Classical swine fever virus

Summary

Alias: Hog cholera virus, classical swine fever virus CSFV, swine fever virus, hog cholera virus HCV, Pestivirus type 2, classical swine fever virus (CSFV) strains, hog cholera virus (HCV) strains

Top Publications

  1. Doceul V, Charleston B, Crooke H, Reid E, Powell P, Seago J. The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor. J Gen Virol. 2008;89:1881-9 pubmed publisher
    b>Classical swine fever virus (CSFV) belongs to the genus Pestivirus and is the causative agent of classical swine fever, a haemorrhagic disease of pigs...
  2. Fiebach A, Guzylack Piriou L, Python S, Summerfield A, Ruggli N. Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7. J Virol. 2011;85:8002-11 pubmed publisher
    ..Here, we report that N(pro) of classical swine fever virus (CSFV) interacts also with IRF7, another mediator of type I IFN induction...
  3. Mayer D, Thayer T, Hofmann M, Tratschin J. Establishment and characterisation of two cDNA-derived strains of classical swine fever virus, one highly virulent and one avirulent. Virus Res. 2003;98:105-16 pubmed
    The virulence of classical swine fever virus (CSFV) strains including established laboratory strains as well as field isolates ranges from avirulent to highly virulent...
  4. Seago J, Hilton L, Reid E, Doceul V, Jeyatheesan J, Moganeradj K, et al. The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3. J Gen Virol. 2007;88:3002-6 pubmed
    b>Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the family Flaviviridae. The N(pro) product of CSFV targets the host's innate immune response and can prevent the production of type I interferon (IFN)...
  5. Ruggli N, Summerfield A, Fiebach A, Guzylack Piriou L, Bauhofer O, Lamm C, et al. Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro. J Virol. 2009;83:817-29 pubmed publisher
    ..We previously showed with classical swine fever virus (CSFV) that deletion of the entire N(pro) gene resulted in attenuation in pigs...
  6. Johns H, Doceul V, Everett H, Crooke H, Charleston B, Seago J. The classical swine fever virus N-terminal protease N(pro) binds to cellular HAX-1. J Gen Virol. 2010;91:2677-86 pubmed publisher
    The positive-stranded RNA genome of classical swine fever virus (CSFV) encodes 12 known proteins. The first protein to be translated is the N-terminal protease (N(pro))...
  7. Tews B, Schürmann E, Meyers G. Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus. J Virol. 2009;83:4823-34 pubmed publisher
    ..E(rns) dimerization-negative mutants of classical swine fever virus were found to be attenuated in pigs even though the virus clearly replicated and induced a significant ..
  8. Tamura T, Sakoda Y, Yoshino F, Nomura T, Yamamoto N, Sato Y, et al. Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in E2 and NS4B. J Virol. 2012;86:8602-13 pubmed publisher
    b>Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious disease of pigs...
  9. Risatti G, Holinka L, Carrillo C, Kutish G, Lu Z, Tulman E, et al. Identification of a novel virulence determinant within the E2 structural glycoprotein of classical swine fever virus. Virology. 2006;355:94-101 pubmed publisher
    b>Classical swine fever virus (CSFV) E2 glycoprotein contains a discrete epitope (TAVSPTTLR, residues 829-837 of CSFV polyprotein) recognized by monoclonal antibody (mAb) WH303, used to differentiate CSFV from related ruminant pestiviruses,..

More Information

Publications273 found, 100 shown here

  1. Risatti G, Holinka L, Fernandez Sainz I, Carrillo C, Lu Z, Borca M. N-linked glycosylation status of classical swine fever virus strain Brescia E2 glycoprotein influences virulence in swine. J Virol. 2007;81:924-33 pubmed publisher
    E2 is one of the three envelope glycoproteins of classical swine fever virus (CSFV)...
  2. Wen G, Chen C, Luo X, Wang Y, Zhang C, Pan Z. Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria. Arch Virol. 2007;152:1565-73 pubmed publisher
    ..Our results provide insight into the structure-function relationship of CSFV NS3 and facilitate our understanding of its role in the replication cycle of CSFV...
  3. Peng W, Hou Q, Xia Z, Chen D, Li N, Sun Y, et al. Identification of a conserved linear B-cell epitope at the N-terminus of the E2 glycoprotein of Classical swine fever virus by phage-displayed random peptide library. Virus Res. 2008;135:267-72 pubmed publisher
    The E2 protein of Classical swine fever virus (CSFV) is an important envelope glycoprotein, which is responsible for inducing protective immune response in swine. Four antigenic domains, A-D, have been mapped on the E2 protein...
  4. Xiao M, Wang Y, Zhu Z, Yu J, Wan L, Chen J. Influence of NS5A protein of classical swine fever virus (CSFV) on CSFV internal ribosome entry site-dependent translation. J Gen Virol. 2009;90:2923-8 pubmed publisher
    ..internal ribosome entry site (IRES) present in the 5' untranslated region (UTR) promotes translation of classical swine fever virus (CSFV) genomes...
  5. Seago J, Goodbourn S, Charleston B. The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3. J Gen Virol. 2010;91:721-6 pubmed publisher
    Classical swine fever is a notifiable disease of pigs. The causative agent, classical swine fever virus (CSFV), is highly contagious and causes mild to severe haemorrhagic disease depending on the virulence of the strain...
  6. Wang P, Wang Y, Zhao Y, Zhu Z, Yu J, Wan L, et al. Classical swine fever virus NS3 enhances RNA-dependent RNA polymerase activity by binding to NS5B. Virus Res. 2010;148:17-23 pubmed publisher
    ..To investigate the effect of NS3 on classical swine fever virus (CSFV) NS5B RNA-dependent RNA polymerase activity (RdRp) activity and NS3-NS5B interaction, RdRp ..
  7. Zhu Z, Wang Y, Yu J, Wan L, Chen J, Xiao M. Classical swine fever virus NS3 is an IRES-binding protein and increases IRES-dependent translation. Virus Res. 2010;153:106-12 pubmed publisher
    ..But, CSFV NS5B was not found to interact with the IRES. The inhibitive effect of NS5B on binding of CSFV NS3 to IRES was supposed to result from the NS3-NS5B interaction which has been documented...
  8. Li X, Wang L, Zhao D, Zhang G, Luo J, Deng R, et al. Identification of host cell binding peptide from an overlapping peptide library for inhibition of classical swine fever virus infection. Virus Genes. 2011;43:33-40 pubmed publisher
    The envelope proteins of classical swine fever virus (CSFV) mediate the binding of CSFV to cell surface molecules and allow CSFV subsequent to enter host cells...
  9. Chang C, Huang C, Deng M, Huang Y, Lin Y, Liu H, et al. Antigenic mimicking with cysteine-based cyclized peptides reveals a previously unknown antigenic determinant on E2 glycoprotein of classical swine fever virus. Virus Res. 2012;163:190-6 pubmed publisher
    Envelope glycoprotein E2 of classical swine fever virus (CSFV) is the major antigen that induces neutralizing antibodies in infected pigs...
  10. Gavrilov B, Rogers K, Fernandez Sainz I, Holinka L, Borca M, Risatti G. Effects of glycosylation on antigenicity and immunogenicity of classical swine fever virus envelope proteins. Virology. 2011;420:135-45 pubmed publisher
    b>Classical swine fever virus (CSFV) harbors three envelope glycoproteins (E(rns), E1 and E2)...
  11. Gladue D, Holinka L, Largo E, Fernandez Sainz I, Carrillo C, O Donnell V, et al. Classical swine fever virus p7 protein is a viroporin involved in virulence in swine. J Virol. 2012;86:6778-91 pubmed publisher
    The nonstructural protein p7 of classical swine fever virus (CSFV) is a small hydrophobic polypeptide with an apparent molecular mass of 6 to 7 kDa...
  12. Gottipati K, Ruggli N, Gerber M, Tratschin J, Benning M, BELLAMY H, et al. The structure of classical swine fever virus N(pro): a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction. PLoS Pathog. 2013;9:e1003704 pubmed publisher
    ..The structures thus establish the mechanism of auto-catalysis and subsequent auto-inhibition of trans-activity of N(pro), and its role in subversion of host immune response. ..
  13. Tamura T, Nagashima N, Ruggli N, Summerfield A, Kida H, Sakoda Y. Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites. Vet Res. 2014;45:47 pubmed publisher
    ..In conclusion, the present study demonstrates that functional Npro influences the innate immune response at local sites of virus replication in pigs and contributes to pathogenicity of CSFV in synergy with viral replication...
  14. Chang C, Huang C, Lin Y, Deng M, Tsai C, Chang W, et al. Identification of antigen-specific residues on E2 glycoprotein of classical swine fever virus. Virus Res. 2010;152:65-72 pubmed publisher
    Envelope glycoprotein E2 of classical swine fever virus (CSFV) is the major antigen that induces neutralizing antibodies in infected pigs...
  15. Tang Q, Guo K, Kang K, Zhang Y, He L, Wang J. Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis. Virus Genes. 2011;42:355-62 pubmed publisher
    Classical swine fever (CSF) caused by virulent strains of classical swine fever virus (CSFV) is a hemorrhagic disease of pigs and is characterized by disseminated intravascular coagulation, thrombocytopenia, and immunosuppression...
  16. Reperant L, Brown I, Haenen O, de Jong M, Osterhaus A, Papa A, et al. Companion Animals as a Source of Viruses for Human Beings and Food Production Animals. J Comp Pathol. 2016;155:S41-53 pubmed publisher
    ..foot-and-mouth disease virus, lumpy skin disease virus, Rift Valley fever virus, porcine circovirus, classical swine fever virus, equine herpesvirus 9, peste des petits ruminants virus and equine infectious anaemia virus...
  17. Yang Y, Shi R, She R, Mao J, Zhao Y, Du F, et al. Fatal disease associated with Swine Hepatitis E virus and Porcine circovirus 2 co-infection in four weaned pigs in China. BMC Vet Res. 2015;11:77 pubmed publisher
    ..and we tested for eight viruses (HEV, Porcine reproductive and respiratory syndrome virus, PCV2, Classical swine fever virus, Porcine epidemic diarrhea virus, Transmissible gastroenteritis coronavirus, Porcine parvovirus and ..
  18. Sookhoo J, Brown Jordan A, Blake L, Holder R, Brookes S, Essen S, et al. Seroprevalence of economically important viral pathogens in swine populations of Trinidad and Tobago, West Indies. Trop Anim Health Prod. 2017;49:1117-1124 pubmed publisher
    ..syndrome virus (PRRSV), porcine respiratory coronavirus (PRCV), porcine circovirus type 2 (PCV-2), and classical swine fever virus (CSFV) in pigs in Trinidad and Tobago (T&T)...
  19. Lussi C, Schweizer M. What can pestiviral endonucleases teach us about innate immunotolerance?. Cytokine Growth Factor Rev. 2016;29:53-62 pubmed publisher
    Pestiviruses including bovine viral diarrhea virus (BVDV), border disease virus (BDV) and classical swine fever virus (CSFV), occur worldwide and are important pathogens of livestock...
  20. Liu L, Wang J, Zhang R, Lin M, Shi R, Han Q, et al. Visual and equipment-free reverse transcription recombinase polymerase amplification method for rapid detection of foot-and-mouth disease virus. BMC Vet Res. 2018;14:263 pubmed publisher
    ..there were no cross-reactions with vesicular stomatitis virus (VSV), encephalomyocarditis virus (EMCV), classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus 2 (PCV2) and ..
  21. Zeng Z, Liu Z, Wang W, Tang D, Liang H, Liu Z. Establishment and application of a multiplex PCR for rapid and simultaneous detection of six viruses in swine. J Virol Methods. 2014;208:102-6 pubmed publisher
    ..three common RNA viruses, including porcine reproductive and respiratory syndrome virus (PRRSV), classical swine fever virus (CSFV), and Japanese encephalitis virus (JEV)...
  22. Zhang H, Qian P, Liu L, Qian S, Chen H, Li X. Virus-like particles of chimeric recombinant porcine circovirus type 2 as antigen vehicle carrying foreign epitopes. Viruses. 2014;6:4839-55 pubmed publisher
    ..by replacing the nuclear localization signal (NLS; at 1-39 aa) of PCV2 capsid protein (Cap) with classical swine fever virus (CSFV) T-cell epitope (1446-1460 aa), CSFV B-cell epitope (693-716 aa) and CSFV T-cell epitope ..
  23. Zhao Y, Cheng G, Hao H, Pan Y, Liu Z, Dai M, et al. In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi. BMC Vet Res. 2016;12:186 pubmed publisher
    ..bursal disease virus, porcine reproductive and respiratory syndrome virus, porcine parvovirus and classical swine fever virus. The results obtained showed that these QdNOs and their metabolites have no inhibitory activity against ..
  24. Krug P, Davis T, O Brien C, LaRocco M, Rodriguez L. Disinfection of transboundary animal disease viruses on surfaces used in pork packing plants. Vet Microbiol. 2018;219:219-225 pubmed publisher
    ..TAD agents such as foot and mouth disease virus (FMDV), African swine fever virus (ASFV) and classical swine fever virus (CSFV) are found in swine products such as blood and feces and are present in the tissues of infected ..
  25. Li X, Li X, Liang J, Cai X, Tao Q, Li Y, et al. IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides -487 to -325 in the 5' flanking region. Mol Immunol. 2018;94:153-165 pubmed publisher
    ..up-regulated in porcine kidney (PK-15) cells following stimulation with double-stranded RNA (dsRNA) or classical swine fever virus (CSFV) infection...
  26. Bruderer U, van de Velde J, Frantzen I, De Bortoli F. Discrimination within epitope specific antibody populations against Classical swine fever virus is a new means of differentiating infection from vaccination. J Immunol Methods. 2015;420:18-23 pubmed publisher
    ..Our findings add a new strategy for the development of marker vaccines and their accompanying discrimination assays and offer an alternative to the devastating stamping out policy for Classical swine fever. ..
  27. Sawford K, do Karmo A, da Conceicao F, Geong M, Tenaya I, Hartawan D, et al. An investigation of classical swine fever virus seroprevalence and risk factors in pigs in Timor-Leste. Prev Vet Med. 2015;122:99-106 pubmed publisher
    b>Classical swine fever virus (CSFV) is a highly infectious pathogen of pigs and believed to be a major constraint to pig production in Timor-Leste...
  28. Almeida S, de Oliveira V, Ventura S, Bofill M, Parkhouse R. Neoplastic transformation of T lymphocytes through transgenic expression of a virus host modification protein. PLoS ONE. 2012;7:e34140 pubmed publisher
    ..In this work we have assessed the impact in vivo of the evasion gene A238L of the African Swine Fever Virus, a gene which inhibits transcription mediated by both NF-κB and NFAT...
  29. Lacasta A, Monteagudo P, Jiménez Marín Ã, Accensi F, Ballester M, Argilaguet J, et al. Live attenuated African swine fever viruses as ideal tools to dissect the mechanisms involved in viral pathogenesis and immune protection. Vet Res. 2015;46:135 pubmed publisher
    African swine fever virus (ASFV) is the causal agent of African swine fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries...
  30. Muñoz Moreno R, Galindo I, Cuesta Geijo M, Barrado Gil L, Alonso C. Host cell targets for African swine fever virus. Virus Res. 2015;209:118-27 pubmed publisher
    ..Among them, African swine fever virus (ASFV) is an evolutionary ancient DNA virus, endemic in Africa, which is nowadays causing an emergent ..
  31. Zhang F, Ye Y, Song D, Guo N, Peng Q, Li A, et al. A simple and rapid identification method for newly emerged porcine Deltacoronavirus with loop-mediated isothermal amplification. Biol Res. 2017;50:30 pubmed publisher
    ..PKoV), porcine astrovirus (PAstV), porcine reproductive and respiratory syndrome virus (PRRSV), classic swine fever virus (CSFV), and porcine circovirus type 2 (PCV2)...
  32. Tran H, Dang H, Nguyen D, Miyazawa K, Kokuho T. Complete Genome Sequencing of a Classical Swine Fever Virus Strain Endemic in Vietnam. Genome Announc. 2018;6: pubmed publisher
    A Vietnamese strain of classical swine fever virus, VN91, was isolated in Hung Yen in 1991. While VN91 has been used as a challenge strain in efficacy tests of vaccines, its genetic background has never been described...
  33. Zhang Y, Liu Y, Xiao F, Liu C, Liang X, Chen J, et al. Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages. J Virol. 2018;92: pubmed publisher
    ..Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and ..
  34. Wu R, Li L, Zhao Y, Tu J, Pan Z. Identification of two amino acids within E2 important for the pathogenicity of chimeric classical swine fever virus. Virus Res. 2016;211:79-85 pubmed publisher
    Our previous study demonstrated that a chimeric classical swine fever virus (CSFV) vSM/CE2 containing the E2 gene of the vaccine C-strain on the genetic background of the virulent CSFV strain Shimen (vSM) was attenuated in swine but ..
  35. Lim S, Song J, Kim J, Hyun B, Kim H, Cho I, et al. Safety of classical swine fever virus vaccine strain LOM in pregnant sows and their offspring. Vaccine. 2016;34:2021-6 pubmed publisher
    The present study aimed to evaluate the safety of the classical swine fever virus (CSFV) vaccine strain LOM in pregnant sows...
  36. Sheng C, Chen Y, Xiao J, Xiao J, Wang J, Li G, et al. Classical swine fever virus NS5A protein interacts with 3'-untranslated region and regulates viral RNA synthesis. Virus Res. 2012;163:636-43 pubmed publisher
    To investigate the function of classical swine fever virus (CSFV) NS5A protein, the experiments for viral RNA synthesis and viral replication were performed in the co-presence of NS5A and NS5B...
  37. Malogolovkin A, Burmakina G, Tulman E, Delhon G, Diel D, Salnikov N, et al. African swine fever virus CD2v and C-type lectin gene loci mediate serological specificity. J Gen Virol. 2015;96:866-73 pubmed publisher
  38. Xia S, Lei J, Du M, Wang Y, Cong X, Xiang G, et al. Enhanced protective immunity of the chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever in pigs by a Salmonella bacterial ghost adjuvant. Vet Res. 2016;47:64 pubmed publisher
    Classical swine fever (CSF) is a highly contagious swine disease caused by classical swine fever virus (CSFV)...
  39. Bou Khalil J, Andreani J, Raoult D, La Scola B. A Rapid Strategy for the Isolation of New Faustoviruses from Environmental Samples Using Vermamoeba vermiformis. J Vis Exp. 2016;: pubmed publisher
    ..that has been isolated from sewage samples is distantly related to the mammalian pathogen African swine fever virus. This virus is also specific to its amoebal host, Vermamoeba vermiformis, a protist common in health care ..
  40. Portugal R, Leitão A, Martins C. Modulation of type I interferon signaling by African swine fever virus (ASFV) of different virulence L60 and NHV in macrophage host cells. Vet Microbiol. 2018;216:132-141 pubmed publisher
    ..The high virulent isolate showed however a more effective control of the downstream ISGs expression pathway. ..
  41. Zakaryan H, Karalova E, Voskanyan H, Ter Pogossyan Z, Nersisyan N, Hakobyan A, et al. Evaluation of hemostaseological status of pigs experimentally infected with African swine fever virus. Vet Microbiol. 2014;174:223-8 pubmed publisher
    African swine fever is a highly contagious hemorrhagic disease of pigs caused by African swine fever virus (ASFV). Hemorrhages are the most frequently reported lesions in acute and subacute forms of ASF...
  42. Hu D, Zhang T, Zhang Z, Wang G, Wang F, Qu Y, et al. Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol. Vet Immunol Immunopathol. 2014;162:122-31 pubmed publisher
    ..The levels of classical swine fever virus (CSFV) antibody against the vaccine, the concentrations of Hsp70 and IL-6 in serum and Hsp70 in tissues,..
  43. Pannhorst K, Fröhlich A, Staubach C, Meyer D, Blome S, Becher P. Evaluation of an Erns-based enzyme-linked immunosorbent assay to distinguish Classical swine fever virus-infected pigs from pigs vaccinated with CP7_E2alf. J Vet Diagn Invest. 2015;27:449-60 pubmed publisher
    Infections with Classical swine fever virus (CSFV) are a major economic threat to pig production...
  44. Cuesta Geijo M, Chiappi M, Galindo I, Barrado Gil L, Muñoz Moreno R, Carrascosa J, et al. Cholesterol Flux Is Required for Endosomal Progression of African Swine Fever Virions during the Initial Establishment of Infection. J Virol. 2016;90:1534-43 pubmed publisher
    African swine fever virus (ASFV) is a major threat for porcine production that has been slowly spreading in Eastern Europe since its first appearance in the Caucasus in 2007...
  45. Huang Y, Deng M, Tsai K, Liu H, Huang C, Wang F, et al. Competitive replication kinetics and pathogenicity in pigs co-infected with historical and newly invading classical swine fever viruses. Virus Res. 2017;228:39-45 pubmed publisher
    ..swine fever (CSF), an economically important and highly contagious disease of pigs, is caused by classical swine fever virus (CSFV). In Taiwan, CSFVs from field outbreaks belong to two distinct genotypes...
  46. Lin Z, Liang W, Kang K, Li H, Cao Z, Zhang Y. Classical swine fever virus and p7 protein induce secretion of IL-1β in macrophages. J Gen Virol. 2014;95:2693-9 pubmed publisher
    b>Classical swine fever virus (CSFV) has a tropism for vascular endothelial cells and immune system cells...
  47. Tomar N, Gupta A, Arya R, Somvanshi R, Sharma V, Saikumar G. Genome sequence of classical Swine Fever virus genotype 1.1 with a genetic marker of attenuation detected in a continuous porcine cell line. Genome Announc. 2015;3: pubmed publisher
    The complete genome sequencing and analysis of a classical swine fever virus (CSFV) detected in a porcine kidney cell line revealed a close relationship with genotype 1.1 viruses circulating in India and China...
  48. Chen X, Yang J, Ji Y, Okoth E, Liu B, Li X, et al. Recombinant Newcastle disease virus expressing African swine fever virus protein 72 is safe and immunogenic in mice. Virol Sin. 2016;31:150-9 pubmed publisher
    ..The etiological agent of ASF is African swine fever virus (ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries...
  49. Chen J, He W, Shen L, Dong H, Yu J, Wang X, et al. The laminin receptor is a cellular attachment receptor for classical Swine Fever virus. J Virol. 2015;89:4894-906 pubmed publisher
    b>Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious, economically important viral disease in many countries...
  50. Guo X, Gao S, Sang S, Jian A, Duan Q, Ji J, et al. Detection system based on magnetoelastic sensor for classical swine fever virus. Biosens Bioelectron. 2016;82:127-31 pubmed publisher
    In this paper, a magnetoelastic (ME) sensing system for the detection of classical swine fever virus (CSFV) is presented. The detection system comprises a test paper and a measurement circuit...
  51. Frouco G, Freitas F, Coelho J, Leitão A, Martins C, Ferreira F. DNA-Binding Properties of African Swine Fever Virus pA104R, a Histone-Like Protein Involved in Viral Replication and Transcription. J Virol. 2017;91: pubmed publisher
    African swine fever virus (ASFV) codes for a putative histone-like protein (pA104R) with extensive sequence homology to bacterial proteins that are implicated in genome replication and packaging...
  52. Aberle D, Muhle Goll C, Bürck J, Wolf M, Reißer S, Luy B, et al. Structure of the membrane anchor of pestivirus glycoprotein E(rns), a long tilted amphipathic helix. PLoS Pathog. 2014;10:e1003973 pubmed publisher
    ..These findings explain the strong membrane binding of the protein and provide clues to establishing the E(rns) membrane contact, processing and secretion. ..
  53. Li L, Yu J, Li Y, Wang J, Li S, Zhang L, et al. Guanylate-Binding Protein 1, an Interferon-Induced GTPase, Exerts an Antiviral Activity against Classical Swine Fever Virus Depending on Its GTPase Activity. J Virol. 2016;90:4412-4426 pubmed publisher
    ..b>Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a highly contagious viral disease ..
  54. Madera R, Gong W, Wang L, Burakova Y, Lleellish K, Galliher Beckley A, et al. Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus challenge. BMC Vet Res. 2016;12:197 pubmed publisher
    ..Our studies provide direct evidence that pigs immunized with one dose KNB-E2 can be protected clinically from CSFV challenge. This protection is likely mediated by high levels of E2-specific and anti-CSFV neutralizing antibodies. ..
  55. Zhou J, Chen J, Zhang X, Gao Z, Liu C, Zhang Y, et al. Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B. J Virol. 2018;92: pubmed publisher
    ..In this study, we confirmed the anti-classical swine fever virus (CSFV) activity of porcine Mx1 in vitro and showed that porcine Mx2 (poMx2), human MxA (huMxA), ..
  56. Yuan J, Zhu M, Deng S, Fan S, Xu H, Liao J, et al. Classical swine fever virus induces pyroptosis in the peripheral lymphoid organs of infected pigs. Virus Res. 2018;250:37-42 pubmed publisher
    b>Classical swine fever virus (CSFV) causes a highly lethal disease in pigs, which is characterized by immunosuppression. Leukopenia is known to be a possible mechanism of immunosuppression during CSFV infection...
  57. Olesen A, Lohse L, Dalgaard M, Woźniakowski G, Belsham G, Bøtner A, et al. Complete genome sequence of an African swine fever virus (ASFV POL/2015/Podlaskie) determined directly from pig erythrocyte-associated nucleic acid. J Virol Methods. 2018;261:14-16 pubmed publisher
    ..The disease is caused by African swine fever virus (ASFV)...
  58. Wang Y, Xiao M, Chen J, Zhang W, Luo J, Bao K, et al. Mutational analysis of the GDD sequence motif of classical swine fever virus RNA-dependent RNA polymerases. Virus Genes. 2007;34:63-5 pubmed
    To define the function of the GDD motif of the RNA-dependent RNA polymerase (RdRp) of classical swine fever virus (CSFV), single amino acid substitutions were introduced into the CSFV NS5B...
  59. Wang F, Deng M, Huang Y, Chang C. Structures and Functions of Pestivirus Glycoproteins: Not Simply Surface Matters. Viruses. 2015;7:3506-29 pubmed publisher
    ..which include economically important animal pathogens such as bovine viral diarrhea virus and classical swine fever virus, possess three envelope glycoproteins, namely Erns, E1, and E2...
  60. Henke J, Carlson J, Zani L, Leidenberger S, Schwaiger T, Schlottau K, et al. Protection against transplacental transmission of moderately virulent classical swine fever virus using live marker vaccine "CP7_E2alf". Vaccine. 2018;36:4181-4187 pubmed publisher
    ..All controls were valid. Thus, it was demonstrated that a single dose vaccination in the sows efficiently protected the offspring against transplacental infection with a moderately virulent CSFV strain. ..
  61. Li Z, Qiao J, He Y, Chen Y, Wang G. Analysis of TTSuV1b antibody in porcine serum and its correlation with four antibodies against common viral infectious diseases. Virol J. 2015;12:125 pubmed publisher
    ..Meanwhile, the antibodies against Classical Swine Fever Virus (CSFV), Pseudorabies Virus (PRV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), and ..
  62. Thomas L, Bishop R, Onzere C, McIntosh M, Lemire K, de Glanville W, et al. Evidence for the presence of African swine fever virus in an endemic region of Western Kenya in the absence of any reported outbreak. BMC Vet Res. 2016;12:192 pubmed publisher
    African swine fever (ASF), caused by African swine fever virus (ASFV), is a severe haemorrhagic disease of pigs, outbreaks of which can have a devastating impact upon commercial and small-holder pig production...
  63. Ning P, Gao L, Zhou Y, Hu C, Lin Z, Gong C, et al. Caveolin-1-mediated endocytic pathway is involved in classical swine fever virus Shimen infection of porcine alveolar macrophages. Vet Microbiol. 2016;195:81-86 pubmed publisher
    ..However, very little is known about the cell invasion mechanism of classical swine fever virus (CSFV) Shimen strain...
  64. Yang L, Lu X, Fang W. Expression and purification of classical swine fever virus E2 protein from Sf9 cells using a modified vector. Biotechnol Lett. 2017;39:1821-1825 pubmed publisher
    To develop a simple method for efficient expression of classical swine fever virus (CSFV) E2 protein. The pFastBac HT B vector (pFastHTB-M1) was modified by adding a melittin signal peptide sequence...
  65. Li W, Wu B, Soca W, An L. Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain. J Virol. 2018;92: pubmed publisher
    b>Classical swine fever virus (CSFV) is the cause of classical swine fever (CSF). Nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that is a key enzyme initiating viral RNA replication by a de novo mechanism...
  66. Luo X, Pan R, Wan C, Liu X, Wu J, Pan Z. Glycosylation of classical swine fever virus E(rns) is essential for binding double-stranded RNA and preventing interferon-beta induction. Virus Res. 2009;146:135-9 pubmed publisher
    ..Many viruses, including classical swine fever virus (CSFV), have developed strategies for counteracting the IFN-alpha/beta response...
  67. Ballester M, Rodríguez F. In situ hybridization with labeled probes: assessment of african Swine Fever virus in formalin-fixed paraffin-embedded tissues. Methods Mol Biol. 2015;1247:209-18 pubmed publisher
    ..Here, we describe an optimized in situ hybridization protocol to detect African swine fever virus (ASFV) DNA in formalin-fixed, paraffin-embedded tissues using digoxigenin-labeled probes.
  68. Reis A, Netherton C, Dixon L. Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus. J Virol. 2017;91: pubmed publisher
    ..In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways. ..
  69. Li W, Wang G, Liang W, Kang K, Guo K, Zhang Y. Integrin β3 is required in infection and proliferation of classical swine fever virus. PLoS ONE. 2014;9:e110911 pubmed publisher
    ..6%, 99% and 81.7% at 24 h, 48 h and 72 h post CSFV infection, respectively. These results demonstrate that integrin β3 is required in CSFV infection and proliferation, which provide a new insight into the mechanism of CSFV infection. ..
  70. Pérez Núñez D, García Urdiales E, Martínez Bonet M, Nogal M, Barroso S, Revilla Y, et al. CD2v Interacts with Adaptor Protein AP-1 during African Swine Fever Infection. PLoS ONE. 2015;10:e0123714 pubmed publisher
    African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully ..
  71. Sheng C, Liu X, Jiang Q, Xu B, Zhou C, Wang Y, et al. Annexin A2 is involved in the production of classical swine fever virus infectious particles. J Gen Virol. 2015;96:1027-32 pubmed publisher
    ..To evaluate the potential involvement of ANXA2 in the life cycle of classical swine fever virus (CSFV), an RNA interference (RNAi) approach was utilized...
  72. Rojas M, Vasconcelos G, Dever T. An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α. Proc Natl Acad Sci U S A. 2015;112:E3466-75 pubmed publisher
    ..motif is conserved among viral orthologs of GADD34, and is necessary for the proteins produced by African swine fever virus, Canarypox virus, and Herpes simplex virus to promote eIF2α dephosphorylation...
  73. Boshoff C, Bastos A, Dube M, Heath L. First molecular assessment of the African swine fever virus status of Ornithodoros ticks from Swaziland. Onderstepoort J Vet Res. 2014;81:E1-5 pubmed publisher
    ..It is caused by the African swine fever virus (ASFV), a deoxyribonucleic acid (DNA)arbovirus...
  74. Yang Y, Qin X, Zhang W, Li Y, Zhang Z. Rapid and specific detection of porcine parvovirus by isothermal recombinase polymerase amplification assays. Mol Cell Probes. 2016;30:300-305 pubmed publisher
    ..porcine circovirus type 2, pseudorabies virus, porcine reproductive and respiratory syndrome virus, classical swine fever virus, and foot-and-mouth disease virus...
  75. Wang J, Chen S, Liao Y, Zhang E, Feng S, Yu S, et al. Mitogen-activated Protein Kinase Kinase 2 (MEK2), a Novel E2-interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway. J Virol. 2016;: pubmed
    ..The effects of the cascade on the replication of classical swine fever virus (CSFV), a fatal pestivirus of pigs, remain unknown...
  76. Suárez M, Sordo Y, Prieto Y, Rodríguez M, Méndez L, Rodríguez E, et al. A single dose of the novel chimeric subunit vaccine E2-CD154 confers early full protection against classical swine fever virus. Vaccine. 2017;35:4437-4443 pubmed publisher
    ..These results suggest that the E2-CD154 antigen could be potentially used under outbreak conditions to stop CSFV spread and for eradication programs in CSF enzootic areas. ..
  77. Liu W, Yang Y, Zhao M, Dong X, Gou H, Pei J, et al. PKR activation enhances replication of classical swine fever virus in PK-15 cells. Virus Res. 2015;204:47-57 pubmed publisher
    ..These results suggest that the activation of PKR during CSFV infection is beneficial to the virus. The virus is able to commandeer the host cell's translation machinery for viral protein synthesis while evading innate immune defenses. ..
  78. Lamp B, Schwarz L, Högler S, Riedel C, Sinn L, Rebel Bauder B, et al. Novel Pestivirus Species in Pigs, Austria, 2015. Emerg Infect Dis. 2017;23:1176-1179 pubmed publisher
    ..The emergence of this novel pestivirus species, provisionally termed Linda virus, in domestic pigs may have implications for classical swine fever virus surveillance and porcine health management.
  79. Gallardo C, Sánchez E, Pérez Núñez D, Nogal M, de León P, Carrascosa Ã, et al. African swine fever virus (ASFV) protection mediated by NH/P68 and NH/P68 recombinant live-attenuated viruses. Vaccine. 2018;36:2694-2704 pubmed publisher
    The risk of spread of African swine fever virus (ASFV) from Russia and Caucasian areas to several EU countries has recently emerged, making it imperative to improve our knowledge and defensive tools against this important pathogen...
  80. He L, Zhang Y, Fang Y, Liang W, Lin J, Cheng M. Classical swine fever virus induces oxidative stress in swine umbilical vein endothelial cells. BMC Vet Res. 2014;10:279 pubmed publisher
    b>Classical swine fever virus (CSFV) infection causes significant losses of pigs, which is characterized by hemorrhage, disseminated intravascular coagulation and leucopenia...
  81. Weber M, Streck A, Silveira S, Mósena A, Silva M, Canal C. Homologous recombination in pestiviruses: identification of three putative novel events between different subtypes/genogroups. Infect Genet Evol. 2015;30:219-24 pubmed publisher
    ..were detected: Bovine viral diarrhea virus 1 (BVDV-1) strain 3156, BVDV-2 strain JZ05-1 and Classical swine fever virus (CSFV) strain IND/UK/LAL-290...
  82. Li Y, Wang X, Sun Y, Li L, Zhang L, Li S, et al. Generation and evaluation of a chimeric classical swine fever virus expressing a visible marker gene. Arch Virol. 2016;161:563-71 pubmed publisher
    b>Classical swine fever virus (CSFV) is a noncytopathogenic virus, and the incorporation of an enhanced green fluorescent protein (EGFP) tag into the viral genome provides a means of direct monitoring of viral infection without ..
  83. Barber C, Netherton C, Goatley L, Moon A, Goodbourn S, Dixon L. Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2? and inhibiting activation of pro-apoptotic CHOP. Virology. 2017;504:107-113 pubmed publisher
    The African swine fever virus DP71L protein recruits protein phosphatase 1 (PP1) to dephosphorylate the translation initiation factor 2? (eIF2?) and avoid shut-off of global protein synthesis and downstream activation of the pro-..
  84. Zhang B, Mi S, Bao F, Guo H, Tu C, Shi J, et al. Complete Genome Sequence of a Sub-Subgenotype 2.1i Isolate of Classical Swine Fever Virus from China. Genome Announc. 2017;5: pubmed publisher
    The complete genome sequence of a sub-subgenotype 2.1i isolate of classical swine fever virus (CSFV), GD317/2011, was determined. Notably, GD317/2011 is distant from the sub-subgenotype 2...
  85. Jelsma T, van der Wal F, Fijten H, Dailly N, Van Dijk E, Loeffen W. Pre-screening of crude peptides in a serological bead-based suspension array. J Virol Methods. 2017;247:114-118 pubmed publisher
    ..of viral proteins: VP2 of canine parvovirus (CPV), gp41 of human immunodeficiency virus (HIV) and E2 of classical swine fever virus (CSFV)...
  86. Ling S, Luo M, Jiang S, Liu J, Ding C, Zhang Q, et al. Cellular Hsp27 interacts with classical swine fever virus NS5A protein and negatively regulates viral replication by the NF-κB signaling pathway. Virology. 2018;518:202-209 pubmed publisher
    b>Classical swine fever virus (CSFV) nonstructural protein NS5A is a multifunctional protein functioning in regulation of viral genome replication, protein translation and assembly by interaction with viral or host proteins...
  87. Simulundu E, Sinkala Y, Chambaro H, Chinyemba A, Banda F, Mooya L, et al. Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs. Onderstepoort J Vet Res. 2018;85:e1-e5 pubmed publisher
  88. Sheng C, Kou S, Jiang Q, Zhou C, Xiao J, Li J, et al. Characterization of the C-terminal sequence of NS5A necessary for the assembly and production of classical swine fever virus infectious particles. Res Vet Sci. 2014;97:449-54 pubmed publisher
    Recent studies show that classical swine fever virus (CSFV) NS5A is an essential replicase component, but it is not known how NS5A participates in viral particle production...
  89. Zhang C, Kang K, Ning P, Peng Y, Lin Z, Cui H, et al. Heat shock protein 70 is associated with CSFV NS5A protein and enhances viral RNA replication. Virology. 2015;482:9-18 pubmed publisher
    The non-structural 5A (NS5A) protein of classical swine fever virus (CSFV) is proven to be involved in viral replication and can also modulate cellular signaling via to its ability to interact with various cellular proteins...
  90. Muangkram Y, Sukmak M, Wajjwalku W. Phylogeographic analysis of African swine fever virus based on the p72 gene sequence. Genet Mol Res. 2015;14:4566-74 pubmed publisher
    African swine fever virus (ASFV) outbreak has been considered as an emerging and re-emerging disease for almost a century...
  91. Granberg F, Torresi C, Oggiano A, Malmberg M, Iscaro C, De Mia G, et al. Complete Genome Sequence of an African Swine Fever Virus Isolate from Sardinia, Italy. Genome Announc. 2016;4: pubmed publisher
    Previous genetic characterization of African swine fever virus isolates from the Italian island of Sardinia, where the virus has been present since 1978, has largely been limited to a few selected genomic regions...
  92. Jenckel M, Blome S, Beer M, Höper D. Quasispecies composition and diversity do not reveal any predictors for chronic classical swine fever virus infection. Arch Virol. 2017;162:775-786 pubmed publisher
    ..Thus, general host and virus factors need further investigation. ..