Human herpesvirus 6B


Alias: Human herpesvirus 6 type B

Top Publications

  1. Nagamata S, Aoshi T, Kawabata A, Yamagishi Y, Nishimura M, Kuwabara S, et al. Identification of CD4 and H-2Kd-restricted cytotoxic T lymphocyte epitopes on the human herpesvirus 6B glycoprotein Q1 protein. Sci Rep. 2019;9:3911 pubmed publisher
    The identification of Human herpesvirus 6B (HHV-6B) epitopes that are recognized by T-cells could contribute to the development of potential vaccines and immunotherapies...
  2. Wang B, Nishimura M, Maekawa Y, Kotari T, Okuno T, Mori Y. Humanization of the murine neutralizing antibodies against human herpesvirus 6B. J Virol. 2019;: pubmed publisher
    Exanthem subitum is a common childhood illness caused by Human herpesvirus 6B (HHV-6B) primary infection. It is occasionally complicated by febrile seizure and even encephalitis...
  3. Vu D, Cordey S, Simonetta F, Brito F, Docquier M, Turin L, et al. Human pegivirus persistence in human blood virome after allogeneic haematopoietic stem-cell transplantation. Clin Microbiol Infect. 2019;25:225-232 pubmed publisher
    ..identified, including ten cytomegalovirus; three Epstein-Barr virus; two herpes simplex virus type 1; one human herpesvirus 6b and one human herpesvirus 7; 18 Merkel cell-PyV; two BK-PyV; three PyV-6; and one JC-PyV...
  4. Lednicky J, Waltzek T, McGeehan E, Loeb J, Hamilton S, Luetke M. Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells. Virol J. 2013;10:213 pubmed publisher
    ..Cytomegalovirus (CMV) was detected in some RPTEC by cytology, an immunofluorescence assay, and PCR. Human Herpesvirus 6B was detected by PCR of DNA extracted from the RPTEC, but was not isolated...
  5. Hill J, Ikoma M, Zerr D, Basom R, Peddu V, Huang M, et al. RNA Sequencing of the In Vivo Human Herpesvirus 6B Transcriptome To Identify Targets for Clinical Assays Distinguishing between Latent and Active Infections. J Virol. 2019;93: pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) DNA is frequently detected in human samples. Diagnostic assays distinguishing HHV-6B reactivation from latency are limited. This has impaired strategies to diagnose and treat HHV-6B-associated diseases...
  6. Keith K, Hartline C, Bowlin T, Prichard M. A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses. Antiviral Res. 2018;159:122-129 pubmed publisher
    ..activity of a set of nucleoside analogs against BK polyomavirus, JC polyomavirus, Epstein-Barr virus, human herpesvirus 6B, and human herpesvirus 8 in an automated 384-well format and utilize qPCR assays to measure the ..
  7. Engdahl E, Niehusmann P, Fogdell Hahn A. The effect of human herpesvirus 6B infection on the MAPK pathway. Virus Res. 2018;256:134-141 pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) is a neurotropic virus that has been repeatedly associated with mesial temporal lobe epilepsy (MTLE). However, the mechanism behind this suggested association is not known...
  8. Yoshikawa T. Betaherpesvirus Complications and Management During Hematopoietic Stem Cell Transplantation. Adv Exp Med Biol. 2018;1045:251-270 pubmed publisher
    Two of the four betaherpesviruses, Cytomegalovirus (CMV) and human herpesvirus 6B (HHV-6B), play an important role in opportunistic infections in hematopoietic stem cell transplant (HSCT) recipients...
  9. Nishimura M, Mori Y. Structural Aspects of Betaherpesvirus-Encoded Proteins. Adv Exp Med Biol. 2018;1045:227-249 pubmed publisher
    ..of teguments is limited, but a recent crystallographic analysis of an essential tegument protein of human herpesvirus 6B is introduced...

More Information


  1. Phan T, Pritchett J, Leifer C, Zerr D, Koelle D, Di Luca D, et al. HHV-6B infection, T-cell reconstitution, and graft-vs-host disease after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2018;53:1508-1517 pubmed publisher
    ..b>Human herpesvirus 6B (HHV-6B) efficiently infects CD4+ T cells and utilizes as a receptor CD134 (OX40), a member of ..
  2. Phan T, Carlin K, Ljungman P, Politikos I, Boussiotis V, Boeckh M, et al. Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. Biol Blood Marrow Transplant. 2018;24:2324-2336 pubmed publisher
    ..Further research is needed to investigate whether antiviral prophylaxis reduces incidence or severity of aGVHD. ..
  3. Mine S, Suzuki K, Sato Y, Fukumoto H, Kataoka M, Inoue N, et al. Evidence for human herpesvirus-6B infection of regulatory T-cells in acute systemic lymphadenitis in an immunocompetent adult with the drug reaction with eosinophilia and systemic symptoms syndrome: a case report. J Clin Virol. 2014;61:448-52 pubmed publisher
  4. Hiramatsu H, Suzuki R, Yamada S, Ihira M, Isegawa Y, Kawamura Y, et al. Analysis of ganciclovir-resistant human herpesvirus 6B clinical isolates using quenching probe PCR methodology. Antimicrob Agents Chemother. 2015;59:2618-24 pubmed publisher
    ..analysis was used to determine the frequency of ganciclovir (GCV) resistance among clinical isolates of human herpesvirus 6B (HHV-6B) obtained from patients with primary viral infection and viral reactivation...
  5. Sedlak R, Hill J, Nguyen T, Cho M, Levin G, Cook L, et al. Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR. J Clin Microbiol. 2016;54:1223-7 pubmed publisher
  6. Halawi M, Khan N, Blake N. Identification of novel CD8+ T cell epitopes in human herpesvirus 6B U11 and U90. Immun Inflamm Dis. 2015;3:118-31 pubmed publisher
    b>Human herpesvirus 6B (HHV6B) infects over 90% of the population, and normally establishes a latent infection, where episodes of reactivation are asymptomatic...
  7. Tang H, Mori Y. Determinants of Human CD134 Essential for Entry of Human Herpesvirus 6B. J Virol. 2015;89:10125-9 pubmed publisher
    ..two key amino acid residues within human CD134 (hCD134) that are required for its interaction with human herpesvirus 6B (HHV-6B) and for HHV-6B entry into cells...
  8. Nagamata S, Nagasaka M, Kawabata A, Kishimoto K, Hasegawa D, Kosaka Y, et al. Human CD134 (OX40) expressed on T cells plays a key role for human herpesvirus 6B replication after allogeneic hematopoietic stem cell transplantation. J Clin Virol. 2018;102:50-55 pubmed publisher
    ..The results possibly indicate that CD134 on T cells plays a key role for HHV-6B replication after allo-HSCT. ..
  9. Engdahl E, Dunn N, Fogdell Hahn A. Investigation of reference gene expression during human herpesvirus 6B infection indicates peptidylprolyl isomerase A as a stable reference gene and TATA box binding protein as a gene up-regulated by this virus. J Virol Methods. 2016;227:47-9 pubmed publisher
    ..We aimed at investigating the expressional stability of commonly used reference genes during Human herpesvirus 6B (HHV-6B) infection...
  10. Forghieri F, Luppi M, Barozzi P, Riva G, Morselli M, Bigliardi S, et al. Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus-6B reactivation. Br J Haematol. 2016;172:561-72 pubmed publisher
    ..Future studies are warranted to investigate a potential association between HHV-6B reactivation and chronic/recurrent benign lymphadenopathy. ..
  11. Engdahl E, Dunn N, Niehusmann P, Wideman S, Wipfler P, Becker A, et al. Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration. J Virol. 2017;91: pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) is a neurotropic betaherpesvirus that achieves latency by integrating its genome into host cell chromosomes...
  12. Hill J, Mayer B, Xie H, Leisenring W, Huang M, Stevens Ayers T, et al. The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality. Blood. 2017;129:2316-2325 pubmed publisher
    ..We used quantitative PCR to test for cytomegalovirus, BK polyomavirus, human herpesvirus 6B, HHV-6A, adenovirus, and Epstein-Barr virus between days 0 and 100 post-HCT...
  13. Schmiedel D, Tai J, Levi Schaffer F, Dovrat S, Mandelboim O. Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells. J Virol. 2016;90:9608-9617 pubmed publisher
    ..This study advances the understanding of HHV-6 biology and the measures it uses to successfully escape immune elimination. ..
  14. Pantry S, Medveczky P. Latency, Integration, and Reactivation of Human Herpesvirus-6. Viruses. 2017;9: pubmed publisher
    ..Paradoxically, the integrated viral genome is often defective especially as seen in iciHHV-6 harboring individuals. Finally, gaps in the field of HHV-6 research are presented and future studies are proposed. ..
  15. Tamai M, Kobayashi N, Shimada K, Oka N, Takahashi M, Tanuma A, et al. Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis. Biochem Biophys Res Commun. 2017;486:706-711 pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis...
  16. Tomoiu A, Gravel A, Tanguay R, Flamand L. Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation. J Virol. 2006;80:10218-28 pubmed publisher
    ..Overall, our results indicate that Ubc9 influences IE2's function and provide new information on the complex interactions that occur between herpesviruses and the sumoylation pathway...
  17. Iampietro M, Morissette G, Gravel A, Dubuc I, Rousseau M, Hasan A, et al. Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes. Eur J Immunol. 2014;44:3573-84 pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients...
  18. Gravel A, Gosselin J, Flamand L. Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies. J Biol Chem. 2002;277:19679-87 pubmed
    ..Overall, the characterization of the HHV-6 IE1B protein presented highlights the similarity and divergence between IE1 from both variants and provides useful information pertaining to the early phase of infection. ..
  19. Lindquester G, Greenamoyer C, Anton E, O Brian J, Pellett P, Dambaugh T. Comparison of a 20 kb region of human herpesvirus 6B with other human beta herpesviruses reveals conserved replication genes and adjacent divergent open reading frames. Arch Virol. 1997;142:193-204 pubmed
    ..The evolution of this region and its potential use in the development of a viral vector system are discussed...
  20. Lindquester G, O Brian J, Anton E, Greenamoyer C, Pellett P, Dambaugh T. Genetic content of a 20.9 kb segment of human herpesvirus 6B strain Z29 spanning the homologs of human herpesvirus 6A genes U40-57 and containing the origin of DNA replication. Arch Virol. 1997;142:103-23 pubmed
    ..Substitutions in the latter region lead to predicted differences in reading frames and protein lengths among HHV-6 isolates. ..
  21. Pellett P, Sánchez Martínez D, Dominguez G, Black J, Anton E, Greenamoyer C, et al. A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope. Virology. 1993;195:521-31 pubmed
    ..These results suggest a complex regulatory mechanism for this gene. ..
  22. Trempe F, Gravel A, Dubuc I, Wallaschek N, Collin V, Gilbert Girard S, et al. Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins. Nucleic Acids Res. 2015;43:6084-98 pubmed publisher
    ..The preferential DNA binding of MBP-U94 to telomeric sequences, its ability to hydrolyze ATP and its exonuclease/helicase activities suggest that U94 possesses all functions required for HHV-6A/B chromosomal integration. ..
  23. Kofod Olsen E, Pettersson S, Wallace M, Abduljabar A, Oster B, Hupp T, et al. Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization. Virology. 2014;448:33-42 pubmed publisher
    ..Our study provides further insight into p53-modulating strategies used by herpesviruses and elucidates a mechanism used by HHV-6B to circumvent the antiviral response. ..
  24. Iampietro M, Gravel A, Flamand L. Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein. J Virol. 2014;88:12910-4 pubmed publisher
    ..In this study, we report a role for the human herpesvirus 6B (HHV-6B) U54 tegument protein in inhibiting MCF-7 breast cancer cell proliferation by inhibiting NFAT ..
  25. Mori J, Kawabata A, Tang H, Tadagaki K, Mizuguchi H, Kuroda K, et al. Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD. PLoS ONE. 2015;10:e0137420 pubmed publisher
    ..These results indicate that U14 is a G2/M checkpoint regulator encoded by HHV-6. ..
  26. Iampietro M, Morissette G, Gravel A, Flamand L. Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein. J Virol. 2014;88:12452-63 pubmed publisher
    b>Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen causing lifelong infections in approximately 95% of humans worldwide...
  27. Yeo W, Isegawa Y, Chow V. The U95 protein of human herpesvirus 6B interacts with human GRIM-19: silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential. J Virol. 2008;82:1011-20 pubmed publisher
    ..The interaction between U95 and GRIM-19 is thus functionally and metabolically significant in HHV-6B-infected cells and may be a means through which HHV-6B modulates cell death signals by interferon and retinoic acid...
  28. L ttichau H, Clark Lewis I, Jensen P, Moser C, Gerstoft J, Schwartz T. A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. J Biol Chem. 2003;278:10928-33 pubmed publisher
    ..It is suggested that vCCL4 during reactivation of the virus in for example monocyte-derived microglia could perhaps be involved in the pathogenesis of the CCR2-dependent disease, multiple sclerosis...
  29. Lindquester G, Inoue N, Allen R, Castelli J, Stamey F, Dambaugh T, et al. Restriction endonuclease mapping and molecular cloning of the human herpesvirus 6 variant B strain Z29 genome. Arch Virol. 1996;141:367-79 pubmed
    ..Hybridization experiments and orientation of several blocks of nucleotide sequence information onto the genomic map indicate that HHV-6A and HHV-6B genomes are colinear. ..
  30. Stamey F, Dominguez G, Black J, Dambaugh T, Pellett P. Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests acquisition of oriLyt by transposition. J Virol. 1995;69:589-96 pubmed
    ..The structures of the amplified segment and its adjacent sequences together suggest that HHV-6B or a progenitor virus acquired oriLyt by transposition from an unknown source...