Human herpesvirus 5

Summary

Alias: Human cytomegalovirus, human herpesvirus type 5, HHV-5, Human cytomegalovirus HCMV, human cytomegalovirus CMV

Top Publications

  1. Fielding C, Aicheler R, Stanton R, Wang E, Han S, Seirafian S, et al. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathog. 2014;10:e1004058 pubmed publisher
    ..Studies into human cytomegalovirus (HCMV) have aided both the identification and characterization of NKG2D ligands (NKG2DLs)...
  2. Engel P, Pérez Carmona N, Albà M, Robertson K, Ghazal P, Angulo A. Human cytomegalovirus UL7, a homologue of the SLAM-family receptor CD229, impairs cytokine production. Immunol Cell Biol. 2011;89:753-66 pubmed publisher
    b>Human cytomegalovirus (HCMV), the ?-herpesvirus prototype, has evolved a wide spectrum of mechanisms to counteract host immunity...
  3. Weekes M, Tan S, Poole E, Talbot S, Antrobus R, Smith D, et al. Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection. Science. 2013;340:199-202 pubmed publisher
    The reactivation of latent human cytomegalovirus (HCMV) infection after transplantation is associated with high morbidity and mortality...
  4. Prod homme V, Tomasec P, Cunningham C, Lemberg M, Stanton R, McSharry B, et al. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. J Immunol. 2012;188:2794-804 pubmed publisher
  5. Ryckman B, Chase M, Johnson D. Human cytomegalovirus TR strain glycoprotein O acts as a chaperone promoting gH/gL incorporation into virions but is not present in virions. J Virol. 2010;84:2597-609 pubmed publisher
    b>Human cytomegalovirus (HCMV) produces the following two gH/gL complexes: gH/gL/gO and gH/gL/UL128-131...
  6. Mücke K, Paulus C, Bernhardt K, Gerrer K, Schön K, Fink A, et al. Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface. J Virol. 2014;88:1228-48 pubmed publisher
    The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cellular transcription...
  7. Prod homme V, Sugrue D, Stanton R, Nomoto A, Davies J, Rickards C, et al. Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. J Gen Virol. 2010;91:2034-9 pubmed publisher
    b>Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor ..
  8. Vanarsdall A, Ryckman B, Chase M, Johnson D. Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans. J Virol. 2008;82:11837-50 pubmed publisher
    ..b>Human cytomegalovirus (HCMV) has the ability to infect a wide variety of human cell types in vivo...
  9. Arnolds K, Lares A, Spencer J. The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4. Virology. 2013;439:122-31 pubmed publisher
    b>Human cytomegalovirus (HCMV) is a member of the Herpesviridae family that manipulates host immune responses and establishes life-long latent infection, in part through mimicry of cytokines, chemokines, and chemokine receptors...

More Information

Publications80

  1. Graf L, Webel R, Wagner S, Hamilton S, Rawlinson W, Sticht H, et al. The cyclin-dependent kinase ortholog pUL97 of human cytomegalovirus interacts with cyclins. Viruses. 2013;5:3213-30 pubmed publisher
    The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics...
  2. Tadagaki K, Tudor D, Gbahou F, Tschische P, Waldhoer M, Bomsel M, et al. Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity. Blood. 2012;119:4908-18 pubmed publisher
    b>Human cytomegalovirus (HCMV) encodes four 7-transmembrane-spanning (7TM) proteins, US28, US27, UL33, and UL78, which present important sequence homology with human chemokine receptors...
  3. Perng Y, Qian Z, Fehr A, Xuan B, Yu D. The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. J Virol. 2011;85:4841-52 pubmed publisher
    In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection...
  4. Montag C, Wagner J, Gruska I, Vetter B, Wiebusch L, Hagemeier C. The latency-associated UL138 gene product of human cytomegalovirus sensitizes cells to tumor necrosis factor alpha (TNF-alpha) signaling by upregulating TNF-alpha receptor 1 cell surface expression. J Virol. 2011;85:11409-21 pubmed publisher
    ..Such a mechanism is also employed by human cytomegalovirus (HCMV), as recently reported by others and us...
  5. Liu Z, Biegalke B. Human cytomegalovirus UL34 binds to multiple sites within the viral genome. J Virol. 2013;87:3587-91 pubmed publisher
    The human cytomegalovirus UL34 gene encodes a sequence-specific DNA binding protein that downregulates expression of the viral immune evasion gene US3. Analysis of the viral genome identified 14 potential UL34 binding sites...
  6. Strang B, Sinigalia E, Silva L, Coen D, Loregian A. Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. J Virol. 2009;83:7581-9 pubmed publisher
    The central enzyme responsible for human cytomegalovirus (HCMV) DNA synthesis is a virally encoded DNA polymerase that includes a catalytic subunit, UL54, and a homodimeric accessory subunit, UL44, the presumptive HCMV DNA polymerase ..
  7. Park B, Spooner E, Houser B, Strominger J, Ploegh H. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. J Exp Med. 2010;207:2033-41 pubmed publisher
    b>Human cytomegalovirus (HCMV) encodes an endoplasmic reticulum (ER)-resident transmembrane glycoprotein, US10, expressed early in the replicative cycle of HCMV as part of the same cluster that encodes the known immunoevasins US2, US3, US6,..
  8. Silva L, Strang B, Lin E, Kamil J, Coen D. Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Virology. 2011;417:268-80 pubmed publisher
    The human cytomegalovirus DNA polymerase subunit UL44 is a phosphoprotein, but its sites and roles of phosphorylation have not been investigated...
  9. Berndt A, Hofmann Winkler H, Tavalai N, Hahn G, Stamminger T. Importance of covalent and noncovalent SUMO interactions with the major human cytomegalovirus transactivator IE2p86 for viral infection. J Virol. 2009;83:12881-94 pubmed publisher
    The major transactivator protein IE2p86 of human cytomegalovirus (HCMV) has previously been shown to undergo posttranslational modification by the covalent attachment of SUMO proteins, termed SUMOylation, which occurs at two lysine ..
  10. O Connor C, Shenk T. Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread. J Virol. 2011;85:3700-7 pubmed publisher
    b>Human cytomegalovirus (HCMV) encodes multiple G protein-coupled receptor (GPCR) homologues, including pUS27, pUS28, pUL33, and pUL78...
  11. Fehr A, Gualberto N, Savaryn J, Terhune S, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog. 2012;8:e1002789 pubmed publisher
    ..During infection, human cytomegalovirus (HCMV), a widespread pathogen, not only phosphorylates the APC coactivator Cdh1 via the multifunctional ..
  12. Fouts A, Comps Agrar L, Stengel K, Ellerman D, Schoeffler A, Warming S, et al. Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proc Natl Acad Sci U S A. 2014;111:8209-14 pubmed publisher
    ..This study provides evidence for a novel mechanism of action for MSL-109 and reveals a previously undescribed aspect of viral entry that may be susceptible to therapeutic intervention. ..
  13. Ashiru O, Bennett N, Boyle L, Thomas M, Trowsdale J, Wills M. NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142. J Virol. 2009;83:12345-54 pubmed publisher
    b>Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells...
  14. Prichard M, Lawlor H, Duke G, Mo C, Wang Z, Dixon M, et al. Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA. Virol J. 2005;2:55 pubmed
    b>Human cytomegalovirus UL114 encodes a uracil-DNA glycosylase homolog that is highly conserved in all characterized herpesviruses that infect mammals...
  15. Poole E, Walther A, Raven K, BENEDICT C, Mason G, Sinclair J. The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner. J Virol. 2013;87:4261-71 pubmed publisher
    It is generally accepted that, following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency in CD34(+) progenitor cells and other derivative cells of the myeloid lineage...
  16. Mason G, Jackson S, Okecha G, Poole E, Sissons J, Sinclair J, et al. Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4? T cells. PLoS Pathog. 2013;9:e1003635 pubmed publisher
    b>Human cytomegalovirus (HCMV) is a widely prevalent human herpesvirus, which, after primary infection, persists in the host for life. In healthy individuals, the virus is well controlled by the HCMV-specific T cell response...
  17. Wille P, Knoche A, Nelson J, Jarvis M, Johnson D. A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells. J Virol. 2010;84:2585-96 pubmed publisher
    b>Human cytomegalovirus (HCMV) depends upon a five-protein complex, gH/gL/UL128-131, to enter epithelial and endothelial cells. A separate HCMV gH/gL-containing complex, gH/gL/gO, has been described...
  18. Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, et al. NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86. J Virol. 2008;82:4250-6 pubmed publisher
    The product of the human cytomegalovirus (HCMV) gene UL144, expressed at early times postinfection, is located in the UL/b' region of the viral genome and is related to members of the tumor necrosis factor receptor superfamily, but it ..
  19. Adler B, Scrivano L, Ruzcics Z, Rupp B, Sinzger C, Koszinowski U. Role of human cytomegalovirus UL131A in cell type-specific virus entry and release. J Gen Virol. 2006;87:2451-60 pubmed
    The human cytomegalovirus (HCMV) genes UL128, UL130 and UL131A are essential for endothelial cell infection...
  20. Lukashchuk V, McFarlane S, Everett R, Preston C. Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection. J Virol. 2008;82:12543-54 pubmed publisher
    The human cytomegalovirus (HCMV) tegument protein pp71, encoded by gene UL82, stimulates viral immediate-early (IE) transcription...
  21. Webel R, Milbradt J, Auerochs S, Schregel V, Held C, Nöbauer K, et al. Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation. J Gen Virol. 2011;92:638-49 pubmed publisher
    The pUL97 protein kinase encoded by human cytomegalovirus is a multifunctional determinant of the efficiency of viral replication and phosphorylates viral as well as cellular substrate proteins...
  22. Ahn J, Brignole E, Hayward G. Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML. Mol Cell Biol. 1998;18:4899-913 pubmed
    Both of the major immediate-early (IE) proteins IE1 and IE2 of human cytomegalovirus (HCMV) as well as input viral DNA and sites of viral IE transcription colocalize with or adjacent to punctate PML domains (PML oncogenic domains [PODs] ..
  23. Isomura H, Stinski M, Murata T, Nakayama S, Chiba S, Akatsuka Y, et al. The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. PLoS ONE. 2010;5:e11901 pubmed publisher
    b>Human cytomegalovirus (HCMV) can be reactivated under immunosuppressive conditions causing several fatal pneumonitis, hepatitis, retinitis, and gastrointestinal diseases...
  24. Omoto S, Mocarski E. Cytomegalovirus UL91 is essential for transcription of viral true late (?2) genes. J Virol. 2013;87:8651-64 pubmed publisher
    b>Human cytomegalovirus-encoded UL91 is a betagamma gene that is essential for viral replication. Here we show that the 111-amino-acid (aa) UL91 protein controls accumulation of true-late (?2) viral transcripts...
  25. Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton R, Schwinzer R, et al. The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells. PLoS Pathog. 2011;7:e1002432 pubmed publisher
    b>Human cytomegalovirus (CMV) exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes...
  26. Feichtinger S, Stamminger T, Müller R, Graf L, Klebl B, Eickhoff J, et al. Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1. J Gen Virol. 2011;92:1519-31 pubmed publisher
    ..are important regulators of cellular processes and are functionally integrated into the replication of human cytomegalovirus (HCMV). Recently, a regulatory impact of CDK activity on the viral mRNA export factor pUL69 was shown...
  27. Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemčovičová I, Wang E, et al. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host Microbe. 2013;13:324-35 pubmed publisher
    ..Here we identify the human cytomegalovirus (HCMV) UL141 glycoprotein as necessary and sufficient to restrict TRAIL DR function...
  28. Fehr A, Yu D. Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts. J Virol. 2011;85:663-74 pubmed publisher
    We have previously reported that a newly annotated gene of human cytomegalovirus (HCMV), UL21a, encodes an early viral protein termed pUL21a...
  29. Yang Z, Bjorkman P. Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor. Proc Natl Acad Sci U S A. 2008;105:10095-100 pubmed publisher
    UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2...
  30. Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, et al. Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. Proc Natl Acad Sci U S A. 2013;110:17510-5 pubmed publisher
    ..cell interaction that is essential for the cell cycle and differentiation state-dependent onset of human cytomegalovirus (HCMV) lytic gene expression...
  31. Oduro J, Uecker R, Hagemeier C, Wiebusch L. Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity. J Virol. 2012;86:9369-83 pubmed publisher
    b>Human cytomegalovirus (HCMV) starts its lytic replication cycle only in the G(0)/G(1) phase of the cell division cycle. S/G(2) cells can be infected but block the onset of immediate-early (IE) gene expression...
  32. Bigley T, Reitsma J, Mirza S, Terhune S. Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. J Virol. 2013;87:7393-408 pubmed publisher
    b>Human cytomegalovirus (HCMV) is a common agent of congenital infection and causes severe disease in immunocompromised patients. Current approved therapies focus on inhibiting viral DNA replication...
  33. Zhou M, Yu Q, Wechsler A, Ryckman B. Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope. J Virol. 2013;87:9680-90 pubmed publisher
    ..b>Human cytomegalovirus (HCMV) gH/gL can be bound by the UL128-131 proteins or gO...
  34. Marshall E, Bierle C, Brune W, Geballe A. Essential role for either TRS1 or IRS1 in human cytomegalovirus replication. J Virol. 2009;83:4112-20 pubmed publisher
    ..b>Human cytomegalovirus (HCMV) encodes two related proteins, pTRS1 and pIRS1, which bind dsRNA and can prevent activation of the ..
  35. Sun Z, Ji Y, Ruan Q, He R, Ma Y, Qi Y, et al. Structure characterization of human cytomegalovirus UL131A, UL130 and UL128 genes in clinical strains in China. Genet Mol Res. 2009;8:1191-201 pubmed publisher
    b>Human cytomegalovirus (HCMV) genetic determinants of endothelial cell tropism, leukocytes and dendritic cells have been identified in the genes UL131A, UL130, and UL128. We examined the structure of these three genes in HCMV...
  36. Savaryn J, Reitsma J, Bigley T, Halligan B, Qian Z, Yu D, et al. Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. J Virol. 2013;87:2463-74 pubmed publisher
    During infection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient viral gene expression, is stabilized. However, the expression of numerous p53-responsive cellular genes is not upregulated...
  37. Ranneberg Nilsen T, Dale H, Luna L, Slettebakk R, Sundheim O, Rollag H, et al. Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44). J Mol Biol. 2008;381:276-88 pubmed publisher
    Here, we report the molecular characterization of the human cytomegalovirus uracil DNA glycosylase (UNG) UL114. Purified UL114 was shown to be a DNA glycosylase, which removes uracil from double-stranded and single-stranded DNA...
  38. O Connor C, Shenk T. Human cytomegalovirus pUL78 G protein-coupled receptor homologue is required for timely cell entry in epithelial cells but not fibroblasts. J Virol. 2012;86:11425-33 pubmed publisher
    b>Human cytomegalovirus (HCMV) encodes four putative G protein-coupled receptors, including pUL78, whose rodent orthologues are known to be important for replication and spread in their hosts...
  39. Strang B, Boulant S, Coen D. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol. 2010;84:1771-84 pubmed publisher
    ..As the structure of the presumptive human cytomegalovirus (HCMV) DNA polymerase processivity factor UL44 is highly homologous to that of PCNA, we hypothesized that ..
  40. Wang L, Li M, Cai M, Xing J, Wang S, Zheng C. A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein. Med Microbiol Immunol. 2012;201:381-7 pubmed publisher
    b>Human cytomegalovirus UL79 protein is recently reported to be required for transcription or efficient accumulation of late viral mRNAs during viral infection...
  41. Xiaofei E, Stadler B, Debatis M, Wang S, Lu S, Kowalik T. RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions. J Virol. 2012;86:5660-73 pubmed publisher
    ..population warrant continued research into new avenues for limiting diseases associated with human cytomegalovirus (HCMV)...
  42. Le V, Trilling M, Hengel H. The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-? signaling. J Virol. 2011;85:13260-70 pubmed publisher
    b>Human cytomegalovirus is a ubiquitous herpesvirus that establishes lifelong latent infection...
  43. Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald K, Semler B, et al. Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. J Virol. 2010;84:9472-86 pubmed publisher
    ..a 21-kDa protein encoded by UL138 (pUL138) as a viral factor inherent to low-passage strains of human cytomegalovirus (HCMV) that is required for latent infection in vitro. pUL138 is encoded on 3.6-, 2.7-, and 1...
  44. Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile Ramos A, et al. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal. 2010;3:ra58 pubmed publisher
    ..a viral G protein (heterotrimeric guanosine triphosphate-binding protein)-coupled receptor encoded by the human cytomegalovirus (HCMV)...
  45. Tran K, Kamil J, Coen D, Spector D. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010;84:10832-43 pubmed publisher
    Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle deregulation, resulting in a G(1)/S arrest, which can be partly attributed to the inactivation of the anaphase-promoting complex (APC)...
  46. Isomura H, Stinski M, Murata T, Yamashita Y, Kanda T, Toyokuni S, et al. The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication. J Virol. 2011;85:6629-44 pubmed publisher
    The regulation of human cytomegalovirus (HCMV) late gene expression by viral proteins is poorly understood, and these viral proteins could be targets for novel antivirals...
  47. Qian Z, Leung Pineda V, Xuan B, Piwnica Worms H, Yu D. Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog. 2010;6:e1000814 pubmed publisher
    ..b>Human cytomegalovirus (HCMV), a large DNA virus, blocks host DNA synthesis and deregulates cell cycle progression...
  48. Wagner S, Arnold F, Wu Z, Schubert A, Walliser C, Tadagaki K, et al. The 7-transmembrane protein homologue UL78 of the human cytomegalovirus forms oligomers and traffics between the plasma membrane and different intracellular compartments. Arch Virol. 2012;157:935-49 pubmed publisher
    The human cytomegalovirus (HCMV) UL78 ORF is considered to encode an orphan 7-transmembrane receptor. However, until now, the UL78 protein (pUL78) has not been characterized...
  49. Strang B, Boulant S, Chang L, Knipe D, Kirchhausen T, Coen D. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012;86:2089-95 pubmed publisher
    ..The localization of proteins and viral DNA within human cytomegalovirus replication compartments is not well characterized...
  50. Vanarsdall A, Chase M, Johnson D. Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells. J Virol. 2011;85:11638-45 pubmed publisher
    A complex of five human cytomegalovirus virus (HCMV) proteins, gH, gL, UL128, UL130, and UL131 (gH/gL/UL128-131), is essential for virus entry into epithelial cells...
  51. Avdic S, Cao J, McSharry B, Clancy L, Brown R, Steain M, et al. Human cytomegalovirus interleukin-10 polarizes monocytes toward a deactivated M2c phenotype to repress host immune responses. J Virol. 2013;87:10273-82 pubmed publisher
    Several human cytomegalovirus (HCMV) genes encode products that modulate cellular functions in a manner likely to enhance viral pathogenesis. This includes UL111A, which encodes homologs of human interleukin-10 (hIL-10)...
  52. Seo J, Yaneva R, Hinson E, Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science. 2011;332:1093-7 pubmed publisher
    Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown...
  53. Close W, Anderson A, Pellett P. Betaherpesvirus Virion Assembly and Egress. Adv Exp Med Biol. 2018;1045:167-207 pubmed publisher
    ..The betaherpesvirus subfamily includes four human herpesviruses (human cytomegalovirus and human herpesviruses 6A, 6B, and 7), as well as viruses that are the basis of important animal models ..
  54. Giovannone A, Reales E, Bhattaram P, Fraile Ramos A, Weimbs T. Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes. Mol Biol Cell. 2017;28:2843-2853 pubmed publisher
    ..b>Human cytomegalovirus (HCMV) acquires its membrane in an intracellular compartment and we show that Stx3-5R strongly reduces the ..
  55. Zhu D, Pan C, Sheng J, Liang H, Bian Z, Liu Y, et al. Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol. 2018;3:503-513 pubmed publisher
    The precise cell type hosting latent human cytomegalovirus (HCMV) remains elusive. Here, we report that HCMV reprogrammes human haematopoietic progenitor cells (HPCs) into a unique monocyte subset to achieve latency...
  56. McVoy M, Wang J, Dittmer D, Bierle C, Swanson E, Fernández Alarcón C, et al. Repair of a Mutation Disrupting the Guinea Pig Cytomegalovirus Pentameric Complex Acquired during Fibroblast Passage Restores Pathogenesis in Immune-Suppressed Guinea Pigs and in the Context of Congenital Infection. J Virol. 2016;90:7715-27 pubmed publisher
    ..in the region of the genome encoding components of the pentameric complex (PC), in particular homologs of human cytomegalovirus (HCMV) proteins UL128, UL130, and UL131A...
  57. Cojohari O, Burrer C, Peppenelli M, Abulwerdi F, Nikolovska Coleska Z, Chan G. BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells. J Virol. 2015;89:5739-46 pubmed publisher
    Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carrier cells...
  58. Halenius A, Momburg F, Reinhard H, Bauer D, Lobigs M, Hengel H. Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing. J Biol Chem. 2006;281:5383-90 pubmed
    The endoplasmic reticulum-resident human cytomegalovirus glycoprotein US6 (gpUS6) inhibits peptide translocation by the transporter associated with antigen processing (TAP) to prevent loading of major histocompatibility complex class I ..
  59. Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui L, et al. Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins. Autophagy. 2016;12:327-42 pubmed publisher
    Autophagy is activated early after human cytomegalovirus (HCMV) infection but, later on, the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 and IRS1, which inhibit autophagy during infection...
  60. Feng L, Sheng J, Vu G, Liu Y, Foo C, Wu S, et al. Human cytomegalovirus UL23 inhibits transcription of interferon-? stimulated genes and blocks antiviral interferon-? responses by interacting with human N-myc interactor protein. PLoS Pathog. 2018;14:e1006867 pubmed publisher
    ..In this study, we show strong evidence that the UL23 protein of human cytomegalovirus (HCMV), a human herpesvirus, specifically interacts with Nmi...
  61. VanDeusen H, Kalejta R. The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication. J Virol. 2015;89:5012-21 pubmed publisher
    ..b>Human cytomegalovirus (HCMV), a betaherpesvirus being investigated for potential roles in human cancers, encodes multiple lytic-..
  62. Misra M, Pandey S, Kapoor R, Sharma R, Agrawal S. Cytotoxic T-lymphocyte antigen 4 gene polymorphism influences the incidence of symptomatic human cytomegalovirus infection after renal transplantation. Pharmacogenet Genomics. 2015;25:19-29 pubmed publisher
    The role of CTLA4 gene polymorphisms in T-cell-mediated immunity in association with human cytomegalovirus (HCMV) infection after transplantation is poorly understood...
  63. Schauflinger M, Fischer D, Schreiber A, Chevillotte M, Walther P, Mertens T, et al. The tegument protein UL71 of human cytomegalovirus is involved in late envelopment and affects multivesicular bodies. J Virol. 2011;85:3821-32 pubmed publisher
    Morphogenesis of human cytomegalovirus (HCMV) is still only partially understood. We have characterized the role of HCMV tegument protein pUL71 in viral replication and morphogenesis...
  64. Liao X, Dong X, Wu C, Wang T, Liu F, Zhou J, et al. Human cytomegalovirus immediate early protein 2 enhances myocardin-mediated survival of rat aortic smooth muscle cells. Virus Res. 2014;192:85-91 pubmed publisher
    b>Human cytomegalovirus (HCMV) may increase the incidence of restenosis and predispose to atherosclerosis...
  65. Proff J, Walterskirchen C, Brey C, Geyeregger R, Full F, Ensser A, et al. Cytomegalovirus-Infected Cells Resist T Cell Mediated Killing in an HLA-Recognition Independent Manner. Front Microbiol. 2016;7:844 pubmed publisher
    In order to explore the potential of HLA-independent T cell therapy for human cytomegalovirus (HCMV) infections, we developed a chimeric antigen receptor (CAR) directed against the HCMV encoded glycoprotein B (gB), which is expressed at ..
  66. Sun X, Chen W, He L, Sheng J, Liu Y, Vu G, et al. Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant. PLoS ONE. 2017;12:e0186791 pubmed publisher
    ..In this study, we employed a novel engineered variant to target a shared mRNA region of human cytomegalovirus (HCMV) immediate early proteins 1 (IE1) and 2 (IE2), which are essential for the expression of viral early ..
  67. Pachnio A, Begum J, Fox A, Moss P. Acyclovir Therapy Reduces the CD4+ T Cell Response against the Immunodominant pp65 Protein from Cytomegalovirus in Immune Competent Individuals. PLoS ONE. 2015;10:e0125287 pubmed publisher
  68. Brock I, Kr ger M, Mertens T, von Einem J. Nuclear targeting of human cytomegalovirus large tegument protein pUL48 is essential for viral growth. J Virol. 2013;87:6005-19 pubmed publisher
    We report the identification of a functional nuclear localization signal (NLS) in the human cytomegalovirus (HCMV) large tegument protein pUL48 that is required for nuclear localization in transfected cells and is essential for viral ..
  69. Sarhan D, Cichocki F, Zhang B, Yingst A, Spellman S, Cooley S, et al. Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells. Cancer Res. 2016;76:5696-5706 pubmed
    b>Human cytomegalovirus (CMV)-induced adaptive natural killer (NK) cells display distinct phenotypic and functional characteristics, including properties of immune memory...
  70. Liu Y, Zhang Z, Zhao X, Wei H, Deng J, Cui Z, et al. Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES. Virus Res. 2012;166:31-42 pubmed publisher
    The tegument protein UL94 is a human cytomegalovirus (HCMV) late protein and its function has yet to be determined...
  71. Reap E, Suryadevara C, Batich K, Sanchez Perez L, Archer G, Schmittling R, et al. Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma. Cancer Res. 2018;78:256-264 pubmed publisher
    Median survival for glioblastoma (GBM) remains <15 months. Human cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific ..