Human herpesvirus 2


Alias: Herpes simplex virus (type 2), Herpes simplex virus type 2, herpes simplex virus type 2 HSV-2, HSV2, Herpes simplex virus 2

Top Publications

  1. Koshizuka T, Kawaguchi Y, Nishiyama Y. Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A. J Gen Virol. 2005;86:527-33 pubmed
    ..The hypothesis that the UL56 protein affects vesicular trafficking in infected cells, potentially by acting as a receptor for motor proteins in neurons, is discussed. ..
  2. Koshizuka T, Kawaguchi Y, Goshima F, Mori I, Nishiyama Y. Association of two membrane proteins encoded by herpes simplex virus type 2, UL11 and UL56. Virus Genes. 2006;32:153-63 pubmed
    ..Fatty acylation of UL11 was important for the formation of the UL11-UL56 protein complex. Taken together, our results identify a novel interaction between two HSV proteins facilitated by mutual interactions with Golgi-derived vesicles. ..
  3. Cairns T, Friedman L, Lou H, Whitbeck J, Shaner M, Cohen G, et al. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. J Virol. 2007;81:5102-11 pubmed
    ..Additional mutagenesis identified L66 and L72 as important for function. Together, our results highlight several key gH residues: R39, Y41, W42, and D44 for gH transport and L66 and L72 for gH/gL structure and function...
  4. Norberg P, Kasubi M, Haarr L, Bergstrom T, Liljeqvist J. Divergence and recombination of clinical herpes simplex virus type 2 isolates. J Virol. 2007;81:13158-67 pubmed
    b>Herpes simplex virus type 2 (HSV-2) infects the genital mucosa and is one of the most common sexually transmitted viruses. Here we sequenced a segment comprising 3...
  5. Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y. Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination. J Virol. 2008;82:5220-33 pubmed publisher
    ..Based on these findings, we propose that UL56 regulates Nedd4 in HSV-2-infected cells, although deletion of UL56 had no apparent effect on viral growth in vitro...
  6. Ushijima Y, Goshima F, Kimura H, Nishiyama Y. Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions. Virol J. 2009;6:168 pubmed publisher
    ..These data suggest that UL56 regulates Nedd4 and functions to facilitate the cytoplasmic transport of virions from TGN to the plasma membrane and/or release of virions from the cell surface. ..
  7. Nourollahpour Shiadeh M, Behboodi Moghadam Z, Adam I, Saber V, Bagheri M, Rostami A. Human infectious diseases and risk of preeclampsia: an updated review of the literature. Infection. 2017;45:589-600 pubmed publisher
    ..Thus, early diagnosis and treatment of bacterial, viral, and parasitic infections could be an effective strategy to reduce the incidence of PE. ..
  8. Ibañez F, Farías M, Retamal Díaz A, Espinoza J, Kalergis A, González P. Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection. Front Microbiol. 2017;8:2108 pubmed publisher
    ..Here, we sought to assess the effect of modulating HO-1 activity over herpes simplex virus type 2 (HSV-2) infection in epithelial cells and neurons...
  9. Severance E, Gressitt K, Buka S, Cannon T, Yolken R. Maternal complement C1q and increased odds for psychosis in adult offspring. Schizophr Res. 2014;159:14-9 pubmed publisher
    ..26, p ≤ 0.004), herpes simplex virus type 2 (R(2)=0.21, p ≤ 0.02), and adenovirus (R(2)=0.25, p ≤ 0.006)...

More Information

Publications204 found, 100 shown here

  1. Gaydos C, Rizzo Price P, Balakrishnan P, Mateta P, Leon S, Verevochkin S, et al. Impact of international laboratory partnerships on the performance of HIV/sexually transmitted infection testing in five resource-constrained countries. Int J STD AIDS. 2011;22:645-52 pubmed publisher laboratories conducted chlamydia/gonorrhoea polymerase chain reaction (PRC)-based assays, herpes simplex virus type 2 enzyme immunoassay (EIA), syphilis serology (rapid plasma regain and Treponema pallidum particle ..
  2. Poggi A, Catellani S, Musso A, Zocchi M. Gammadelta T lymphocytes producing IFNgamma and IL-17 in response to Candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation. Curr Med Chem. 2009;16:4743-9 pubmed the response to mycobacterial infections and certain viruses, including coxsakie virus B3 and herpes simplex virus type 2. Vdelta1 T cells are resident in the mucosal-associated lymphoid tissue and are reported to participate ..
  3. Kahraman H, Tunger A, Senol S, Gazi H, Avci M, Ormen B, et al. [Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. Mikrobiyol Bul. 2017;51:277-285 pubmed publisher
    ..multiplex PCR (Seeplex meningitis-V1 ACE Detection kits herpes simplex virus-1 (HSV1), herpes simplex virus-2 (HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (..
  4. Medjeldi S, Bouslama L, Benabdallah A, Essid R, Haou S, Elkahoui S. Biological activities, and phytocompounds of northwest Algeria Ajuga iva (L) extracts: Partial identification of the antibacterial fraction. Microb Pathog. 2018;121:173-178 pubmed publisher
    ..Virus type B-3 (CVB-3), Adenovirus type 5 (ADV-5), Respiratory Syncytial Virus type B (RSV-B) and Herpes Simplex Virus type 2 (HSV-2) showed an activity against Coxsackie Virus...
  5. Żołnierczyk A, Mączka W, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015;103:71-82 pubmed publisher
    ..In addition, IXN shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
  6. Bodilsen J, Storgaard M, Larsen L, Wiese L, Helweg Larsen J, Lebech A, et al. Infectious meningitis and encephalitis in adults in Denmark: a prospective nationwide observational cohort study (DASGIB). Clin Microbiol Infect. 2018;24:1102.e1-1102.e5 pubmed publisher
    ..zoster virus (n = 61) was most common in viral meningitis followed by enterovirus (n = 50) and herpes simplex virus type 2 (n = 46)...
  7. Dhont N, Luchters S, Muvunyi C, Vyankandondera J, De Naeyer L, Temmerman M, et al. The risk factor profile of women with secondary infertility: an unmatched case-control study in Kigali, Rwanda. BMC Womens Health. 2011;11:32 pubmed publisher
    ..Presence of HIV, herpes simplex virus type 2 (HSV-2), or Treponema pallidum antibodies, and bacterial vaginosis (BV), were significantly more common ..
  8. Schelar E, Polis C, Essam T, Looker K, Bruni L, Chrisman C, et al. Multipurpose prevention technologies for sexual and reproductive health: mapping global needs for introduction of new preventive products. Contraception. 2016;93:32-43 pubmed publisher
    ..We examined four indicators relevant to MPTs in development: HIV prevalence, herpes simplex virus type 2 prevalence (HSV-2), human papillomavirus prevalence (HPV) and the proportion of women with unmet need ..
  9. Bernstein D, Bravo F, Pullum D, Shen H, Wang M, Rahman A, et al. Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs. Antivir Chem Chemother. 2015;24:19-27 pubmed publisher
    ..N-methanocarbathymidine was effective as therapy for acute and recurrent genital HSV-2 disease in the guinea pig models. ..
  10. de la Torre A, Valdés Camacho J, de Mesa C, Uauy Nazal A, Zuluaga J, Ramírez Páez L, et al. Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin. BMC Infect Dis. 2019;19:91 pubmed publisher
    ..PCR in AH was done for viral origin such as Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV1), Herpes simplex virus type 2 (HSV2), Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and Mycobacterium tuberculosis...
  11. Benito Leon J, Laurence M. The Role of Fungi in the Etiology of Multiple Sclerosis. Front Neurol. 2017;8:535 pubmed publisher
    ..The low risk of MS during childhood and its moderate association with herpes simplex virus type 2 suggest genital exposure to microbes (including fungi) should be investigated as a possible trigger...
  12. Cepeda A, Nowotny K, Frankeberger J, Onge J, Valdez A. Biological Risk and Infection Profiles of Young Adult Male Mexican American Gang Members. Public Health Rep. 2018;133:551-558 pubmed publisher
    ..001). Compared with men in the national sample, more men in the gang-affiliated sample had herpes simplex virus type 2 (64/174 [36.8%] vs 18/147 [12.2%], P < .001), chlamydia (10/176 [5.7%] vs 1/135 [0.7%], P = ...
  13. Grund J, Bryant T, Jackson I, CURRAN K, Bock N, Toledo C, et al. Association between male circumcision and women's biomedical health outcomes: a systematic review. Lancet Glob Health. 2017;5:e1113-e1122 pubmed publisher
    ..found for five outcomes, with male circumcision protecting against cervical cancer, cervical dysplasia, herpes simplex virus type 2, chlamydia, and syphilis...
  14. Morrison C, Chen P, Kwok C, Baeten J, Brown J, Crook A, et al. Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis. PLoS Med. 2015;12:e1001778 pubmed publisher
    ..73-1.41) compared to those at higher risk of bias (p(interaction) = 0.003). Neither age nor herpes simplex virus type 2 infection status modified the HC-HIV relationship...
  15. Lewalle P, Pochon C, Michallet M, Turlure P, Brissot E, Paillard C, et al. [Prophylaxis of infections post-allogeneic transplantation: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)]. Bull Cancer. 2019;106:S23-S34 pubmed publisher
    ..These recommendations concern the prophylaxis of infections caused by HSV1, HSV2, varicella zoster, and hepatitis B, as well as anti-bacterial and digestive decontamination prophylaxis, prevention ..
  16. Liu G, Fennelly G, Kazacos K, Grose C, Dobroszycki J, Saffra N, et al. Baylisascaris procyonis and Herpes Simplex Virus 2 Coinfection Presenting as Ocular Larva Migrans with Granuloma Formation in a Child. Am J Trop Med Hyg. 2015;93:612-4 pubmed publisher
    ..procyonis, the raccoon ascarid. Herpes simplex virus type 2 (HSV-2) infection of the retina is the result of either primary infection or reactivated disease...
  17. Monjo A, Pringle E, Thornbury M, Duguay B, Monro S, Hetu M, et al. Photodynamic Inactivation of Herpes Simplex Viruses. Viruses. 2018;10: pubmed publisher
    ..Photoactivated Orthoquin inhibited herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) infection of target cells in a dose-dependent manner across a broad range of sub-cytotoxic ..
  18. Ibragimova Z, Anan ko G, Kostina N, Teplyakova T, Mazurkova N. Toxicity and Antiviral Activity of the Extracts of Submerged Mycelium of Nematophagous Duddingtonia flagrans Fungus in Vero Cell Culture. Bull Exp Biol Med. 2015;160:246-8 pubmed publisher
    ..Ethanol extract of the fungus exhibited higher in vitro antiviral activity against Herpes simplex virus type 2, ectromelia virus, and vaccinia virus than water extract, which can be due to higher content of ..
  19. Wang N, Zhen Y, Jin Y, Wang X, Li N, Jiang S, et al. Combining different types of multifunctional liposomes loaded with ammonium bicarbonate to fabricate microneedle arrays as a vaginal mucosal vaccine adjuvant-dual delivery system (VADDS). J Control Release. 2017;246:12-29 pubmed publisher
    ..In addition, vaginal vaccination of the engineered HSV2 antigen gD-loaded proSMMAs successfully protected mice from the virus challenge...
  20. Fortner R, Terry K, Bender N, Brenner N, Hufnagel K, Butt J, et al. Sexually transmitted infections and risk of epithelial ovarian cancer: results from the Nurses' Health Studies. Br J Cancer. 2019;120:855-860 pubmed publisher
    ..Antibodies indicating past infection with Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus type 2, and against human papillomavirus oncogenes (L1 and E6+E7 oncoproteins of types 16, 18, 45) were ..
  21. Picone O. [Genital herpes and pregnancy: Epidemiology, clinical manifestations, prevention and screening. Guidelines for clinical practice from the French College of Gynecologists and Obstetrician (CNGOF)]. Gynecol Obstet Fertil Senol. 2017;45:642-654 pubmed publisher
    ..It is most often due to HSV2 (NP2)...
  22. Varo R, Buck W, Kazembe P, PHIRI S, Andrianarimanana D, Weigel R. Seroprevalence of CMV, HSV-2 and HBV among HIV-Infected Malawian Children: A Cross-sectional Survey. J Trop Pediatr. 2016;62:220-6 pubmed publisher
    ..We examined the prevalence of seromarkers for cytomegalovirus (CMV), herpes simplex virus type 2 (HSV-2) and hepatitis B virus (HBV) infections among HIV-infected, antiretroviral treatment (ART)-naï..
  23. Hartline C, Keith K, Eagar J, Harden E, Bowlin T, Prichard M. A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses. Antiviral Res. 2018;159:104-112 pubmed publisher facilitate the parallel evaluation of antiviral activity against herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, cytomegalovirus, vaccinia virus, cowpox virus, and adenovirus...
  24. Gumbe A, McLellan Lemal E, Gust D, Pals S, Gray K, Ndivo R, et al. Correlates of prevalent HIV infection among adults and adolescents in the Kisumu incidence cohort study, Kisumu, Kenya. Int J STD AIDS. 2015;26:929-40 pubmed publisher
    ..parallel rapid HIV testing, and laboratory testing for pregnancy, gonorrhoea, chlamydia, syphilis, and herpes simplex virus type 2. Multivariate logistic regression was used to identify variables associated with prevalent HIV ..
  25. Li F, Zhu C, Deng F, Wong M, Lu H, Feng X. Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies. PLoS ONE. 2017;12:e0186373 pubmed publisher
    ..The association between Herpes simplex virus type 2 (HSV-2) and AgP was inconclusive (2 studies: p = 0.20, OR = 3.46, 95% CI = 0.51-23.51)...
  26. Retamal Díaz A, Weiss K, Tognarelli E, Freire M, Bueno S, Herold B, et al. US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Front Immunol. 2017;8:1523 pubmed publisher
  27. Gale S, Berrett A, Erickson L, Brown B, Hedges D. Association between virus exposure and depression in US adults. Psychiatry Res. 2018;261:73-79 pubmed publisher
    ..status, antidepressant use, exposure to hepatitis A, hepatitis B, herpes simplex virus type 1, herpes simplex virus type 2, human immunodeficiency virus, and cytomegalovirus, and sociodemographic variables and evaluated ..
  28. Tobian A, Kacker S, Quinn T. Male circumcision: a globally relevant but under-utilized method for the prevention of HIV and other sexually transmitted infections. Annu Rev Med. 2014;65:293-306 pubmed publisher
    Randomized trials have demonstrated that male circumcision (MC) reduces heterosexual acquisition of HIV, herpes simplex virus type 2, human papillomavirus (HPV), and genital ulcer disease among men, and it reduces HPV, genital ulcer ..
  29. Hu H, Scheidell J, Xu X, Coatsworth A, Khan M. Associations between blood lead level and substance use and sexually transmitted infection risk among adults in the United States. Environ Res. 2014;135:21-30 pubmed publisher
    ..five years younger or older and multiple partnerships), self-reported STI, and biologically-confirmed herpes simplex virus type 2 (HSV-2) infection...
  30. Marsden V, Donaghy H, Bertram K, Harman A, Nasr N, Keoshkerian E, et al. Herpes simplex virus type 2-infected dendritic cells produce TNF-α, which enhances CCR5 expression and stimulates HIV production from adjacent infected cells. J Immunol. 2015;194:4438-45 pubmed publisher
    ..Therefore, these results suggest that HSV-2 infection of DCs in the skin during primary or recurrent genital herpes may enhance HIV-1 infection of adjacent DCs, thus contributing to acquisition of HIV-1 through herpetic lesions. ..
  31. Otieno F, Ndivo R, Oswago S, Pals S, Chen R, Thomas T, et al. Correlates of prevalent sexually transmitted infections among participants screened for an HIV incidence cohort study in Kisumu, Kenya. Int J STD AIDS. 2015;26:225-37 pubmed publisher
    ..Structural interventions may be beneficial in addressing educational and socio-economic barriers, and increasing the uptake of health-promoting practices. ..
  32. Casassa E, Nicol P, Viraben R, Gaudin C, Bulai Livideanu C, Mengelle C, et al. [Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia]. Ann Dermatol Venereol. 2018;145:182-186 pubmed publisher
    ..Skin biopsies ruled out carcinoma but were consistent with HSV infection. A local swab was positive for HSV2. Treatment with valaciclovir and intravenous acyclovir (ACV) at the recommended doses was ineffective...
  33. Luo L, Reilly K, Xu J, Wang G, Ding G, Wang N, et al. Prevalence and correlates of Trichomonas vaginalis infection among female sex workers in a city in Yunnan Province, China. Int J STD AIDS. 2016;27:469-75 pubmed publisher
    ..30). In multivariate analyses, adjusted odds ratios of TV infection were 3.0 (95% CI 1.47-6.01) for herpes simplex virus type 2 seropositive, 2.4 (95% CI 1.37-4.14) for Chlamydia trachomatis infection, 2.6 (95% CI 1.30-5...
  34. Oh J, Lee M, Kim Y, Lee H. OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production. Sci Rep. 2016;6:19089 pubmed publisher
  35. Botta G, Bizzarri B, Garozzo A, Timpanaro R, Bisignano B, Amatore D, et al. Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses. Bioorg Med Chem. 2015;23:5345-51 pubmed publisher
    ..and RNA viruses, including Poliovirus type 1, Echovirus type 9, Herpes simplex virus type 1 (HSV-1), Herpes simplex virus type 2 (HSV-2), Coxsackievirus type B3 (Cox B3), Adenovirus type 2 and type 5 and Cytomegalovirus (CMV)...
  36. Liu Y, Xu X, Zhang B, Gu J, Meng F, Liu H, et al. Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells. Viruses. 2018;10: pubmed publisher
    ..These observations indicate that BBI may have therapeutic potential for the prevention and treatment of HSV-2 infections. ..
  37. Damelin L, Fernandes M, Tiemessen C. Alginate microbead-encapsulated silver complexes for selective delivery of broad-spectrum silver-based microbicides. Int J Antimicrob Agents. 2015;46:394-400 pubmed publisher
    ..We show that a silver saccharinate-benzimidazole complex (AgSB) exhibited activity against HIV-1, herpes simplex virus type 2 (HSV-2) and Neisseria gonorrhoeae at concentrations significantly below LD(50) levels for the vaginal ..
  38. Goncalez T, Blatyta P, Santos F, Montebello S, Esposti S, Hangai F, et al. Does offering human immunodeficiency virus testing at the time of blood donation reduce transfusion transmission risk and increase disclosure counseling? Results of a randomized controlled trial, São Paulo, Brazil. Transfusion. 2015;55:1214-22 pubmed publisher
    ..Few candidate donors chose HIV testing (n = 81, 1.3%). There was no significant difference in herpes simplex virus Type 2 (HSV-2) prevalence (a marker of sexual risk) among donors during intervention weeks compared to control ..
  39. Ramirez Fort M, Zeng J, Feily A, Ramirez Pacheco L, Jenrette J, Mayhew D, et al. Radiotherapy-induced reactivation of neurotrophic human herpes viruses: Overview and management. J Clin Virol. 2018;98:18-27 pubmed publisher
    ..It can also differentiate between herpetic infection and radionecrosis. The MicroTrak® HSV1/HSV2/VZV staining kit has high sensitivity and specificity in acute lesions, is also the most rapid means to confirm ..
  40. Operario D, Gamarel K, Grin B, Lee J, Kahler C, Marshall B, et al. Sexual Minority Health Disparities in Adult Men and Women in the United States: National Health and Nutrition Examination Survey, 2001-2010. Am J Public Health. 2015;105:e27-34 pubmed publisher
    ..sexual minority men had greater odds of mental health problems, testing positive for HIV and herpes simplex virus type 2 and self-reported gonorrhea and chlamydia...
  41. McGee D, Smith A, Poncil S, PATTERSON A, Bernstein A, Racicot K. Cervical HSV-2 infection causes cervical remodeling and increases risk for ascending infection and preterm birth. PLoS ONE. 2017;12:e0188645 pubmed publisher
    ..Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection...
  42. Stuve O, Marder E, Okai A, Stettner M, Kieseier B. Heat exposure and bicycling trigger recurrent aseptic meningitis: a case report. BMC Neurol. 2014;14:230 pubmed publisher
    Aseptic meningitis associated with herpes simplex virus type 2 often has a relapsing-remitting clinical phenotype. Factors that lead to disease activation and reactivation are currently incompletely understood...
  43. Wang J, Yuan S, Zhu D, Tang H, Wang N, Chen W, et al. Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component. Nat Commun. 2018;9:3668 pubmed publisher
  44. Wang K, Mahalingam G, Imai Y, Pesnicak L, Margolis T, Margolis T, et al. Cell type specific accumulation of the major latency-associated transcript (LAT) of herpes simplex virus type 2 in LAT transgenic mice. Virology. 2009;386:79-87 pubmed publisher
    ..These data indicate that HSV-2 LAT promoter activity is not restricted to neurons and that LAT accumulation in ganglionic neurons is likely regulated by cell-specific factors. ..
  45. Vilhelmova Ilieva N, Jacquet R, Quideau S, Galabov A. Ellagitannins as synergists of ACV on the replication of ACV-resistant strains of HSV 1 and 2. Antiviral Res. 2014;110:104-14 pubmed publisher
    ..herpes simplex virus type 1 (HSV-1) strain was markedly higher compared to that on the ACV-resistant herpes simplex virus type 2 (HSV-2)...
  46. Kenney J, Derby N, Aravantinou M, Kleinbeck K, Frank I, Gettie A, et al. Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides. AIDS Res Hum Retroviruses. 2014;30:1117-24 pubmed publisher
    Epidemiological studies suggest that prevalent herpes simplex virus type 2 (HSV-2) infection increases the risk of HIV acquisition, underscoring the need to develop coinfection models to evaluate promising prevention strategies...
  47. Pérez Hernández M, Gadea I, Escribano J, Tabarés E, Gómez Sebastián S. Expression and characterization of the gD protein of HSV-2 fused to the tetramerization domain of the transcription factor p53. Protein Expr Purif. 2015;115:54-60 pubmed publisher
    The highly immunogenic glycoprotein D (gD) of herpes simplex virus type 2 (HSV-2) is a very important element for entry of this virus into host cells...
  48. Shindo K, Kato A, Koyanagi N, Sagara H, Arii J, Kawaguchi Y. Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene. J Virol. 2016;90:457-73 pubmed publisher
    ..Therefore, our study clarified the biological differences between HSV-1 Us3 and HSV-2 Us3, which may be relevant to viral pathogenesis in vivo. ..
  49. Galus A, Mallet J, Lembo D, Cagno V, Djabourov M, Lortat Jacob H, et al. Hexagonal-shaped chondroitin sulfate self-assemblies have exalted anti-HSV-2 activity. Carbohydr Polym. 2016;136:113-20 pubmed publisher
    The initial step in mucosal infection by the herpes simplex virus type 2 (HSV-2) requires its binding to certain glycosaminoglycans naturally present on host cell membranes...
  50. Fujimoto Y, Ozaki K, Iwamori N, Takakuwa H, Ono E. Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells. Acta Virol. 2016;60:41-8 pubmed
    Cell entry of herpes simplex virus type 2 (HSV-2) requires the interaction of viral glycoprotein D (gD) with the receptor nectin-1 and herpesvirus entry mediator (HVEM)...
  51. Andersen Nissen E, Chang J, Thomas K, Adams D, Celum C, Sanchez J, et al. Herpes Simplex Virus Suppressive Therapy in Herpes Simplex Virus-2/Human Immunodeficiency Virus-1 Coinfected Women Is Associated With Reduced Systemic CXCL10 But Not Genital Cytokines. Sex Transm Dis. 2016;43:761-764 pubmed
    ..Alternative therapies are needed to reduce persistent mucosal inflammation that may enhance transmission of HSV-2 and HIV-1. ..
  52. Yanez A, Harrell T, Sriranganathan H, Ives A, Bertke A. Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons. Pathogens. 2017;6: pubmed publisher
    Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease...
  53. Kleinstein S, Shea P, Allen A, Koelle D, Wald A, Goldstein D. Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2). Genes Immun. 2019;20:112-120 pubmed publisher
    b>Herpes simplex virus type 2 (HSV-2) is an incurable viral infection with severity ranging from asymptomatic to frequent recurrences...
  54. Desai D, Bhutkar M, Kulkarni S. Infectivity and growth kinetics of Herpes Simplex Virus type-2 in MOLT4 CCR5+ and CEM CCR5+ T cell lines. Microb Pathog. 2018;123:82-88 pubmed publisher
    ..The data suggests that T-cells can support growth of HSV-2 which might contribute to changes in gene expression of T-cells. This is an important aspect that needs to be further investigated in relation of HIV-1/HSV-2 viral synergy. ..
  55. Khandaker G, Zimbron J, Lewis G, Jones P. Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med. 2013;43:239-57 pubmed publisher
    ..Evidence for herpes simplex virus type 2 (HSV-2) and Toxoplasma gondii was mixed; some studies reported up to a doubling of schizophrenia risk...
  56. Busse R, Scacioc A, Krick R, Pérez Lara Ã, Thumm M, Kühnel K. Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding. Biophys J. 2015;108:2223-34 pubmed publisher
    ..ITC measurements showed that the yeast PROPPIN family members Atg18, Atg21, and Hsv2 bind PtdIns3P and PtdIns(3,5)P2 with high affinities in the nanomolar to low-micromolar range and have two ..
  57. Visalli R, Ziobrowski H, Badri K, He J, Zhang X, Arumugam S, et al. Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 2015;25:3168-71 pubmed publisher
    ..1-10 μM) and with minimal cellular cytotoxicity. IC50 values for antiviral activity against HSV-2 186 were 1.6, 0.6, 0.9, 7.2, and 0.9 μM for compounds 1-5, respectively. ..
  58. Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, et al. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial. Lancet Glob Health. 2017;5:e1133-e1141 pubmed publisher
  59. Alsallaq R, Schiffer J, Longini I, Wald A, Corey L, Abu Raddad L. Population level impact of an imperfect prophylactic vaccine for herpes simplex virus-2. Sex Transm Dis. 2010;37:290-7 pubmed publisher
    ..The vaccine's short-term impact in a high prevalence setting in Africa would be a substantial decrease in incidence, whereas its immediate impact on prevalence would be small and would increase slowly over time. ..
  60. Aumakhan B, Gange S, Beyrer C, Gaydos C, Minkoff H, Merenstein D, et al. Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study. Int J STD AIDS. 2011;22:273-7 pubmed publisher
    We identified demographic, clinical and biological determinants of herpes simplex virus type 2 (HSV-2) shedding among HIV-infected participants in the Women's HIV Interagency Study (WIHS)...
  61. Horn E, Turkheimer E, Strachan E. Psychological distress, emotional stability, and emotion regulation moderate dynamics of herpes simplex virus type 2 recurrence. Ann Behav Med. 2015;49:187-98 pubmed publisher
    b>Herpes simplex virus type 2 (HSV-2) genital lesion recurrence is modulated by psychological factors, but no such link with viral shedding (and thus asymptomatic transmission) has been observed in humans...
  62. Nielsen K, Knudsen T. [Elsberg syndrome]. Ugeskr Laeger. 2013;175: pubmed
    ..In many instances the aetiology is herpes simplex virus type 2 (HSV-2) reactivation from sensory neurons...
  63. Schiffer J, Wald A, Selke S, Corey L, Magaret A. The kinetics of mucosal herpes simplex virus-2 infection in humans: evidence for rapid viral-host interactions. J Infect Dis. 2011;204:554-61 pubmed publisher
    b>Herpes simplex virus type 2 (HSV-2) reactivations in the genital tract are responsible for mucocutaneous lesions and transmission and manifest as discrete shedding episodes...
  64. Patel P, Bush T, Mayer K, Desai S, Henry K, Overton E, et al. Prevalence and risk factors associated with herpes simplex virus-2 infection in a contemporary cohort of HIV-infected persons in the United States. Sex Transm Dis. 2012;39:154-60 pubmed publisher
    We compared the herpes simplex virus type 2 (HSV-2) seroprevalence in a contemporary HIV cohort with the general US population and determined risk factors for HSV-2 infection among HIV-infected persons...
  65. Kaufmann J, Flechtner J. Evolution of rational vaccine designs for genital herpes immunotherapy. Curr Opin Virol. 2016;17:80-86 pubmed publisher a novel treatment modality for genital herpes, a sexually transmitted disease mainly caused by herpes simplex virus type 2. The approaches to identify potential vaccine antigens have evolved from classic virus attenuation and ..
  66. Slotta Huspenina J, Drecoll E, Feith M, Habermehl D, Combs S, Weichert W, et al. MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus. J Transl Med. 2018;16:109 pubmed publisher
    ..025): non-responders showed upregulation of hsa-miR-1323, hsa-miR-3678-3p, hsv2-miR-H7-3p, hsa-miR-194*, hsa-miR-3152, kshv-miR-K12-4-3p, hsa-miR-665 and hsa-miR-3659 and downregulation of hsa-..
  67. Nakubulwa S, Kaye D, Bwanga F, Tumwesigye N, Mirembe F. Genital infections and risk of premature rupture of membranes in Mulago Hospital, Uganda: a case control study. BMC Res Notes. 2015;8:573 pubmed publisher
    ..syphilis, Neisseria gonorrhea, Chlamydia trachomatis, Group B Streptococcus, Bacterial vaginosis, Herpes Simplex Virus Type 2 and candidiasis) and premature rupture of membranes in Mulago hospital, Uganda...
  68. Swain M, Peet R, Galloway D. Characterization of the gene encoding herpes simplex virus type 2 glycoprotein C and comparison with the type 1 counterpart. J Virol. 1985;53:561-9 pubmed
    ..62 to 0.64. Recently, a herpes simplex virus type 2 glycoprotein previously designated gF and now designated gC was mapped to a homologous location...
  69. Mocarski E, Guo H, Kaiser W. Necroptosis: The Trojan horse in cell autonomous antiviral host defense. Virology. 2015;479-480:160-6 pubmed publisher
    ..Herpes simplex virus (HSV)1 and HSV2 incorporate both RHIM and Casp8 suppression strategies within UL39-encoded ICP6 and ICP10, respectively, which are ..
  70. Finnen R, Banfield B. Alphaherpesvirus Subversion of Stress-Induced Translational Arrest. Viruses. 2016;8:81 pubmed publisher
    ..Many viruses target SGs for disruption and/or modification, including the alphaherpesvirus herpes simplex virus type 2 (HSV-2)...
  71. Martinez Martin N, Viejo Borbolla A, Alcami A. Herpes simplex virus particles interact with chemokines and enhance cell migration. J Gen Virol. 2016;97:3007-3016 pubmed publisher
    ..Moreover, we found that HSV particles increase cell migration independently of chemokine binding to envelope gG. This work provides insights into HSV manipulation of the host immune system. ..
  72. Li X, Zhang S, Lei J, Zhu Y, Zhou X, Xiao J, et al. Prophylactic herpes simplex virus type 2 vaccine adjuvanted with a universal CD4 T cell helper peptide induces long-term protective immunity against lethal challenge in mice. Int Immunopharmacol. 2018;61:100-108 pubmed publisher
  73. Awasthi S, Huang J, Shaw C, Friedman H. Blocking herpes simplex virus 2 glycoprotein E immune evasion as an approach to enhance efficacy of a trivalent subunit antigen vaccine for genital herpes. J Virol. 2014;88:8421-32 pubmed publisher
    b>Herpes simplex virus 2 (HSV-2) subunit antigen vaccines targeting virus entry molecules have failed to prevent genital herpes in human trials...
  74. Xu J, Zhang C, Hu Q, Chu Z, Zhang J, Li Y, et al. Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships. BMC Infect Dis. 2014;14:642 pubmed publisher
    ..We assessed whether RDU was associated with HIV, syphilis, and herpes simplex virus type 2 (HSV-2) within the context of multiple sexual partnerships and unprotected sex...
  75. Tobian A, Kigozi G, Redd A, Serwadda D, Kong X, Oliver A, et al. Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda. J Infect Dis. 2012;205:486-90 pubmed publisher
    Male circumcision reduces acquisition of herpes simplex virus type 2 (HSV-2) in men. We assessed whether male circumcision reduces HSV-2 infection among female partners...
  76. Kuypers J, Boughton G, Chung J, Hussey L, Huang M, Cook L, et al. Comparison of the Simplexa HSV1 & 2 Direct kit and laboratory-developed real-time PCR assays for herpes simplex virus detection. J Clin Virol. 2015;62:103-5 pubmed publisher
    ..75 min, were compared to those of laboratory-developed real-time PCR assays (LDT) for detection of HSV1 and HSV2. Samples tested included 168 cerebral spinal fluid (CSF) collected prospectively and 150 tested retrospectively: 81 ..
  77. Glinšek Biškup U, Uršič T, Petrovec M. Laboratory diagnosis and epidemiology of herpes simplex 1 and 2 genital infections. Acta Dermatovenerol Alp Pannonica Adriat. 2015;24:31-5 pubmed
    Herpes simplex virus types 1 and 2 are the main cause of genital ulcers worldwide. Although herpes simplex virus type 2 is the major cause of genital lesions, herpes simplex virus type 1 accounts for half of new cases in developed ..
  78. Korr G, Thamm M, Czogiel I, Poethko Mueller C, Bremer V, Jansen K. Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. BMC Infect Dis. 2017;17:471 pubmed publisher
    ..We tested serum samples from DEGS participants for HSV1 and HSV2 immunoglobulin G...
  79. Fernandez Gerlinger M, Greffe S, Meffre A, Grenet J, Au S, Bojanova M, et al. HSV-2 meningoencephalitis in an immunocompetent young man: what is the pathogenesis and what is the treatment?. J Clin Virol. 2015;69:40-3 pubmed publisher
    Herpes simplex encephalitis is rarely caused by herpes simplex virus type 2 (HSV-2) after the neonatal period. The pathogenesis of HSV-2 encephalitis is not known and its treatment has not been discussed...
  80. Tang S, Guo N, Patel A, Krause P. Herpes simplex virus 2 expresses a novel form of ICP34.5, a major viral neurovirulence factor, through regulated alternative splicing. J Virol. 2013;87:5820-30 pubmed publisher
    ..5 splicing and promotion of ICP34.5? expression. Our results suggest that the expression of ICP34.5? and ICP34.5? is tightly regulated in HSV-2 and likely contributes to viral pathogenesis. ..
  81. Busse R, Scacioc A, Schalk A, Krick R, Thumm M, Kühnel K. Analyzing Protein-Phosphoinositide Interactions with Liposome Flotation Assays. Methods Mol Biol. 2016;1376:155-62 pubmed publisher
    ..In this protocol we use the PROPPIN Hsv2 (homologous with swollen vacuole phenotype 2) as an example to demonstrate the influence of liposome lipid ..
  82. Hanci D, Ulusoy S, Muluk N, Cingi C. Do viral infections have a role in benign paroxysmal positional vertigo?. B-ENT. 2015;11:211-8 pubmed
    ..The control group consisted of 461 healthy subjects. In both groups, serologic analysis of viral agents (HSV1, HSV2, Herpes zoster, EBV, CMV, adenovirus, influenza, and parainfluenza virus) was performed...
  83. Petro C, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs W, et al. HSV-2 ?gD elicits Fc?R-effector antibodies that protect against clinical isolates. JCI Insight. 2016;1: pubmed
    ..Rapid clearance and the absence of latent virus suggest that ?gD-2 elicits sterilizing immunity. ..
  84. Péré H, Raşcanu A, LeGoff J, Matta M, Bois F, Lortholary O, et al. Herpes simplex virus type 2 (HSV-2) genital shedding in HSV-2-/HIV-1-co-infected women receiving effective combination antiretroviral therapy. Int J STD AIDS. 2016;27:178-85 pubmed publisher
    ..Reactivation of genital HSV-2 replication frequently occurred despite effective cART in HSV-2-/HIV-1-co-infected women. Genital HSV-2 replication under cART does not influence cervicovaginal HIV-1 RNA or DNA shedding. ..
  85. Patel E, Manucci J, Kahle E, Lingappa J, Morrow R, Piwowar Manning E, et al. Precision of the Kalon Herpes Simplex Virus Type 2 IgG ELISA: an international inter-laboratory assessment. BMC Infect Dis. 2015;15:398 pubmed publisher
    ..In populations with optimal diagnostic accuracy, Kalon is a reliable stand-alone method for on-site HSV-2 IgG antibody detection. ..
  86. Wang K, Goodman K, Li D, Raffeld M, Chavez M, Cohen J. A Herpes Simplex Virus 2 (HSV-2) gD Mutant Impaired for Neural Tropism Is Superior to an HSV-2 gD Subunit Vaccine To Protect Animals from Challenge with HSV-2. J Virol. 2016;90:562-74 pubmed publisher
    A recent phase 3 trial with soluble herpes simplex virus 2 (HSV-2) glycoprotein D (gD2t) in adjuvant failed to show protection against genital herpes...
  87. Bayliss R, Piguet V. The Ticking CLOCK of HSV-2 Pathology. J Invest Dermatol. 2018;138:17-19 pubmed publisher
    b>Herpes simplex virus type 2 (HSV-2) is the causative agent of genital herpes. Matsuzawa et al have demonstrated that, in a mouse model, HSV-2 pathology is influenced by the time infection occurs...
  88. Veselenak R, Milligan G, Miller A, Pyles R, Bourne N. Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2. Virology. 2018;518:349-357 pubmed publisher
    ..This transcription-based array will be useful for dissection of immunity during reactivation from latency, an infection outcome that is not well recapitulated by other animal models. ..
  89. Kristen H, Santana S, Sastre I, Recuero M, Bullido M, Aldudo J. Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells. Neurobiol Aging. 2015;36:2737-47 pubmed publisher
  90. Joshi P. Multiple strokes associated with herpes simplex virus type-2 infection: case report. J Neurovirol. 2016;22:251-3 pubmed publisher
  91. Quispe Calla N, Vicetti Miguel R, Boyaka P, Hall Stoodley L, Kaur B, Trout W, et al. Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. Mucosal Immunol. 2016;9:1571-1583 pubmed publisher
    ..Using a mouse model of genital herpes simplex virus type 2 (HSV-2) infection, we herein found that DMPA and LNG similarly reduced genital expression of the ..
  92. Spicknall I, Looker K, Gottlieb S, Chesson H, Schiffer J, Elmes J, et al. Review of mathematical models of HSV-2 vaccination: Implications for vaccine development. Vaccine. 2018;: pubmed publisher
    Development of a vaccine against herpes simplex virus type 2 (HSV-2), a life-long sexually-transmitted infection (STI), would be a major step forward in improving global sexual and reproductive health...