Epstein-Barr virus


Alias: Human herpesvirus 4, Epstein-Barr virus EBV, Human herpesvirus type 4, Epstein-Barr-virus EBV, EPV, HHV-4

Top Publications

  1. Liu H, Chen C, Wu C, Huang Y, Liu S, Liang Y, et al. Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 2012;8:e1002690 pubmed publisher
    ..Collectively, our results not only uncover a novel mechanism underlying LMP1-mediated Cdc42 activation, namely LMP1 interaction with FGD4, but also functionally link FGD4 to NPC tumorigenesis. ..
  2. Zhu J, Liao G, Shan L, Zhang J, Chen M, Hayward G, et al. Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4. J Virol. 2009;83:5219-31 pubmed publisher
    ..We propose that BGLF4 contributes to effective EBV lytic cycle progression, not only through phosphorylation of EBV lytic DNA replication and virion proteins, but also by interfering with the EBNA1 replication function. ..
  3. Lan Y, Hsiao J, Chang K, Chang J, Chen C, Lai H, et al. Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9. J Virol. 2012;86:6656-67 pubmed publisher
  4. Bentz G, Whitehurst C, Pagano J. Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9. J Virol. 2011;85:10144-53 pubmed publisher
    ..We propose that LMP1, by interaction with Ubc9, modulates sumoylation processes, which regulate signal transduction pathways that affect phenotypic changes associated with oncogenesis. ..
  5. Endo K, Shackelford J, Aga M, Yoshizaki T, Pagano J. Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer. J Gen Virol. 2013;94:507-13 pubmed publisher
    ..Taken together, our results suggest that SATB1 functions as a pro-metastatic effector of LMP1 signalling in EBV-positive NPC. ..
  6. Gross H, Barth S, Palermo R, Mamiani A, Hennard C, Zimber Strobl U, et al. Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting. Virology. 2010;397:299-310 pubmed publisher
  7. Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, Pagano J. Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma. Br J Cancer. 2011;104:1160-7 pubmed publisher
    ..This study strengthens the association of EMT with the metastatic behaviour of NPC. These results suggest that induction of Snail by the EBV oncoprotein LMP1 has a pivotal role in EMT in NPC. ..
  8. Saha A, Bamidele A, Murakami M, Robertson E. EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5. J Virol. 2011;85:2079-88 pubmed publisher
    ..This report demonstrates a possible role for the candidate tumor suppressor ING genes in the biology of EBV-associated cancers. ..
  9. Zhao Y, Wang Y, Zeng S, Hu X. LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis. J Clin Pathol. 2012;65:41-5 pubmed publisher
    ..27 (95% CI 1.10 to 4.69) in the random-effects model. LMP1 expression is positively associated with metastasis in NPC, thus LMP1 detection in primary NPC might be an effective and feasible means to predict metastasis. ..

More Information

Publications167 found, 100 shown here

  1. Robinson A, Kwek S, Hagemeier S, Wille C, Kenney S. Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency. J Virol. 2011;85:8940-53 pubmed publisher
    ..These results suggest that Oct-1 acts as a positive regulator of EBV lytic gene expression and that this effect is at least partially mediated through its interaction with the viral protein BRLF1. ..
  2. Matsuura H, Kirschner A, Longnecker R, Jardetzky T. Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex. Proc Natl Acad Sci U S A. 2010;107:22641-6 pubmed publisher
    ..Multiple regions of gH/gL, including its two extreme ends, are functionally important, consistent with the multiple roles of gH/gL in EBV entry. ..
  3. Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, et al. Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. J Virol. 2011;85:11255-64 pubmed publisher
    ..Our findings indicate that LMP1 can induce a CPC-like rather than a CSC-like phenotype in epithelial cells and suggest that LMP1-induced phenotypic changes contribute to the development of NPC. ..
  4. Terrin L, Dal Col J, Rampazzo E, Zancai P, Pedrotti M, Ammirabile G, et al. Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. J Virol. 2008;82:10175-87 pubmed publisher
  5. Maier S, Staffler G, Hartmann A, Höck J, Henning K, Grabusic K, et al. Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol. 2006;80:9761-71 pubmed
  6. Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo C, et al. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010;12:351-61 pubmed publisher
    ..Homologues encoded by other herpesviruses share the deneddylase activity. Thus, these enzymes are likely to have a key function in the virus life cycle by inducing a replication-permissive S-phase-like cellular environment...
  7. Morris M, Dawson C, Wei W, O Neil J, Stewart S, Jia J, et al. Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. J Gen Virol. 2008;89:2806-20 pubmed publisher
    ..Identification of these LMP1-regulated genes helps to define the mechanism(s) by which this oncoprotein influences cellular pathways that regulate terminal differentiation, cell motility and inflammation. ..
  8. Horst D, van Leeuwen D, Croft N, Garstka M, Hislop A, Kremmer E, et al. Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol. 2009;182:2313-24 pubmed publisher
    ..In this way, EBV BNLF2a-mediated evasion from HLA class I-restricted T cell immunity contributes to creating a window for undetected virus production...
  9. Gore M, Hutt Fletcher L. The BDLF2 protein of Epstein-Barr virus is a type II glycosylated envelope protein whose processing is dependent on coexpression with the BMRF2 protein. Virology. 2009;383:162-7 pubmed publisher
  10. Kis L, Takahara M, Nagy N, Klein G, Klein E. IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines. Blood. 2006;107:2928-35 pubmed
  11. Ndour P, Ouk T, Brocqueville G, Mougel A, Vanhecke E, Feuillard J, et al. Inhibition of tumor necrosis factor-induced phenotypes by short intracellular versions of latent membrane protein-1. Cell Signal. 2010;22:303-13 pubmed publisher
    ..These data demonstrate that LMP1 derived molecules can be used to design compounds with potential therapeutic roles in diseases due to TNF overactivation. ..
  12. Rechsteiner M, Berger C, Zauner L, Sigrist J, Weber M, Longnecker R, et al. Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection. J Virol. 2008;82:1739-47 pubmed
    ..Thus, our findings suggest that LMP2B negatively regulates the function of LMP2A in preventing the switch from latent to lytic EBV replication. ..
  13. Pan S, Tai C, Lin C, Hsu W, Chou S, Lai C, et al. Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. Carcinogenesis. 2009;30:366-75 pubmed publisher
    ..Together, these studies reveal a new function of EBNA2 in cell-cycle regulation and may shed light on the role of EBNA2 in EBV-mediated tumorigenesis...
  14. Heather J, Flower K, Isaac S, Sinclair A. The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1. J Gen Virol. 2009;90:1450-4 pubmed publisher
  15. Han Z, Marendy E, Wang Y, Yuan J, Sample J, Swaminathan S. Multiple roles of Epstein-Barr virus SM protein in lytic replication. J Virol. 2007;81:4058-69 pubmed
    ..Thus, SM plays a role in multiple steps of lytic cycle EBV gene expression and that it is transcript-specific in both activation and repression functions. ..
  16. Verweij F, van Eijndhoven M, Hopmans E, Vendrig T, Wurdinger T, Cahir McFarland E, et al. LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-?B activation. EMBO J. 2011;30:2115-29 pubmed publisher
    The ubiquitous Epstein Barr virus (EBV) exploits human B-cell development to establish a persistent infection in ?90% of the world population...
  17. Tan E, Sam C. Biological properties of TW01 cells expressing latent membrane protein-1 gene of EBV-derived from nasopharyngeal carcinoma cells at different stages of malignancy. Exp Oncol. 2007;29:166-74 pubmed
    ..It could be inferred from the present study that LMP1 genes derived from two patients with different stages of NPC differed in their gene sequences that manifested in distinct biological properties. ..
  18. Rowe M, Glaunsinger B, van Leeuwen D, Zuo J, Sweetman D, Ganem D, et al. Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion. Proc Natl Acad Sci U S A. 2007;104:3366-71 pubmed
    ..This effect could lead to escape from T cell recognition and elimination of EBV-producing cells, thereby allowing generation of viral progeny in the face of memory T cell responses. ..
  19. Meckes D, Menaker N, Raab Traub N. Epstein-Barr virus LMP1 modulates lipid raft microdomains and the vimentin cytoskeleton for signal transduction and transformation. J Virol. 2013;87:1301-11 pubmed publisher
    ..These findings indicate that LMP1 reorganizes membrane and cytoskeleton microdomains to modulate signal transduction. ..
  20. Rovedo M, Longnecker R. Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity. J Virol. 2007;81:84-94 pubmed
    ..A restoration of Lyn levels, but not a change in LMP2A levels, was also observed in cells coexpressing LMP2B with LMP2A. From these results, we conclude that LMP2B modulates LMP2A activity. ..
  21. Li R, Wang L, Liao G, Guzzo C, Matunis M, Zhu H, et al. SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function. J Virol. 2012;86:5412-21 pubmed publisher
    ..Thus, SUMO binding by BGLF4 modulates BGLF4 function and affects the efficiency of lytic EBV replication. ..
  22. Kung C, Meckes D, Raab Traub N. Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta. J Virol. 2011;85:4399-408 pubmed publisher
    ..These findings indicate that LMP1 activates multiple distinct signaling pathways and suggest that PKC? functions as a master regulator of EGFR, STAT3, and ERK activation by LMP1-CTAR1. ..
  23. Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, et al. Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell Lymphoma, nasal type (ENKL): differences in biologic and clinical behaviors of LMP1-positive and -negative ENKL. Clin Cancer Res. 2012;18:2164-72 pubmed publisher
    ..3% and 12.5%, respectively (P = 0.001, log-rank test). LMP1 expression shows correlations with phosphorylation of RelA and Akt and possibly has a favorable impact on clinical outcome in ENKL. ..
  24. Chen Y, Liu M, Chang Y, Wu C, Hu C, Chen J. Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells. J Virol. 2008;82:8124-37 pubmed publisher
    ..These results suggest that LMP1 triggers the PI3K/Akt pathway to inactivate FOXO3a and decrease DDB1, which can lead to repression of DNA repair and may contribute to genomic instability in human epithelial cells. ..
  25. Touitou R, O Nions J, Heaney J, Allday M. Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells. J Gen Virol. 2005;86:1269-77 pubmed
    ..In actively proliferating lymphoblastoid cell lines, EBNAs 3A, 3B and 3C appear to be remarkably stable, with no evidence of either de novo synthesis or proteasome-mediated degradation. ..
  26. Chang L, Liu S, Kuo C, Wang W, Chuang J, Bianchi E, et al. Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM. J Mol Biol. 2008;379:231-42 pubmed publisher
    ..This fact explains why the expression of RanBPM enhances the transactivation activity of Rta. Taken together, the present results indicate a new role of RanBPM in regulating a viral protein that is critical to EBV lytic activation. ..
  27. Wang J, Doong S, Teng S, Lee C, Tsai C, Chen M. Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway. J Virol. 2009;83:1856-69 pubmed publisher
    ..The data presented here thus suggest a novel mechanism by which herpesviral protein kinases suppress host innate immune responses and facilitate virus replication. ..
  28. Wen W, Iwakiri D, Yamamoto K, Maruo S, Kanda T, Takada K. Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes. J Virol. 2007;81:1037-42 pubmed
  29. Park R, Heston L, Shedd D, Delecluse H, Miller G. Mutations of amino acids in the DNA-recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments. Virology. 2008;382:145-62 pubmed publisher
    ..Furthermore, these mutant ZEBRA proteins delineate several stages in the processes of nuclear re-organization which accompany lytic EBV replication. ..
  30. Zuo J, Currin A, Griffin B, Shannon Lowe C, Thomas W, Ressing M, et al. The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation. PLoS Pathog. 2009;5:e1000255 pubmed publisher
  31. Anastasiadou E, Boccellato F, Vincenti S, Rosato P, Bozzoni I, Frati L, et al. Epstein-Barr virus encoded LMP1 downregulates TCL1 oncogene through miR-29b. Oncogene. 2010;29:1316-28 pubmed publisher
  32. Wang H, Nicholas M, Conway K, Sen P, Diz R, Tisch R, et al. EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. J Immunol. 2006;177:2793-802 pubmed
    ..These data further implicate TLRs in the etiology of SLE and suggest a mechanistic link between EBV infection and SLE. ..
  33. Chang L, Wang J, Doong S, Lee C, Chang C, Tsai C, et al. Epstein-Barr virus BGLF4 kinase downregulates NF-?B transactivation through phosphorylation of coactivator UXT. J Virol. 2012;86:12176-86 pubmed publisher
    ..Taking the data together, transcription involving UXT may also be important for EBV lytic protein expression, whereas BGLF4-mediated phosphorylation of UXT at Thr3 plays a critical role in promoting the lytic cycle. ..
  34. Gastaldello S, Chen X, Callegari S, Masucci M. Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells. PLoS Pathog. 2013;9:e1003664 pubmed publisher
  35. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006;281:7863-72 pubmed
    ..These results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK. However, TAK1 is not an exclusive intermediate for NF-kappaB activation in LMP1 signaling. ..
  36. Liu Y, Tan Y, Wang Z, Zeng L, Lu Z, Li L, et al. Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Int J Mol Med. 2008;21:153-62 pubmed
  37. Lucchesi W, Brady G, Dittrich Breiholz O, Kracht M, Russ R, Farrell P. Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol. 2008;82:7456-66 pubmed publisher
    ..The results indicate that differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2 may be the basis for the much weaker B-cell transformation activity of type 2 Epstein-Barr virus strains compared to type 1 strains...
  38. Maruo S, Wu Y, Ito T, Kanda T, Kieff E, Takada K. Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth. Proc Natl Acad Sci U S A. 2009;106:4419-24 pubmed publisher
  39. Feederle R, Mehl Lautscham A, Bannert H, Delecluse H. The Epstein-Barr virus protein kinase BGLF4 and the exonuclease BGLF5 have opposite effects on the regulation of viral protein production. J Virol. 2009;83:10877-91 pubmed publisher
    ..The BGLF4/BGLF5 enzyme pair builds a regulatory loop that allows fine-tuning of virus protein production, which is required for efficient viral replication. ..
  40. Song Y, Kang M. Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation. Virus Genes. 2010;41:174-80 pubmed publisher
    ..Taken together, LMP1 activates alternative NF-kappaB pathway through functional NIK and IKKalpha that is regulated by TRAF2 or TRAF3. ..
  41. Desbien A, Kappler J, Marrack P. The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim. Proc Natl Acad Sci U S A. 2009;106:5663-8 pubmed publisher
    ..Thus, BHRF1 does not act by simply absorbing the excess Bim produced while cells prepare for death. Rather, BHRF1 may act either by binding preferentially the most lethal form of Bim or by acting catalytically on Bim to block apoptosis. ..
  42. Mancao C, Hammerschmidt W. Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival. Blood. 2007;110:3715-21 pubmed
  43. Knight J, Sharma N, Robertson E. Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase. Proc Natl Acad Sci U S A. 2005;102:18562-6 pubmed
    ..That EBNA3C has exploited this association suggests that other human malignancies might use a similar strategy to regulate the Rb protein. ..
  44. Hino R, Uozaki H, Inoue Y, Shintani Y, Ushiku T, Sakatani T, et al. Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A. Cancer Res. 2008;68:1427-35 pubmed publisher
  45. Reimer J, Backovic M, Deshpande C, Jardetzky T, Longnecker R. Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis. J Virol. 2009;83:734-47 pubmed publisher
    ..The mutations generated here indicate important structural domains, as well as regions important for function in fusion, within EBV gB. ..
  46. Kalla M, Schmeinck A, Bergbauer M, Pich D, Hammerschmidt W. AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. Proc Natl Acad Sci U S A. 2010;107:850-5 pubmed publisher
    ..Our data indicate that the viral BZLF1 protein is crucial both to establish latency and to escape from it. Our data also indicate that EBV has evolved to appropriate its host's mode of methylating DNA for its own epigenetic regulation. ..
  47. Kong Q, Hu L, Cao J, Huang Y, Xu L, Liang Y, et al. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog. 2010;6:e1000940 pubmed publisher
    ..Taken together, our data indicate that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC...
  48. Rowe C, Matsuura H, Jardetzky T, Longnecker R. Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42). Virology. 2011;415:122-31 pubmed publisher
    ..Using purified gp42, gH/gL, and HLA, we found these proteins associate 1:1:1 by gel filtration suggesting that gp42 dimerization or multimerization does not occur or is a transient event undetectable by our methods. ..
  49. Li R, Zhu J, Xie Z, Liao G, Liu J, Chen M, et al. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe. 2011;10:390-400 pubmed publisher
    ..Identification of key cellular targets of the conserved herpesvirus kinases will facilitate the development of broadly effective antiviral strategies...
  50. Iempridee T, Das S, Xu I, Mertz J. Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. J Virol. 2011;85:7836-48 pubmed publisher
    ..We conclude that TGF-? induces EBV lytic reactivation via the canonical Smad pathway by activating BZLF1 gene expression through multiple SBEs acting in concert. ..
  51. Arcipowski K, Bishop G. TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1. J Immunol. 2012;189:5165-70 pubmed publisher
    ..These data suggest that TRAF-mediated signaling pathways, such as those of LMP1, may be more diverse than previously appreciated. This finding has significant implications for receptor and TRAF-targeted therapies. ..
  52. Liu S, Wang W, Hong Y, Chuang J, Lu P, Chang L. Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta. Virus Res. 2006;119:163-70 pubmed
  53. Lee C, Chen J, Wang J, Kimura K, Takemoto A, Lu C, et al. Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II. J Virol. 2007;81:5166-80 pubmed
  54. Backovic M, Jardetzky T, Longnecker R. Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity. J Virol. 2007;81:9596-600 pubmed
    ..These data demonstrate that the bulky and hydrophobic EBV loop residues, which differ from the more hydrophilic HSV-1 residues and appear more compatible with membrane insertion, are essential for EBV gB-dependent fusion. ..
  55. Anderson L, Longnecker R. An auto-regulatory loop for EBV LMP2A involves activation of Notch. Virology. 2008;371:257-66 pubmed
    ..The observation that LMP2A activates its own promoter suggests that LMP2A exploits the Notch pathway in order to control its own expression and may explain EBNA2-independent expression of LMP2A in EBV-associated malignancies. ..
  56. Huang S, Hsieh M, Chen C, Chen Y, Chen J, Chen M, et al. Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3? arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity. J Gen Virol. 2012;93:139-49 pubmed publisher
    ..Based on these results, we hypothesize that through the disruption of CDK1 and CDK2 activities, EBV Rta might contribute to cell cycle arrest in EBV-infected epithelial cells during viral reactivation. ..
  57. Wu L, Nakano H, Wu Z. The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem. 2006;281:2162-9 pubmed
    ..Thus, LMP1 utilizes two distinct pathways to activate NF-kappaB: a major one through CTAR2/TRAF6/TAK1/IKKbeta (canonical pathway) and a minor one through CTAR1/TRAF3/NIK/IKKalpha (noncanonical pathway). ..
  58. Huye L, Ning S, Kelliher M, Pagano J. Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol. 2007;27:2910-8 pubmed
    ..We suggest that RIP may serve as a general activator of IRF7, responding to and transmitting the signals from various stimuli, and that ubiquitination may be a general mechanism for enhancing the activity of IRF7. ..
  59. Cameron J, Yin Q, Fewell C, Lacey M, McBride J, Wang X, et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol. 2008;82:1946-58 pubmed
  60. Le Clorennec C, Ouk T, Youlyouz Marfak I, Panteix S, Martin C, Rastelli J, et al. Molecular basis of cytotoxicity of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in EBV latency III B cells: LMP1 induces type II ligand-independent autoactivation of CD95/Fas with caspase 8-mediated apoptosis. J Virol. 2008;82:6721-33 pubmed publisher
  61. Chen J, Hu C, Hou J, Shao Q, Yan L, Zhu X, et al. Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma. J Transl Med. 2010;8:30 pubmed publisher
    ..These results suggest that the mTOR signaling pathway is regulated by LMP1 expression in NPC. LMP1 and the genes in the mTOR pathway such as p-P70S6K and p-4EBP1 may be potential prognostic biomarkers. ..
  62. Verma D, Bais S, Gaillard M, Swaminathan S. Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J Virol. 2010;84:11781-9 pubmed publisher
    ..These data suggest a model whereby SM, a viral protein, recruits and co-opts the function of cellular SRp20 in alternative splicing. ..
  63. Zuo J, Quinn L, Tamblyn J, Thomas W, Feederle R, Delecluse H, et al. The Epstein-Barr virus-encoded BILF1 protein modulates immune recognition of endogenously processed antigen by targeting major histocompatibility complex class I molecules trafficking on both the exocytic and endocytic pathways. J Virol. 2011;85:1604-14 pubmed publisher
    ..The results also emphasize the merits of including functional T cell recognition assays to gain a more complete picture of immunoevasin effects on the antigen presentation pathway. ..
  64. Horst D, Favaloro V, Vilardi F, van Leeuwen H, Garstka M, Hislop A, et al. EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP. J Immunol. 2011;186:3594-605 pubmed publisher
    ..These results illustrate how EBV exploits a cellular pathway for TA protein biogenesis to achieve immune evasion, and they highlight the exquisite adaptation of this virus to its host...
  65. Yu H, Lu J, Zuo L, Yan Q, Yu Z, Li X, et al. Epstein-Barr virus downregulates microRNA 203 through the oncoprotein latent membrane protein 1: a contribution to increased tumor incidence in epithelial cells. J Virol. 2012;86:3088-99 pubmed publisher
    ..Inhibitors of Jun N-terminal protein kinase (JNK) and NF-?B blocked miR-203 downregulation. These results imply that EBV promotes malignancy by downregulating cellular miR-203, which contributes to the etiology of NPC. ..
  66. Chen A, Zhao B, Kieff E, Aster J, Wang F. EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J Virol. 2006;80:10139-50 pubmed
  67. Anderton E, Yee J, Smith P, Crook T, White R, Allday M. Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma. Oncogene. 2008;27:421-33 pubmed publisher
    ..Our results may also explain the selection pressure that gives rise to a subset of BL that retain expression of the EBNA3 proteins...
  68. Lo A, To K, Lo K, Lung R, Hui J, Liao G, et al. Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci U S A. 2007;104:16164-9 pubmed
    ..The data provide insight into the discrepancy between LMP1 transcript and protein detection in NPC and highlight the role of the EBV miRNAs in regulating LMP1 downstream signaling to promote cancer development. ..
  69. Zhao B, Mar J, Maruo S, Lee S, Gewurz B, Johannsen E, et al. Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 2011;108:337-42 pubmed publisher
    ..EBNA3C also up-regulated MYC 1.3-fold and down-regulated CDKN2A exons 2 and 3, shared by p16 and p14, 1.4-fold, with false discovery rates < 5 × 10(-4). ..
  70. Horst D, Burmeister W, Boer I, van Leeuwen D, Buisson M, Gorbalenya A, et al. The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection. J Virol. 2012;86:9175-87 pubmed publisher
    ..These findings extend our understanding of the molecular basis for the shutoff function of BGLF5 that is conserved in gammaherpesviruses but not in alpha- and betaherpesviruses. ..
  71. Chiu S, Wu M, Wu C, Chen Y, Lin S, Hsu J, et al. Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle. J Virol. 2014;88:4962-75 pubmed publisher
    ..These findings identify a novel viral gene with an important role in contributing to a better understanding of the EBV life cycle. ..
  72. Barth S, Pfuhl T, Mamiani A, Ehses C, Roemer K, Kremmer E, et al. Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. Nucleic Acids Res. 2008;36:666-75 pubmed
    ..Our results are compatible with the notion that EBV-miR-BART2 inhibits transition from latent to lytic viral replication. ..
  73. van Gent M, Griffin B, Berkhoff E, van Leeuwen D, Boer I, Buisson M, et al. EBV lytic-phase protein BGLF5 contributes to TLR9 downregulation during productive infection. J Immunol. 2011;186:1694-702 pubmed publisher
    ..Reducing the levels of a pattern-recognition receptor capable of sensing the presence of EBV provides a mechanism by which the virus could obstruct host innate antiviral responses. ..
  74. Shair K, Bendt K, Edwards R, Nielsen J, Moore D, Raab Traub N. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. J Virol. 2012;86:5352-65 pubmed publisher
    ..This study is the first to characterize the effects of LMP2 on tumor initiation and promotion and to identify an effect of the combined expression of LMP1 and LMP2 on the increase of carcinoma development. ..
  75. Liao G, Huang J, Fixman E, Hayward S. The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor. J Virol. 2005;79:245-56 pubmed
    ..The data also suggest that BBLF2/3 may serve as a contact interface for cell proteins involved in replication of EBV oriLyt. ..
  76. Boccellato F, Anastasiadou E, Rosato P, Kempkes B, Frati L, Faggioni A, et al. EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells. J Virol. 2007;81:2274-82 pubmed
    ..These findings suggest that EBNA2 interferes with the GC phenotype. ..
  77. Tsai C, Li H, Lu Y, Hsueh C, Liang Y, Chen C, et al. Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling. Cancer Res. 2006;66:11668-76 pubmed
    ..38%), suggesting that overexpression of these proteins is observed in NPC tumor. Overall, these results support a mechanistic link between JNK-AP-1 signaling and DNA methylation induced by the EBV oncogene product LMP1. ..
  78. Li D, Qian L, Chen C, Shi M, Yu M, Hu M, et al. Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation. J Immunol. 2009;182:1799-809 pubmed publisher
    ..The data indicate that Zta may act as an inhibitor of the MHC class II pathway, suppressing CIITA transcription and thus interfering with the expression of MHC class II molecules...
  79. Park R, Wang ondu R, Heston L, Shedd D, Miller G. Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog. J Biol Chem. 2011;286:9748-62 pubmed publisher
    ..We discuss conformational changes in the mutant viral AP-1 proteins that may lead to formation of nuclear aggresomes. ..
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    ..These findings illustrate how the carboxy-terminal domain of LMP1 supports survival of B cells in the presence of the deleterious effects of the complex regulation of this viral oncogene. ..
  81. Paschos K, Parker G, Watanatanasup E, White R, Allday M. BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV. Nucleic Acids Res. 2012;40:7233-46 pubmed publisher
    ..B cell lines carrying EBV encoding a conditional EBNA3C-oestrogen receptor-fusion revealed that this epigenetic repression of BIM was reversible, but took more than 3 weeks from when EBNA3C was inactivated. ..
  82. Fotheringham J, Coalson N, Raab Traub N. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through ?v-integrin membrane translocation. J Virol. 2012;86:10308-20 pubmed publisher
    ..The specific effects of LMP2A on an integrin with a diverse repertoire of ligand specificities could promote migration of different cell types and be initiated by multiple chemoattractants. ..
  83. Nagamine M, Takahara M, Kishibe K, Nagato T, Ishii H, Bandoh N, et al. Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma. Virus Genes. 2007;34:47-54 pubmed
  84. Thornburg N, Raab Traub N. Induction of epidermal growth factor receptor expression by Epstein-Barr virus latent membrane protein 1 C-terminal-activating region 1 is mediated by NF-kappaB p50 homodimer/Bcl-3 complexes. J Virol. 2007;81:12954-61 pubmed
    ..The distinct forms of NF-kappaB that are induced by LMP1 CTAR1 likely activate distinct cellular genes. ..
  85. Motsch N, Pfuhl T, Mrazek J, Barth S, Grässer F. Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol. 2007;4:131-7 pubmed
    ..It is possible that the induction of miR-146a plays a role in the induction or maintenance of EBV latency by modulating innate immune responses to the virus infected host cell. ..
  86. Lee C, Huang Y, Lin S, Chang Y, Chang Y, Takada K, et al. Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion production. J Virol. 2008;82:11913-26 pubmed publisher
    ..UL kinases of alpha- and betaherpesviruses also induce the disassembly of the nuclear lamina through similar sites on lamin A/C, suggesting a conserved mechanism for the nuclear egress of herpesviruses. ..
  87. Feederle R, Bannert H, Lips H, Müller Lantzsch N, Delecluse H. The Epstein-Barr virus alkaline exonuclease BGLF5 serves pleiotropic functions in virus replication. J Virol. 2009;83:4952-62 pubmed publisher
    ..The present study provides an overview of BGLF5's functions that will guide future molecular studies. We anticipate that the 293/DeltaBGLF5 cell line will be instrumental in such developments...
  88. Verma D, Ling C, Johannsen E, Nagaraja T, Swaminathan S. Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein. J Virol. 2009;83:8041-50 pubmed publisher
    ..These data indicate that feedback regulation of immediate-early and early genes occurs during the lytic cycle of EBV regulation. ..
  89. Meng Q, Hagemeier S, Kuny C, Kalejta R, Kenney S. Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant. J Virol. 2010;84:4524-33 pubmed publisher
    ..These results suggest that essential roles of EBV-PK during lytic viral replication include the phosphorylation and dispersion of lamin A/C. ..
  90. Zuercher E, Butticaz C, Wyniger J, Martinez R, Battegay M, Boffi El Amari E, et al. Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-?b activation. PLoS ONE. 2012;7:e32168 pubmed publisher
  91. Fukuda M, Longnecker R. Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway. J Virol. 2007;81:9299-306 pubmed
    ..These results suggest that constitutive activation of the Ras/PI3-K/Akt pathway by LMP2A is a key factor for LMP2A-mediated transformation. ..
  92. Wu L, Fossum E, Joo C, Inn K, Shin Y, Johannsen E, et al. Epstein-Barr virus LF2: an antagonist to type I interferon. J Virol. 2009;83:1140-6 pubmed publisher
    ..This demonstrates a novel immune evasion mechanism of EBV LF2 in blocking cellular IRF7-mediated innate immunity. ..