Dengue virus

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Top Publications

  1. Onyango C, Loparev V, Lidechi S, Bhullar V, Schmid D, Radford K, et al. Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections. J Clin Microbiol. 2017;55:2035-2044 pubmed publisher
    ..pneumoniae, Mycobacterium tuberculosis, and Bartonella), and 13 viruses (parechovirus, dengue virus, Nipah virus, varicella-zoster virus, mumps virus, measles virus, lyssavirus, herpes simplex viruses 1 and 2, ..
  2. Grice I, Mariottini G. Glycans with Antiviral Activity from Marine Organisms. Results Probl Cell Differ. 2018;65:439-475 pubmed publisher
    ..marine-sourced glycans have exhibited antiviral activity against African swine fever virus, cytomegalovirus, dengue virus, Epstein-Barr virus, encephalomyocarditis virus, human immunodeficiency virus, hepatitis C virus, herpes ..
  3. Deng Y, Zeng L, Bao W, Xu P, Zhong G. [Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016;28:106-9 pubmed publisher
    ..for Disease Control and Prevention (CDC) on February 7th and Chinese CDC on February 9th, respectively, though Dengue virus were negative reported by Ganzhou CDC on February 6th...
  4. van Weelden M, Viola G, Kozu K, Aikawa N, Ivo C, Silva C. [Disseminated histoplamosis in adolescent mimicking granulomatosis with polyangiitis]. Rev Bras Reumatol. 2015;: pubmed publisher
    ..Serologic test for hepatitis, cytomegalovirus, human immunodeficiency virus, Epstein-Barr virus, toxoplasmosis, dengue virus and antistreptolysin O were all negative...
  5. Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016;16:653-660 pubmed publisher
    ..The virus was not detected in their urine or serum. Tests for dengue virus, chikungunya virus, Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus, HIV, Treponema ..
  6. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..signal intensity without any cross-hybridization for the other insect-borne pathogens tested, which included dengue virus, tick-borne encephalitis virus, Japanese encephalitis virus, Xinjiang hemorrhagic fever virus, spotted fever ..
  7. Demir T, Kilic S. Zika virus: a new arboviral public health problem. Folia Microbiol (Praha). 2016;61:523-527 pubmed
    ..Virus is closely related with other flaviviruses; dengue virus, yellow fever virus, West Nile virus, and Japanese encephalitis virus phylogenetically...
  8. Smith J, Jeng S, McWeeney S, Hirsch A. A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. J Virol. 2017;91: pubmed publisher
    ..The recent reemergence and spread of flaviviruses, including dengue virus (DENV), West Nile virus (WNV), and Zika virus (ZIKV), highlight the importance of performing basic research on ..
  9. Lin H, Yip B, Huang L, Wu S. Zika virus structural biology and progress in vaccine development. Biotechnol Adv. 2018;36:47-53 pubmed publisher
    ..With its compact surface, ZIKV is more thermally stable than the dengue virus (DENV). ZIKV E proteins have a characteristic "herringbone" structure with a single glycosylation site...

More Information

Publications307 found, 100 shown here

  1. Pattabhi S, Wilkins C, Dong R, Knoll M, Posakony J, Kaiser S, et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015;90:2372-87 pubmed publisher
    ..load in cultured cells that were infected with viruses of the family Flaviviridae, including West Nile virus, dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (..
  2. Tan L, Wang J, Zeng F, Zhang Y, Fang C, Nie C, et al. [Analysis of clinical characteristics of the 12 cases of neonatal dengue fever in Guangzhou in 2014 and literatures review]. Zhonghua Er Ke Za Zhi. 2015;53:943-7 pubmed
    ..The course of disease is mild, lack of specific clinical symptoms, and the prognosis is good. Mother to infant vertical transmission of dengue virus is one of the ways of transmission.
  3. Gerold G, Bruening J, Weigel B, Pietschmann T. Protein Interactions during the Flavivirus and Hepacivirus Life Cycle. Mol Cell Proteomics. 2017;16:S75-S91 pubmed publisher
    ..b>Dengue virus, Zika virus and hepatitis C virus belong to the most prominent human pathogenic Flaviviridae With a ..
  4. Chen M, Aoki Utsubo C, Kameoka M, Deng L, Terada Y, Kamitani W, et al. Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane. Sci Rep. 2017;7:15931 pubmed publisher
    Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae...
  5. Freire J, Rego de Figueiredo I, Valle J, Veiga A, Andreu D, Enguita F, et al. siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model. J Control Release. 2017;245:127-136 pubmed publisher
    ..approach in which the siRNA is delivered by pepM or pepR, two cell-penetrating peptides (CPPs) derived from the dengue virus capsid protein. These peptides have a dual role: siRNA delivery into cells and direct action as bioportides, i...
  6. Sheng Z, Gao N, Wang Z, Cui X, Zhou D, Fan D, et al. Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis. Front Cell Infect Microbiol. 2017;7:272 pubmed publisher
    Flaviviruses including Dengue virus (DENV), Yellow fever virus (YFV), West Nile virus (WNV), and Japanese encephalitis virus (JEV) are global health problems that caused several serious diseases such as fever, hemorrhagic fever, and ..
  7. Wang J, Chen S, Liao Y, Zhang E, Feng S, Yu S, et al. Mitogen-activated Protein Kinase Kinase 2 (MEK2), a Novel E2-interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway. J Virol. 2016;: pubmed
    ..is involved in the replication of several members of the Flaviviridae family including hepatitis C virus and dengue virus. The effects of the cascade on the replication of classical swine fever virus (CSFV), a fatal pestivirus of ..
  8. Tamura T, Fukuhara T, Uchida T, Ono C, Mori H, Sato A, et al. Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag. J Virol. 2018;92: pubmed publisher
    ..We successfully generated recombinant viruses carrying the split-luciferase gene, including dengue virus, Japanese encephalitis virus, hepatitis C virus (HCV), and bovine viral diarrhea virus...
  9. Baharuddin A, Hassan A, Sheng G, Nasir S, Othman S, Yusof R, et al. Current approaches in antiviral drug discovery against the Flaviviridae family. Curr Pharm Des. 2014;20:3428-44 pubmed
    ..the strategies used towards the discovery of antiviral drugs, focusing on rational drug design against Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), Yellow Fever virus (YFV) and Hepatitis C ..
  10. Drew V, Barro L, Seghatchian J, Burnouf T. Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: design, technologies, and future prospects for developing countries. Blood Transfus. 2017;15:512-521 pubmed publisher
    ..Areas with a tropical climate have an increased risk of Zika virus, Dengue virus, West Nile virus and Chikungunya, and impoverished countries face economical limitations which hinder efforts ..
  11. Weber E, Finsterbusch K, LINDQUIST R, Nair S, Lienenklaus S, Gekara N, et al. Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses. J Virol. 2014;88:12202-12 pubmed publisher
    Vector-borne flaviviruses, such as tick-borne encephalitis virus (TBEV), West Nile virus, and dengue virus, cause millions of infections in humans...
  12. Adungo F, Yu F, Kamau D, Inoue S, Hayasaka D, Posadas Herrera G, et al. Development and Characterization of Monoclonal Antibodies to Yellow Fever Virus and Application in Antigen Detection and IgM Capture Enzyme-Linked Immunosorbent Assay. Clin Vaccine Immunol. 2016;23:689-97 pubmed publisher
    ..showed strong reactivity with wild-type YF virus and recombinant protein with no detectable cross-reactivity to dengue virus or Japanese encephalitis virus...
  13. Chong S, Mohamad Zaini R, Suraiya S, Lee K, Lim J. The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection. Malar J. 2017;16:2 pubmed publisher
    ..The first case reported was in 2005. Since then, several concurrent infections have been reported between the dengue virus (DENV) and the malaria protozoans, Plasmodium falciparum and Plasmodium vivax...
  14. Poonsiri T, Wright G, Diamond M, Turtle L, Solomon T, Antonyuk S. Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus. J Virol. 2018;92: pubmed publisher
    ..JEV) is a mosquito-transmitted flavivirus that is closely related to other emerging viral pathogens, including dengue virus (DENV), West Nile virus (WNV), and Zika virus (ZIKV)...
  15. Liang G, Li X, Gao X, Fu S, Wang H, Li M, et al. Arboviruses and their related infections in China: A comprehensive field and laboratory investigation over the last 3 decades. Rev Med Virol. 2017;: pubmed publisher
    ..of the relationships between viruses and human/animal diseases indicated that Japanese encephalitis virus, dengue virus, severe fever with thrombocytopenia syndrome virus, tick-borne encephalitis virus, Crimean-Congo hemorrhagic ..
  16. Kudchodkar S, Choi H, Reuschel E, Esquivel R, Jin Ah Kwon J, Jeong M, et al. Rapid response to an emerging infectious disease - Lessons learned from development of a synthetic DNA vaccine targeting Zika virus. Microbes Infect. 2018;: pubmed publisher
    ..effective new vaccines against infectious pathogens such as influenza, Human immunodeficiency virus (HIV), dengue virus (DENV), chikungunya virus (CHIKV), Ebola virus, and Zika virus (ZIKV) have proven challenging...
  17. Tezcan S, Kızıldamar S, Ulger M, Aslan G, Tiftik N, Ozkul A, et al. [Flavivirus seroepidemiology in blood donors in Mersin province, Turkey]. Mikrobiyol Bul. 2014;48:606-17 pubmed
    Among the vector-borne flaviviruses, West Nile virus (WNV), tick-borne encephalitis virus (TBEV) and Dengue virus (DENV) constitute the most frequently-observed pathogens with significant public health impact in endemic regions throughout ..
  18. Clarke B, Roby J, Slonchak A, Khromykh A. Functional non-coding RNAs derived from the flavivirus 3' untranslated region. Virus Res. 2015;206:53-61 pubmed publisher
    ..The flavivirus genus includes important human pathogens such as dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), tick-borne ..
  19. Ai J, Xie Z, Liu G, Chen Z, Yang Y, Li Y, et al. Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study. BMC Infect Dis. 2017;17:494 pubmed publisher
    ..against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients' hospitalization...
  20. Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, et al. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. J Immunol. 2018;201:53-68 pubmed publisher
    ..Of note, NS5s from other flaviviruses, including Japanese encephalitis virus, West Nile virus, Zika virus, and dengue virus, can also induce RANTES expression, suggesting the significance of NS5-induced RANTES expression in flavivirus ..
  21. Ye Z, Huang Y, Jiang P, Zheng Z, Xiong Y, Xu J, et al. [Analysis of clinical characteristic of 158 inpatients with dengue fever in Guangzhou area during the 2014 epidemic]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:300-5 pubmed publisher
    ..27% ). (3) It was found that in the acute phase (0 - 5 days of the onset), serum dengue virus antibody IgM (DF-IgM) was positive in 63.54% of the patients (61/96), and 92...
  22. Benelli G, Lo Iacono A, Canale A, Mehlhorn H. Mosquito vectors and the spread of cancer: an overlooked connection?. Parasitol Res. 2016;115:2131-7 pubmed publisher
    ..During dengue virus infection, high viral titers, macrophage infiltration, and tumor necrosis factor alpha production in the local ..
  23. You J, Hou S, Malik Soni N, Xu Z, Kumar A, Rachubinski R, et al. Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling. J Virol. 2015;89:12349-61 pubmed publisher
    ..Chief among these pathogens are the flaviviruses, which include dengue virus and West Nile virus...
  24. Gizzi A, Grove T, Arnold J, Jose J, Jangra R, Garforth S, et al. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature. 2018;558:610-614 pubmed publisher
    ..protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus 2 and HIV3,4...
  25. Punyadee N, Mairiang D, Thiemmeca S, Komoltri C, Pan Ngum W, Chomanee N, et al. Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection. J Virol. 2015;89:1587-607 pubmed publisher
    ..Herein, we investigated the role of MPs in dengue virus (DENV) infection. Infection of various susceptible cells by DENV led to apoptotic death and MP release...
  26. Moreira J, Bressan C, Brasil P, Siqueira A. Epidemiology of acute febrile illness in Latin America. Clin Microbiol Infect. 2018;24:827-835 pubmed publisher
    ..2%) individuals. The most frequently reported pathogen during the study periods was dengue virus (DENV) (14 studies), followed by chikungunya virus (nine studies) and Zika virus (seven studies)...
  27. Carod Artal F, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. Lancet Neurol. 2013;12:906-919 pubmed publisher
    ..However, overlap of these categories is possible. In endemic countries and after travel to these regions, dengue should be considered in patients presenting with fever and acute neurological manifestations. ..
  28. Ciccozzi M, Lo Presti A, Cella E, Giovanetti M, Lai A, El Sawaf G, et al. Phylogeny of Dengue and Chikungunya viruses in Al Hudayda governorate, Yemen. Infect Genet Evol. 2014;27:395-401 pubmed publisher
    ..b>Dengue virus (DENV) outbreaks have been reported with increasing frequency in several governorates since the year 2000, and ..
  29. Zhang B, Salieb Beugelaar G, Nigo M, Weidmann M, Hunziker P. Diagnosing dengue virus infection: rapid tests and the role of micro/nanotechnologies. Nanomedicine. 2015;11:1745-61 pubmed publisher
    Due to the progressive spread of the dengue virus and a rising incidence of dengue disease, its rapid diagnosis is important for developing countries and of increasing relevance for countries in temperate climates...
  30. Mateo R, Nagamine C, Kirkegaard K. Suppression of Drug Resistance in Dengue Virus. MBio. 2015;6:e01960-15 pubmed publisher
    b>Dengue virus is a major human pathogen responsible for 400 million infections yearly. As with other RNA viruses, daunting challenges to antiviral design exist due to the high error rates of RNA-dependent RNA synthesis...
  31. Millman A, Esposito D, Biggs H, Decenteceo M, Klevos A, Hunsperger E, et al. Chikungunya and Dengue Virus Infections Among United States Community Service Volunteers Returning from the Dominican Republic, 2014. Am J Trop Med Hyg. 2016;94:1336-41 pubmed publisher
    ..We assessed the incidence of chikungunya virus (CHIKV) and dengue virus (DENV) infection and illnesses and evaluated adherence to mosquito avoidance measures among volunteers/staff ..
  32. Gómez Calderón C, Mesa Castro C, Robledo S, Gomez S, Bolivar Avila S, Diaz Castillo F, et al. Antiviral effect of compounds derived from the seeds of Mammea americana and Tabernaemontana cymosa on Dengue and Chikungunya virus infections. BMC Complement Altern Med. 2017;17:57 pubmed publisher
    The transmission of Dengue virus (DENV) and Chikungunya virus (CHIKV) has increased worldwide, due in part to the lack of a specific antiviral treatment...
  33. Dalugama C, Gawarammana I. Dengue hemorrhagic fever complicated with transient diabetic ketoacidosis: a case report. J Med Case Rep. 2017;11:302 pubmed publisher
    ..Transient hyperglycemia with ketoacidosis, such as in our patient, has not been reported in the literature. Dengue virus inducing a transient pancreatitis during the viremic phase, however, is a possibility.
  34. Reynolds C, Suleyman O, Ortega Prieto A, Skelton J, Bonnesoeur P, Blohm A, et al. T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses. Sci Rep. 2018;8:672 pubmed publisher
    ..Analysis of ZIKV immunity is confounded by the fact that several related Flaviviruses infect humans, including Dengue virus 1-4, West Nile virus and Yellow Fever virus...
  35. Chotiwan N, Roehrig J, Schlesinger J, Blair C, Huang C. Molecular determinants of dengue virus 2 envelope protein important for virus entry in Fc?RIIA-mediated antibody-dependent enhancement of infection. Virology. 2014;456-457:238-46 pubmed publisher
    ..ADE) of infection may cause severe illness in patients suffering a secondary infection by a heterologous dengue virus (DENV) serotype...
  36. Sahu R, Verma R, Jain A, Garg R, Singh M, Malhotra H, et al. Neurologic complications in dengue virus infection: a prospective cohort study. Neurology. 2014;83:1601-9 pubmed publisher
    ..predictors of central and peripheral nervous system involvement, and their outcome in patients with dengue virus infection (DENV)...
  37. Du Y, Zhang B, Li Y, Ma H, Huang X, Xu B. [Discovery and whole genome sequences analysis of a dengue virus type 1 strain isolated in Henan province]. Zhonghua Yu Fang Yi Xue Za Zhi. 2015;49:892-5 pubmed
    ..The imported case was diagnosed as dengue virus 1 serotype infection. Dengue 1 strain was isolated using Vero cells successfully...
  38. Saez Llorens X, Tricou V, Yu D, Rivera L, Tuboi S, Garbes P, et al. Safety and immunogenicity of one versus two doses of Takeda's tetravalent dengue vaccine in children in Asia and Latin America: interim results from a phase 2, randomised, placebo-controlled study. Lancet Infect Dis. 2017;17:615-625 pubmed publisher
    ..been licensed, but there remains urgent medical need for a vaccine that is safe and effective against all four dengue virus serotypes (DENV-1-4) in recipients of all ages...
  39. Alagarasu K, Patil P, Shil P, Seervi M, Kakade M, Tillu H, et al. In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2. Peptides. 2017;92:23-30 pubmed publisher
    ..In the present study, we investigated the in-vitro effect of LL-37 on dengue virus type 2 (DENV-2) infection and replication in Vero E6 cells...
  40. Martínez J, Hernandez J, Urcuqui Inchima S. [Role of dendritic cells in infection by dengue virus: targets for replication and immune response]. Rev Chilena Infectol. 2017;34:249-256 pubmed publisher
    Dengue fever, caused by dengue virus (DENV) infection, is one of the most important diseases in the world, not only due to the high morbidity/mortality rates it causes, but also because of its great economic and social impact in tropical/..
  41. Niu G, Pang Z, Guan C, Qi J, Li D. Dengue virus envelope domain III protein based on a tetravalent antigen secreted from insect cells: Potential use for serological diagnosis. Virus Res. 2015;201:73-8 pubmed publisher
    ..we developed a tetravalent protein by connecting the receptor-binding envelope domain III (EDIII) of the four dengue virus serotypes in the order of D1-D3-D4-D2...
  42. da Moura A, de Melo Santos M, Oliveira C, Guedes D, de Carvalho Leandro D, da Cruz Brito M, et al. Vector competence of the Aedes aegypti population from Santiago Island, Cape Verde, to different serotypes of dengue virus. Parasit Vectors. 2015;8:114 pubmed publisher
    Dengue is an arboviral disease caused by dengue virus (DENV), whose main vectors are the mosquitoes Aedes aegypti and Aedes albopictus. A...
  43. Yen T, Trovoada Dos Santos M, Tseng L, Chang S, Cheng C, Carvalho A, et al. Seroprevalence of antibodies against dengue virus among pregnant women in the Democratic Republic of Sao Tome and Principe. Acta Trop. 2016;155:58-62 pubmed publisher
    ..In this serological survey, dengue virus (DENV) transmission was demonstrated by using serum samples collected from 78 pregnant women in the Democratic ..
  44. Amraoui F, Failloux A. Chikungunya: an unexpected emergence in Europe. Curr Opin Virol. 2016;21:146-150 pubmed publisher
    ..b>Dengue virus (DENV) and chikungunya virus (CHIKV) are both transmitted by the mosquito Aedes albopictus present in 20 ..
  45. Añez G, Volkova E, Jiang Z, Heisey D, Chancey C, Fares R, et al. Collaborative study to establish World Health Organization international reference reagents for dengue virus Types 1 to 4 RNA for use in nucleic acid testing. Transfusion. 2017;57:1977-1987 pubmed publisher
    Dengue is the most important reemerging mosquito-borne viral disease worldwide. Caused by dengue virus (DENV), a member of the genus Flavivirus in the Flaviviridae family, dengue can be asymptomatic (approx...
  46. Magnani D, Ricciardi M, Bailey V, Gutman M, Pedreño Lopez N, Silveira C, et al. Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys. Mol Ther. 2017;25:2323-2331 pubmed publisher
    ..Here, we used recombinant adeno-associated viruses (rAAVs) to deliver the anti-dengue virus 3 (DENV3) nAb P3D05...
  47. Rocha B, Guilarde A, Argolo A, Tassara M, da Silveira L, Junqueira I, et al. Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil. Infect Dis Poverty. 2017;6:116 pubmed publisher
    ..0 software. Four hundred fifty-two patients (452/632, 71.5%) were diagnosed with dengue. The dengue virus (DENV) serotypes were identified in 243 cases. DENV-4 was detected in 135 patients (55.6%), DENV-1 in 91 (37...
  48. Patil R, Bajpai S, Ghosh K, Shetty S. Microparticles as prognostic biomarkers in dengue virus infection. Acta Trop. 2018;181:21-24 pubmed publisher
    Promising biomarkers which may help predict the risk of developing severe dengue virus infection (DVI) are lacking and will be helpful. Thus the main aim of this study was to analyze the role of cell-derived microparticles (MP) in DVI...
  49. Lai J, Wang M, Huang C, Wu C, Hung L, Yang C, et al. Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells. EMBO Rep. 2018;19: pubmed publisher
    ..Herein, we demonstrate that infection with dengue virus (DENV), an RNA virus, activates TLR9 in human dendritic cells (DCs)...
  50. Wewer C, Khandelia H. Different footprints of the Zika and dengue surface proteins on viral membranes. Soft Matter. 2018;14:5615-5621 pubmed publisher
    ..b>Dengue virus (DENV), which is also a flavivirus, causes significant clinical harm in equatorial regions...
  51. Cox Singh J, Hiu J, Lucas S, Divis P, Zulkarnaen M, Chandran P, et al. Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. Malar J. 2010;9:10 pubmed publisher
    ..Dengue haemorrhagic shock was suspected and a post-mortem examination performed. Investigations for dengue virus were negative. Blood for malaria parasites indicated hyperparasitaemia and single species P...
  52. Zhang G, Hussain M, Asgari S. Regulation of arginine methyltransferase 3 by a Wolbachia-induced microRNA in Aedes aegypti and its effect on Wolbachia and dengue virus replication. Insect Biochem Mol Biol. 2014;53:81-8 pubmed publisher
    ..Wolbachia have been shown to reduce the host life span by about 50% and inhibit replication and transmission of dengue virus (DENV) in the mosquito vector, Aedes aegypti...
  53. Li Y, Li Q, Wong Y, Liew L, Kang C. Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy. Biochim Biophys Acta. 2015;1848:2244-52 pubmed publisher
    Non-structural (NS) proteins of dengue virus (DENV) are important for viral replication. There are four membrane proteins that are coded by viral genome...
  54. Mareze V, Borio C, Bilen M, Fleith R, Mirazo S, Mansur D, et al. Tests in mice of a dengue vaccine candidate made of chimeric Junin virus-like particles and conserved dengue virus envelope sequences. Appl Microbiol Biotechnol. 2016;100:125-33 pubmed publisher
    Two new vaccine candidates against dengue virus (DENV) infection were generated by fusing the coding sequences of the self-budding Z protein from Junin virus (Z-JUNV) to those of two cryptic peptides (Z/DENV-P1 and Z/DENV-P2) conserved on ..
  55. Phillips S, Soderblom E, Bradrick S, Garcia Blanco M. Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication. MBio. 2016;7:e01865-15 pubmed publisher
    b>Dengue virus is the most prevalent cause of arthropod-borne infection worldwide...
  56. Waggoner J, Ballesteros G, Gresh L, Mohamed Hadley A, Tellez Y, Sahoo M, et al. Clinical evaluation of a single-reaction real-time RT-PCR for pan-dengue and chikungunya virus detection. J Clin Virol. 2016;78:57-61 pubmed publisher
    b>Dengue virus (DENV) and chikungunya virus (CHIKV) now co-circulate throughout tropical regions of the world, with billions of people living at risk of infection...
  57. Simmons M, Myers T, Guevara C, Jungkind D, Williams M, Houng H. Development and Validation of a Quantitative, One-Step, Multiplex, Real-Time Reverse Transcriptase PCR Assay for Detection of Dengue and Chikungunya Viruses. J Clin Microbiol. 2016;54:1766-1773 pubmed publisher
    b>Dengue virus (DENV) and chikungunya virus (CHIKV) are important human pathogens with common transmission vectors and similar clinical presentations...
  58. Hu T, Zhang H, Feng Y, Fan J, Tang T, Liu Y, et al. Epidemiological and molecular characteristics of emergent dengue virus in Yunnan Province near the China-Myanmar-Laos border, 2013-2015. BMC Infect Dis. 2017;17:331 pubmed publisher
    ..A total of 232 dengue virus (DENV)-positive sera were randomly collected for sequence analysis of the capsid/premembrane region of DENV ..
  59. Collins M, Metz S. Progress and Works in Progress: Update on Flavivirus Vaccine Development. Clin Ther. 2017;39:1519-1536 pubmed publisher
    ..flaviviruses are transmitted by mosquitos and have expanded in geographic distribution in recent years, with dengue virus being the most prevalent, infecting approximately 400 million people each year...
  60. Rogers T, Goodwin E, Briney B, Sok D, Beutler N, Strubel A, et al. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors. Sci Immunol. 2017;2: pubmed publisher
    Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV...
  61. Chen L, Wang H, Guo T, Xiao C, Liu L, Zhang X, et al. A rapid point-of-care test for dengue virus-1 based on a lateral flow assay with a near-infrared fluorescent dye. J Immunol Methods. 2018;456:23-27 pubmed publisher
    Dengue fever is caused by the dengue virus (DENV), and DENV1 is the prevalent epidemic serotype in south China...
  62. Rivino L, Kumaran E, Jovanovic V, Nadua K, Teo E, Pang S, et al. Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection. J Virol. 2013;87:2693-706 pubmed publisher
    b>Dengue virus (DENV) is the principal arthropod-borne viral pathogen afflicting human populations...
  63. Cheung Y, Chen K, Chen H, Seng E, Chu J. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014;111:93-9 pubmed publisher
    ..Currently, there is no approved vaccine or effective antiviral drug for dengue virus infection...
  64. Kiesgen S, Liebers N, Cremer M, Arnold U, Weber T, Keller A, et al. A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor. Protein Eng Des Sel. 2014;27:331-7 pubmed publisher
    ..diminish the antitumor efficacy of ribonuclease or toxin-based immunoagents, we explored a fusion peptide from dengue virus that has been reported to be involved in the endosomal escape of the virus...
  65. Saavedra Rodriguez K, Beaty M, Lozano Fuentes S, Denham S, Garcia Rejon J, Reyes Solis G, et al. Local evolution of pyrethroid resistance offsets gene flow among Aedes aegypti collections in Yucatan State, Mexico. Am J Trop Med Hyg. 2015;92:201-9 pubmed publisher
    The mosquito Aedes aegypti is the major vector of the four serotypes of dengue virus (DENV1-4). Previous studies have shown that Ae...
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    We report a dengue virus (DENV) co-infection in a Belgian traveler after a three-weeks holiday to Thailand. The patient recovered well without any complication...
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    b>Dengue virus (DENV) is an important human pathogen causing millions of disease cases and thousands of deaths worldwide...
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    ..In the present study, we investigated dengue virus non structural protein 3 (dvNS3), for its RNAi-suppressor activity in human cell lines...
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    ..response in infected cells decreases autophagosome turnover, reduces ROS production and limits reproduction of dengue virus. Blocking ATM activation, which is an early response to infection, decreases transcription of ER stress ..
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    ..Comparative studies with West Nile and Dengue virus NS1 structures reveal conserved features, but diversified electrostatic characteristics on both inner and outer ..
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    ..b>Dengue virus IgM in serum was equivocal and dengue virus IgG was detected in the serum...
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    Effective novel peptide inhibitors which targeted the domain III of the dengue envelope (E) protein by blocking dengue virus (DENV) entry into target cells, were identified...
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    ..Our own work has shown that the NS2B/3 protease complex of the flavivirus dengue virus binds and cleaves STING, and that an inability to degrade murine STING may contribute to host restriction in ..
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    ..The severity of thrombocytopenia is an indicator of the severity of dengue virus infection. We investigated whether diabetes is associated with thrombocytopenia in dengue-infected patients...
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    ..a 9-year-old Thai boy who exhibited signs and symptoms of dengue shock syndrome; all the children had secondary dengue virus infections, documented by serology and reverse transcriptase polymerase chain reaction...
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    b>Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy...
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    ..Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), we show that infection creates an endogenous source of cytosolic ..
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    ..belongs to Flavivirus genus; Flaviviridae family jointly with other medically important flaviviruses including dengue virus and West Nile virus...
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    An outbreak of dengue virus (DENV) occurred in Yunnan province. More than 2,000 individuals were infected from August to November 2013...
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    Aedes aegypti (L.) is the main vector of dengue virus and more recently chikungunya virus in Latin America...
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    The dengue virus (DENV) has four well-known serotypes, namely DENV1 to DENV4, which together cause 50-100 million infections worldwide each year...
  83. McBurney S, Sunshine J, Gabriel S, Huynh J, Sutton W, Fuller D, et al. Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine. 2016;34:3500-7 pubmed publisher
    We describe the preclinical development of a dengue virus vaccine targeting the dengue virus serotype 2 (DENV2) envelope domain III (EDIII)...
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    ..Moreover, the vaccine complex elicited enhanced systemic antibody response that neutralized wild type of dengue virus and promoted the systemic cellular immune responses...
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    Activated microglial cells are present in dengue virus (DENV)-infected brains; however, the possible effects of DENV on microglia remain unclear...
  86. Pryke K, Abraham J, Sali T, Gall B, Archer I, Liu A, et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio. 2017;8: pubmed publisher
    ..a cellular state antagonistic to growth of currently emerging viruses: Zika virus, Chikungunya virus, and dengue virus. We also show that this molecule is capable of eliciting cellular responses that are predictive of ..
  87. Suphatrakul A, Duangchinda T, Jupatanakul N, Prasittisa K, Onnome S, Pengon J, et al. Multi-color fluorescent reporter dengue viruses with improved stability for analysis of a multi-virus infection. PLoS ONE. 2018;13:e0194399 pubmed publisher
    ..The reported design of multi-color DENV2 should be useful for high-throughput analyses, single-cell analysis, and characterizations of interference and superinfection in animal models. ..
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    ..These infections, which include dengue virus, influenza and malaria, generate substantial morbidity and mortality...
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    ..study, we evaluated the cellular response of human monocyte-derived DCs (mdDCs) infected with recombinant dengue virus type 1 (DV1) strains carrying a single point mutation in the NS3hel protein (L435S or L480S)...
  90. Tan C, Wong P, Li M, Yang H, Chong C, Lee L, et al. Membrane feeding of dengue patient's blood as a substitute for direct skin feeding in studying Aedes-dengue virus interaction. Parasit Vectors. 2016;9:211 pubmed publisher
    ..Nevertheless, mosquito numbers will need to be increased to compensate for lower feeding rate in MFA. ..
  91. Avila Bonilla R, Yocupicio Monroy M, Marchat L, De Nova Ocampo M, Del Ángel R, Salas Benito J. Analysis of the miRNA profile in C6/36 cells persistently infected with dengue virus type 2. Virus Res. 2017;232:139-151 pubmed publisher
    b>Dengue virus (DENV) is the most important arbovirus in the world; DENV is transmitted by the Aedes genus of mosquitoes and can establish a life-long persistent infection in mosquitoes...
  92. Zhu S, Luo H, Liu H, Ha Y, Mays E, Lawrence R, et al. p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection. Antiviral Res. 2017;145:70-81 pubmed publisher
    ..In comparison to ZIKV, Dengue virus (DENV), another Flavivirus infected Müller cells more efficiently but induced much lower pro-inflammatory ..