Newcastle disease virus B1


Alias: Newcastle disease virus strain B1

Top Publications

  1. Tsunekuni R, Ito H, Otsuki K, Kida H, Ito T. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants. Virus Genes. 2010;40:252-5 pubmed publisher
    ..These results suggest that in addition to the F cleavage site sequence, these two amino acids in HN protein are also related to the pathogenicity of NDV in chickens...
  2. Cornax I, Diel D, Rue C, Estevez C, Yu Q, Miller P, et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol. 2013;94:1189-1194 pubmed publisher
    ..These results indicate that the F and HN proteins are determinants of NDV macrophage host range. This represents the first description of productive NDV infection in macrophages. ..
  3. Samal S, Khattar S, Kumar S, Collins P, Samal S. Coordinate deletion of N-glycans from the heptad repeats of the fusion F protein of Newcastle disease virus yields a hyperfusogenic virus with increased replication, virulence, and immunogenicity. J Virol. 2012;86:2501-11 pubmed publisher
    ..These results illustrate the effects of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and HR2 coordinately downregulate viral fusion and virulence. ..
  4. Khattar S, Yan Y, Panda A, Collins P, Samal S. A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity. J Virol. 2009;83:7779-82 pubmed publisher
    ..While most of the mutations had surprisingly little effect, mutation at conserved residue Y526 reduced the neuraminidase, receptor binding, and fusion activities and attenuated viral virulence in eggs and young birds...
  5. Samal S, Khattar S, Paldurai A, Palaniyandi S, Zhu X, Collins P, et al. Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity. J Virol. 2013;87:10083-93 pubmed publisher
    ..We conclude that these wild-type residues in the NDV F CT have an effect on regulating F protein biological functions and thus modulating viral replication and pathogenesis. ..
  6. Qin Z, Ma B, He Y, Wang Y, Cui Z. [Newcastle disease virus heredity mutation and correlation of HN and F gene]. Wei Sheng Wu Xue Bao. 2006;46:227-32 pubmed
    ..The sequences of HN gene in Chinese isolates had an identity of more than 97%. But there was only 79.2% - 80.7% in HN nucleotide homology among the Chinese isolates and La Sota (vaccine). ..
  7. Qiu X, Fu Q, Meng C, Yu S, Zhan Y, Dong L, et al. Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection. Acta Virol. 2016;60:71-7 pubmed
  8. Rajmani R, Gandham R, Gupta S, Sahoo A, Singh P, Kumar R, et al. HN Protein of Newcastle Disease Virus Induces Apoptosis Through SAPK/JNK Pathway. Appl Biochem Biotechnol. 2015;177:940-56 pubmed publisher
    ..The results of our study provide an insight into the mechanism through which HN induces apoptosis. ..
  9. Esmaelizad M, Ashtiani M. Comparative analysis of sialidase protein in velogenic and lentogenic strains of Newcastle disease virus. Acta Virol. 2015;59:194-8 pubmed
    ..We suggest these six amino acids might play an effective role in the pathogenesis of NDV. ..

More Information


  1. Kumar C, Kumar S. Species based synonymous codon usage in fusion protein gene of Newcastle disease virus. PLoS ONE. 2014;9:e114754 pubmed publisher
    ..The present study provides a basic understanding of the mechanism involved in codon usage among species. ..
  2. Wang L, Suo X, Chen F, Zheng S. Expression of Newcastle disease virus (NDV) M protein from a recombinant plasmid prolongs the survival of NDV-infected chicken embryos and enhances the virus replication. Acta Virol. 2009;53:105-10 pubmed
    ..These data indicated that the expression of M protein in the NDV-infected chicken embryos primarily prolonged their survival and consequently enhanced virus replication. ..
  3. Zhao W, Hu H, Zsak L, Yu Q, Yang Z. HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism. Virus Genes. 2013;47:27-33 pubmed publisher
    ..These results demonstrated that the HN protein C-terminal extension of NDV is not the determinant of the virus enteric tropism. ..
  4. Duan Z, Chen J, He L, Xu H, Li Q, Hu S, et al. [Matrix protein of Newcastle disease virus interacts with avian nucleophosmin B23. 1 in HEK-293T cells]. Wei Sheng Wu Xue Bao. 2013;53:730-6 pubmed
    ..1 was demonstrated by Co-IP assays. These results suggested that NDV M protein interacted with avian nucleophosmin B23. 1 and the nucleolar localization of M might be regulated via interaction with B23. 1. ..
  5. Duan Z, Li J, Zhu J, Chen J, Xu H, Wang Y, et al. A single amino acid mutation, R42A, in the Newcastle disease virus matrix protein abrogates its nuclear localization and attenuates viral replication and pathogenicity. J Gen Virol. 2014;95:1067-73 pubmed publisher
    ..This is the first report to show that a basic residue mutation in the NDV M protein abrogates its nuclear localization and attenuates viral replication and pathogenicity. ..
  6. Duan Z, Chen J, Xu H, Zhu J, Li Q, He L, et al. The nucleolar phosphoprotein B23 targets Newcastle disease virus matrix protein to the nucleoli and facilitates viral replication. Virology. 2014;452-453:212-22 pubmed publisher
    ..Collectively, we show that B23 facilitates NDV replication by targeting M to the nucleolus, demonstrating for the first time a direct role for nucleolar protein B23 in a paramyxovirus replication process. ..
  7. Wang Y, Ge J, Ding Y, Xie X, Bu Z. [Evaluation of Newcastle disease virus with derivated hemagglutinin-neuraminidase gene of mesogenic strain]. Wei Sheng Wu Xue Bao. 2008;48:638-43 pubmed
    ..The HN gene derivated from mesogenic strain dose not alter the lentogenic property of NDV LaSota strain. NDV can be manipulated by gene replacement in the future for use as a vaccine candidate. ..
  8. Qiu X, Zhan Y, Meng C, Wang J, Dong L, Sun Y, et al. Identification and functional analysis of phosphorylation in Newcastle disease virus phosphoprotein. Arch Virol. 2016;161:2103-16 pubmed publisher
    ..This study sheds light on the mechanism by which P protein phosphorylation affects NDV replication and transcription. ..
  9. Zhao W, Zhang Z, Zsak L, Yu Q. Effects of the HN gene C-terminal extensions on the Newcastle disease virus virulence. Virus Genes. 2013;47:498-504 pubmed publisher
    ..These results suggest that the HN protein C-terminal extension may contribute to the reduced virulence in some low virulence NDV strains. ..
  10. Gu M, Liu W, Xu L, Cao Y, Yao C, Hu S, et al. Positive selection in the hemagglutinin-neuraminidase gene of Newcastle disease virus and its effect on vaccine efficacy. Virol J. 2011;8:150 pubmed publisher
  11. Chu F, Wen H, Zhang W, Lin B, Zhang Y, Sun C, et al. 'a'-Position-mutated and G4-mutated hemagglutinin-neuraminidase proteins of Newcastle disease virus impair fusion and hemagglutinin-neuraminidase-fusion interaction by different mechanisms. Intervirology. 2013;56:27-36 pubmed publisher
  12. Sun C, Wen H, Chen Y, Chu F, Lin B, Ren G, et al. Roles of the highly conserved amino acids in the globular head and stalk region of the Newcastle disease virus HN protein in the membrane fusion process. Biosci Trends. 2015;9:56-64 pubmed publisher
    ..It was also proven that the headless HN of NDV could promote the fusion event mediated by F. Thus, it revealed a novel mechanism in F activation of NDV. ..
  13. Rajmani R, Gupta S, Singh P, Gandham R, Sahoo A, Chaturvedi U, et al. HN protein of Newcastle disease virus sensitizes HeLa cells to TNF-?-induced apoptosis by downregulating NF-?B expression. Arch Virol. 2016;161:2395-405 pubmed publisher
    ..The results of the study provide a mechanistic insight into the apoptotic action of HN protein along with TNF-?, which could be valuable in treating tumor types that are naturally resistant to TNF-?. ..
  14. Adu Gyamfi E, Kim L, Jardetzky T, Lamb R. Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion. J Virol. 2016;90:9172-81 pubmed publisher
    ..Specifically, our data strongly support the notion that the short linker between the head and stalk plays a role in "conformational switching" of the head group to facilitate F-HN interaction and triggering. ..
  15. Tan Y, Ling T, Tan W, Yusoff K, Tey B. Purification of recombinant nucleocapsid protein of Newcastle disease virus from unclarified feedstock using expanded bed adsorption chromatography. Protein Expr Purif. 2006;46:114-21 pubmed
    ..The results of the present study show that the IMA-EBAC developed could be used to combine the clarification, concentration and initial purification steps into a single-step operation. ..
  16. Kim S, Xiao S, Paldurai A, Collins P, Samal S. Role of C596 in the C-terminal extension of the haemagglutinin-neuraminidase protein in replication and pathogenicity of a highly virulent Indonesian strain of Newcastle disease virus. J Gen Virol. 2014;95:331-6 pubmed publisher
    ..These results indicate that this attenuating mechanism in avirulent strains such as Ulster can be applied directly to a highly virulent strain recently in circulation. ..
  17. Kusumaningtyas E, Tan W, Zamrod Z, Eshaghi M, Yusoff K. Existence of two forms of L protein of Newcastle disease virus isolates due to a compensatory mutation in Domain V. Arch Virol. 2004;149:1859-65 pubmed
    ..This compensatory mutation does not correlate with the pathogenicity of the viral strains but it may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses. ..
  18. Sun Y, Jin N, Mi Z, Li X, Lian H, Li P. [Induction of apoptosis in human hepatoma cell line SMMC7721 by Newcastle disease virus HN gene]. Zhonghua Zhong Liu Za Zhi. 2005;27:279-82 pubmed
    ..Significant apoptosis in SMMC7721 cells can be induced by NDV HN gene. Apoptosis may be resulted from the decrease of mitochondrial trans-membrane potential and activation of Caspase-3...
  19. Kim S, Wanasen N, Paldurai A, Xiao S, Collins P, Samal S. Newcastle disease virus fusion protein is the major contributor to protective immunity of genotype-matched vaccine. PLoS ONE. 2013;8:e74022 pubmed publisher
    ..Our findings showed that genotype-matched vaccines can provide protection to chickens by efficiently preventing spread of virus, primarily due to the F protein...
  20. Battisti A, Meng G, Winkler D, McGinnes L, Plevka P, Steven A, et al. Structure and assembly of a paramyxovirus matrix protein. Proc Natl Acad Sci U S A. 2012;109:13996-4000 pubmed publisher
    ..Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly...
  21. McGinnes L, Morrison T. Inhibition of receptor binding stabilizes Newcastle disease virus HN and F protein-containing complexes. J Virol. 2006;80:2894-903 pubmed publisher
    ..Furthermore, the results show that not only receptor binding but also F protein cleavage are necessary for disassociation of the HN and F protein-containing complexes...
  22. Porotto M, Salah Z, Devito I, Talekar A, Palmer S, Xu R, et al. The second receptor binding site of the globular head of the Newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion. J Virol. 2012;86:5730-41 pubmed publisher
    ..We suggest a general model for paramyxovirus fusion activation in which receptor engagement at site II plays an active role in F activation...
  23. Mahon P, Mirza A, Iorio R. Role of the two sialic acid binding sites on the newcastle disease virus HN protein in triggering the interaction with the F protein required for the promotion of fusion. J Virol. 2011;85:12079-82 pubmed publisher
  24. Gravel K, McGinnes L, Reitter J, Morrison T. The transmembrane domain sequence affects the structure and function of the Newcastle disease virus fusion protein. J Virol. 2011;85:3486-97 pubmed publisher
    ..These results show that the specific sequence of the TM domain of the NDV F protein is important for the conformation of the preactivation form of the ectodomain, the interactions of the protein with HN protein, and fusion activity...
  25. Jain S, McGinnes L, Morrison T. Thiol/disulfide exchange is required for membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2007;81:2328-39 pubmed publisher
    ..In the presence of HN protein, only the reduced form may proceed to refold into additional intermediates, leading to the fusion of membranes...
  26. Swanson K, Wen X, Leser G, Paterson R, Lamb R, Jardetzky T. Structure of the Newcastle disease virus F protein in the post-fusion conformation. Virology. 2010;402:372-9 pubmed publisher
    ..Electrostatic and temperature factor analysis of the F structures points to regions of these proteins that may be functionally important in their membrane fusion activity...
  27. Sui H, Bai Y, Wang K, Li X, Song C, Fu F, et al. The anti-tumor effect of Newcastle disease virus HN protein is influenced by differential subcellular targeting. Cancer Immunol Immunother. 2010;59:989-99 pubmed publisher
    ..The membrane-anchored form of the HN protein appears to be an ideal candidate to develop as an immunotherapeutic agent for NSCLC...
  28. Laliberte J, McGinnes L, Morrison T. Incorporation of functional HN-F glycoprotein-containing complexes into newcastle disease virus is dependent on cholesterol and membrane lipid raft integrity. J Virol. 2007;81:10636-48 pubmed publisher
  29. Ravindra P, Tiwari A, Sharma B, Rajawat Y, Ratta B, Palia S, et al. HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells. Arch Virol. 2008;153:749-54 pubmed publisher
    ..Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells...
  30. Qin Z, Xu H, Ouyang W, Wang Y, Wang L, Yuan X, et al. [Correlation of the neutralization index in chicken embryo with the homologies of F and HN gene of different Newcastle-disease isolates]. Wei Sheng Wu Xue Bao. 2008;48:226-33 pubmed
    ..05, r = 0.20 or 0.19) with the F gene, and non-correlated with 374 nt segment. This implied that the genetic mutations of HN resulted in antigenic variations of these viruses and the search for new vaccines would be necessary...
  31. Jarahian M, Watzl C, Fournier P, Arnold A, Djandji D, Zahedi S, et al. Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase. J Virol. 2009;83:8108-21 pubmed publisher
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  32. Jain S, McGinnes L, Morrison T. Overexpression of thiol/disulfide isomerases enhances membrane fusion directed by the Newcastle disease virus fusion protein. J Virol. 2008;82:12039-48 pubmed publisher
    ..These results suggest that isomerases belonging to the PDI family catalyze the production of free thiols in F protein, and free thiols in F protein facilitate membrane fusion mediated by F protein...
  33. Ayll n J, Villar E, Mu oz Barroso I. Mutations in the ectodomain of newcastle disease virus fusion protein confer a hemagglutinin-neuraminidase-independent phenotype. J Virol. 2010;84:1066-75 pubmed publisher
    ..The data are discussed in terms of alterations of the refolding pathway and/or the stability of the prefusion and fusion conformations...
  34. Alamares J, Elankumaran S, Samal S, Iorio R. The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties. Virus Res. 2010;147:153-7 pubmed publisher
    ..Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN-antagonistic activity between the two V proteins...
  35. Bose S, Song A, Jardetzky T, Lamb R. Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells. J Virol. 2014;88:3925-41 pubmed publisher
  36. Mirza A, Iorio R. A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation. J Virol. 2013;87:8813-5 pubmed publisher
    ..Here, we demonstrate that a nearby L97A substitution, though previously shown to block fusion, allows efficient HN-F complex formation and likely acts by preventing changes in the HN stalk required for triggering of the bound F protein...
  37. Sasaki M, Setiyono A, Handharyani E, Rahmadani I, Taha S, Adiani S, et al. Molecular detection of a novel paramyxovirus in fruit bats from Indonesia. Virol J. 2012;9:240 pubmed publisher
    ..Phylogenetic analysis showed that these virus sequences were related to henipavirus or rubulavirus. This study indicates the presence of novel paramyxoviruses among fruit bat populations in Indonesia...
  38. Talekar A, Moscona A, Porotto M. Measles virus fusion machinery activated by sialic acid binding globular domain. J Virol. 2013;87:13619-27 pubmed publisher
  39. Pegg C, Hoogland C, Gorman J. Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase. Glycoconj J. 2017;34:181-197 pubmed publisher
  40. Sun J, Han Z, Qi T, Zhao R, Liu S. Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein. J Biol Chem. 2017;292:20141-20161 pubmed publisher
    ..Collectively, our results indicate that CG-1B has anti-NDV activity by binding to N-glycans on HN glycoprotein. ..