Tick-borne encephalitis virus

Summary

Alias: tick-borne encephalitis virus TBEV, TBEV, tick-borne encephalitis virus TBE virus, FSME virus

Top Publications

  1. Stadler K, Allison S, Schalich J, Heinz F. Proteolytic activation of tick-borne encephalitis virus by furin. J Virol. 1997;71:8475-81 pubmed
    ..In vivo, prM cleavage was blocked by a furin inhibitor, and infection of the furin-deficient cell line LoVo yielded only immature virions, suggesting that furin is essential for cleavage activation of flaviviruses. ..
  2. Lorenz I, Allison S, Heinz F, Helenius A. Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum. J Virol. 2002;76:5480-91 pubmed
  3. Schrauf S, Kurz M, Taucher C, Mandl C, Skern T. Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease. J Gen Virol. 2012;93:504-515 pubmed publisher
    Mature protein C of tick-borne encephalitis virus (TBEV) is cleaved from the polyprotein precursor by the viral NS2B/3 protease (NS2B/3(pro))...
  4. Reperant L, Brown I, Haenen O, de Jong M, Osterhaus A, Papa A, et al. Companion Animals as a Source of Viruses for Human Beings and Food Production Animals. J Comp Pathol. 2016;155:S41-53 pubmed publisher
    ..The current list of viruses provides an objective basis for more in-depth analysis of the risk of companion animals as sources of viruses for human and food production animal health. ..
  5. Carod Artal F. Infectious diseases causing autonomic dysfunction. Clin Auton Res. 2018;28:67-81 pubmed publisher
    ..Autonomic dysfunction may be responsible for additional morbidity in some infectious diseases. ..
  6. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..This optimized liquid array detection system was high-throughput and highly specific and sensitive in screening of the insect-borne pathogens. It was promising in detection of these pathogens for molecular epidemiological studies. ..
  7. Elkhateeb E, Tag El Din Hassan H, Sasaki N, Torigoe D, Morimatsu M, Agui T. The role of mouse 2',5'-oligoadenylate synthetase 1 paralogs. Infect Genet Evol. 2016;45:393-401 pubmed publisher
    ..However, the role of other paralogs is unknown and should wait for further investigation. ..
  8. Dai S, Zhang Y, Zhang T, Zhang B, Wang H, Deng F. Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening. Viruses. 2018;10: pubmed publisher
    ..including Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), and tick-borne encephalitis virus (TBEV)...
  9. Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, et al. Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles. J Virol. 2018;92: pubmed publisher
    ..GBF1 is a key protein in the cellular secretory pathway and is essential in the life cycle of many viruses, also targeted by viperin, implicating GBF1 as a novel putative drug target. ..

More Information

Publications182 found, 100 shown here

  1. Gerold G, Bruening J, Weigel B, Pietschmann T. Protein Interactions during the Flavivirus and Hepacivirus Life Cycle. Mol Cell Proteomics. 2017;16:S75-S91 pubmed publisher
    ..Finally, we will give a perspective on future challenges in Flaviviridae interaction proteomics and why we believe these challenges should be met. ..
  2. Tavernier P, Sys S, De Clercq K, De Leeuw I, Caij A, De Baere M, et al. Serologic screening for 13 infectious agents in roe deer (Capreolus capreolus) in Flanders. Infect Ecol Epidemiol. 2015;5:29862 pubmed publisher
    ..Nevertheless, their meaning as sentinels should not be neglected in the absence of other wild cervid species. ..
  3. Clarke B, Roby J, Slonchak A, Khromykh A. Functional non-coding RNAs derived from the flavivirus 3' untranslated region. Virus Res. 2015;206:53-61 pubmed publisher
    ..West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Murray Valley encephalitis virus (MVEV)...
  4. Liang G, Li X, Gao X, Fu S, Wang H, Li M, et al. Arboviruses and their related infections in China: A comprehensive field and laboratory investigation over the last 3 decades. Rev Med Virol. 2017;: pubmed publisher
  5. Ai J, Xie Z, Liu G, Chen Z, Yang Y, Li Y, et al. Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. BMC Infect Dis. 2017;17:494 pubmed publisher
    ..antibody against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum...
  6. Boucher A, Herrmann J, Morand P, Buzelé R, Crabol Y, Stahl J, et al. Epidemiology of infectious encephalitis causes in 2016. Med Mal Infect. 2017;47:221-235 pubmed publisher
    ..g., measles). ..
  7. Kuchuloria T, Imnadze P, Mamuchishvili N, Chokheli M, Tsertsvadze T, Endeladze M, et al. Hospital-Based Surveillance for Infectious Etiologies Among Patients with Acute Febrile Illness in Georgia, 2008-2011. Am J Trop Med Hyg. 2016;94:236-42 pubmed publisher
    ..West Nile virus (WNV), Crimean-Congo hemorrhagic fever virus, Coxiella burnetii, tick-borne encephalitis virus (TBEV), hantavirus, Salmonella enterica serovar Typhi (S. Typhi), and Rickettsia typhi...
  8. Jarmer J, Zlatkovic J, Tsouchnikas G, Vratskikh O, Strauß J, Aberle J, et al. Variation of the specificity of the human antibody responses after tick-borne encephalitis virus infection and vaccination. J Virol. 2014;88:13845-57 pubmed publisher
    ..Our study provides new insights into the immune response to an important human pathogen that is of relevance for the design of novel vaccines. ..
  9. Lindblom A, Wallménius K, Sjöwall J, Fryland L, Wilhelmsson P, Lindgren P, et al. Prevalence of Rickettsia spp. in Ticks and Serological and Clinical Outcomes in Tick-Bitten Individuals in Sweden and on the Åland Islands. PLoS ONE. 2016;11:e0166653 pubmed publisher
    ..and Borrelia spp., in accordance with previous studies in Sweden. Symptoms of rickettsial disease were in most of the cases vague and general that were difficult to differentiate from other tick-borne diseases. ..
  10. Yun S, Lee Y, Choi W, Kim H, Chong S, Chang K, et al. Molecular detection of severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses in ixodid ticks collected from vegetation, Republic of Korea, 2014. Ticks Tick Borne Dis. 2016;7:970-978 pubmed publisher
    ..nested RT-PCR for the detection of severe fever with thrombocytopenia virus (SFTSV), tick-borne encephalitis virus (TBEV), Powassan virus (POWV), Omsk hemorrhagic fever virus (OHFV), and Langat virus (LGTV)...
  11. Da Rold G, Ravagnan S, Soppelsa F, Porcellato E, Soppelsa M, Obber F, et al. Ticks are more suitable than red foxes for monitoring zoonotic tick-borne pathogens in northeastern Italy. Parasit Vectors. 2018;11:137 pubmed publisher
    ..The high prevalence of Babesia cf. microti in foxes and its absence in ticks strongly suggests that I. ricinus is not the vector of this pathogen. ..
  12. Leonova G, Kondratov I, Maystrovskaya O, Takashima I, Belikov S. Louping ill virus (LIV) in the Far East. Arch Virol. 2015;160:663-73 pubmed publisher
    ..e. the British subtype (LIV-Brit). The possibility is discussed of a single introduction of the virus to the Far Eastern region (Japan and Primorsky Krai) from a single natural locus more than 50 years ago. ..
  13. Földvári G, Siroký P, Szekeres S, Majoros G, Sprong H. Dermacentor reticulatus: a vector on the rise. Parasit Vectors. 2016;9:314 pubmed publisher
    ..reticulatus. ..
  14. Matsuda M, Yamanaka A, Yato K, Yoshii K, Watashi K, Aizaki H, et al. High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon. Sci Rep. 2018;8:16624 pubmed publisher
    ..The assay may also contribute to the evaluation of vaccine efficacy and assist in routine surveillance and outbreak response to flaviviruses. ..
  15. Khasnatinov M, Liapunov A, Manzarova E, Kulakova N, Petrova I, Danchinova G. The diversity and prevalence of hard ticks attacking human hosts in Eastern Siberia (Russian Federation) with first description of invasion of non-endemic tick species. Parasitol Res. 2016;115:501-10 pubmed publisher
    ..Phylogenetic analysis of mt 16S rRNA gene fragments suggests multiple independent routes of tick migration to Eastern Siberia. Possible implications to human health and epidemiology of tick-borne infections are discussed. ..
  16. Marlina S, Radzi S, Lani R, Sieng K, Rahim N, Hassan H, et al. Seroprevalence screening for the West Nile virus in Malaysia's Orang Asli population. Parasit Vectors. 2014;7:597 pubmed publisher
  17. Potokar M, Jorgacevski J, Zorec R. Astrocytes in Flavivirus Infections. Int J Mol Sci. 2019;20: pubmed publisher
    ..on the responses of astrocytes to infection by neurotropic flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), and Japanese encephalitis virus (JEV), which have all been confirmed to ..
  18. Jaenson T, Petersson E, Jaenson D, Kindberg J, Pettersson J, Hjertqvist M, et al. The importance of wildlife in the ecology and epidemiology of the TBE virus in Sweden: incidence of human TBE correlates with abundance of deer and hares. Parasit Vectors. 2018;11:477 pubmed publisher
    ..ricinus and created new TBEV foci, which resulted in increased incidence of human TBE...
  19. Izuogu A, McNally K, Harris S, Youseff B, Presloid J, Burlak C, et al. Interferon signaling in Peromyscus leucopus confers a potent and specific restriction to vector-borne flaviviruses. PLoS ONE. 2017;12:e0179781 pubmed publisher
    ..leucopus will yield mechanistic insight into efficient control of virus replication and may inform the development of antiviral therapeutics. ..
  20. Mansfield K, Cook C, Ellis R, Bell Sakyi L, Johnson N, Alberdi P, et al. Tick-borne pathogens induce differential expression of genes promoting cell survival and host resistance in Ixodes ricinus cells. Parasit Vectors. 2017;10:81 pubmed publisher
    ..However, the tick cellular responses to infection with the flaviviruses tick-borne encephalitis virus (TBEV) and louping ill virus (LIV), which cause tick-borne encephalitis and louping ill respectively, are less clear...
  21. Egyed L, Rónai Z, Dan A. Hungarian tick-borne encephalitis viruses isolated from a 0.5-ha focus are closely related to Finnish strains. Ticks Tick Borne Dis. 2018;9:1064-1068 pubmed publisher
    ..These isolates obviously have a common origin and are probably connected by migrating birds. These are the first published complete Hungarian TBEV sequences.
  22. Rigaud E, Jaulhac B, Garcia Bonnet N, Hunfeld K, Femenia F, Huet D, et al. Seroprevalence of seven pathogens transmitted by the Ixodes ricinus tick in forestry workers in France. Clin Microbiol Infect. 2016;22:735.e1-9 pubmed publisher
    ..tularensis by ticks and a different west/east distribution of Babesia species in France. The frequency and potential severity of these diseases justify continued promotion of methods of prevention of I. ricinus bites. ..
  23. Oechslin C, Heutschi D, Lenz N, Tischhauser W, Péter O, Rais O, et al. Prevalence of tick-borne pathogens in questing Ixodes ricinus ticks in urban and suburban areas of Switzerland. Parasit Vectors. 2017;10:558 pubmed publisher
    ..Carriage of multiple pathogens was repeatedly observed, demonstrating the risk of acquiring multiple infections as a consequence of a tick bite. ..
  24. Zohaib A, Sarfraz A, Kaleem Q, Ye J, Mughal M, Navid M, et al. The Yin and Yang of Antiviral Innate Immunity in Central Nervous System. Curr Pharm Des. 2016;22:648-55 pubmed
    ..Louis encephalitis virus (SLEV), La Crosse virus, tick borne encephalitis virus (TEBE) and polio virus...
  25. Monticelli J, Geremia N, D Agaro P, Petix V, Luzzati R. Aseptic central nervous system infections in adults: what predictor for unknown etiological diagnosis?. Neurol Sci. 2018;39:863-870 pubmed publisher
    ..We suggest that potential infectious agents causing undiagnosed cases should be investigated among non-bacterial, non-opportunistic, and non-seasonal organisms. ..
  26. Barzon L. Ongoing and emerging arbovirus threats in Europe. J Clin Virol. 2018;107:38-47 pubmed publisher
    ..The identification of emerging outbreaks is however challenging and requires a high degree of awareness and laboratory capacity, especially for the most neglected but potentially threatening pathogens. ..
  27. Blazevic J, Rouha H, Bradt V, Heinz F, Stiasny K. Membrane Anchors of the Structural Flavivirus Proteins and Their Role in Virus Assembly. J Virol. 2016;90:6365-6378 pubmed publisher
    ..Our data thus provide new insights into the biological functions of E TMDs and extend their role during viral polyprotein processing to additional functions in particle assembly and maturation. ..
  28. Tkachev S, Tikunov A, Babkin I, Livanova N, Livanov S, Panov V, et al. Occurrence and genetic variability of Kemerovo virus in Ixodes ticks from different regions of Western Siberia, Russia and Kazakhstan. Infect Genet Evol. 2017;47:56-63 pubmed publisher
    ..and East Kazakhstan province (Kazakhstan) were analyzed for the presence of KEMV and tick-borne encephalitis virus (TBEV) RNA...
  29. Miorin L, Maiuri P, Marcello A. Visual detection of Flavivirus RNA in living cells. Methods. 2016;98:82-90 pubmed publisher
    ..Conclusions driven by this approached are discussed in the wider context Flavivirus infection. ..
  30. Rastogi M, Sharma N, Singh S. Flavivirus NS1: a multifaceted enigmatic viral protein. Virol J. 2016;13:131 pubmed publisher
    ..of this group include dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus tick borne encephalitis virus and Zika Virus. These are endemic in many parts of the world...
  31. Fevola C, Kuivanen S, Smura T, Vaheri A, Kallio Kokko H, Hauffe H, et al. Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. J Med Virol. 2017;: pubmed publisher
    ..were the most common causative agents of neurological infections in Finland. No LCMV or LV infections were detected. We conclude there was no association of LV with neurological diseases in this patient cohort...
  32. Ciliberti A, Gavier Widén D, Yon L, Hutchings M, Artois M. Prioritisation of wildlife pathogens to be targeted in European surveillance programmes: Expert-based risk analysis focus on ruminants. Prev Vet Med. 2015;118:271-84 pubmed publisher
    ..This work highlights the relevance of developing such lists for preparedness. ..
  33. Narankhajid M, Yeruult C, Gurbadam A, Battsetseg J, Aberle S, Bayartogtokh B, et al. Some aspects on tick species in Mongolia and their potential role in the transmission of equine piroplasms, Anaplasma phagocytophilum and Borrelia burgdorferi L. Parasitol Res. 2018;117:3557-3566 pubmed publisher
    ..In addition, zoonotic agents such as the avian B. garinii and A. phagocytophilum were also detected, outlining a high risk for exposed humans. ..
  34. Beran J, Lattanzi M, Xie F, Moraschini L, Galgani I. Second five-year follow-up after a booster vaccination against tick-borne encephalitis following different primary vaccination schedules demonstrates at least 10 years antibody persistence. Vaccine. 2018;: pubmed publisher
    ..Here, we report anti-TBE virus (TBEV) antibody persistence from 6 to 10 years post-booster administration...
  35. Grygorczuk S, Czupryna P, Pancewicz S, Swierzbinska R, Kondrusik M, Dunaj J, et al. Intrathecal expression of IL-5 and humoral response in patients with tick-borne encephalitis. Ticks Tick Borne Dis. 2018;9:896-911 pubmed publisher
    ..to assess the role of an early specific humoral response in human infection with a tick-borne encephalitis virus (TBEV) and the role of IL-5 as its potential mediator and marker...
  36. Leonova G, Belikov S, Kondratov I. Characteristics of far eastern strains of tick-borne encephalitis virus. Arch Virol. 2017;162:2211-2218 pubmed publisher
    ..biological, molecular and genetic characteristics of a collection of ten strains of tick-borne encephalitis virus (TBEV) isolated in Primorsky Krai before 1960 and stored in a lyophilized state for a prolonged period (over 65 years) ..
  37. Krbková L, Štroblová H, Bednářová J. Clinical course and sequelae for tick-borne encephalitis among children in South Moravia (Czech Republic). Eur J Pediatr. 2015;174:449-58 pubmed publisher
    ..blood cells, protein, impairment of blood-cerebrospinal fluid (CSF) barrier and tick-borne encephalitis virus (TBEV)-specific antibodies. Subjective complaints and objective neurological deficits were investigated...
  38. Talactac M, Yoshii K, Maeda H, Kusakisako K, Hernandez E, Tsuji N, et al. Virucidal activity of Haemaphysalis longicornis longicin P4 peptide against tick-borne encephalitis virus surrogate Langat virus. Parasit Vectors. 2016;9:59 pubmed publisher
    ..Lastly, while the in vitro virucidal capacity of longicin P4 was confirmed in this study, the role of the endogenous tick longicin in the antiviral defense of H. longicornis against LGTV still remains to be demonstrated. ..
  39. Černý J, Selinger M, Palus M, Vavrušková Z, Tykalová H, Bell Sakyi L, et al. Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells. Virus Genes. 2016;52:309-16 pubmed publisher
    ..reading frame (uORF) was recently identified in the 5' untranslated region of some tick-borne encephalitis virus (TBEV) strains. However, it is not known if the peptide encoded by TBEV uORF (TuORF) is expressed in infected cells...
  40. Stoltz M, Sundström K, Hidmark Ã, Tolf C, Vene S, Ahlm C, et al. A model system for in vitro studies of bank vole borne viruses. PLoS ONE. 2011;6:e28992 pubmed publisher
    ..Corresponding infections with CPXV and LV induced IFN-β but not Mx2, while TBEV induced both IFN-β and Mx2...
  41. Krylova N, Smolina T, Leonova G. Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains. Viral Immunol. 2015;28:272-81 pubmed publisher
    Although studies have established that immune mechanisms are important in controlling tick-borne encephalitis virus (TBEV) infection, the interactions of different TBEV strains with cells of innate and adaptive immunity are not well ..
  42. Stock N, Escadafal C, Achazi K, Cissé M, Niedrig M. Development and characterization of polyclonal peptide antibodies for the detection of Yellow fever virus proteins. J Virol Methods. 2015;222:110-6 pubmed publisher
    ..The antisera described in this study offer new possibilities for use in YFV research and for the development of novel diagnostic tests. ..
  43. Paillard L, Jones K, Evans A, Berret J, Jacquet M, Lienhard R, et al. Serological signature of tick-borne pathogens in Scandinavian brown bears over two decades. Parasit Vectors. 2015;8:398 pubmed publisher
    ..to Borrelia burgdorferi sensu lato, the causative agent of Lyme borreliosis, and tick-borne encephalitis virus (TBEV) had increased over time...
  44. Brackney D, Armstrong P. Transmission and evolution of tick-borne viruses. Curr Opin Virol. 2016;21:67-74 pubmed publisher
    ..In addition, remaining questions and future directions for research are discussed. ..
  45. Pressman E. Heterocomplexes of tick-borne encephalitis structural and non-structural proteins. FEBS Lett. 1993;333:268-70 pubmed
    ..Also, the trimer E-NS1-NS3 can be isolated. It is proposed that this trimer is the viral replicative complex. ..
  46. Haviernik J, Stefanik M, Fojtíková M, Kali S, Tordo N, Rudolf I, et al. Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses. Viruses. 2018;10: pubmed publisher
    ..72 ± 0.19 µM. Antiviral activities and acceptable cytotoxicity profiles suggest that arbidol could be a promising candidate for further investigation as a potential therapeutic agent in selective treatment of flaviviral infections. ..
  47. Stupica D, Strle F, Avšič Županc T, Logar M, Pečavar B, Bajrović F. Tick borne encephalitis without cerebrospinal fluid pleocytosis. BMC Infect Dis. 2014;14:614 pubmed publisher
    ..The disease caused by European subtype of tick borne encephalitis virus has typically a biphasic clinical course with the second phase presenting as meningitis, ..
  48. Muto M, Bazartseren B, Tsevel B, Dashzevge E, Yoshii K, Kariwa H. Isolation and characterization of tick-borne encephalitis virus from Ixodes persulcatus in Mongolia in 2012. Ticks Tick Borne Dis. 2015;6:623-9 pubmed publisher
    Tick-borne encephalitis virus (TBEV) is a zoonotic virus belonging to the genus Flavivirus, in the family Flaviviridae. The virus, which is endemic in Europe and northern parts of Asia, causes severe encephalitis...
  49. Levanov L, Vera C, Vapalahti O. Prevalence estimation of tick-borne encephalitis virus (TBEV) antibodies in dogs from Finland using novel dog anti-TBEV IgG MAb-capture and IgG immunofluorescence assays based on recombinant TBEV subviral particles. Ticks Tick Borne Dis. 2016;7:979-982 pubmed publisher
    ..Serological assays for diagnosis of TBE in dogs are mainly based on purified and inactivated TBEV antigens...
  50. Elyan D, Moustafa L, NOORMAL B, Jacobs J, Aziz M, Hassan K, et al. Serological evidence of flaviviruses infection among acute febrile illness patients in Afghanistan. J Infect Dev Ctries. 2014;8:1176-80 pubmed publisher
    ..in 2008 through 2010 to determine the seroepidemiology of West Nile virus (WNV), tick-borne encephalitis virus (TBEV) and dengue viruses (DENV) using commercial ELISA kits...
  51. Calzolari M, Zé Zé L, Vázquez A, Sánchez Seco M, Amaro F, Dottori M. Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects. Infect Genet Evol. 2016;40:381-388 pubmed publisher
  52. Csank T, Bhide K, Bencúrová E, Dolinská S, Drzewnioková P, Major P, et al. Detection of West Nile virus and tick-borne encephalitis virus in birds in Slovakia, using a universal primer set. Arch Virol. 2016;161:1679-83 pubmed publisher
    ..was detected in swab and brain samples, whereas one brain sample was positive for tick-borne encephalitis virus (TBEV). The WNV sequences clustered with lineages 1 and 2...
  53. Barkhash A, Babenko V, Voevoda M, Romaschenko A. [Polymorphism of CD209 and TLR3 genes in populations of North Eurasia]. Genetika. 2016;52:697-704 pubmed
    ..We suggested that predisposition to tick-borne encephalitis in Central Asian Mongoloid populations can be predetermined by a different set of genes and their polymorphisms than in the Russian population. ..
  54. Barkhash A, Yurchenko A, Yudin N, Ignatieva E, Kozlova I, Borishchuk I, et al. A matrix metalloproteinase 9 (MMP9) gene single nucleotide polymorphism is associated with predisposition to tick-borne encephalitis virus-induced severe central nervous system disease. Ticks Tick Borne Dis. 2018;9:763-767 pubmed publisher
    ..3%; P = 0.01), as well as with the population control group (32.5%; P = 0.042). The results suggest that the MMP9 gene may affect genetic predisposition to TBE in a Russian population. ..
  55. MickienÄ— A, PakalnienÄ— J, Nordgren J, Carlsson B, Hagbom M, Svensson L, et al. Polymorphisms in chemokine receptor 5 and Toll-like receptor 3 genes are risk factors for clinical tick-borne encephalitis in the Lithuanian population. PLoS ONE. 2014;9:e106798 pubmed publisher
    Tick-borne encephalitis virus (TBEV) infections can be asymptomatic or cause moderate to severe injuries of the nervous system...
  56. Zöldi V, Papp T, Rigó K, Farkas J, Egyed L. A 4-year study of a natural tick-borne encephalitis virus focus in Hungary, 2010-2013. Ecohealth. 2015;12:174-82 pubmed publisher
    ..For survival, the virus needs a territory with continuously dense rodent and tick population, although observed TBEV prevalence was low both in ticks and in rodents...
  57. Bílý T, Palus M, Eyer L, Elsterová J, Vancová M, Růžek D. Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons. Sci Rep. 2015;5:10745 pubmed publisher
    Tick-borne encephalitis virus (TBEV) causes serious, potentially fatal neurological infections that affect humans in endemic regions of Europe and Asia. Neurons are the primary target for TBEV infection in the central nervous system...
  58. Klaus C, Gethmann J, Hoffmann B, Ziegler U, Heller M, Beer M. Tick infestation in birds and prevalence of pathogens in ticks collected from different places in Germany. Parasitol Res. 2016;115:2729-40 pubmed publisher
    ..Additionally, ticks collected from birds were examined for several pathogens: Tick-borne encephalitis virus (TBEV) and Sindbisvirus with real-time RT-PCR, Flaviviruses, Simbuviruses and Lyssaviruses with broad-range standard RT-..
  59. Kjelland V, Paulsen K, Rollum R, Jenkins A, Stuen S, Soleng A, et al. Tick-borne encephalitis virus, Borrelia burgdorferi sensu lato, Borrelia miyamotoi, Anaplasma phagocytophilum and Candidatus Neoehrlichia mikurensis in Ixodes ricinus ticks collected from recreational islands in southern Norway. Ticks Tick Borne Dis. 2018;9:1098-1102 pubmed publisher
    ..In all, 4158 questing Ixodes ricinus ticks were analyzed. For detection of tick-borne encephalitis virus (TBEV), nymphs (3690) were analyzed in pools of ten. To detect Borrelia burgdorferi sensu lato, B...
  60. Adelshin R, Melnikova O, Karan L, Andaev E, Balakhonov S. Complete Genome Sequences of Four European Subtype Strains of Tick-Borne Encephalitis Virus from Eastern Siberia, Russia. Genome Announc. 2015;3: pubmed publisher
    Three tick-borne encephalitis virus (TBEV) strains were isolated from Ixodes persulcatus ticks, and one was isolated from a shrew in the territory of eastern Siberia (Russia)...
  61. Sormunen J, Klemola T, Vesterinen E, Vuorinen I, Hytönen J, Hänninen J, et al. Assessing the abundance, seasonal questing activity, and Borrelia and tick-borne encephalitis virus (TBEV) prevalence of Ixodes ricinus ticks in a Lyme borreliosis endemic area in Southwest Finland. Ticks Tick Borne Dis. 2016;7:208-215 pubmed publisher
    ..ricinus abundance, seasonal questing activity, and their Borrelia spp. and tick-borne encephalitis virus (TBEV) prevalence were evaluated in a Lyme borreliosis endemic area in Southwest Finland, Seili Island, where a previous ..
  62. Palus M, Sohrabi Y, Broman K, Strnad H, Síma M, Ruzek D, et al. A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus. BMC Neurosci. 2018;19:39 pubmed publisher
    ..We have previously found that BALB/c mice exhibit intermediate susceptibility to the infection of TBE virus (TBEV), STS mice are highly resistant, whereas the recombinant congenic strain CcS-11, carrying 12...
  63. Lieskovská J, Páleníková J, Širmarová J, Elsterová J, Kotsyfakis M, Campos Chagas A, et al. Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells. Parasite Immunol. 2015;37:70-8 pubmed publisher
    ..In summary, we present here that tick salivary cystatin negatively affects IFN-β responses which may consequently increase the pathogen load after transmission via tick saliva. ..
  64. Kazarina A, Japiņa K, Keišs O, Salmane I, Bandere D, Capligina V, et al. Detection of tick-borne encephalitis virus in I. ricinus ticks collected from autumn migratory birds in Latvia. Ticks Tick Borne Dis. 2015;6:178-80 pubmed publisher
    ..removed during autumn 2010 from 55 birds belonging to 10 species for the presence of tick-borne encephalitis virus (TBEV). In total, TBEV RNA was detected in 14% of I. ricinus tick samples obtained from different birds species...
  65. Nakayasu M, Hirano M, Muto M, Kobayashi S, Kariwa H, Yoshii K. Development of a serodiagnostic IgM-ELISA for tick-borne encephalitis virus using subviral particles with strep-tag. Ticks Tick Borne Dis. 2018;9:1391-1394 pubmed publisher
    Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans...
  66. Drelich A, Andreassen Ã, Vainio K, KruszyÅ„ski P, WÄ…sik T. Prevalence of tick-borne encephalitis virus in a highly urbanized and low risk area in Southern Poland. Ticks Tick Borne Dis. 2014;5:663-7 pubmed publisher
    The knowledge of the exact distribution of tick-borne encephalitis virus (TBEV) endemic foci is crucial to plan and implement the optimal prevention of tick-borne encephalitis (TBE), including a vaccination program...
  67. Rieille N, Bressanelli S, Freire C, Arcioni S, Gern L, Péter O, et al. Prevalence and phylogenetic analysis of tick-borne encephalitis virus (TBEV) in field-collected ticks (Ixodes ricinus) in southern Switzerland. Parasit Vectors. 2014;7:443 pubmed publisher
    ..Western Europe, the castor bean tick, Ixodes ricinus, is the principal vector of the tick-borne encephalitis virus (TBEV)...
  68. Tezcan S, Kızıldamar S, Ulger M, Aslan G, Tiftik N, Ozkul A, et al. [Flavivirus seroepidemiology in blood donors in Mersin province, Turkey]. Mikrobiyol Bul. 2014;48:606-17 pubmed
    Among the vector-borne flaviviruses, West Nile virus (WNV), tick-borne encephalitis virus (TBEV) and Dengue virus (DENV) constitute the most frequently-observed pathogens with significant public health impact in endemic regions throughout ..
  69. Ehlen L, Tödtmann J, Specht S, Kallies R, Papies J, Muller M, et al. Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses. Virol J. 2016;13:74 pubmed publisher
    ..fever virus (RVFV), vesicular stomatitis virus (VSV), West Nile virus (WNV), and tick-borne encephalitis virus (TBEV) was tested...
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    ..primary neural cultures from different brain regions in response to infection with tick-borne encephalitis virus (TBEV), West Nile virus (WNV), and Zika virus (ZIKV)...
  71. Mohd Shukri M, Ling Kho K, Ghane Kisomi M, Lani R, Marlina S, Muhd Radzi S, et al. Seroprevalence report on tick-borne encephalitis virus and Crimean-Congo hemorrhagic fever virus among Malaysian's farm workers. BMC Public Health. 2015;15:704 pubmed publisher
    Tick-borne encephalitis virus (TBEV) and Crimean-Congo haemorrhagic fever virus (CCHFV) are important tick-borne viruses...
  72. Chernokhaeva L, Rogova Y, Vorovitch M, Romanova L, Kozlovskaya L, Maikova G, et al. Protective immunity spectrum induced by immunization with a vaccine from the TBEV strain Sofjin. Vaccine. 2016;34:2354-61 pubmed publisher
    ..The TBE virus (TBEV) includes three main subtypes: European, Siberian and Far-Eastern, and two new Asiatic variants, phylogenetically ..
  73. Nikitin A, Morozov I. [Exoskeleton anomalies among taiga tick males from populations of the Asiatic part of Russia]. Parazitologiia. 2017;51:38-44 pubmed
    ..Schulze, 1930) is the main and most epidemiologically dangerous vector of tick-born encephalitis virus (TBEV) and Borrelia in most parts of Russia's territory (Alekseev et al., 2008)...
  74. Cuber P, Andreassen Ã, Vainio K, Asman M, Dudman S, Szilman P, et al. Risk of exposure to ticks (Ixodidae) and the prevalence of tick-borne encephalitis virus (TBEV) in ticks in Southern Poland. Ticks Tick Borne Dis. 2015;6:356-63 pubmed publisher
    ..the results of the first study on seasonal activity of ticks and prevalence of tick-borne encephalitis virus (TBEV) in nymphs from the Silesian Province (Southern Poland)...
  75. Veje M, Nolskog P, Petzold M, Bergström T, Lindén T, Peker Y, et al. Tick-Borne Encephalitis sequelae at long-term follow-up: a self-reported case-control study. Acta Neurol Scand. 2016;134:434-441 pubmed publisher
    Tick-borne encephalitis (TBE), caused by the TBE virus (TBEV), is a major neurotropic infection throughout Europe and Asia, with a considerable risk of neurological sequelae...
  76. Jensen B, Ocias L, Andersen N, Dessau R, Krogfelt K, Skarphedinsson S. [Tick-borne infections in Denmark]. Ugeskr Laeger. 2017;179: pubmed
    ..These tick-borne infections should be a differential diagnostic consideration during the tick season in Denmark. We review the distribution, clinical manifestations, diagnosis and treatment of these microorganisms. ..
  77. Talactac M, Yoshii K, Hernandez E, Kusakisako K, Galay R, Fujisaki K, et al. Synchronous Langat Virus Infection of Haemaphysalis longicornis Using Anal Pore Microinjection. Viruses. 2017;9: pubmed publisher
    The tick-borne encephalitis virus (TBEV) serocomplex of flaviviruses consists of arboviruses that cause important diseases in animals and humans...
  78. Krylova N, Leonova G, Maystrovskaya O, Popov A, Artyukov A. Mechanisms of Antiviral Activity of the Polyphenol Complex from Seagrass of the Zosteraceae Family against Tick-Borne Encephalitis Virus. Bull Exp Biol Med. 2018;: pubmed publisher
    ..Antiviral action of the test compound is determined by direct inactivation of the virus and inhibition of virus replication at the early stage, which attests to potential of this compound in the treatment of tick-borne encephalitis. ..
  79. Balling A, Plessow U, Beer M, Pfeffer M. Prevalence of antibodies against tick-borne encephalitis virus in wild game from Saxony, Germany. Ticks Tick Borne Dis. 2014;5:805-9 pubmed publisher
    ..TBE) is the most important tick-transmitted viral disease in Europe and is caused by the flavivirus TBE-virus (TBEV)...
  80. Ershova A, Gra O, Lyaschuk A, Grunina T, Tkachuk A, Bartov M, et al. Recombinant domains III of Tick-Borne Encephalitis Virus envelope protein in combination with dextran and CpGs induce immune response and partial protectiveness against TBE virus infection in mice. BMC Infect Dis. 2016;16:544 pubmed
    E protein of tick-borne encephalitis virus (TBEV) and other flaviviruses is located on the surface of the viral particle...
  81. Eyer L, Kondo H, Zouharova D, Hirano M, Valdes J, Muto M, et al. Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness. J Virol. 2017;91: pubmed publisher
    Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available...
  82. Weisheit S, Villar M, Tykalová H, Popara M, Loecherbach J, Watson M, et al. Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis. Parasit Vectors. 2015;8:599 pubmed publisher
    ..and proteomes of two Ixodes spp cell lines infected with the flavivirus tick-borne encephalitis virus (TBEV) were analysed...
  83. Teterina N, Maximova O, Kenney H, Liu G, Pletnev A. MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives. Antiviral Res. 2016;127:57-67 pubmed publisher
    ..strategy to control the neurovirulent phenotype of a model chimeric tick-borne encephalitis/dengue type 4 virus (TBEV/DEN4), containing the structural protein genes of a highly virulent TBEV in the genetic backbone of non-..
  84. Sakai M, Muto M, Hirano M, Kariwa H, Yoshii K. Virulence of tick-borne encephalitis virus is associated with intact conformational viral RNA structures in the variable region of the 3'-UTR. Virus Res. 2015;203:36-40 pubmed publisher
    Tick-borne encephalitis virus (TBEV) is maintained between ticks and mammals in nature and causes severe neurological disease in human. However, the mechanism of viral pathogenicity is unknown...
  85. Ignatieva E, Igoshin A, Yudin N. A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection. BMC Evol Biol. 2017;17:259 pubmed publisher
    Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness...
  86. Zlobin V, Pogodina V, Kahl O. A brief history of the discovery of tick-borne encephalitis virus in the late 1930s (based on reminiscences of members of the expeditions, their colleagues, and relatives). Ticks Tick Borne Dis. 2017;8:813-820 pubmed publisher
  87. Fuzik T, Formanová P, Ruzek D, Yoshii K, Niedrig M, Plevka P. Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. Nat Commun. 2018;9:436 pubmed publisher
    Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown...
  88. Weissbach F, Hirsch H. Comparison of Two Commercial Tick-Borne Encephalitis Virus IgG Enzyme-Linked Immunosorbent Assays. Clin Vaccine Immunol. 2015;22:754-60 pubmed publisher
    Despite the availability of protective vaccines, tick-borne encephalitis virus (TBEV) infections have been increasingly reported to the European Centre for Disease Prevention and Control in the past 2 decades...
  89. Jääskeläinen A, Tonteri E, Pieninkeroinen I, Sironen T, Voutilainen L, Kuusi M, et al. Siberian subtype tick-borne encephalitis virus in Ixodes ricinus in a newly emerged focus, Finland. Ticks Tick Borne Dis. 2016;7:216-223 pubmed publisher
    ..Three Siberian subtype TBE virus (TBEV) strains were isolated from the ticks and three mammals were positive for TBEV antibodies...
  90. Zhang X, Zheng Z, Shu B, Mao P, Bai B, Hu Q, et al. Isolation and characterization of a Far-Eastern strain of tick-borne encephalitis virus in China. Virus Res. 2016;213:6-10 pubmed publisher
    Tick-borne encephalitis virus (TBEV) is a leading cause of human neurological infection in many parts of Europe and Asia...
  91. Nagy A, Nagy O, Tarcsai K, Farkas A, Takacs M. First detection of tick-borne encephalitis virus RNA in clinical specimens of acutely ill patients in Hungary. Ticks Tick Borne Dis. 2018;9:485-489 pubmed publisher
    Tick-borne encephalitis virus (TBEV) is one of the endemic flaviviruses in Hungary, which is responsible for human infections every year...
  92. Kunze U. The International Scientific Working Group on Tick-Borne Encephalitis (ISW TBE): Review of 17 years of activity and commitment. Ticks Tick Borne Dis. 2016;7:399-404 pubmed publisher
    ..Group has been composed of internationally recognized scientific experts from tick-borne encephalitis virus (TBEv)-endemic and non-endemic regions with extensive personal expertise in the field and a high level of commitment to ..