Human herpesvirus 1

Summary

Alias: Herpes simplex virus 1, Herpes simplex virus type 1, Human herpesvirus type 1, herpes simplex virus 1 HSV-1, herpes simplex virus HSV-1, herpes simplex virus type 1 HSV-1, herpes simplex virus type 1 HSV1, herpes simplex virus type-1 HSV-1, HSV-1, HSV1, Human Herpesvirus-1

Top Publications

  1. Conway J, Cockrell S, Copeland A, Newcomb W, Brown J, Homa F. Labeling and localization of the herpes simplex virus capsid protein UL25 and its interaction with the two triplexes closest to the penton. J Mol Biol. 2010;397:575-86 pubmed publisher
    The herpes simplex virus type 1 UL25 protein is one of seven viral proteins that are required for DNA cleavage and packaging...
  2. Everett R, Parsy M, Orr A. Analysis of the functions of herpes simplex virus type 1 regulatory protein ICP0 that are critical for lytic infection and derepression of quiescent viral genomes. J Virol. 2009;83:4963-77 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) immediate-early regulatory protein ICP0 is important for stimulating the initiation of the lytic cycle and efficient reactivation of latent or quiescent infection...
  3. Cuchet Lourenço D, Boutell C, Lukashchuk V, Grant K, Sykes A, Murray J, et al. SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes. PLoS Pathog. 2011;7:e1002123 pubmed publisher
    Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus...
  4. Blondeau C, Pelchen Matthews A, Mlcochova P, Marsh M, Milne R, Towers G. Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M. J Virol. 2013;87:13124-33 pubmed publisher
    ..In this study, we demonstrate that herpes simplex virus 1 (HSV-1) is targeted by tetherin...
  5. Rice S, Davido D. HSV-1 ICP22: hijacking host nuclear functions to enhance viral infection. Future Microbiol. 2013;8:311-21 pubmed publisher
    ..Thus, future work on ICP22 is likely to reveal novel mechanisms by which herpesviruses, and possibly other DNA viruses, manipulate the host cell nucleus to enhance their replication. ..
  6. Baines J, Wills E, Jacob R, Pennington J, Roizman B. Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane. J Virol. 2007;81:800-12 pubmed
    ..The present study focuses on glycoprotein M (gM), a type III integral membrane protein of herpes simplex virus 1 (HSV-1) that likely contains eight transmembrane domains...
  7. Lubinski J, Lazear H, Awasthi S, Wang F, Friedman H. The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo. J Virol. 2011;85:3239-49 pubmed publisher
    b>Herpes simplex virus 1 (HSV-1) glycoprotein E (gE) mediates cell-to-cell spread and functions as an IgG Fc receptor (Fc?R) that blocks the Fc domain of antibody targeting the virus or infected cell...
  8. Lilley C, Chaurushiya M, Boutell C, Everett R, Weitzman M. The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog. 2011;7:e1002084 pubmed publisher
  9. Livingston C, DeLuca N, Wilkinson D, Weller S. Oligomerization of ICP4 and rearrangement of heat shock proteins may be important for herpes simplex virus type 1 prereplicative site formation. J Virol. 2008;82:6324-36 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) DNA replication occurs in replication compartments that form in the nucleus by an ordered process involving a series of protein scaffold intermediates...

More Information

Publications105 found, 100 shown here

  1. Peng H, Nogueira M, Vogel J, Kristie T. Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components. Proc Natl Acad Sci U S A. 2010;107:2461-6 pubmed publisher
    ..This coupling provides a novel function for HCF-1 and insights into the mechanisms of modulating chromatin during DNA replication...
  2. Muylaert I, Zhao Z, Andersson T, Elias P. Identification of conserved amino acids in the herpes simplex virus type 1 UL8 protein required for DNA synthesis and UL52 primase interaction in the virus replisome. J Biol Chem. 2012;287:33142-52 pubmed
    ..Hybrid replisomes derived from herpes simplex virus type 1 (HSV-1) and equine herpesvirus type 1 (EHV-1) failed to support DNA replication in cells...
  3. Tanaka M, Nishiyama Y, Sata T, Kawaguchi Y. The role of protein kinase activity expressed by the UL13 gene of herpes simplex virus 1: the activity is not essential for optimal expression of UL41 and ICP0. Virology. 2005;341:301-12 pubmed
    b>Herpes simplex virus 1 (HSV-1) UL13 is a viral protein kinase that is packaged into virions and regulates optimal expression of ICP0 and a subset of late (gamma) proteins, including UL41 in infected cells...
  4. Thurlow J, Murphy M, Stow N, Preston V. Herpes simplex virus type 1 DNA-packaging protein UL17 is required for efficient binding of UL25 to capsids. J Virol. 2006;80:2118-26 pubmed
    b>Herpes simplex virus type 1 packages its DNA genome into a precursor capsid, referred to as the procapsid...
  5. Lomonte P, Morency E. Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0. FEBS Lett. 2007;581:658-62 pubmed
    The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity...
  6. Chouljenko V, Iyer A, Chowdhury S, Kim J, Kousoulas K. The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB. J Virol. 2010;84:8596-606 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) and the UL20 protein (UL20p) are strictly required for virus-induced cell fusion, and mutations within either the gK or UL20 gene cause extensive cell fusion (syncytium formation)...
  7. Wang L, Liu L, Che Y, Wang L, Jiang L, Dong C, et al. Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein. Virol J. 2010;7:156 pubmed publisher
    ..Together, our data support the notion that biological events mediated by a VP26 - CTMP-7 interaction aid in viral capsid enveloping and egress from the cell during the HSV-1 infectious process...
  8. Lomonte P, Thomas J, Texier P, Caron C, Khochbin S, Epstein A. Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1. J Virol. 2004;78:6744-57 pubmed
    This study describes the physical and functional interactions between ICP0 of herpes simplex virus type 1 and class II histone deacetylases (HDACs) 4, 5, and 7...
  9. Chen Y, Bai P, Mackay S, Korza G, Carson J, Kuchta R, et al. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. J Virol. 2011;85:968-78 pubmed publisher
    ..Importantly, this provides a simple mechanism for generating a two-polymerase replisome at the replication fork. ..
  10. Foster T, Melancon J, Olivier T, Kousoulas K. Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization. J Virol. 2004;78:13262-77 pubmed
    Final envelopment of the cytoplasmic herpes simplex virus type 1 (HSV-1) nucleocapsid is thought to occur by budding into trans-Golgi network (TGN)-derived membranes...
  11. Trus B, Newcomb W, Cheng N, Cardone G, Marekov L, Homa F, et al. Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17 heterodimers to DNA-Filled HSV-1 capsids. Mol Cell. 2007;26:479-89 pubmed
    ..Its binding may signal that the C-capsid is ready to exit the nucleus. ..
  12. Lin F, Ding Q, Guo H, Zheng A. The herpes simplex virus type 1 infected cell protein 22. Virol Sin. 2010;25:1-7 pubmed publisher
    As one of the immediate-early (IE) proteins of herpes simplex virus type 1 (HSV-1), ICP22 is a multifunctional viral regulator that localizes in the nucleus of infected cells...
  13. Loret S, Lippé R. Biochemical analysis of infected cell polypeptide (ICP)0, ICP4, UL7 and UL23 incorporated into extracellular herpes simplex virus type 1 virions. J Gen Virol. 2012;93:624-34 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) capsids assemble in the nucleus but acquire their teguments from various cellular compartments...
  14. Taylor T, Knipe D. Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. J Virol. 2004;78:5856-66 pubmed
    ..and mass spectrometry to identify over 50 cellular and viral proteins that are associated with the herpes simplex virus 1 (HSV-1) ICP8 single-stranded DNA-binding protein...
  15. Li H, Baskaran R, Krisky D, Bein K, Grandi P, Cohen J, et al. Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. Virology. 2008;375:13-23 pubmed publisher
    ICP0 is a multi-functional herpes simplex virus type 1 (HSV-1) immediate-early (IE) gene product that contributes to efficient virus growth and reactivation from latency...
  16. Zhang J, Nagel C, Sodeik B, Lippé R. Early, active, and specific localization of herpes simplex virus type 1 gM to nuclear membranes. J Virol. 2009;83:12984-97 pubmed publisher
    Thirteen different glycoproteins are incorporated into mature herpes simplex virus type 1 (HSV-1) virions. Five of them play important roles during entry, while others intervene during egress of the virus...
  17. Ko D, Cunningham A, Diefenbach R. The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). J Virol. 2010;84:1397-405 pubmed publisher
    In this study a number of herpes simplex virus type 1 (HSV-1) proteins were screened, using a yeast-two-hybrid assay, for interaction with the tegument protein pUL48 (VP16)...
  18. Jin H, Yan Z, Ma Y, Cao Y, He B. A herpesvirus virulence factor inhibits dendritic cell maturation through protein phosphatase 1 and Ikappa B kinase. J Virol. 2011;85:3397-407 pubmed publisher
    ..Deletions or mutations in either domain abolish the activity of ?(1)34.5. These results suggest that the control of I?B kinase dephosphorylation by ?(1)34.5 represents a critical viral mechanism to disrupt dendritic cell functions. ..
  19. Zenner H, Mauricio R, Banting G, Crump C. Herpes simplex virus 1 counteracts tetherin restriction via its virion host shutoff activity. J Virol. 2013;87:13115-23 pubmed publisher
    ..We investigated the tetherin sensitivity and possible countermeasures of herpes simplex virus 1 (HSV-1)...
  20. Mostafa H, Davido D. Herpes simplex virus 1 ICP22 but not US 1.5 is required for efficient acute replication in mice and VICE domain formation. J Virol. 2013;87:13510-9 pubmed publisher
    The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22), is required for efficient replication in restrictive cells, for virus-induced chaperone-enriched (VICE) domain formation, and for normal ..
  21. McGeoch D, Dalrymple M, Davison A, Dolan A, Frame M, McNab D, et al. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol. 1988;69 ( Pt 7):1531-74 pubmed
    We have determined the DNA sequence of the long unique region (UL) in the genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained 107,943 residues and had a base composition of 66.9% G + C...
  22. Douglas M, Diefenbach R, Homa F, Miranda Saksena M, Rixon F, Vittone V, et al. Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. J Biol Chem. 2004;279:28522-30 pubmed
    ..There is increasing evidence that the retrograde transport of herpes simplex virus type 1 along sensory axons is mediated by cytoplasmic dynein, but the viral and cellular proteins involved are ..
  23. Trus B, Cheng N, Newcomb W, Homa F, Brown J, Steven A. Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1. J Virol. 2004;78:12668-71 pubmed
    ..Its architecture resembles those of bacteriophage portal/connector proteins. ..
  24. Döhner K, Radtke K, Schmidt S, Sodeik B. Eclipse phase of herpes simplex virus type 1 infection: Efficient dynein-mediated capsid transport without the small capsid protein VP26. J Virol. 2006;80:8211-24 pubmed
    Cytoplasmic dynein,together with its cofactor dynactin, transports incoming herpes simplex virus type 1 (HSV-1) capsids along microtubules (MT) to the MT-organizing center (MTOC)...
  25. Taddeo B, Roizman B. The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A. J Virol. 2006;80:9341-5 pubmed
    ..Since the GST-mvhs nuclease-defective mutant protein failed to cleave the synthetic RNAs, the results unambiguously attribute the activity to vhs. ..
  26. Kuddus R, DeLuca N. DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4. J Virol. 2007;81:9230-7 pubmed
    The human herpes simplex virus type 1 regulatory protein ICP4 binds DNA as a dimer and forms a single protein-DNA complex (A complex) with short DNA probes...
  27. Foster T, Chouljenko V, Kousoulas K. Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K. J Virol. 2008;82:6310-23 pubmed publisher
    b>Herpes simplex virus type 1 glycoprotein K (gK) and the UL20 protein (UL20p) are coordinately transported to the trans-Golgi network (TGN) and cell surfaces and are required for cytoplasmic virion envelopment at the TGN...
  28. Bryant K, Yan Z, Dreyfus D, Knipe D. Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication. J Virol. 2012;86:6825-34 pubmed publisher
    b>Herpes simplex virus 1 (HSV-1) ICP8 is a single-stranded DNA-binding protein that is necessary for viral DNA replication and exhibits recombinase activity in vitro...
  29. Howard P, Howard T, Johnson D. Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments. J Virol. 2013;87:403-14 pubmed publisher
  30. Nozawa N, Kawaguchi Y, Tanaka M, Kato A, Kato A, Kimura H, et al. Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. J Virol. 2005;79:6947-56 pubmed
    The UL51 gene of herpes simplex virus type 1 (HSV-1) encodes a phosphoprotein whose homologs are conserved throughout the herpes virus family...
  31. Svobodova S, Bell S, Crump C. Analysis of the interaction between the essential herpes simplex virus 1 tegument proteins VP16 and VP1/2. J Virol. 2012;86:473-83 pubmed publisher
    The incorporation of tegument proteins into the herpes simplex virus 1 (HSV-1) virion during virion assembly is thought to be a complex, multistage process occurring via numerous interactions between the tegument and the capsid, within ..
  32. Cun W, Hong M, Liu L, Dong C, Luo J, Li Q. Structural and functional characterization of herpes simplex virus 1 immediate-early protein infected-cell protein 22. J Biochem. 2006;140:67-73 pubmed
    Of the five HSV1 immediate-early proteins, infected-cell protein 22 (ICP22), the product of the Us1 gene, is a member whose function is less understood...
  33. Everett R, Orr A. Herpes simplex virus type 1 regulatory protein ICP0 aids infection in cells with a preinduced interferon response but does not impede interferon-induced gene induction. J Virol. 2009;83:4978-83 pubmed publisher
    ..lines of evidence indicate that interferon-mediated innate responses are involved in controlling herpes simplex virus type 1 (HSV-1) infection and that the viral immediate-early regulatory protein ICP0 augments HSV-1 replication ..
  34. Lilley C, Chaurushiya M, Boutell C, Landry S, Suh J, Panier S, et al. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. EMBO J. 2010;29:943-55 pubmed publisher
    The ICP0 protein of herpes simplex virus type 1 is an E3 ubiquitin ligase and transactivator required for the efficient switch between latent and lytic infection...
  35. Roller R, Bjerke S, Haugo A, Hanson S. Analysis of a charge cluster mutation of herpes simplex virus type 1 UL34 and its extragenic suppressor suggests a novel interaction between pUL34 and pUL31 that is necessary for membrane curvature around capsids. J Virol. 2010;84:3921-34 pubmed publisher
    ..We have previously reported identification of charge cluster mutants of herpes simplex virus type 1 UL34 that localize properly to the inner nuclear membrane, indicating interaction with UL31, but fail ..
  36. Schipke J, Pohlmann A, Diestel R, Binz A, Rudolph K, Nagel C, et al. The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virus. J Virol. 2012;86:3682-700 pubmed publisher
    The largest tegument protein of herpes simplex virus type 1 (HSV1), pUL36, is a multivalent cross-linker between the viral capsids and the tegument and associated membrane proteins during assembly that upon subsequent cell entry releases ..
  37. Gu H, Liang Y, Mandel G, Roizman B. Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proc Natl Acad Sci U S A. 2005;102:7571-6 pubmed
  38. Halford W, Weisend C, Grace J, Soboleski M, Carr D, Balliet J, et al. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J. 2006;3:44 pubmed
    The herpes simplex virus type 1 (HSV-1) ICP0 protein is an E3 ubiquitin ligase, which is encoded within the HSV-1 latency-associated locus. When ICP0 is not synthesized, the HSV-1 genome is acutely susceptible to cellular repression...
  39. Lee C, Bu L, Rennie P, Jia W. An HSV-1 amplicon system for prostate-specific expression of ICP4 to complement oncolytic viral replication for in vitro and in vivo treatment of prostate cancer cells. Cancer Gene Ther. 2007;14:652-60 pubmed publisher
  40. Javouhey E, Gibert B, Arrigo A, Diaz J, Diaz Latoud C. Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein. Virology. 2008;376:31-41 pubmed publisher
    US11 protein, one of herpes simplex virus type 1 (HSV-1) true late gene products, plays a role in the virally induced post-transcriptional control of gene expression...
  41. Cockrell S, Sanchez M, Erazo A, Homa F. Role of the UL25 protein in herpes simplex virus DNA encapsidation. J Virol. 2009;83:47-57 pubmed publisher
    The herpes simplex virus protein UL25 attaches to the external vertices of herpes simplex virus type 1 capsids and is required for the stable packaging of viral DNA...
  42. Cockrell S, Huffman J, Toropova K, Conway J, Homa F. Residues of the UL25 protein of herpes simplex virus that are required for its stable interaction with capsids. J Virol. 2011;85:4875-87 pubmed publisher
    The herpes simplex virus 1 (HSV-1) UL25 gene product is a minor capsid component that is required for encapsidation, but not cleavage, of replicated viral DNA...
  43. Kato A, Liu Z, Minowa A, Imai T, Tanaka M, Sugimoto K, et al. Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells. J Virol. 2011;85:9599-613 pubmed publisher
    Us3 is a serine-threonine protein kinase encoded by herpes simplex virus 1 (HSV-1). We have identified UL47, a major virion protein, as a novel physiological substrate of Us3...
  44. Kalamvoki M, Roizman B. HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation. Proc Natl Acad Sci U S A. 2014;111:E611-7 pubmed publisher
    ..Knockout of STING in mice was reported to exacerbate the pathogenicity of herpes simplex virus 1 (HSV-1)...
  45. Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y. The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids. J Virol. 2008;82:1094-106 pubmed
    The protein encoded by the UL14 gene of herpes simplex virus type 1 (HSV-1) and HSV-2 is expressed late in infection and is a minor component of the virion tegument...
  46. Boutell C, Everett R, Hilliard J, Schaffer P, Orr A, Davido D. Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3 ubiquitin ligase activity of ICP0 in a cell type-dependent manner. J Virol. 2008;82:10647-56 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic infection and the reactivation of quiescent viral genomes from latency...
  47. Xing J, Wu F, Pan W, Zheng C. Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells. Virus Res. 2010;153:71-81 pubmed publisher
  48. Kazlauskas D, Venclovas C. Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase. Bioinformatics. 2014;30:2093-7 pubmed publisher
    ..The role of these enzymes in recovering stalled replication forks suggests mechanistic and functional similarities with herpesviral proteins. venclovas@ibt.lt Supplementary data are available at Bioinformatics online. ..
  49. Boutell C, Sadis S, Everett R. Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro. J Virol. 2002;76:841-50 pubmed
    ..We have previously shown that herpes simplex virus type 1 ICP0, itself a RING finger protein, induces the proteasome-dependent degradation of several cellular ..
  50. Poon A, Benetti L, Roizman B. U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress. J Virol. 2006;80:3752-64 pubmed
    ..5 kinase, the release of virus particles from nuclei was impeded in some cells, suggesting that the U(S)3 kinase affects the modification of the nuclear membrane more efficiently than the U(S)3.5 kinase. ..
  51. Orvedahl A, Alexander D, Talloczy Z, Sun Q, Wei Y, Zhang W, et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe. 2007;1:23-35 pubmed
    ..Here we show that the herpes simplex virus type 1 (HSV-1)-encoded neurovirulence protein ICP34...
  52. Zabierowski S, DeLuca N. Stabilized binding of TBP to the TATA box of herpes simplex virus type 1 early (tk) and late (gC) promoters by TFIIA and ICP4. J Virol. 2008;82:3546-54 pubmed publisher
    ..The stabilized binding of TFIID by TFIIA may in turn allow ICP4 to more efficiently activate transcription from non-INR containing promoters. ..
  53. Gu H, Roizman B. The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. J Virol. 2009;83:181-7 pubmed publisher
    ICP0, an alpha (immediate-early) protein of herpes simplex virus 1, performs at least two key functions...
  54. Daubeuf S, Singh D, Tan Y, Liu H, Federoff H, Bowers W, et al. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009;113:3264-75 pubmed publisher
    ..ICP0 inhibition of the TLR response serves to uncouple the innate and adaptive immune response, thereby playing a key role in HSV pathogenesis and persistence. ..
  55. McGraw H, Awasthi S, Wojcechowskyj J, Friedman H. Anterograde spread of herpes simplex virus type 1 requires glycoprotein E and glycoprotein I but not Us9. J Virol. 2009;83:8315-26 pubmed publisher
    ..We sought to better define the roles of gE, gI, and Us9 in herpes simplex virus type 1 (HSV-1) anterograde spread using a compartmentalized primary neuron culture system...
  56. Leib D, Alexander D, Cox D, Yin J, Ferguson T. Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses. J Virol. 2009;83:12164-71 pubmed publisher
    ..It is critical for the degradation of intracellular pathogens and for promoting antigen presentation. Herpes simplex virus type 1 (HSV-1) infection induces an autophagy response, but this response is antagonized by the HSV-1 ..
  57. Chouljenko V, Iyer A, Chowdhury S, Chouljenko D, Kousoulas K. The amino terminus of herpes simplex virus type 1 glycoprotein K (gK) modulates gB-mediated virus-induced cell fusion and virion egress. J Virol. 2009;83:12301-13 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1)-induced cell fusion is mediated by viral glycoproteins and other membrane proteins expressed on infected cell surfaces...
  58. Guo L, Wu W, Liu L, Wang L, Zhang Y, Wu L, et al. Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb. PLoS ONE. 2012;7:e45749 pubmed publisher
    ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) immediate early protein that functions as a general repressor of a subset of cellular and viral promoters in transient expression systems...
  59. Thurlow J, Rixon F, Murphy M, Targett Adams P, Hughes M, Preston V. The herpes simplex virus type 1 DNA packaging protein UL17 is a virion protein that is present in both the capsid and the tegument compartments. J Virol. 2005;79:150-8 pubmed
    The UL17 protein of herpes simplex virus type 1 is essential for packaging the viral genome into the procapsid, a spherical assembly intermediate, and is present in the mature virus particle...
  60. Yang K, Baines J. The putative terminase subunit of herpes simplex virus 1 encoded by UL28 is necessary and sufficient to mediate interaction between pUL15 and pUL33. J Virol. 2006;80:5733-9 pubmed
    ..Previous results indicated that the putative terminase subunits of herpes simplex virus 1 (HSV-1) encoded by U(L)15 and U(L)28 (designated pU(L)15 and pU(L)28, respectively) coimmunoprecipitate ..
  61. Melroe G, Silva L, Schaffer P, Knipe D. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 2007;360:305-21 pubmed
    ..b>Herpes simplex virus 1 (HSV-1) has been shown to block efficient interferon expression by multiple mechanisms...
  62. Fulmer P, Melancon J, Baines J, Kousoulas K. UL20 protein functions precede and are required for the UL11 functions of herpes simplex virus type 1 cytoplasmic virion envelopment. J Virol. 2007;81:3097-108 pubmed
    Egress of herpes simplex virus type 1 (HSV-1) from the nucleus of the infected cell to extracellular spaces involves a number of distinct steps, including primary envelopment by budding into the perinuclear space, de-envelopment into the ..
  63. Kalamvoki M, Qu J, Roizman B. Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene. J Virol. 2008;82:1701-13 pubmed
    In wild-type herpes simplex virus 1-infected cells, the major regulatory protein ICP4 resides in the nucleus whereas ICP0 becomes dynamically associated with proteasomes and late in infection is translocated and dispersed in the cytoplasm...
  64. Wisner T, Wright C, Kato A, Kawaguchi Y, Mou F, Baines J, et al. Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase. J Virol. 2009;83:3115-26 pubmed publisher
    ..By this packaging, US3 might be brought close to the gB CT tail, leading to phosphorylation and triggering fusion between the virion envelope and the outer NM. ..
  65. Lukashchuk V, Everett R. Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx. J Virol. 2010;84:4026-40 pubmed publisher
    b>Herpes simplex virus type 1 (HSV-1) immediate-early gene product ICP0 activates lytic infection and relieves cell-mediated repression of viral gene expression...
  66. Kalamvoki M, Roizman B. Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes. J Virol. 2010;84:9709-17 pubmed publisher
  67. Wild P, de Oliveira A, Sonda S, Schraner E, Ackermann M, Tobler K. The herpes simplex virus 1 U(S)3 regulates phospholipid synthesis. Virology. 2012;432:353-60 pubmed publisher
    b>Herpes simplex virus type 1 capsids bud at nuclear and Golgi membranes for envelopment by phospholipid bilayers...
  68. Strand S, Leib D. Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis. J Virol. 2004;78:13562-72 pubmed
    The virion host shutoff (vhs) protein of herpes simplex virus type 1 causes the degradation of host and viral mRNA immediately upon infection of permissive cells...
  69. Derakhshan M, Willcocks M, Salako M, Kass G, Carter M. Human herpesvirus 1 protein US3 induces an inhibition of mitochondrial electron transport. J Gen Virol. 2006;87:2155-9 pubmed
    ..Here, it is reported that Human herpesvirus 1 (HHV-1, herpes simplex virus 1) and influenza virus reduced mitochondrial respiration, whilst Measles virus, cytomegalovirus, ..
  70. Jacobson J, Yang K, Baines J, Homa F. Linker insertion mutations in the herpes simplex virus type 1 UL28 gene: effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation. J Virol. 2006;80:12312-23 pubmed
    The UL28 protein of herpes simplex virus type 1 (HSV-1) is one of seven viral proteins required for the cleavage and packaging of viral DNA...
  71. Preston V, Murray J, Preston C, McDougall I, Stow N. The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genome. J Virol. 2008;82:6654-66 pubmed publisher
    Studies on the herpes simplex virus type 1 UL25-null mutant KUL25NS have shown that the capsid-associated UL25 protein is required at a late stage in the encapsidation of viral DNA...
  72. Durand L, Roizman B. Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1. J Virol. 2008;82:10591-9 pubmed publisher
    ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) regulatory protein that regulates the accumulation of a subset of late (gamma(2)) proteins exemplified by U(L)38, U(L)41, and U(S)11...
  73. Snyder A, Polcicova K, Johnson D. Herpes simplex virus gE/gI and US9 proteins promote transport of both capsids and virion glycoproteins in neuronal axons. J Virol. 2008;82:10613-24 pubmed publisher
    ..Our observations suggest that gE/gI and US9 function in the neuron cell body to promote the loading of capsids and glycoprotein-containing vesicles onto microtubule motors that ferry HSV structural components toward axon tips. ..
  74. Leege T, Fuchs W, Granzow H, Kopp M, Klupp B, Mettenleiter T. Effects of simultaneous deletion of pUL11 and glycoprotein M on virion maturation of herpes simplex virus type 1. J Virol. 2009;83:896-907 pubmed publisher
    ..deletion of either gene had only moderate effects on replication of the related alphaherpesviruses herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PrV) in cell culture, simultaneous deletion of both genes resulted in a ..
  75. Mou F, Wills E, Baines J. Phosphorylation of the U(L)31 protein of herpes simplex virus 1 by the U(S)3-encoded kinase regulates localization of the nuclear envelopment complex and egress of nucleocapsids. J Virol. 2009;83:5181-91 pubmed publisher
    b>Herpes simplex virus 1 nucleocapsids bud through the inner nuclear membrane (INM) into the perinuclear space to obtain a primary viral envelope...
  76. Bowman J, Orlando J, Davido D, Kushnir A, Schaffer P. Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. J Virol. 2009;83:8733-43 pubmed publisher
    Of the five herpes simplex virus type 1 immediate early (IE) proteins, the least is known about the function of ICP22 during productive infection and latency...
  77. Maringer K, Elliott G. Recruitment of herpes simplex virus type 1 immediate-early protein ICP0 to the virus particle. J Virol. 2010;84:4682-96 pubmed publisher
    Although the herpes simplex virus type 1 (HSV-1) tegument is comprised of a large number of viral and cellular proteins, how and where in the cell these proteins are recruited into the virus structure is poorly understood...
  78. Albright B, Nellissery J, Szczepaniak R, Weller S. Disulfide bond formation in the herpes simplex virus 1 UL6 protein is required for portal ring formation and genome encapsidation. J Virol. 2011;85:8616-24 pubmed publisher
    The herpes simplex virus 1 (HSV-1) UL6 portal protein forms a 12-subunit ring structure at a unique capsid vertex which functions as a conduit for the encapsidation of the viral genome...
  79. Melancon J, Luna R, Foster T, Kousoulas K. Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopment. J Virol. 2005;79:299-313 pubmed
    Multiple amino acid changes within herpes simplex virus type 1 (HSV-1) gB and gK cause extensive virus-induced cell fusion and the formation of multinucleated cells (syncytia)...
  80. Bowman B, Welschhans R, Jayaram H, Stow N, Preston V, Quiocho F. Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1. J Virol. 2006;80:2309-17 pubmed
    ..The herpes simplex virus type 1 UL25 protein is incorporated into the capsid during DNA packaging, and previous studies of a null ..
  81. Fraser K, Rice S. Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II. J Virol. 2007;81:5091-101 pubmed
    ..We previously showed that herpes simplex virus type 1 (HSV-1) infection rapidly triggers the loss of RNAP II forms bearing serine 2 phosphorylation (Ser-2P ..
  82. Mijatov B, Cunningham A, Diefenbach R. Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37. Virology. 2007;368:26-31 pubmed
    The herpes simplex virus type 1 (HSV-1) structural tegument proteins pUL36 (VP1/2) and pUL37 are essential for secondary envelopment during the egress of viral particles...
  83. Desai P, Sexton G, Huang E, Person S. Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures. J Virol. 2008;82:11354-61 pubmed publisher
    The herpes simplex virus type 1 (HSV-1) UL37 gene encodes a 120-kDa polypeptide which resides in the tegument structure of the virion and is important for morphogenesis...
  84. Roberts A, Abaitua F, O Hare P, McNab D, Rixon F, Pasdeloup D. Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1. J Virol. 2009;83:105-16 pubmed publisher
    Studies with herpes simplex virus type 1 (HSV-1) have shown that secondary envelopment and virus release are blocked in mutants deleted for the tegument protein gene UL36 or UL37, leading to the accumulation of DNA-containing capsids in ..
  85. Bastian T, Rice S. Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression. J Virol. 2009;83:128-39 pubmed publisher
    Previous studies have shown that the herpes simplex virus type 1 (HSV-1) immediate-early protein ICP22 alters the phosphorylation of the host cell RNA polymerase II (Pol II) during viral infection...
  86. Bowman J, Schaffer P. Origin of expression of the herpes simplex virus type 1 protein U(S)1.5. J Virol. 2009;83:9183-94 pubmed publisher
    ICP22, an immediate-early protein of herpes simplex virus type 1 (HSV-1), is required for viral replication in nonpermissive cell types and for expression of a class of late viral proteins which includes glycoprotein C...
  87. O Hara M, Rixon F, Stow N, Murray J, Murphy M, Preston V. Mutational analysis of the herpes simplex virus type 1 UL25 DNA packaging protein reveals regions that are important after the viral DNA has been packaged. J Virol. 2010;84:4252-63 pubmed publisher
    The herpes simplex virus type 1 (HSV-1) UL25 gene encodes a minor capsid protein, pUL25, that is essential for packaging the full-length viral genome...
  88. Page H, Read G. The virion host shutoff endonuclease (UL41) of herpes simplex virus interacts with the cellular cap-binding complex eIF4F. J Virol. 2010;84:6886-90 pubmed publisher
    ..All Vhs proteins that degrade mRNAs associated with eIF4F. However, simply tethering an active endonuclease to eIF4F is not sufficient to degrade mRNAs. Binding to eIF4H may also be required. ..
  89. Dauber B, Pelletier J, Smiley J. The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner. J Virol. 2011;85:5363-73 pubmed publisher
    The herpes simplex virus 1 (HSV-1) virion host shutoff protein (vhs) degrades viral and cellular mRNAs...
  90. Ren Y, Bell S, Zenner H, Lau S, Crump C. Glycoprotein M is important for the efficient incorporation of glycoprotein H-L into herpes simplex virus type 1 particles. J Gen Virol. 2012;93:319-29 pubmed publisher
    b>Herpes simplex virus type 1 glycoprotein M (gM) is a type III membrane protein conserved throughout the family Herpesviridae. However, despite this conservation, gM is classed as a non-essential protein in most alphaherpesviruses...
  91. Shiflett L, Read G. mRNA decay during herpes simplex virus (HSV) infections: mutations that affect translation of an mRNA influence the sites at which it is cleaved by the HSV virion host shutoff (Vhs) protein. J Virol. 2013;87:94-109 pubmed publisher
    ..The results indicate that mutations in an mRNA that affect its translation affect the sites at which it is cut by Vhs and suggest that Vhs is directed to its preferred cut sites during translation initiation. ..
  92. Poon A, Gu H, Roizman B. ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. Proc Natl Acad Sci U S A. 2006;103:9993-8 pubmed
    ..We conclude that the U(S)3 protein kinase blocks histone deacetylation by a mechanism distinct from that of ICP0 and that debilitated histone deacetylation contributes to the permissiveness of U2OS cells for DeltaICP0 mutants. ..