Y, Zhou M, Yamaguchi M, Komatsu T, Takeuchi K, Itoh M, et al. Human metapneumovirus M2-2 protein inhibits viral transcription and replication. Microbes Infect. 2010;12:135-45 pubmed publisher
    M2-2 protein of human metapneumovirus (HMPV) is encoded by one of two overlapping open reading frames within M2 mRNA. The precise function of HMPV M2-2 protein remains unknown...
  9. Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks B, et al. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. J Immunol. 2010;184:1168-79 pubmed publisher
    ..Recently, the RNA helicase retinoic acid-inducible gene I (RIG-I) has been shown to sense HMPV. In this study, we investigated the abilities of two prototype strains of HMPV (A1 [NL\1\00] and B1 [NL\1\99]) to ..

More Information

Publications141 found, 100 shown here

  1. Chang A, Masante C, Buchholz U, Dutch R. Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate. J Virol. 2012;86:3230-43 pubmed publisher
    b>Human metapneumovirus (HMPV) is a major worldwide respiratory pathogen that causes acute upper and lower respiratory tract disease. The mechanism by which this virus recognizes and gains access to its target cell is still largely unknown...
  2. Sun J, Wei Y, Rauf A, Zhang Y, Ma Y, Zhang X, et al. Methyltransferase-defective avian metapneumovirus vaccines provide complete protection against challenge with the homologous Colorado strain and the heterologous Minnesota strain. J Virol. 2014;88:12348-63 pubmed publisher
    ..aMPV), and Newcastle disease virus (NDV), human pathogens such as human respiratory syncytial virus, human metapneumovirus, human parainfluenza virus type 3, and measles virus, and highly lethal emerging pathogens such as Nipah ..
  3. Gong Y, Yang S, Chen G, Chen Y, Huang Y, Ning H, et al. A metagenomics study for the identification of respiratory viruses in mixed clinical specimens: an application of the iterative mapping approach. Arch Virol. 2017;162:2003-2012 pubmed publisher
    ..parainfluenza virus (HPIV), human parechovirus, influenza A virus, respiratory syncytial virus (RSV), and human metapneumovirus. This is the first study reporting the complete genome sequences of HRV-A101, HRV-C3, HPIV-4a, and RSV, as ..
  4. Dube F, Kaba M, Robberts F, Ah Tow L, Lubbe S, Zar H, et al. Respiratory microbes present in the nasopharynx of children hospitalised with suspected pulmonary tuberculosis in Cape Town, South Africa. BMC Infect Dis. 2016;16:597 pubmed
    ..Using quadratic discriminant analysis, human metapneumovirus, C...
  5. Nenna R, Evangelisti M, Frassanito A, Scagnolari C, Pierangeli A, Antonelli G, et al. Respiratory syncytial virus bronchiolitis, weather conditions and air pollution in an Italian urban area: An observational study. Environ Res. 2017;158:188-193 pubmed publisher
    ..1%) rhinovirus, 26 (6.6%) human bocavirus, 20 (5.1%) human metapneumovirus, and 16 (2.2%) other viruses...
  6. Li H, Ma Y, Escaffre O, Ivanciuc T, Komaravelli N, Kelley J, et al. Role of hydrogen sulfide in paramyxovirus infections. J Virol. 2015;89:5557-68 pubmed publisher
    ..GYY4137 also significantly reduced replication and inflammatory chemokine production induced by human metapneumovirus (hMPV) and Nipah virus (NiV), suggesting a broad inhibitory effect of H2S on paramyxovirus infections...
  7. Liu B, Li N, Shen Y, Bao X, Fabrizio T, Elbahesh H, et al. The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis. J Virol. 2016;90:4369-4382 pubmed publisher
    ..a check on replication of influenza A and B viruses in cell culture but does not inhibit Sendai virus or human metapneumovirus, two paramyxoviruses...
  8. Morris S, Pell L, Rahman M, Dimitris M, Mahmud A, Islam M, et al. Maternal vitamin D supplementation during pregnancy and lactation to prevent acute respiratory infections in infancy in Dhaka, Bangladesh (MDARI trial): protocol for a prospective cohort study nested within a randomized controlled trial. BMC Pregnancy Childbirth. 2016;16:309 pubmed
    ..by polymerase chain reaction (PCR) for 8 viruses (influenza A/B, parainfluenza 1/2/3, RSV, adenovirus, and human metapneumovirus), and nasal carriage density of Streptococcus pneumoniae...
  9. Chen Y, Lin X, Li H, Hua Z, Lin M, Huang W, et al. [Etiological analysis and establishment of a discriminant model for lower respiratory tract infections in hospitalized patients]. Zhonghua Jie He He Hu Xi Za Zhi. 2017;40:909-914 pubmed publisher
    ..Cytomegalovirus, and other virus like adenovirus, human parainfluenza virus, respiratory syncytial virus, human metapneumovirus, human boca virus were also detected fewly...
  10. Fukutani K, Nascimento Carvalho C, Van der Gucht W, Wollants E, Khouri R, Dierckx T, et al. Pathogen transcriptional profile in nasopharyngeal aspirates of children with acute respiratory tract infection. J Clin Virol. 2015;69:190-6 pubmed publisher
    ..multiplex detection of different pathogens: RNA viruses Parainfluenza virus (PIV 1-3) and RSV A-B in 21%, Human metapneumovirus (hMPV) in 5%, Bocavirus (BoV), CoV, Influenza virus (IV) A in 3% and, Rhinovirus (RV) in 2% of samples, ..
  11. Sonawane A, Shastri J, Bavdekar S. Respiratory Pathogens in Infants Diagnosed with Acute Lower Respiratory Tract Infection in a Tertiary Care Hospital of Western India Using Multiplex Real Time PCR. Indian J Pediatr. 2019;: pubmed publisher
    ..4%), Human rhinovirus (25.6%), Adenovirus (22%), Human Parainfluenza viruses (11%), Human bocavirus (9.8), Human metapneumovirus A / B (8.5%), Influenza A (H1N1) pdm 09 (6.1%), Parechovirus (3.7%), Human coronaviruses (3...
  12. Chan C, Low J, Wyone W, Oon L, Tan B. Survey of Respiratory Virus in Patients Hospitalised for Acute Exacerbations of Heart Failure - A Prospective Observational Study. Ann Acad Med Singapore. 2018;47:445-450 pubmed
    ..rhinovirus, parainfluenza virus (HPIV), human coronavirus (HcoV), adenoviurs, human bocavirus (HboV), human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). Twenty-five (13%) had RVs detected by RV multiplex PCR...
  13. Shean R, Makhsous N, Stoddard G, Lin M, Greninger A. VAPiD: a lightweight cross-platform viral annotation pipeline and identification tool to facilitate virus genome submissions to NCBI GenBank. BMC Bioinformatics. 2019;20:48 pubmed publisher
    ..The pipeline has been validated on human immunodeficiency virus, human parainfluenza virus 1-4, human metapneumovirus, human coronaviruses (229E/OC43/NL63/HKU1/SARS/MERS), human enteroviruses/rhinoviruses, measles virus, ..
  14. Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Tligui H, Seffar M, et al. Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco. Int J Infect Dis. 2014;28:164-70 pubmed publisher
    ..15), pallor (OR 2.27, 95% CI 1.34-3.84), having rhonchi on auscultation (OR 2.45, 95% CI 1.58-3.79), and human metapneumovirus infection (OR 2.13, 95% CI 1.13-4...
  15. Weinberger R, Riffelmann M, Kennerknecht N, Hülße C, Littmann M, O Brien J, et al. Long-lasting cough in an adult German population: incidence, symptoms, and related pathogens. Eur J Clin Microbiol Infect Dis. 2018;37:665-672 pubmed publisher
    ..parapertussis, human metapneumovirus, influenza virus A and rhinovirus, parainfluenza virus, Mycoplasma pneumonia, and respiratory syncytial ..
  16. Stone J, Vemulapati B, Bradel Tretheway B, Aguilar H. Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins. J Virol. 2016;90:10762-10773 pubmed publisher
    ..viruses, including measles virus, mumps virus, parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the deadly zoonotic henipaviruses Hendra and Nipah virus (NiV)...
  17. Lu L, Yan Y, Yang B, Xiao Z, Feng X, Wang Y, et al. Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China. BMC Infect Dis. 2015;15:431 pubmed publisher
    ..Human bocavirus, human metapneumovirus, and mycoplasma pneumoniae were detected by polymerase chain reaction...
  18. Leber A, Everhart K, Daly J, Hopper A, Harrington A, Schreckenberger P, et al. Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples. J Clin Microbiol. 2018;56: pubmed publisher
    ..identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus, human rhinovirus/enterovirus, influenza virus A, influenza virus A H1, influenza virus A H1-2009, ..
  19. Vasileiou S, Turney A, Kuvalekar M, Mukhi S, Watanabe A, Lulla P, et al. Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections. Haematologica. 2019;: pubmed publisher
    ..respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause ..
  20. Marcone D, Durand L, Azziz Baumgartner E, Vidaurreta S, Ekstrom J, Carballal G, et al. Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina. BMC Infect Dis. 2015;15:447 pubmed publisher
    ..The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized ..
  21. Bønnelykke K, Vissing N, Sevelsted A, Johnston S, Bisgaard H. Association between respiratory infections in early life and later asthma is independent of virus type. J Allergy Clin Immunol. 2015;136:81-86.e4 pubmed publisher
    ..picornaviruses, coronaviruses 229E and OC43, parainfluenza viruses 1-3, influenza viruses AH1, AH3, and B, human metapneumovirus, adenoviruses, and bocavirus) and 3 pathogenic airway bacteria (Streptococcus pneumoniae, Haemophilus ..
  22. Sun H, Sun Q, Jiang W, Chen Z, Huang L, Wang M, et al. Prevalence of rhinovirus in wheezing children: a comparison with respiratory syncytial virus wheezing. Braz J Infect Dis. 2016;20:179-83 pubmed publisher
    ..for respiratory viruses, by using polymerase chain reaction method for rhinovirus, human bocavirus, and human metapneumovirus, and direct immunofluorescence assay to test for respiratory syncytial virus, adenovirus, parainfluenza ..
  23. Hutspardol S, Essa M, Richardson S, Schechter T, Ali M, Krueger J, et al. Significant Transplantation-Related Mortality from Respiratory Virus Infections within the First One Hundred Days in Children after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015;21:1802-7 pubmed publisher
    ..Viruses were parainfluenza (35%), respiratory syncytial virus (28%), influenza (22%), adenovirus (7%), human metapneumovirus (4%), coronavirus (2%), and rhinovirus (2%)...
  24. Ieven M, Coenen S, Loens K, Lammens C, Coenjaerts F, Vanderstraeten A, et al. Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries. Clin Microbiol Infect. 2018;24:1158-1163 pubmed publisher
    ..viruses and human respiratory syncytial virus as well as human rhinovirus, human coronavirus and human metapneumovirus were detected significantly more frequently in LRTI patients than in controls...
  25. Kurai D, Sasaki Y, Saraya T, Ishii H, Tsukagoshi H, Kozawa K, et al. Pathogen profiles and molecular epidemiology of respiratory viruses in Japanese inpatients with community-acquired pneumonia. Respir Investig. 2016;54:255-63 pubmed publisher
    ..5% (n=8) and 11.8% (n=9) of cases, respectively. Streptococcus pneumoniae and human metapneumovirus were the most frequently detected bacterium and virus, respectively...
  26. Prasetyo A, Desyardi M, Tanamas J, Suradi -, Reviono -, Harsini -, et al. Respiratory viruses and torque teno virus in adults with acute respiratory infections. Intervirology. 2015;58:57-68 pubmed publisher
    ..67), and/or had pneumonia (80%, OR = 4.0). Human rhinovirus (HRV) A43 predominated. Influenza A H3N2, human metapneumovirus (HMPV) subtypes A1 and A2, the influenza B virus, human adenovirus B, and human coronavirus OC43 were also ..
  27. Oumei H, Xuefeng W, Jianping L, Kunling S, Rong M, Zhenze C, et al. Etiology of community-acquired pneumonia in 1500 hospitalized children. J Med Virol. 2017;: pubmed publisher
    ..4%), parainfluenza virus types 2 and 3 type (3.1 %), parainfluenza virus type 1 (2.9%), and human metapneumovirus (0.3%). Co-infections were identified in 128 (18.5%) of the 691 cases...
  28. El Kholy A, Mostafa N, Ali A, El Sherbini S, Ismail R, Magdy R, et al. Risk factors of prolonged hospital stay in children with viral severe acute respiratory infections. J Infect Dev Ctries. 2014;8:1285-93 pubmed publisher
    ..9%), adenovirus (6.2%), parainfluenza viruses (PIVs1-3) (5.1%), human metapneumovirus (HMPV) (4.5%), influenza A (1.4%), and influenza B (0.6%)...
  29. Homaira N, Luby S, Petri W, Vainionpaa R, Rahman M, Hossain K, et al. Incidence of respiratory virus-associated pneumonia in urban poor young children of Dhaka, Bangladesh, 2009-2011. PLoS ONE. 2012;7:e32056 pubmed publisher
    ..We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time ..
  30. Zhang Y, Sun J, Wei Y, Li J. A Reverse Genetics Approach for the Design of Methyltransferase-Defective Live Attenuated Avian Metapneumovirus Vaccines. Methods Mol Biol. 2016;1404:103-21 pubmed publisher
    ..which includes many important human pathogens such as human respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and human parainfluenza virus type 3 (PIV3)...
  31. Do A, van Doorn H, Nghiem M, Bryant J, Hoang T, Do Q, et al. Viral etiologies of acute respiratory infections among hospitalized Vietnamese children in Ho Chi Minh City, 2004-2008. PLoS ONE. 2011;6:e18176 pubmed publisher
    ..24%), influenza virus A and B (17%), human bocavirus (16%), enterovirus (9%), human coronavirus (8%), human metapneumovirus (7%), parainfluenza virus 1-3 (6%), adenovirus (5%), and human rhinovirus A (4%)...
  32. Ren J, Liu G, Go J, Kolli D, Zhang G, Bao X. Human metapneumovirus M2-2 protein inhibits innate immune response in monocyte-derived dendritic cells. PLoS ONE. 2014;9:e91865 pubmed publisher
    b>Human metapneumovirus (hMPV) is a leading cause of lower respiratory infection in young children, the elderly and immunocompromised patients. Repeated hMPV infections occur throughout life...
  33. Lai S, Liao S, Wong K, Lin T. Defective innate immune responses to respiratory syncytial virus infection in ovalbumin-sensitized mice. J Microbiol Immunol Infect. 2017;50:17-25 pubmed publisher
    ..Mice were subsequently infected with either respiratory syncytial virus (RSV) or human metapneumovirus (hMPV)...
  34. Costa E, Rodríguez Domínguez M, Clari M, Giménez E, Galán J, Navarro D. Comparison of the performance of 2 commercial multiplex PCR platforms for detection of respiratory viruses in upper and lower tract respiratory specimens. Diagn Microbiol Infect Dis. 2015;82:40-3 pubmed publisher
    ..than that of the CLART® PneumoVir assay for human bocavirus, influenza A virus/H3N2, influenza B virus, human metapneumovirus, and parainfluenza virus, whereas the sensitivity of the latter was higher for most targeted viruses ..
  35. Pancham K, Sami I, Perez G, Huseni S, Kurdi B, Rose M, et al. Human Metapneumovirus Infection is Associated with Severe Respiratory Disease in Preschool Children with History of Prematurity. Pediatr neonatol. 2016;57:27-34 pubmed publisher
    b>Human metapneumovirus (HMPV) is a recently discovered respiratory pathogen of the family Paramyxoviridae, the same family as that of respiratory syncytial virus (RSV)...
  36. El Najjar F, Cifuentes Muñoz N, Chen J, Zhu H, Buchholz U, Moncman C, et al. Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog. 2016;12:e1005922 pubmed publisher
    ..We show that infection of human bronchial airway cells with human metapneumovirus (HMPV), a recently identified paramyxovirus which causes significant respiratory disease, results in ..
  37. Ye C, Zhu W, Yu J, Li Z, Fu Y, Lan Y, et al. Viral pathogens among elderly people with acute respiratory infections in Shanghai, China: Preliminary results from a laboratory-based surveillance, 2012-2015. J Med Virol. 2017;89:1700-1706 pubmed publisher
    ..rhinovirus (HRV), human para-influenza virus (PIV), adenovirus (ADV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), human coronavirus (hCoVs), and human bocavirus (hBoV)...
  38. Huang H, Tsai C, Chang J, Hsu T, Lin S, Lee C. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis. Clin Microbiol Infect. 2018;24:1055-1063 pubmed publisher
    ..five viruses were calculated: influenza A virus (FluA), influenza B virus, respiratory syncytial virus, human metapneumovirus and adenovirus...
  39. Palacios G, Lowenstine L, Cranfield M, Gilardi K, Spelman L, Lukasik Braum M, et al. Human metapneumovirus infection in wild mountain gorillas, Rwanda. Emerg Infect Dis. 2011;17:711-3 pubmed publisher
    ..Human-to-gorilla transmission may explain human metapneumovirus in 2 wild mountain gorillas that died during a respiratory disease outbreak in Rwanda in 2009...
  40. Cui B, ZHANG D, Pan H, Zhang F, Farrar J, Law F, et al. Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China. BMC Infect Dis. 2015;15:124 pubmed publisher
    ..syncytial viruses (RSV A and B), human coronaviruses (hCoV: 229E, OC43, HKU1, NL63), human metapneumoviruses (hMPV A and B), parainfluenza viruses (PIV1-4), human rhinoviruses (HRV A, B, C), enteroviruses (EV), adenoviruses (ADV), ..
  41. Wen S, Williams J. New Approaches for Immunization and Therapy against Human Metapneumovirus. Clin Vaccine Immunol. 2015;22:858-66 pubmed publisher
    b>Human metapneumovirus (HMPV) is a paramyxovirus discovered in 2001 in the Netherlands. Studies have identified HMPV as an important causative agent of acute respiratory disease in infants, the elderly, and immunocompromised individuals...
  42. Lefebvre A, Manoha C, Bour J, Abbas R, Fournel I, Tiv M, et al. Human metapneumovirus in patients hospitalized with acute respiratory infections: A meta-analysis. J Clin Virol. 2016;81:68-77 pubmed publisher
    This meta-analysis aimed to estimate the prevalence of human metapneumovirus (hMPV) infections in patients hospitalized for acute respiratory infection (ARI) and to study factors associated with this prevalence...
  43. Diab M, Vitenshtein A, Drori Y, Yamin R, Danziger O, Zamostiano R, et al. Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1. Oncotarget. 2016;7:66468-66479 pubmed publisher
    ..This leads to the induction of anti-viral genes and inhibition of virus growth. Human Metapneumovirus (HMPV) is a major respiratory virus that causes an upper and lower respiratory tract infection in children...
  44. Di Paola N, Cunha M, Durigon G, Berezin E, Durigon E, Oliveira D, et al. Complete Genome Sequence of a Human Metapneumovirus Isolate Collected in Brazil. Genome Announc. 2018;6: pubmed publisher
    Here, we present the complete genome sequence of a human metapneumovirus isolate collected from a hospitalized infant suffering from acute respiratory disease...
  45. Bouvet D, Gaudy Graffin C, Garot D, Sunder S, de Gialluly C, Goudeau A. Diagnosis of community-acquired acute respiratory illness: From conventional microbiological methods to molecular detection (multiplex). Pathol Biol (Paris). 2015;63:69-73 pubmed publisher
    ..some of the influenza virus A (15/51, 29%) infections identified by multiplex PCR and some (7/15, 47%) human metapneumovirus and (5/12, 42%) respiratory syncytial virus infections, but it did not detect all the adenovirus ..
  46. Lay M, Céspedes P, Palavecino C, León M, Díaz R, Salazar F, et al. Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice. Eur J Immunol. 2015;45:1680-95 pubmed publisher
    b>Human metapneumovirus (hMPV) is a leading cause of acute respiratory tract infections in children and the elderly. The mechanism by which this virus triggers an inflammatory response still remains unknown...
  47. Essa S, Owayed A, Altawalah H, Khadadah M, Behbehani N, Al Nakib W. The Prevalence of Human Bocavirus, Human Coronavirus-NL63, Human Metapneumovirus, Human Polyomavirus KI and WU in Respiratory Tract Infections in Kuwait. Med Princ Pract. 2015;24:382-7 pubmed publisher
    The aim of this study was to investigate the prevalence of human coronavirus (HCoV)-NL63, human metapneumovirus (hMPV), human bocavirus (Boca), human polyomavirus KI (KIV) and human polyomavirus WU (WUV) in respiratory tract infections (..
  48. Haynes A, Fowlkes A, Schneider E, Mutuc J, Armstrong G, Gerber S. Human Metapneumovirus Circulation in the United States, 2008 to 2014. Pediatrics. 2016;137: pubmed publisher
    b>Human metapneumovirus (HMPV) infection causes respiratory illness, including bronchiolitis and pneumonia...
  49. Samuel S, Nanjappa S, Cooper C, Greene J. Human Metapneumovirus Infection in Immunocompromised Patients. Cancer Control. 2016;23:442-445 pubmed
    b>Human metapneumovirus (HMPV) is a pathogen associated with respiratory tract infection and is related to avian pneumovirus...
  50. Rodríguez L, Olmedillas E, Mas V, Vázquez M, Cano O, Terrón M, et al. Generation of monoclonal antibodies specific of the postfusion conformation of the Pneumovirinae fusion (F) protein. J Virol Methods. 2015;224:1-8 pubmed publisher
    ..The antibodies reported here should assist in the characterization of the structural changes that the F protein of human metapneumovirus or respiratory syncytial virus experiences during the process of membrane fusion.
  51. Zhang Y, Sakthivel S, Bramley A, Jain S, Haynes A, Chappell J, et al. Serology Enhances Molecular Diagnosis of Respiratory Virus Infections Other than Influenza in Children and Adults Hospitalized with Community-Acquired Pneumonia. J Clin Microbiol. 2017;55:79-89 pubmed publisher
    ..reverse transcription-PCR (RT-PCR) and serology for the diagnosis of respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza virus 1 to 3 (PIV1, PIV2, and PIV3), and adenovirus (AdV) infections...
  52. González L, Vazquez Y, Mora J, Palavecino C, Bertrand P, Ferres M, et al. Evaluation of monoclonal antibodies that detect conserved proteins from Respiratory Syncytial Virus, Metapneumovirus and Adenovirus in human samples. J Virol Methods. 2018;254:51-64 pubmed publisher
    Human Respiratory Syncytial Virus (hRSV), human Metapneumovirus (hMPV) and Adenovirus (ADV), are three of the most prevalent viruses responsible for pneumonia and bronchiolitis in children and elderly worldwide, accounting for a high ..
  53. Diaz J, Morales Romero J, Pérez Gil G, Bedolla Barajas M, Delgado Figueroa N, García Román R, et al. Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study. Ital J Pediatr. 2015;41:33 pubmed publisher
    ..In the study population, metapneumovirus (hMPV) was the most frequent virus (22%), followed by adenovirus (hAD) (16%), respiratory syncytial virus (RSV) (14%), ..
  54. Erickson J, Lu P, Wen S, Hastings A, Gilchuk P, Joyce S, et al. Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype. J Immunol. 2015;195:4319-30 pubmed publisher
    ..gene expression profiles of impaired epitope-specific lung TCD8 to functional spleen TCD8 in the same human metapneumovirus-infected mice...
  55. von Lilienfeld Toal M, Berger A, Christopeit M, Hentrich M, Heussel C, Kalkreuth J, et al. Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur J Cancer. 2016;67:200-212 pubmed publisher
    ..on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus...
  56. Owor B, Masankwa G, Mwango L, Njeru R, Agoti C, Nokes D. Human metapneumovirus epidemiological and evolutionary patterns in Coastal Kenya, 2007-11. BMC Infect Dis. 2016;16:301 pubmed publisher
    b>Human metapneumovirus (HMPV) is an important global cause of severe acute respiratory infections in young children and the elderly...
  57. Iroh Tam P, Zhang L, Cohen Z. Impact of a Transition from Respiratory Virus Shell Vial to Multiplex PCR on Clinical Outcomes and Cost in Hospitalized Children. Children (Basel). 2017;4: pubmed publisher
    ..7%) and 112 were tested positive by SV (11.1%, p < 0.05). Excluding human rhinovirus (HRV) and human metapneumovirus (hMPV) from the analysis, patients with a positive test from SV had more comorbidities (p = 0...
  58. Ison M. Antiviral Treatments. Clin Chest Med. 2017;38:139-153 pubmed publisher
    ..infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus,..
  59. Jung H, Kang B, Ra S, Seo K, Jegal Y, Jun J, et al. Elucidation of Bacterial Pneumonia-Causing Pathogens in Patients with Respiratory Viral Infection. Tuberc Respir Dis (Seoul). 2017;80:358-367 pubmed publisher
    ..001): pneumonia in patients with influenza virus (type A/B), rhinovirus, and human metapneumovirus infections was caused by similar bacteria, and the findings indicated that Staphylococcus aureus pneumonia ..
  60. Li Y, Lund C, Nervik I, Loevenich S, Døllner H, Anthonsen M, et al. Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection. Sci Rep. 2018;8:883 pubmed publisher
    ..Recently, TSLP was found to be upregulated in human airway cells upon human metapneumovirus (hMPV) infection, yet it remains unclear if the two isoforms are regulated differently during hMPV ..
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    ..PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (..
  62. Cunha B, Irshad N, Connolly J. Adult human metapneumonovirus (hMPV) pneumonia mimicking Legionnaire's disease. Heart Lung. 2016;45:270-2 pubmed publisher
    ..We present a most unusual case of human metapneumonovirus pneumonia (hMPV) with some characteristic extrapulmonary findings characteristic of LD, e.g...
  63. Finianos M, Issa R, Curran M, Afif C, Rajab M, Irani J, et al. Etiology, seasonality, and clinical characterization of viral respiratory infections among hospitalized children in Beirut, Lebanon. J Med Virol. 2016;88:1874-81 pubmed publisher
    ..were human Rhinovirus (hRV, 23%), Respiratory Syncytial Virus (RSV, 19%), human Bocavirus (hBov, 15%), human Metapneumovirus (hMPV, 10%), and human Adenovirus (hAdV, 10%)...
  64. Ali A, Akhund T, Warraich G, Aziz F, Rahman N, Umrani F, et al. Respiratory viruses associated with severe pneumonia in children under 2 years old in a rural community in Pakistan. J Med Virol. 2016;88:1882-90 pubmed publisher
    ..for assessment by multiplex RT-PCR for eight viruses and their subtypes, including RSV, influenza virus, human metapneumovirus, enterovirus/rhinovirus, coronavirus, parainfluenza virus, adenovirus, and human bocavirus...
  65. Guan L, Zhao L, Zhou H, Nie K, Li X, Zhang D, et al. Reverse transcription genome exponential amplification reaction assay for rapid and universal detection of human rhinoviruses. Arch Virol. 2016;161:1891-8 pubmed publisher
    ..Echo30, and PV1-3 or with other common respiratory viruses including FluA H3, FluB, PIV1-4, ADV3, RSVA, RSVB and HMPV. With in vitro-transcribed RNA containing the amplified regions of HRV-A60, HRV-B06 and HRV-C07 as templates, the ..
  66. Bashir U, Nisar N, Arshad Y, Alam M, Ashraf A, Sadia H, et al. Respiratory syncytial virus and influenza are the key viral pathogens in children <2 years hospitalized with bronchiolitis and pneumonia in Islamabad Pakistan. Arch Virol. 2017;162:763-773 pubmed publisher
    ..5%, Influenza-B: 7%, Adenovirus: 8.4% and HmPV: 5.2%. A single, dual or multiple viral pathogens were detected in 43%, 27% and 5.2% patients respectively...
  67. Garcia Garcia M, Calvo C, Moreira A, Cañas J, Pozo F, Sastre B, et al. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. Medicine (Baltimore). 2017;96:e6787 pubmed publisher
    ..5%) parainfluenza virus (PIV); 9 (4.2%) adenovirus; 10 (4.7%) bocavirus; and 7 (3.3%) metapneumovirus (hMPV). Infants with bronchiolitis had higher levels of TSLP (P?=?.02), IL-33 (P<.001), and periostin (P?=?...
  68. Piralla A, Mariani B, Rovida F, Baldanti F. Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009-2016) in Northern Italy. J Clin Virol. 2017;92:48-51 pubmed publisher
    ..8%), influenza B virus (9/226, 4.0%), human coronaviruses (9/226, 4.0%), cytomegalovirus (9/226, 4.0%) and human metapneumovirus (1/226, 0.4%)...
  69. Ramaekers K, Keyaerts E, Rector A, Borremans A, Beuselinck K, Lagrou K, et al. Prevalence and seasonality of six respiratory viruses during five consecutive epidemic seasons in Belgium. J Clin Virol. 2017;94:72-78 pubmed publisher
    ..included in this analysis: Influenza viruses (IAV & IBV), Human respiratory syncytial virus (hRSV), Human metapneumovirus (hMPV), Adenovirus (ADV) and Human parainfluenza virus (hPIV)...
  70. Cohen C, Moyes J, Tempia S, Groome M, Walaza S, Pretorius M, et al. Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants. Pediatrics. 2016;137: pubmed publisher
    ..4; 95% CI 1.3-1.6) and human metapneumovirus-associated (IRR 1.4; 95% CI 1.1-2.0) LRTI, with a similar trend observed for influenza (IRR 1.2; 95% CI 0...
  71. Othman H, Abu Elhamed W, Hassan D, Soliman M, Abdel Baset R. Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two. J Infect Dev Ctries. 2016;10:283-9 pubmed publisher
    ..Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are among the commonest viral causes of severe ALRTI...
  72. Chen J, Lam H, Yip C, Wong S, Chan J, Ma E, et al. Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection. J Clin Microbiol. 2016;54:1820-1825 pubmed publisher
    ..Substantial agreement was found for most respiratory targets, but significant differences were observed in human metapneumovirus (P = 0.001) and parainfluenza virus type 3 (P = 0.031)...
  73. Esposito S, Scala A, Bianchini S, Presicce M, Mori A, Sciarrabba C, et al. Partial comparison of the NxTAG Respiratory Pathogen Panel Assay with the Luminex xTAG Respiratory Panel Fast Assay V2 and singleplex real-time polymerase chain reaction for detection of respiratory pathogens. Diagn Microbiol Infect Dis. 2016;86:53-7 pubmed publisher
    ..003), human metapneumovirus (P < 0.001), human rhinovirus/human enterovirus (P = 0.009) and human adenovirus (P < 0.001)...
  74. Ursic T, Miksić N, Lusa L, Strle F, Petrovec M. Viral respiratory infections in a nursing home: a six-month prospective study. BMC Infect Dis. 2016;16:637 pubmed
    ..In residents, influenza A virus, respiratory syncytial virus, and human metapneumovirus were detected most commonly, whereas in NH staff rhinovirus and influenza A virus prevailed...
  75. Shahani L, Ariza Heredia E, Chemaly R. Antiviral therapy for respiratory viral infections in immunocompromised patients. Expert Rev Anti Infect Ther. 2017;15:401-415 pubmed publisher
    Respiratory viruses (influenza, parainfluenza, respiratory syncytial virus, coronavirus, human metapneumovirus, and rhinovirus) represent the most common causes of respiratory viral infections in immunocompromised patients...
  76. Yeşilbaş O, Sevketoglu E, Kihtir H, Talip Petmezci M, Bato E, Balkaya S, et al. [A case of bronchiolitis obliterans secondary to human metapneumovirus bronchiolitis]. Mikrobiyol Bul. 2016;50:606-612 pubmed
    b>Human metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family...
  77. Hang L, Do L, Van T, Nguyen S, Hoang P, Pham H, et al. Viral co-infections among children with confirmed measles at hospitals in Hanoi, Vietnam, 2014. Asian Pac J Trop Med. 2017;10:171-174 pubmed publisher
    ..Influenza A/H1N1pdm09; A/H3N2 and influenza B; Parainfluenza 1, 2, 3; Respiratory Synctial Virus, RSV; human Metapneumovirus, hMPV; Adenovirus and Picornavirus). Twenty-one cases (38...
  78. You H, Chang S, Yu H, Li C, Chen C, Liao W. Simultaneous detection of respiratory syncytial virus and human metapneumovirus by one-step multiplex real-time RT-PCR in patients with respiratory symptoms. BMC Pediatr. 2017;17:89 pubmed publisher
    Both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are important viral pathogens causing respiratory tract infection (RTI) in the pediatric population...
  79. Anderson E, Carosone Link P, Yogev R, Yi J, Simoes E. Effectiveness of Palivizumab in High-risk Infants and Children: A Propensity Score Weighted Regression Analysis. Pediatr Infect Dis J. 2017;36:699-704 pubmed publisher
    ..hospitalized with lower respiratory tract infection and whose nasopharyngeal aspirates were tested for human metapneumovirus (HMPV) and RSV were the subjects of the trial...
  80. Hastings A, Gilchuk P, Joyce S, Williams J. Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells. Vaccine. 2016;34:2663-70 pubmed publisher
    b>Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five...
  81. Yang H, He H, Tan B, Liu E, Zhao X, Zhao Y. Human metapneumovirus uses endocytosis pathway for host cell entry. Mol Cell Probes. 2016;30:231-237 pubmed publisher
    b>Human metapneumovirus (hMPV) is a prevalent pathogen worldwide and causes various respiratory infections. Although it is a critical pathogen in pediatric patients, it is unclear how it enters host cells...
  82. González A, Lay M, Jara E, Espinoza J, Gómez R, Soto J, et al. Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection. Virulence. 2017;8:685-704 pubmed publisher
    Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly...
  83. Hilmes M, Daniel Dunnavant F, Singh S, Ellis W, Payne D, Zhu Y, et al. Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol. 2017;47:1745-1750 pubmed publisher
    b>Human metapneumovirus (HMPV) was identified in 2001 and is a common cause of acute respiratory illness in young children...
  84. Tzannou I, Nicholas S, Lulla P, Aguayo Hiraldo P, Misra A, Martinez C, et al. Immunologic Profiling of Human Metapneumovirus for the Development of Targeted Immunotherapy. J Infect Dis. 2017;216:678-687 pubmed publisher
    b>Human metapneumovirus (hMPV) is a respiratory virus detected in ≥9% of allogeneic hematopoietic stem cell transplant (HSCT) recipients, in whom it can cause significant morbidity and mortality...
  85. Ábrego L, Mirazo S, Delfraro A, Franco D, Castillo M, Gaitan M, et al. Genotypes of human metapneumovirus circulating during 2010-2012 in children from Panama. J Med Virol. 2017;: pubmed publisher
    b>Human metapneumovirus (HMPV) is a common causative agent of severe respiratory tract infections in children under 5 years old, the elderly and immunocompromised patients, being responsible for 5-15% of all viral respiratory infections ..
  86. Lemaitre E, Allee C, Vabret A, Eterradossi N, Brown P. Single reaction, real time RT-PCR detection of all known avian and human metapneumoviruses. J Virol Methods. 2018;251:61-68 pubmed publisher
    Current molecular methods for the detection of avian and human metapneumovirus (AMPV, HMPV) are specifically targeted towards each virus species or individual subgroups of these...
  87. Grützmacher K, Köndgen S, Keil V, Todd A, Feistner A, Herbinger I, et al. Codetection of Respiratory Syncytial Virus in Habituated Wild Western Lowland Gorillas and Humans During a Respiratory Disease Outbreak. Ecohealth. 2016;13:499-510 pubmed
    ..A total of 15 gorilla and 15 human fecal samples and 80 human throat swabs were tested for HRSV, human metapneumovirus, and other respiratory viruses...
  88. Chughtai A, Wang Q, Dung T, Macintyre C. The presence of fever in adults with influenza and other viral respiratory infections. Epidemiol Infect. 2017;145:148-155 pubmed
    ..by virus: human rhinovirus (25·3%, 19/75), influenza A virus (30%, 3/10), coronavirus (28·6%, 2/7), human metapneumovirus (28·6%, 2/7), respiratory syncytial virus (14·3%, 4/28) and parainfluenza virus (8·3%, 1/12)...
  89. Diab M, Glasner A, Isaacson B, Bar On Y, Drori Y, Yamin R, et al. NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection. Eur J Immunol. 2017;47:692-703 pubmed publisher
    ..Natural killer (NK) cells are capable of killing various pathogens upon stimulation of activating receptors. Human metapneumovirus (HMPV) is a respiratory virus, which was discovered in 2001 and is responsible for acute respiratory tract ..
  90. Kodama F, Nace D, Jump R. Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults. Infect Dis Clin North Am. 2017;31:767-790 pubmed publisher
    ..Other noninfluenza respiratory viral pathogens include human metapneumovirus, parainfluenza virus, rhinovirus, coronavirus, and adenovirus...
  91. Ren Y, Choi E, Zhang K, Chen Y, Ye S, Deng X, et al. Detection of Nuclear Protein Profile Changes by Human Metapneumovirus M2-2 Protein Using Quantitative Differential Proteomics. Vaccines (Basel). 2017;5: pubmed publisher
    b>Human metapneumovirus (hMPV) is a leading cause of lower respiratory infection in pediatric populations globally...
  92. Cheemarla N, Banos Lara M, Naidu S, Guerrero Plata A. Neutrophils regulate the lung inflammatory response via ?? T cell infiltration in an experimental mouse model of human metapneumovirus infection. J Leukoc Biol. 2017;101:1383-1392 pubmed publisher
    ..elucidate the role of neutrophils in respiratory antiviral defense, we used an experimental mouse model of human metapneumovirus (HMPV) infection...